TW201638546A - Heat exchanger, heat exchange apparatus, heater and heat exchanging method - Google Patents

Abstract

The objective of the present invention is to provide a heat exchanger having a configuration and structure capable of efficiently heating fluid inside a fluid flow path. In the present invention, a substantially S-shaped loop (SLTE) is formed at a substantial central part (C) and a substantially helical winding tube (STE) is formed at an outer periphery of the loop (SLTE). A fluid inlet (12) and a fluid outlet (13) are arranged along a direction substantially similar to or substantially opposite to a side part (S). The loop (SLTE), the winding tube (STE), the fluid inlet (12) and the fluid outlet (13) are substantially arranged on the same plane. A cross-section of the winding tube (STE) is formed into a substantially elliptical shape. A flat rate of the substantially elliptical shape is within a range of 30% to 70%. Each tube (T) that constitutes the winding tube (STE) is fixed at the adjacent side part (S) with thermal welding.

Description

Heat exchanger, heat exchange device, warmer and heat exchange method

The present invention relates to a heat exchanger, a heat exchange device, a warmer, and a heat exchange method which are disposed in the middle of a blood purification circuit used for hemodialysis, blood purification treatment, hypothermia treatment, and the like. These systems are used for both warming and cooling.

The present invention is generally directed to a so-called substantially spirally wound tube (winding tube) constituting a heat exchanger. Further, the present invention relates to a heat exchange device for flowing a liquid (processed liquid) such as blood, a dialysate or a replenishing liquid into the heat exchanger constituted by the above-mentioned winding tube, by For example, a heater (heater) or a cooling device warms or cools the outer side (outer surface) of the winding tube, and performs heat exchange by heat conduction on the wall surface of the winding tube, thereby treating the internal liquid (treated) Liquid) for heat exchange.

More specifically, the present invention relates to a heat exchange device for flowing a liquid (processed liquid) such as blood, dialysate, replenishing liquid, or the like into a tube (winding tube) which is wound in a substantially spiral shape. In the heat exchanger configured, the outer side of the winding tube is heated or cooled by, for example, a heater (heater) or a cooling device, and heat is applied by heat conduction on the outer surface of the winding tube. Exchange, thereby warming or cooling the internal liquid. In particular, the present invention relates to an improvement of a heat exchanger and a heat exchange device having a shape and a structure capable of efficiently heating or cooling a liquid (processed liquid) in a flow path, and a heat exchange method using the same.

Moreover, the present invention relates to a heat exchanger, a heat exchange device, and the use of the same In the heat exchange method, the heat exchanger is configured by joining a liquid (processed liquid) tube and a treatment liquid tube, and the pair of tubes (composite tubes) are configured as a wound tube, the heat exchange device is for blood The liquid to be treated such as the replenishing liquid and the treatment liquid (warm water, cold water) are respectively circulated in the heat exchanger constituted by the winding tube (composite tube), and the liquid to be treated is heated by the treatment liquid The internal treated liquid is heated or cooled by cooling, that is, by heat conduction from the outer surface of the winding tube.

In the blood purification treatment method, the blood taken out from the patient is subjected to extracorporeal circulation, and is carried out by a blood purifier (filled with a hollow fiber membrane as a filter, a particulate adsorbent, etc.). The treatment for the purpose of removing unnecessary substances by membrane separation and adsorption. At this time, a double filtration treatment method in which the replenishing solution or the dialysate is introduced into the blood purifier or the filtered plasma is further flowed into the other blood purifier is performed. The extracorporeal blood lines are again sent back to the patient's body after purification. Therefore, in order to prevent the blood of the patient from being cooled in the extracorporeal circulation, there is a need to warm the blood by the heat exchange device.

Further, in the hypothermia treatment method, in order to achieve protection and resuscitation of the brain, the patient's body temperature is lowered to 32 ° C to 34 ° C to cool the blood, and after the resuscitation, the blood is warmed to restore the temperature. Treatment.

At present, a heat exchanger (hereinafter also referred to as a heat exchanger unit) that forms a liquid flow path using a tube, a bag, a sheet, a bellows, a hollow fiber membrane, or the like formed of a material such as plastic or metal has been put to practical use.

The heat exchanger is disposed in the middle of the extracorporeal circuit, and the liquid to be treated flows into the heat exchanger, and the heat exchanger is brought into contact with the heating device (heater) or the cooling device, and the constituent materials (plastic) , metal), and flowing in the heat exchanger The treated liquid is subjected to heat exchange to warm or cool the liquid to be treated (blood, plasma or replenishing solution, dialysate, etc.).

In the heating and cooling methods, the method of heating and cooling the liquid flowing inside can be widely divided by directly contacting the heat exchanger (the outer surface) with the heater or the cooling device, and adding A method in which warm, cooled water (heat medium) flows into a heat exchanger to exchange heat with the liquid to be treated flowing in the heat medium and the heat exchanger.

[Prior Art 1]

In the case of the substantially central portion C, the present invention has a so-called "substantial S-shaped circuit SLTE", and is wound around the outer circumference of the circuit SLTE. The invention of a heat exchanger having a flexible tube body (forming a winding tube) in a "substantially spiral shape" (in order to explain the components of the invention described in the patent document in an easy-to-understand manner, the figure number and the symbol are indicated In order to distinguish from the symbol of the invention, the <I> is added to the figure number and symbol of the patent document.

Specifically, in the figure <1>, the flexible tube body <1> of a predetermined length is first bent into an S shape, and then the flexible tube body <1> which starts to draw the S-shaped direction is started. Along with and in contact with the curve for ending the drawing of the S word, the flexible tube body <1> ending the drawing of the S-shaped direction is brought along and in contact with the curve for starting the drawing of the S-word, and the above-described operation is repeated for a predetermined number of times. The flexible tube bodies <1> that are in contact with each other are bonded to each other.

In Fig. 2, an example in which the liquid inlet <2> and the fluid outlet <3> of the flexible tube body <1> of Fig. <1> are oriented in substantially opposite directions is described. Hereinafter, in order to simplify the description, the "flexible pipe body" is simply referred to as "pipe or pipe T".

The heat exchanger of Patent Document 1 is used in a temperature control manner in which a winding tube is fixed by a heating heater (hot plate) so that the surface temperature of a portion to which the temperature sensor is fixed becomes The set temperature.

The conventional heat exchange device 601 uses a substantially rectangular heater 521 as illustrated in FIG. 19, and the winding tube STE in which the temperature sensor TS is mounted on the heat exchanger 611 is not in contact with the warmer 521. The portion (hereinafter referred to as a non-contact portion NCP) heats the heat exchanger 611 to control the temperature of the liquid in the heat exchanger 611 to a predetermined temperature. Further, a heating portion 523 is attached to a surface opposite to the surface of the heat exchanger 611 that is in contact with the warmer 521 (the metal wire ML is embedded therein) ("U", "D" at the end of the symbol in the figure "Means of the upper side and the lower side respectively".

More specifically, when the heater 521 is heated from both the U direction and the lower D direction of the upper portion of the heat exchanger 611, a pair of upper heater 521U and lower heater 521D are used. The upper warming portion 523U, the upper warmer 521U, the heat exchanger 611, the lower warmer 521D, and the lower warming portion 523D are arranged to overlap each other as shown in Fig. 20 .

The temperature sensor TS is connected to the temperature controller TC (also referred to as "temperature controller") via the heating line HL, so that the surface (non-contact portion NCP) of the warmer 521 near the temperature sensor TS becomes The method of setting the temperature is controlled.

[Priority Technology 2]

Patent Document 2 discloses an extracorporeal circulation circuit and an extracorporeal circulation system for liquid heating/cooling, in which a flow path portion or the like is formed into a unitary and planar sheet by plastic, and at least a downstream side is formed as a crucible. The cross section of the meandering flow path portion (second flow path portion) has a substantially semi-arc shape, and the second flow path portion has a flat surface for adhering to the heating/cooling plate. surface.

