JPH0753626Y2 - Plasma cooling / warming bag - Google Patents

Description

[Detailed description of the device]

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bag for cooling and heating plasma which is applied to cryofiltration.

[0002]

2. Description of the Related Art Cryofiltration is a treatment method in which plasma separated from a patient's blood is cooled and the resulting gel-like substance (pathogenic substance) is filtered off, which is effective for patients with rheumatism and the like. It is getting attention because it exists. The cryofiltration will be explained with reference to FIG. 4. Blood is sent from its source to the primary filter 3'through the operation of the blood pump 1'through the blood supply line 2 ', where it is separated into blood cells and plasma. The separated blood cells are sent to the blood cell return line 4'for remixing with the purified plasma described below. On the other hand, plasma is sent from the plasma line 6'through the cooling coil section 7'on the line 6'to the secondary filter 8'by operating the plasma pump 5 ', where it is filtered. The plasma is cooled to about 4 ° C. in the coil portion 7 ′, and the cryogel of the high molecular weight substance produced by this cooling is removed from the plasma by the filtration treatment with the secondary filter. The filtrate from the secondary filter, that is, purified plasma, is returned to the purified plasma return line 9'and remixed with the blood cells returned from the primary filter 3 ', and then the original liquid temperature is heated in the heating bag 10'. While being warmed up, it is returned to the supply source.

Conventionally, as a method of cooling plasma, a tube through which plasma passes is coiled as shown by reference numeral 7'in FIG. 4, and this coiled tube is placed in an air-cooled or water-cooled thermostatic chamber (not shown). However, this has the following problems.

(A) Since it is necessary to attach a constant temperature bath to the cryofiltration device, the size of the entire device becomes large and it is difficult to move it.

(B) When the tube is coiled,
In order to eliminate the risk of tube blockage due to tube breakage, the tube must be made thick (for example, 0.8 mm or more), which reduces cooling efficiency.

(C) The refrigerant (water, antifreeze liquid, etc.) may be scattered when the tube is discarded. For this reason, the worker and the surroundings may be wet with the refrigerant, or the refrigerant may splash on the cryovibration device, causing a failure.

The present invention has been made for the purpose of eliminating such conventional problems.

[0008]

The present invention comprises an outer bag for filling a cooling or heating medium, and an inner bag for cooling or heating plasma enclosed in the outer bag. An inlet part and an outlet part for the medium, and an inner bag is provided with an inlet part and an outlet part for plasma drawn to the outside of the outer bag, and the inlet part and the outlet part The present invention relates to a plasma cooling / warming bag having a zigzag passage formed therebetween.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT An embodiment of the present invention will be described below with reference to the accompanying drawings. The bag of the present invention is shown in FIG.
As is clear from FIGS. 2 to 2, the outer bag 1 and the inner bag 2 enclosed in the outer bag 1 are provided.

The outer bag 1 is for filling a cooling or heating medium such as cooling water or heating water, and is made of a thermoplastic film, for example, a front and back film 1
It is obtained by four-way sealing a and 1b (see FIG. 2) by applying heat sealing means. In the figure, 1c is a seal part.

An inlet side tube 3 which forms an inlet for the medium is attached to one side of the lower side of the outer bag 1, and an outlet side tube 4 which forms the same outlet is attached to the other side of the upper side.

The inner bag 2 is for cooling or heating plasma, and is made of a thermoplastic plastic film like the outer bag 1. For example, the front and back films 2a, 2b.
(See FIG. 2) except for the zigzag passage 5 and heat sealing. In the figure, 2c is a seal part.

The thickness of the front and back films 2a, 2b is preferably as thin as possible in consideration of the heat exchange efficiency, but if it is too thin, the strength of the bag will become a problem, so it is usually about 0.1 to 0.5 mm. Is appropriately selected and determined from the range.

An inlet side tube 6 forming an inlet of plasma is attached to one end side of the zigzag passage 5, and an outlet side tube 7 forming an outlet thereof is attached to the other end side thereof. , 7 penetrate the seal portion 1c of the outer bag 1 and are drawn out to the outside.

A connection port 8 and a cap 9 for opening and closing the connection port 8 can be provided at the mouths of the plasma inlet and outlet tubes 6 and 7. Although not shown in the figure,
Similar means can be applied to the mouths of the inlet and outlet tubes 3, 4 of the cooling or heating medium.

A medium for cooling or heating can be filled in the outer bag 1 in advance.