[Prior Art 3]

In general, the liquid flow path of the bag-shaped or sheet-shaped heat exchanger is formed by welding a portion corresponding to the flow path by high-frequency processing or the like to form a plurality of partitions which are formed in a meandering or curved shape. The liquid flow path is formed inside. The heat exchanger is heated by a heater, and a liquid such as blood or a chemical liquid is caused to flow through the liquid flow path to perform heating.

[Prior Art 4]

As another heat exchanger, a metal bellows shape, a thread shape, a plurality of tubular, and a hollow fiber-shaped heat exchanger made of plastic have been put to practical use. The warm water or the cooling water flows therein to warm and cool the liquid. Typically, water that has been warmed or cooled in the water channel is pumped to the heat exchanger to exchange heat with the liquid.

[Previous Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Application Laid-Open No. 3096817 (refer to the specification paragraphs [0016], [0021], <FIG. 1>, <FIG. 2>)

[Patent Document 2] Japanese Patent Laid-Open Publication No. 2008-173139 (refer to Abstract, <Fig. 1)

According to the invention of the present inventors, the invention described in the patent document 1 has the following problems.

[Question 1]

In the invention of Patent Document 1, although a flexible plastic such as a vinyl chloride resin is used as a tube, the plastic materials are basically safe in addition to thermal conductivity, and are considered to be safe for use in a medical field. Sex, and the tube wall is formed thicker. Thus, since the wall thickness increases in reality, the heat exchange rate by the thicker tube wall is extremely low. Further, according to research by the inventors of the present invention, it has been found that one of the reasons for the low heat transfer rate (more accurately, the "total heat transfer rate" is very low) is that, in addition to the low thermal conductivity of the original plastic material, The cross section of the tube is so-called "circular (substantially "true circle")", and it is in contact with the heater (heater), so the heating area is small, and heat is difficult to transfer to the tube section (liquid flow path). The central part (lower heating efficiency) is also a big reason.

[Question 2]

Further, in the production of the winding tube of the heat exchanger described in Patent Document 1, the side portions of the adjacent tubes are fixed by a solvent or an adhesive, and the solvent is applied. Uneven and problem with the working environment. Therefore, it is desirable to have a heat exchanger which can be easily bonded and heated with high efficiency without using a solvent.

[Question 3]

In the heating of the heat exchanger described in Patent Document 1, although the hot plate is heated by the heating wire, the portion in contact with the winding tube is cooled by the hot plate, so that the portion not in contact with the winding tube becomes excessive. The high temperature causes a local temperature unevenness to increase. If the high temperature portion reaches 42 ° C or higher, in the case of blood, the heat is transferred to the blood to denature the blood protein.

[Question 4]

The invention described in Patent Document 1 further discloses the following problems.

The warmed liquid is blood (plasma), a fluid supplement added to the blood, and a dialysate which is indirectly contacted with blood by a membrane or the like.

If the blood reaches 42 ° C or higher, the blood protein is denatured, so the set temperature is only about 42 ° C, and the temperature sensor TS must be installed at the highest temperature, so that the position becomes about 42 ° C or less. The way to control.

The portion that becomes the highest temperature is the non-contact portion NCP, and it is necessary to set the portion that is the highest temperature to the set temperature.

The temperature of the warmer 521 can be accurately controlled to a set value, which is the non-contact portion NCP and is a surface (NCPTS) near the mounting position of the temperature sensor TS.

Therefore, even if the liquid in the heat exchanger 611 of the contact portion CP is set to, for example, 42 ° C, the liquid can be heated only at a temperature much lower than 42 ° C, and the temperature is naturally lowered (cooled). The tendency is that the heating efficiency is not good.

According to the research by the inventors of the present invention, the invention described in Patent Document 2 has the following problems.

[Question 4]

When the heating/cooling plate is adhered only to the flat portion of the (second) flow path portion formed in a meandering shape, it is different from the both sides (upper U side and lower D side) than for heating/cooling. In the case of warming, the heating efficiency on the opposite side (upper U side) of the flat portion (the lower D side) is inferior.

[Question 5]

Further, in the case of a sheet formed of a rigid plastic sheet, in reality, a complete flat surface is not formed due to shrinkage during molding, and a slight uneven portion is likely to be formed in a portion where a flow path is formed, although it is not a hard material. Deformed by pressurization, but with heating plate The adhesion will be worse.

Further, in the prior art 3, in the case where the pattern of the liquid flow path is formed, there is a case where the heater is not properly adhered to the heater or the liquid flow path is deformed by the pressure to cause uneven heating. However, there is a problem that it is difficult to form a correct internal flow path.

Further, in the prior art 4, although local temperature unevenness does not occur as in the case of a hot plate, the heat exchangers still have the advantages of high cost of parts, processing, and assembly, and even complicated structures, and bubbles. The poor discharge will cause problems such as blood coagulation or a large amount of blood filling.

In order to solve the above problems, the inventors of the present invention have repeatedly studied the results, and found that in a heat exchanger (unit) composed of a spiral tube, by setting a specific structure, the overall heat transfer rate can be greatly improved (the liquid to be treated) The heat transfer rate), and achieve the invention. That is, the present invention is as follows.

The present invention first provides inventions [1] to [3] (hereinafter referred to as invention group 1) relating to the following heat exchangers.

[1] The present invention provides a heat exchanger (11, 111), which is a liquid heat exchanger (11, 111), characterized in that the heat exchanger (11, 111) is an inflow port having a liquid and The tube of the outflow port is formed, and a substantially S-shaped circuit (SLTE) is formed in the substantially central portion (C), and a substantially spiral winding tube (STE) is formed on the outer circumference of the circuit (SLTE). The liquid inflow port (12) and the liquid outflow port (13) are disposed adjacent to or apart from each other in substantially the same direction as one direction of the side portion (S) of the heat exchanger. The position is disposed at a separate position in a direction substantially opposite to one direction of the side portion (S) and one direction of the other side portion (S), the loop (SLTE), the winding tube (STE), The liquid inflow port (12) and the liquid outflow port (13) are disposed on substantially the same plane, and the cross section of the winding tube (STE) is formed into a substantially elliptical shape, and the flattening ratio of the substantially ellipse is 30 to 70. In the range of %, the side portions (S) adjacent to the respective tubes (T) constituting the winding tube (STE) are fixed by heat welding.

[2] The present invention further provides a heat exchanger (211), which is a liquid heat exchanger (211), characterized in that the heat exchanger (211) is a tube having a liquid inlet and an outlet. In the substantially central portion (C), a substantially spiral winding tube (STE) is formed by the tube, and the liquid inflow port (12) and the liquid outflow port (13) are oriented toward the heat. One direction of the side (S) of the exchanger is substantially the same direction, disposed at an adjacent or separate position, or substantially in one direction toward the side (S) and one direction of the other side (S) The opposite direction is disposed at a separate position, and the winding tube (STE), the liquid inflow port (12), and the liquid outflow port (13) are disposed on substantially the same plane, and the winding tube (STE) The cross section is formed in a substantially elliptical shape, and the flattening ratio of the substantially elliptical shape is in the range of 30 to 70%, and the side portions (S) adjacent to the respective tubes (T) constituting the winding tube (STE) are Heat welded and fixed.

[3] The present invention further provides a heat exchanger (311), characterized in that in a heat exchanger (311) for liquid, a pair of composite pipes (TW) are formed, and the pair of composite pipes (TW) It is composed of a plurality of tubes each having a liquid inlet and an outlet for treating a liquid and a liquid to be treated as a heat medium, and the liquid to be treated (BLT) and the liquid to be treated (TLT) The side portions (S) are joined to each other, and a winding tube (STEW) for winding the composite tube (TW) into a substantially spiral shape is formed on the outer circumference of the substantially central portion (C), and the composite tube (TW) is formed in the composite tube (TW). The liquid to be treated (32) and the liquid to be treated (43) are disposed adjacent to each other in substantially the same direction as the one side of the heat exchanger side (S), and the liquid outflow port (33) And the treatment liquid inflow port (42) is disposed adjacent to each other in substantially the same direction as one direction of the side portion (S), the liquid inflow port (32) and the treatment liquid outflow port (43), and the liquid outflow port ( 33) and the treatment liquid inflow port (42), which is disposed apart in one direction of the same side portion (S), or along one direction of the side portion (S) and The one side portion (S) is disposed in one direction, and the winding tube (STEW), the liquid inflow port (32), the processing liquid outflow port (43), the liquid outflow port (33), and the processing liquid inflow port (42) are disposed. , arranged on substantially the same plane.

The present invention further provides inventions [4] to [6] (hereinafter referred to as invention group 2) relating to the following heat exchange devices.

[4] The present invention provides a heat exchange device (1), which is a heat exchange device (1) for performing heat exchange of liquid, characterized in that it has a heat exchanger (21) having a heat exchange portion; and an invention [1] The heat exchanger (11, 111, 211) for fluids described in [2]; the heat exchanger (21) has a substantially plate-shaped upper body (22U) and a lower body (22D), The upper body (22U) and the lower body (22D) are mounted on a surface opposite to the contact surface with the heat exchangers (11, 111, 211), and the heat exchange portion (23) having a substantially planar shape including a heat source is attached. The heat exchanger (11, 111, 211) is disposed between the upper body (22U) and the lower body (22D).

[5] The present invention provides a heat exchange device (101), which is a heat exchange device (101) for performing heat exchange between liquids, comprising: a heat insulating material (51); and the invention described in [3] The liquid heat exchanger (311); the heat insulating material (51) has a substantially plate-shaped upper body (52U) and a lower body (52D) between the upper body (52U) and the lower body (52D), The above heat exchanger (311) is disposed.

[6] The present invention provides a heat exchange device 201, which is a heat exchange device (201) for performing heat exchange between liquids, comprising: the heat exchanger (21); and the heat described in the invention [3] The exchanger (311); the heat exchanger (21) has a substantially plate-shaped upper body (22U) and a lower body (22D), the upper body (22U) and the lower body (22D), and the heat exchanger (311) The surface on the opposite side of the contact surface is provided with a substantially planar heat exchange portion (23), and the heat exchanger (311) is disposed between the upper body (22U) and the lower body (22D).

The present invention further provides inventions [7] to [8] (hereinafter referred to as invention group 3) relating to the following heat exchange methods.

[7] The present invention provides a heat exchange method for performing a liquid to be treated and a liquid to be treated The heat exchanger according to the invention [3], wherein the heat exchanger (311) having the winding tube (STEW) described above is used, and the following steps (1) to (3) are included: (1) a step of introducing the liquid to be treated from the liquid inflow port (32) into the liquid pipe (BLT) to flow the liquid to be treated to the liquid outflow port (33), and (2) using the liquid as the processing liquid. Temperature-adjusted warm water or cooling water, the step of introducing the treatment liquid into the treatment liquid treatment liquid pipe (TLT) from the treatment liquid inlet (42), and flowing the treatment liquid toward the treatment liquid outlet (43) And (3) a step of performing heat exchange between the liquid to be treated and the liquid to be treated via the liquid pipe (BLT) and the wall surface of the processing liquid pipe (TLT); and performing the liquid to be treated by the processing liquid Heating or cooling is performed to carry out heat exchange of the above-mentioned liquid to be treated.

[8] The present invention provides a heat exchange method comprising the heat exchange device (101, 201) described in the invention [5] or [6], and comprising the step (1) described in the invention [7] To (3), the liquid to be treated is heated or cooled by treating the liquid, thereby performing heat exchange of the liquid to be treated.

The present invention further provides inventions [9] to [10] (hereinafter referred to as invention group 4) relating to the following heat exchange devices.

[9] The present invention provides a heat exchange device (1001, 1101), which is a heat exchange device (1001, 1101) for performing heat exchange of liquid, characterized in that it has a heat exchanger for circulating the liquid (11, 111, 211, 511); and a warmer (21, 121) having a heating portion; the heat exchanger (11, 111, 211, 511) and the warmer (21, 121) have both The shape observed on the upper (U) side is a substantially circular ring shape or a substantially circular shape. The diameter of the heat exchanger (11, 111, 211, 511) is formed to be substantially the same as the diameter of the warmer (21, 121), and the warmer (21, 121) is in contact with the heat exchanger ( 11.111, 211, 511) on the opposite side of the contact surface, the substantially planar heating portion (23, 123) is mounted on the warmer (21, 121) and the heat exchanger (11, Between the contact portions (CP) of 111, 211, and 511), a temperature sensor (TS) is disposed, and a temperature controller (TC) is connected to the temperature sensor (TS) at the contact portion (CP) The position controls the set temperature of the liquid flowing through the heat exchangers (11, 111, 211, 511).

[10] The present invention provides the heat exchange device (1001, 1101) according to the invention [9], wherein the heat exchanger (11, 111, 211, 511) is provided with an inlet and a flow having the liquid The outlet pipe is configured to form a substantially spiral winding tube (STE) on the outer circumference of the substantially central portion (C) so as to face the side substantially opposite or substantially opposite to the heat exchanger ( In one direction of S), the liquid inflow port (12) and the liquid outflow port (13) are disposed, and the winding tube (STE), the liquid inflow port (12), and the liquid outflow port (13) are disposed in a substantial manner. On the same plane.

[11] The present invention provides the heat exchange device (1001, 1101) according to the invention [9], characterized in that the warmer (21, 121) is capable of sandwiching the heat exchanger (11) from both sides. , 111, 211, 511), having a pair of upper warmers (21U, 121U) and lower warmers (21D, 121D), above the upper warmer (21U, 121U) and the lower warmer (21D, 121D) and The surface on which the heat exchangers (11, 111, 211, and 511) are in contact with each other is a surface on the opposite side, and upper heating portions (23U, 123U) and lower heating portions (23D, 123D) are attached.

The heat exchange device (1001, 1101) according to any one of the inventions [9] to [11] wherein the heat exchanger (11, 111, 211, 511 is fixed) And a casing (31) of the above warmer (21, 121), the casing (31) having a pair of upper casing (31U) and a lower casing (31D), in the heat exchanger (11, 111, 211) 511) and the warmer (21, 121) are disposed in the outer casing (31), according to the upper casing (31U), the upper heating portion (23U, 123U), the upper heater (21U, 121U), and the heat The exchangers (11, 111, 211, 511), the lower heating sections (23D, 123D), the lower warmers (22D, 122D), and the lower casing (31D) are arranged in this order.

The present invention further provides inventions [13] to [14] (hereinafter referred to as invention group 5) relating to the following heat exchangers.

[13] The present invention provides a heat exchanger (11, 111, 211) for use in the heat exchange device (1001, 1101) described in the invention [10], characterized in that the heat exchange device (1001, 1101) The heat exchanger (11, 111, 211) is a substantially elliptical cross section of the winding tube (STE), and the flattening ratio of the substantially elliptical shape is 70%.

[14] The present invention provides a heat exchanger (511) for use in the heat exchange device (1001, 1101) of the invention [10], characterized in that the upper heater (21U, 121U) and the lower portion are heated (21D, 121D), the heat exchanger (511) composed of the heat exchanger (511) of the heat exchange device (1001, 1101) and a coiled tube (STE) having a substantially circular cross section. The pressurization was performed, and the cross section of the winding tube (STE) was formed into a substantially elliptical shape; the flattening ratio of the substantially elliptical shape was 70%.

The present invention further provides inventions [15] to [16] (hereinafter referred to as invention group 6) relating to the following warmers.