FIG. 3 schematically shows a situation in which the bag of the present invention is applied to the plasma cooling part of the cryovibration device in place of the conventional cooling coil 7 '(see FIG. 4).
The tubes 3 and 4 forming the inlet and outlet of the refrigerant are filled with the refrigerant, for example, the cooling water 10 (see FIG. 2), and the forward and backward paths 12a and 1 of the refrigerant circulation line including the cooler 11 are provided.
It is connected to 2b through an appropriate connecting means 13. The cooling water is circulated between the outer bag 1 and the cooler 11 by operating a circulation pump (not shown) provided in the circulation system. In order to prevent the cold heat from being dissipated from the outer bag 1, the bag of the present invention may be housed in the cool box 14 as shown in phantom in FIG.

On the other hand, the tubes 6 and 7 forming the inlet and outlet for plasma are incorporated into the plasma line 6'of the device shown in FIG. 4 by connection to said line 6 '. Therefore, the plasma sent by operating the plasma pump 5 ′ (see FIG. 4) enters from the tube 6 into the zigzag passage 5 in the inner bag 2 connected thereto, and while passing through the passage 5, the outer bag 1 It is cooled by heat exchange with the cooling water filled inside. This cooling is performed with good thermal efficiency because the inner bag 2 has a thin thickness (for example, 0.1 to 0.5 mm). The cooled plasma 15 (see FIG. 2) enters the second filter 8 ′ (see FIG. 4) from the other end of the zigzag passage 5 through the tube 7 connected to the zigzag passage 5, and undergoes a predetermined filtering process.

As described above, since the plasma is cooled by heat exchange with the circulating cooling water in the outer bag 1 while passing through the zigzag passage 5 in the inner bag 2, the cooling equipment is simply a cooler and a circulation pump. In addition, since the circulating water can be sufficiently cooled to a predetermined temperature with a circulating water amount of about 1 liter per minute, the above equipment may be extremely small, and the cooling coil portion 7 '(Fig. 4). (See) can be made smaller than the conventional device that cools by applying a constant temperature bath.

After the cryoff isolation operation,
After the whole circuit is replaced with physiological saline or the like, the tubes 6 and 7 at the inlet and outlet of the plasma are removed from the plasma line 6 ', and then the connection ports 8 of these tubes are closed by the cap 9.

On the other hand, the circulation pump and the cooler are stopped,
At the connecting means 13, the tubes 3 and 4 are removed. In this case, for example, by removing the tubes 3 and 4 in a state where both sides of the connecting means 13 are clamped and sealed by applying appropriate clamping means, it is possible to prevent the refrigerant from scattering when the tubes are removed. Alternatively, a refrigerant tank may be provided at an appropriate place in the refrigerant circulation system, and the tubes 3 and 4 may be removed after the refrigerant is collected from the outer bag 1 into the tank.

After being used for cooling the plasma, all the plasma is recovered from the zigzag passage 5 of the inner bag 2 of the bag,
Even if the refrigerant is or is not recovered from the inside of the outer bag 1, it is harmless, so that the bag can be discarded as it is.

The bag of the present invention can be applied to heating plasma instead of cooling it. In the case of heating, a heater is installed instead of the cooler 11.

[0024]

According to the present invention, the following effects can be obtained.

(A) Since a circulation pump and a cooler (or a heater) for circulatingly cooling (or heating) the cooling water (or heating water) in the outer bag may be simply provided, a conventional constant temperature bath is provided. The cryovibration device can be downsized compared to the type.

(B) Since the zigzag passage of plasma is formed in the inner bag, the wall thickness of the diaphragm can be made thinner than that of the conventional coil system, and the cooling (or heating) efficiency can be improved.

(C) After use, since no harmful substances remain in the bag, it can be disposable.

[Brief description of drawings]

FIG. 1 is a partially cutaway front view showing an embodiment of the present invention.

FIG. 2 is a cross-sectional view of a use state taken along line 2-2 of FIG.

FIG. 3 is an explanatory view schematically showing one usage situation of the product of the present invention.

FIG. 4 is an explanatory view of a conventional cryovibration device.

[Explanation of symbols]

 1 Outer bag 2 Inner bag 3 Tube 4 Tube 5 Zigzag passage 6 Tube 7 Tube 8 Connection port 9 Cap

Claims (1)

[Scope of utility model registration request] 1. An outer bag for filling a cooling or heating medium, and an inner bag for plasma cooling or heating enclosed in the outer bag, wherein the outer bag has an inlet and an outlet for the medium. The inner bag is provided with an inlet portion and an outlet portion for the plasma drawn to the outside of the outer bag, and a zigzag passage is formed between the inlet portion and the outlet portion. A bag for plasma cooling and heating characterized by being