[15] The present invention provides a warmer (21, 121) mounted to a heat exchanger (11, 111, 211, 511) having a substantially circular shape, and is characterized in that the warmer (21) 121), the shape observed from the upper (U) side has a substantially circular ring shape or a substantially circular shape, and the diameter is formed as a heat exchanger having a substantially circular shape as viewed from the upper (U) side (11) The diameters of 111, 211, and 511) are substantially the same, and the surface on the opposite side of the surface where the warmers (21, 121) are in contact with the heat exchangers (11, 111, 211, and 511) is substantially flat. The temperature heating unit (23, 123) is provided with a temperature sensor (TS) at a position of a contact portion (CP) with the heat exchanger (11, 111, 211, 511).

[16] The present invention provides the warmer (21, 121) according to the invention [15], wherein the heat exchanger (11, 111, 211, 511) is sandwiched from both sides, There is a pair of upper warmers (21U, 121U) and lower warmers (21D, 121D), and the upper heater (21U, 121U) and the lower warmer (21D, 121D) and the above heat The surface on which the exchanger (11, 111, 211, 511) contacts is the opposite side surface, and the upper heating portion (23U, 123U) and the lower heating portion (23D, 123D) are attached to the heat exchanger (11). The position of the contact portion (CP) of 111, 211, and 511) is provided with a temperature sensor (TS).

The present invention can achieve the following advantageous effects.

The heat exchangers 11, 111, and 211 of the invention group 1 of the present invention and the heat exchange device 1 of the invention group 2 are:

(1) The winding tube STE having a substantially elliptical (flat) cross section formed with the heat exchanger 21 The body 22 having a substantially plate shape (the upper body 22U and the lower body 22D) has good adhesion and can increase the contact area. Further, since the distance from the heat exchange portion 23 of the heat exchanger 21 to the center portion LC of the liquid flow path of the winding tube STE becomes short, the heat exchange efficiency can be improved.

(2) Based on (1), the length of the winding tube STE (fluid flow path) can be shortened, and the overall size can be reduced.

(3) Since the side portions S of the adjacent tubes T constituting the winding tube STE are fixed by heat fusion, the problem of uneven application of the solvent and the working environment as in Patent Document 1 can be eliminated. Similarly, the use of these heat exchange methods (Invention Group 3) can of course exert the above effects.

Further, the heat exchanger 311 of the invention group 1 of the present invention (and the heat exchange devices 101 and 201 of the invention group 2): a tube (composite pipe) TW which is a pair of the liquid pipe BLT to be treated and the processing liquid pipe TLT. By the winding pipe STEW, the liquid to be treated (blood, replenishing liquid, etc.) flows through the liquid to be treated BLT, and the processing liquid (warming water, cooling water) flows through the processing liquid pipe TLT. The treatment liquid (warmed water, cooling water) in the liquid pipe TLT is treated, and the liquid to be treated (blood, replenishing liquid, etc.) in the liquid to be treated BLT is heated or cooled via the pipe wall, thereby:

(1) The heat exchanger itself can be manufactured simply and inexpensively. Moreover, since the pair of tubes (composite tubes) TW are wound in a substantially planar shape, the overall size can be reduced.

(2) The performance specification can be easily adjusted by adjusting the lengths of the liquid pipe BLT to be treated and the liquid pipe TLT.

(3) the liquid to be treated (blood, replenishing liquid, etc.) introduced into the liquid pipe BLT to be treated, and air is less likely to enter the inside of the liquid pipe BLT, in particular, even When the blood flows, it is still not easy to coagulate.

(4) Even if the heating or cooling water flowing through the processing liquid pipe TLT is a low flow rate, the heat exchange effect can be sufficiently enhanced. Furthermore, although the heat exchange efficiency depends on the length of the tube, as long as the flow rate is in the range of 100 to 300 mL/min, the heat exchange efficiency can be sufficiently improved. Therefore, the overall device is not too large, and the accessory device can be simplified.

(5) Since the heating or cooling water flows in the processed liquid pipe TLT to be wound, the heating or cooling water does not substantially become turbulent on the way, and the temperature unevenness is not easily caused.

(6) The heat-welded portion is not damaged or leaked as in the conventional bag-shaped heat exchanger.

(7) It does not cause the material to melt at a local high temperature part or the risk of blood denaturation as in the heater type heating method, and does not occur if it is not attached to the heater, the heating performance will drastically decrease. The situation.

(8) If heat is exchanged by further covering the heat insulating material 51, the heat exchange efficiency is improved.

(9) Further, by heating the above-described winding tube STEW to the heat exchanger 21, the heat exchange efficiency is further improved.

Similarly, the above effects can be exerted by using these heat exchange methods (Invention Group 3).

The present invention has the following advantageous effects.

In the heat exchange devices 1001 and 1101 of the invention group 4 of the present invention (consisting of the heat exchangers 11, 111, 211, 311, and 511 of the invention group 5 and the warmers 21 and 121 of the invention group 6):

(1) Since the heat exchanger 11 (hereinafter, the heat exchangers 111, 211, and 511 are the same) and The heater 21 (hereinafter, the warmer 121 is also the same) has a substantially circular shape and is formed substantially in the same size (diameter) (if the diameter of the heat exchanger 11 is set to 100, the diameter of the warmer 21) In the range of 90 to 110, therefore, when the heat exchanger 11 and the warmer 21 are overlapped and arranged, or even in the heating direction, the heating region of the heat exchanger 11 is fixed. , and can be heated evenly.

Thereby, only the heat exchanger 11 can be heated intensively, and the heating efficiency can be improved.

(2) The temperature sensor TS is disposed between the warmer 21 and the contact portion CP of the heat exchanger 11, and the set temperature is controlled at the position of the contact portion CP, whereby the liquid (blood, etc.) can be kept in actual The temperature is set to prevent the liquid to be treated (blood, etc.) from being excessively warmed. Further, the heating temperature can be increased without lowering the heating temperature of the heat exchanger 11.

(3) The heating efficiency can be further improved by making the cross section of the winding tube STE constituting the heat exchanger 11 substantially elliptical.

1, 101, 201, 1001, 1101‧‧‧ heat exchange device

11, 111, 211, 311, 511 ‧ ‧ heat exchangers

12, 32, 512, 632 ‧ ‧ liquid inflow (treated liquid / blood, room temperature water)

13, 33, 513, 633 ‧ ‧ liquid outflow (treated liquid / blood, room temperature water)

21,121,521‧‧‧heat exchangers (heating machines, heating machines, cooling machines)

21D, 121D, 521D‧‧‧ lower heater

21U, 121U, 521U‧‧‧ upper warmer

22‧‧‧Ontology

22D‧‧‧lower ontology

22M‧‧‧ Groove Department

22U‧‧‧ upper body

23, 123, 523‧ ‧ heat exchange section (heating section, heating section, cooling section)

23D, 123D, 523D‧‧‧ lower heating section

23U, 123U, 523U‧‧‧ upper heating department

31‧‧‧ Shell

31D‧‧‧ lower casing

31U‧‧‧Upper casing

42, 642‧‧ ‧ treatment liquid inlet (treatment liquid / warm water, cold water)

43,643‧‧‧Processing liquid outflow (treatment liquid / warm water, cold water)

51‧‧‧Insulation

52‧‧‧ body

52D‧‧‧lower ontology

52M‧‧‧ Groove Department

52U‧‧‧ upper body

a‧‧‧Long radius

b‧‧‧Short radius

B‧‧‧Bolts

BH‧‧‧Bolt head

BL‧‧‧Liquid (treated liquid/blood)

BLT‧‧‧Liquid tube (for treated liquid/blood)

C‧‧‧ Central Department

CP‧‧‧Contacts

FLT‧‧‧Processed liquid pipe (for treated liquid / normal temperature water)

HL‧‧ electric hotline

LC‧‧‧ Distance to the center of the stream

ML‧‧‧ metal wire

MLD‧‧‧low metal wire

MLU‧‧‧Upper metal wire

MP‧‧‧Metal plate

MPD‧‧‧ lower metal plate

MPU‧‧‧Upper metal plate

N‧‧‧ nuts

P‧‧‧ pump

SLTE‧‧‧ roughly S-shaped circuit

STE, STEW‧‧‧ roughly spiral winding tube

T‧‧‧ tube

TC‧‧‧temperature control device

TL‧‧‧ treatment liquid (warm water, cold water)

TLT‧‧‧Processing liquid pipe (for treatment liquid / warm water, cold water)

TS‧‧‧Temperature Sensor

TW‧‧‧Composite tube

W‧‧‧ Washer

Fig. 1 is a general view (perspective view) of the heat exchanger 11 according to the first embodiment of the present invention, which is fixed to the heat exchanger 21.

2 is an overall view (a schematic plan view) of the heat exchanger 11 according to the first embodiment of the present invention and the heat exchanger 111 according to the second embodiment, wherein (A) is the first embodiment and (B) is the second embodiment. .

Fig. 3 is a perspective view (perspective view) of a heat exchanger 211 according to a third embodiment of the present invention.

Fig. 4 is a schematic view showing an example of a method of manufacturing the heat exchangers 1, 111 and 211 of the present invention.

5(A) and (B) are heat exchangers 1, 111, 211 constituting the present invention, and conventional ones. A cross-sectional view of the winding tube of the heat exchanger 501.

Fig. 6 is an enlarged cross-sectional view showing a winding tube STE constituting the heat exchangers 1, 111 and 211 of the present invention.

Fig. 7 is a plan view showing a heat exchanger 311 according to a fourth embodiment of the present invention.

Fig. 8 is a partial cross-sectional view of Fig. 7, (A) is a cross-sectional view taken along line A-A, (B) is a cross-sectional view taken along line B-B, and (C) is a cross-sectional view taken along line C-C.

Fig. 9 is a partially enlarged cross-sectional view of the heat exchange device 101 (201) in which the heat exchanger 311 is attached to the heat insulating material 51 (heat exchanger 21), and the heat exchanger 311 corresponds to Fig. 8(C).

Fig. 10 is a plan view of the heat exchanger 311 used in the second embodiment.

Fig. 11 is a plan view of the heat exchanger 511 used in Comparative Example 2.

Fig. 12 is a plan view of the heat exchanger 611 used in Comparative Example 3.

Fig. 13 is a partially enlarged cross-sectional view showing the heat exchange device 1001 of the present invention, wherein Fig. (A) is a cross-sectional view, and (B) is a cross-sectional view taken along line A-A' of Fig. (A).

Figure 14 is a partially enlarged cross-sectional view of the warmer 21 of the present invention.

Figure 15 is an exploded view of the warmer 21 of the present invention.

Figure 16 is an exploded view of the warmer 121 of the present invention.

Fig. 17 is a schematic view showing the heat exchange device 1001 of the present invention and the heat exchange device 1 used in a heating test.

Fig. 18 is a schematic view showing an embodiment of another heat exchange device 1101 of Fig. 17.

Fig. 19 is a schematic view showing a conventional heat exchange device 601 and a heat exchange device 601 used for a heating test.

20 is a partially enlarged cross-sectional view of a conventional warmer 521.

Hereinafter, the present invention will be described in detail with reference to the drawings.

Hereinafter, in order to clearly describe the present invention, the following definitions are made based on the description of the drawings.

(Definition 1) The term "base end PE side" means an end portion on the side where the liquid inflow port 12 and the liquid outflow port 13 are attached as illustrated in Figs. 2 and 7 . When the center of the base end PE side is set to a position where the clock is approximately 9 o'clock, it means a period from the maximum to 7:30 to approximately 10:30.

In addition, in the description of the present case, the "... side" may be described as "...direction" (the same applies to the "... side" below).

(Definition 2) The "end DE side" is an end portion on the opposite side to the "base end PE side" as exemplified in Figs. 1 and 2 . When the center of the end DE side is set to a position of approximately three o'clock of the clock, it means a period from approximately 1:30 to approximately 4:30.

(Definition 3) The "upper U side" means the outer side of the paper surface as illustrated in Figs. 1 and 2 .

(Definition 4) The "lower D side" means the inside of the paper surface as illustrated in Figs. 1 and 2 .

(Definition 5) The "length L direction" is as illustrated in Figs. 1 and 2, and means the direction from the base end PE side to the end DE side of the heat exchanger.

(Definition 6) The "first side portion S1 side" is the lower right side of the paper surface as exemplified in Figs. 2 and 7 . When the center of the first side portion S1 is set to a position of approximately six o'clock of the clock, it is intended to be a period from approximately 4:30 to approximately 7:30.

(Definition 7) The "second side portion S2 side" is the upper left side of the paper surface as exemplified in Figs. 2 and 7 . When the center of the second side portion S2 side is set to approximately 12 points of the clock The position means the period from approximately 10:30 to approximately 1:30.

(Definition 8) The simple "side S (side or direction)" means "base end PE side", "end DE side", "first side S1 side", and "second side S2 side". , "Upper U side", "Lower D side", all directions between these.

The "one direction of the side portion S" means "the base end PE side", the "end side DE side", the "first side portion S1 side", and the "second side portion S2 side", and all directions between these .

The "one direction of the other side portion S" means a direction other than "one direction of the side portion S".

For example, the "one direction of the side portion S" refers to the direction of the end DE side, the first side portion S1 side, and the second side portion S2 side in the case of the base end PE side, and all directions therebetween.

[Heat exchangers 11, 111, 211, 311]

The present invention includes the first invention group including the heat exchangers 11, 111, and 211 of the first to third embodiments and the heat exchanger 311 of the fourth embodiment.

In the following, in order to avoid complication of the symbols, for example, "heat exchangers 11, 111, 211, and 311" and the like are simply referred to as "heat exchangers 11" and the like. It should be noted that even if it is described as "heat exchanger 11" or the like, the portion common to the "heat exchanger 11" includes "heat exchangers 11, 111, 211, and 311".

In the description and the drawings of the invention, the heat exchanger 11 of the first embodiment of the first invention group will be mainly described in order to prevent the complication of the description and the symbols. The heat exchangers 111 and 211 of the second embodiment to the third embodiment of the first invention group and the heat exchanger 311 of the fourth embodiment are only different from the heat exchanger 11 of the first embodiment ( Description of the shape, structure, and method of use.

The heat exchangers 111, 211, and 311 of the second embodiment to the fourth embodiment are described with different reference numerals only for the portions different from the heat exchanger 11 of the first embodiment. The symbols of the common part remain unchanged.

(heat exchanger 11) (first embodiment)

As illustrated in FIG. 1 and FIG. 2(A), the heat exchanger 11 forms a so-called "substantial S-shaped circuit SLTE" in the substantially central portion C, and a so-called "winding tube STE" is formed on the outer circumference of the circuit SLTE. .

The winding tube STE is a portion that is wound in a so-called "substantially spiral" shape and is wound by a flexible tubular body (hereinafter, simply described as "tube, tube T" for simplicity of description).

The liquid inflow port 12 and the liquid outflow port 13 (only composed of the tube T of the substantially linear portion) are disposed adjacent to each other in substantially the same direction. In the example of FIG. 1 and FIG. 2(A), it is arrange|positioned by the adjacent direction in the substantially the same direction as the one side of the side part S (base-end part PE - the 2nd side part S2 direction).

In other words, the base end portion PE - the second side portion S2 side is disposed in one direction toward the side portion S in substantially the same direction so as to follow the base end portion PE - end portion DE direction.

More specifically, as described in Patent Document 1 of the present applicant, the tube T of a predetermined length is first bent into an S shape, and then the tube T that starts to draw the S-shaped direction is brought along and is in contact with the end drawing S. The curve of the word is such that the tube T in the S direction is drawn along and in contact with the curve for starting the S word, and the above-described operation is repeated for a predetermined number of times, so that the side portions S of the tubes T that are in contact with each other are thermally welded as described later. Fixed.

(heat exchanger 111) (second embodiment)

Further, in the heat exchanger 111 of Fig. 2(B), the liquid inflow port 12 and the liquid outflow port 13 are disposed at separate positions in a direction substantially opposite to each other. In the illustration of Fig. 2(B), the liquid inflow port 12 is oriented in a direction opposite to one direction of the side portion S (the base end portion PE - the second side portion S2 direction), and the liquid outflow port 13 is oriented toward The direction of the other side portion S (the end portion DE - the first side portion S1 direction) is substantially opposite to each other and is disposed at a separate position.

Further, an example is described in which (i) the liquid inflow port 12 is formed on the base end portion PE - the second side portion S2 side, along the direction of the base end portion PE - end portion DE, (ii) The liquid outflow port 13 is directed to the distal end portion DE-first side portion S1 side in one direction of the substantially opposite side portion S.

(heat exchanger 211) (third embodiment)

The heat exchanger 211 of Fig. 3 removes the substantially S-shaped circuit SLTE and is formed only by the winding tube STE.

The liquid inflow port 12 and the liquid outflow port 13 are disposed at separate positions in substantially the same direction. In the example of FIG. 3, (i) the liquid inflow port 12 is oriented substantially in the same direction as the one side of the side portion S (the base end portion PE - the second side portion S2 direction), and (ii) the liquid outflow port 13 is It is disposed at a separate position in substantially the same direction as one direction (a substantially intermediate position of the proximal end portion PE) facing the same side portion S. More specifically, (i) the liquid inflow port 12 is disposed on the proximal end portion PE - the second side portion S2 side, and (ii) the fluid outflow port is provided along the base end portion PE-end portion DE direction. The 13 is disposed substantially at the center of the base end portion PE side, and is disposed in one direction of the substantially opposite side portion S.

In the heat exchangers 1, 111, the above-described circuit SLTE, the winding tube STE, the liquid inflow port 12, and the liquid outflow port 13 are substantially disposed on the same plane.

On the other hand, in the heat exchanger 211 which is only a winding tube, the winding tube STE, the liquid inflow port 12, and the liquid outflow port 13 are substantially disposed on the same plane.

The heat exchangers 11, 111, and 211 formed in Fig. 1, Fig. 2, and Fig. 3, the cross section of the winding tube STE is formed into a so-called "substantially elliptical shape" (flat shape), and the adjacent tube T is formed. The side portions S are thermally welded to each other and fixed.

As shown in Fig. 6, when the long radius of the substantially ellipse is a and the short radius is b, the flatness f is defined as f = [1 - (b / a)] × 100%.

The flattening ratio f thus defined is preferably in the range of 30 to 70%.

In the case of too small (less than 30%), the heating efficiency is low. If it is too large (more than 70%), the liquid flow path in the upper U-lower D direction becomes too small (narrow), and there is winding. The possibility that the tube STE is blocked on the way.

The tube T is preferably a heat-fusible thermoplastic material typified by a soft polyvinyl chloride resin, for example, other polyolefin resins (polyethylene, polypropylene resin, etc.), polyethylene terephthalate. A material that can be thermally welded like an ester resin.

The wall thickness of the tube T is in the range of 0.4 to 1.5 mm, preferably in the range of 0.5 to 0.8 mm.

If it is too thin (less than 0.4 mm), it will break during heat welding, which may increase the possibility of liquid leakage. On the other hand, if it is too thick (more than 1.5 mm), since the hot working becomes difficult, the heating efficiency (thermal conductivity) at the time of actually performing the heating operation is also lowered, which is not preferable.

(Manufacturing method of winding tube STE)

For example, as shown in FIG. 4, between the metal plate MP (consisting of the upper metal plate MPU and the lower metal plate MPD), the winding tubes STE of the embodiments 1 to 3 (Figs. 1 to 3) are sandwiched, and the upper metal is interposed. The winding tube STE is pressed between the plate MPU and the lower metal plate MPD to be formed into a substantially elliptical shape (flat shape).

The tubes T constituting the winding tubes STE adjacent to each other are not bonded to each other, so that even if no gap is reserved, the upper metal plate MPU and the lower metal plate MPD are slowly Pressurization is performed so that the tubes T are adjacent to each other in a close contact state, and can be uniformly expanded while being deformed into a substantially elliptical shape (flat shape).

(heating, welding treatment)

Next, for example, in a heating chamber, heating is performed in a state of being sandwiched between the upper and lower metal plates MPU and MPD at a predetermined heat treatment temperature (100 to 130 ° C) and a treatment time (0.5 to 2 hours).

The tube T is semi-melted by heat, and the side portions S of the adjacent tubes T that are in contact with each other are welded to each other and fixed.

Although the flatness ratio f is preferably in the range of 30 to 70% as described above, the above control can be restricted by the gap CL between the upper and lower metal plates MPU and MPD. In the illustration of FIG. 4, the gap can be defined by the bolt B (including the bolt head BH), the nut N, and the washer W.

The winding tube STE having a substantially elliptical cross section processed as described above is sandwiched and adhered to the heat exchanger 21 as shown in FIG. 1 and FIG. 3 (in the case of a heating machine, also referred to as a heating plate or heating) In the case of a cooling device, a Peltier element or the like, a so-called "substantially plate-shaped" body 22 (having a pair of upper body 22U and lower body 22D) is used to circulate the liquid. The inside of the STE is used for heat exchange (warming).

(heat exchanger 21)

The heat exchanger 21 is provided with a heat exchange unit, and is combined with a heat exchanger (unit) to constitute a heat exchange unit. That is, specifically, the heat exchange unit 23 (the above-described heating device or cooling device) is attached to either one of the heat exchangers 1, 111, and 211, or preferably a substantially plate-shaped body attached to both surfaces. 22 (a pair of upper body 22U and lower body 22D) constitutes a heat exchange device.

For the heat exchange unit 23, for example, a flat rubber heater, a ceramic heater, or the like (a metal wire for heating is disposed inside), and a Peltier element or the like is used as the cooling device.

The substantially plate-shaped main body 22 thus constituted is preferably metallic (iron, aluminum, copper) having good electrical conductivity. The heat exchange portion 23 (planar heater, Peltier element) is attached to the surface on the surface side and the opposite side that are in contact with the heat exchangers 1, 111, and 211, respectively, to eliminate temperature unevenness (refer to The upper surface 23U and the lower surface 23D of Fig. 5(A) are hereinafter described only as 23).

The winding tube STE having a substantially elliptical (flat) cross section is formed to have good adhesion to the substantially plate-shaped main body 22 (the upper main body 22U and the lower main body 22D) of the heat exchanger 21, and the area (contact area) of the contact portion CP is good. It is also enlarged (refer to FIG. 4, FIG. 5(A), FIG. 6), and since the distance LC from the center portion of the cross section (liquid flow path) of the winding tube STE is shortened, heat exchange (warming or cooling) is performed. The efficiency is getting better.

Further, as shown in the heat exchanger 211 of FIG. 3, only the winding tube STE, the tube T (liquid outflow port 13) protruding from the center portion C is placed in the body 22 formed on the heat exchanger 21 (upper portion) When the groove 22M of the main body 22U is sandwiched, the winding tube STE and the liquid inflow port 12 can be disposed on substantially the same plane.

[Heat exchange device 1]

The heat exchanger 21 and the heat exchangers (11, 111, 211) constitute the heat exchange device 1 (see Figs. 1 and 3).

As described above, the heat exchanger 21 has a substantially plate shape and is a pair of upper body 22U and lower body 22D. Further, it has a heat exchange portion 23 on a substantially flat surface.

The upper body 22U and the lower body 22D are attached to the contact faces of the heat exchangers (11, 111, 211), and the substantially planar heat exchange portion 23 is attached.

The heat exchanger (11, 111, 211) is disposed between the upper body 22U and the lower body 22D.

[How to use heat exchange device 1 and heat exchanger 11]

An example of a method of using the heat exchange device 1 and the heat exchanger 11 of the present invention will be described.

(for the heat exchanger 21 fixed)

The heat exchanger 11 composed of the winding tube is sandwiched between the substantially plate-shaped main body 22 (the upper main body 22U and the lower main body 22D) of the heat exchanger 21 and fixed.

(precharge)

From the liquid inflow port 12, the liquid flows into the winding tube ST and the circuit SLTE.

While the air is discharged from the liquid outflow port 13, the fluid is filled in the winding tube ST and the circuit SLTE, and the air is completely ejected.

(warming)

The liquid to be treated is self-heated while being warmed or cooled by the heat exchanger 21 The inflow port 12 flows into the winding tube STE, the circuit SLT, and is discharged from the liquid outflow port 13.

(heat exchanger 311) (fourth embodiment)

Fig. 7 is a plan view showing the heat exchanger 311 of the fourth embodiment.

The difference between the heat exchanger 311 and the heat exchanger 211 of FIG. 3 is that instead of the tube T of the monomer, the liquid tube BLT to be treated (so-called liquid is a liquid to be treated, such as blood, replenishing liquid, etc.) and the treatment liquid are used. A tube in which the side portions S of the tube TLT (the so-called treatment liquid is warm water, cold water, etc.) are joined to each other (hereinafter also referred to as a composite tube) TW (for the purpose of distinguishing from the tube T of FIG. 3, it is described as the tube TW) ( 8(A) and 8(B)).

The tube TW may be formed by bonding (joining) the individual treated liquid tubes BLT and the side portions S of the processing liquid tubes TLT to each other by a solvent, an adhesive, heat welding, or the like, or integrally formed by extrusion molding. form. The tube TW is wound, and the side portions S are further bonded (joined) by a solvent, an adhesive, a heat seal or the like to form a winding tube STEW.

The heat exchanger 311 does not form the substantially S-shaped circuit SLTE, but forms the composite pipe TW only by the winding pipe STEW (described as the winding pipe STEW in order to distinguish it from the winding pipe STE of FIG. 3) (refer to FIG. 8). (C)).

The cross section of the liquid pipe BLT and the process liquid pipe TLT constituting the winding pipe STEW is substantially circular (substantially a true circle), but may be an ellipse as shown in the above paragraph [0029].

In the case of an ellipse, in order to exchange heat with the wall surfaces of the side portions S of the liquid pipe BLT and the liquid pipe TLT, the contact areas of the side portions S are preferably larger. Therefore, it is preferably an elongated ellipse in the longitudinal direction. The flattening ratio of the preferred ellipse is substantially the same as the aforementioned paragraph [0029].

In the illustration (countercurrent contact) of FIG. 7, the liquid inlet 32 to be treated and the processing liquid outlet 43 (arrangement position P(I)) are arranged in the same direction, respectively. In the adjacent position. The liquid to be treated outlet 33 and the processing liquid inflow port 42 (arrangement position P(II)) are also disposed in the same direction in the adjacent positions.

The liquid inflow port 32 and the process liquid outflow port 43, and the liquid outflow port 33 and the process liquid inflow port 42 are disposed at separate positions in opposite directions.

In the example of FIG. 7, the liquid inlet 32 to be treated and the liquid discharge outlet 43 are disposed in the same direction as the one direction of the side portion S (the base end portion PE - the second side portion S2 direction). Adjacent location.

The liquid outflow port 33 and the process liquid inflow port 42 are also disposed in the adjacent positions in the same direction as the one direction (the substantially intermediate portion of the end portion DE) toward the side portion S.

The liquid inflow port 32 and the process liquid outflow port 43 are oriented in a direction opposite to one direction of the side portion S (base end portion PE - second side portion S2 direction), and the liquid outflow port 33 and the process liquid inflow port 42 are The direction is opposite to the one side of the other side portion S (a substantially intermediate portion of the end portion DE), and is disposed at a separate position.

The liquid to be treated BL (such as blood) and the liquid to be treated TL (warm water, etc.) are brought into contact with each other in the opposite direction as described above, and heat exchange (heating) of the liquid BL (blood or the like) is performed.

The substantially linear portion of the composite pipe TW extends from the liquid inflow port 32 to the processing liquid outflow port 43 (the base end portion PE - the second side portion S2 direction) in the end DE direction and extends to the middle of the second side portion S2. .

Further, the substantially linear portion of the composite pipe TW extends from the substantially central portion C to the liquid discharge port 33 to be treated - the liquid inlet 42 (P (II)) (substantially the center of the end portion DE). In the heat exchanger 311, the composite pipe STEW, the liquid to be treated is wound The inflow port 32 - the treatment liquid outflow port 43 (P(I)), the liquid to be treated outlet 33 - the treatment liquid inflow port 42 (P (II)) are also disposed on substantially the same plane.

Further, the heat exchanger 311 will be described in detail.

As shown in Fig. 7, two tubes made of soft polyvinyl chloride resin (which may also be the resin material described in the other paragraph [0031]) are adjacent to each other (the liquid pipe BLT to be treated and the liquid pipe TLT). The state is wound into a substantially spiral shape, and the wall surface is bonded (joined) by a solvent (may be described in another paragraph [0039] (heat exchanger 311)), and is produced (including a wound composite pipe STEW). Heat exchanger 311.

In a liquid pipe BLT, a liquid (blood, replenishing liquid, or the like) to be warmed or cooled is caused to flow from the liquid inflow port 32 to the liquid outflow port 33.

In another treatment liquid pipe TLT, temperature-adjusted warm water or cooling water flows from the treatment liquid inlet 42 to the treatment liquid discharge port 43.

The liquid to be treated flowing in the liquid pipe BLT and the treatment liquid flowing in the process liquid pipe TLT are heat-exchanged through the wall surface of the pipe.

The processing liquid for warming or cooling (warm water or cooling water) is circulated from the processing liquid inflow port 42 toward the processing liquid outflow port 43 from the temperature-controlled thermostatic groove, and is circulated in the processing liquid pipe TLT using a pump . As the flow rate of the treatment liquid, it is usually sufficient to obtain a flow rate of 100 to 300 mL/min.

In the case of cooling by the heat exchanger of the present invention, in the hypothermia treatment method, it is used for the purpose of lowering the blood to a range of 32 to 34 ° C, etc., in the case of heating, by The extracorporeal circulation is used to warm a liquid such as blood or a replenishing solution, or when used in a recovery temperature of a hypothermia treatment.

The two tubes (the treated liquid tube BLT and the treated liquid tube TLT) of the wound composite tube are generally used to be substantially the same length.

The heat exchange performance can be controlled by appropriately changing the temperature of the warming or cooling water and the length of the tube. Therefore, according to the findings of the inventors of the present invention, although the length of the tube is not intentionally limited, for example, when the liquid at room temperature is heated at a low flow rate of 100 mL/min or less and warm water of 42 ° C, the tube length is longer. Good for 2.5 to 3.5m.

Further, the tube has a diameter of 2 to 5 mm, and a wall thickness of preferably 0.4 to 1.5 mm, more preferably 0.5 to 0.8 mm. Therefore, if it is too thick, the heat transfer will be deteriorated, and if it is too thin, the tube will be easily bent at the time of production of the winding tube STEW, and thus it is not preferable.

(heat insulation material 51)

In the present invention, the heat exchanger 311 can cover (mount; use) the heat insulating material 51 for heat exchange as needed.

The heat insulating material 51 as described above is not particularly limited, but is preferably made of a material such as a polyethylene resin, a polyphenylene resin, or a urethane resin (foam or non-foam resin).

The heat insulating material 51 is formed in a substantially plate shape similarly to the heat exchanger 21, and is constituted by the main body 52 (the upper main body 52U and the lower main body 52D), and a groove 52M into which the composite pipe TW is inserted is formed.

Further, the heat exchanger 311 is the same as the heat exchangers 11, 111, and 211. As described in the above paragraphs [0033] to [0034], the heat exchanger 21 can be mounted (combined) for heat exchange.

[Heat exchange device 1001]

The heat exchange device 1001 of the present invention, as exemplified in Fig. 13, further includes heat exchangers (11, 111, 211, and 511) to be described later and warmers (21, 121) to be described later.

Hereinafter, in order to avoid complication of the symbols, for example, the heat exchangers (11, 111, 211, 511) and the like are simply referred to as "heat exchangers 11" and the like. Even if it is described as "heat exchanger 11" or the like, the portion common to "heat exchanger 11" includes "heat exchangers 11, 111, 211, and 511". The same applies to the case of the warmers 21 and 121.

Hereinafter, in the description and drawings of the invention, the heat exchanger 11 will be mainly described in order to avoid clarification and symbolization. The other heat exchangers 111, 211, and 511 will be described only in parts (shapes, structures) and methods of use different from the heat exchanger 11.

The heat exchangers 111, 211, and 511 are described with different reference numerals only for members different from the heat exchanger 11. The symbols of the common components remain as they are. The same applies to the case of the warmers 21 and 121.

The heat exchanger 11 can be warmed from one side (for example, the lower D side) by a warmer (also referred to as a heat exchanger) 21, but preferably from both sides (for example, the upper U side and the lower D side). Warm up.

In this case, the warmer 21 is composed of a pair of upper warmers 21U and a lower warmer 21D.

A warming portion (also referred to as heat exchange) to be described later is attached to a surface of the warmer 21 (the upper warmer 21U and the lower warmer 21D) on the side opposite to the heat exchangers 11, 111, 211, and 511. Part 23 (upper warmer 23U, lower warmer 23D).

Hereinafter, in order to avoid complication of the symbols, the warmer 21 (the upper warmer 21U and the lower warmer 21D) and the warming portion 23 (the upper warmer 23U and the lower warmer 23D) are only described as heating. The heater 21 and the heating unit 23. Even if it is described as the warmer 21 and the warming part 23, (the upper warmer 21U and the lower warmer 21D), (the upper warmer 23U and the lower warmer 23D) are contained.

Hereinafter, in the description and drawings of the invention, in order to avoid complication of explanation and symbols, The warmer 21 and the warming unit 23 will be described in addition to the case where there is a need for explanation.

The heat exchanger 11, the warmer 21, and the warming portion 23 are fixed to the outer casing 31 (also referred to as "fixing jig") as shown in Fig. 13 and used.

The outer casing 31 is composed of an upper outer casing 31U and a lower outer casing 31D.

The upper casing 31U, the upper warming portion 23U, the upper warmer 21U, the heat exchanger 11, the lower warmer 21D, the lower warmer 23D, and the lower casing 31D are arranged to overlap each other.

The outer casing 31 may be any one of metal, plastic, wood, etc., as long as the heat received from the warming portion 23 is not diffused to the outside.

In addition, it can be either covered or bottomed, or uncovered or bottomless. The shape may also be substantially circular (approximately elliptical), or rectangular.

The temperature sensor TS is disposed in the contact portion CP between the warmer 21 and the tube T (winding tube STE) of the heat exchanger 11 so that the temperature of the contact portion CP becomes the set temperature by the temperature controller TC. Control it.

The temperature sensor TS can use, for example, a thermocouple, a resistance thermometer, a thermistor, an IC temperature sensor, or the like.

The temperature sensor TS is attached to the lower D side of the upper warmer 21U or the upper U side of the lower warming portion 21D. In other words, on the lower D side (upper U side) of the upper heater 21U (lower heating portion 21D), a groove (hole) is formed from the side portion S direction, and the temperature sensor TS is buried in the groove. (hole). It is also clamped and fixed between the lower D side (upper U side) of the upper warmer 21U (lower warming portion 21D) and the tube T (winding tube STE) of the heat exchanger 11.

The tube T constituting the heat exchanger 11 (the heat exchangers 111 and 211 are also the same) The cross section may be formed in a so-called "substantially elliptical shape" (Fig. 5(A)) during the forming process of the tube, and formed into a substantially circular shape during the forming and processing of the tube as in the heat exchanger 511. (substantially true circle)" (Fig. 5 (B)), between the upper casing 31U, the lower heating portion 23U, the upper warmer 21U and the lower warmer 21D, the lower warming portion 23D, the lower casing 31D Pressurize and deform it into a substantially elliptical shape.

Even when the temperature sensor TS is disposed as described above, the heating efficiency is also increased when the cross section of the tube T (winding tube STE) is "substantially round" (substantially true). (Refer to the embodiment described later), but in the case of "substantially elliptical", the heating efficiency rises remarkably.

In the case of "substantially elliptical", as described above, it is preferred to set the flattening ratio f in the range of 30 to 70%. It is mentioned later.

Further, the tube T (winding tube STE) has a wall thickness of 0.4 to 1.5 mm, preferably formed in the range of 0.5 to 0.8 mm. It is mentioned later.

[heater 21, 121]

The warmers 21 and 121 have a substantially flat shape, as illustrated in FIGS. 15 to 18, and have a configuration in which the heat exchanger 11 is planarly arranged by the upper portion and the lower portion of the warmers 21 and 121. The winding tube STE is partially sandwiched, and only the portion is heated intensively to perform thermal conductance.

The form in which the warmer 21 is viewed from the upper U side has a form of "a substantially circular ring shape (the center portion C is a substantially circular space)" as illustrated in FIGS. 15 and 17 .

The width W1 of the substantially circular portion is formed to be substantially the same as the width W2 of the winding tube STE. Thereby, it is possible to concentrate only the portion of the winding tube STE.

Further, as another aspect, the warming portion 121 of FIGS. 16 and 18 has a form of "substantially circular (note that the center portion C does not have a substantially circular space)". These forms of the warmers 21 and 121 are identical in such a manner as to be substantially the same as the form (substantially circular) observed from the upper U side of the heat exchanger 11 .

Further, the heaters 21 and 121 and the heat exchanger 11 are also formed to have substantially the same size for the size (diameter) of the "substantially circular ring shape" and the "substantially round shape".

By substantially the same size is meant as follows. That is, if the diameter of the heat exchanger 11 is set to 100, the diameters of the warmers 21, 121 are preferably formed to be 90 to 110. If the diameter is too large (more than 110), a useless space is formed to bring the portion above the set temperature, and the internal liquid is excessively warmed.

On the other hand, if the diameters of the warmers 21 and 121 are too small (less than 90), the length of the tube which is not heated is formed, so that the heat generation is increased, and sufficient heating cannot be performed.

As described above, by forming the shapes of the warmers 21, 121 and the heat exchanger 11 into a substantially circular ring shape, a substantially circular shape, and substantially the same size (diameter), the heat exchanger 11 can be used. When the warmers 21 and 121 are arranged to overlap each other, or even if they are shifted in the rotational direction during heating, the heating region of the heat exchanger 11 is fixed, and the heating can be performed uniformly.

Thereby, only the heat exchanger 11 can be concentrated and heated, and the heating efficiency can be improved.

Moreover, the warmers 21 and 121 have a form of a "substantially plate shape" as viewed from the side S direction.

That is, regarding the warmers 21 and 121, the former has a so-called substantially circular ring shape, and the latter has a substantially circular plate shape.

Since the warmers 21 and 121 are in the above-described form, they are also referred to as "warming plates".

Hereinafter, in order to simplify the symbols, the warmers 21 and 121 are only described as "heater 21". And explain.

In the warmer 21, it is preferable that the metallic (iron, aluminum, copper) material having good conductivity is formed into a flat plate shape.

The warmer 21 has a pair of upper warmers 21U and a lower warmer 21D in the case where the heat exchanger 11 is sandwiched between the upper U side and the lower D side. The surface of the warmer 21U and the lower warmer 21D that is in contact with the heat exchanger 11 and the surface on the opposite side are respectively attached with a heating portion (also referred to as a heat exchange portion) 23 (the upper portion is heated). Part 23U, lower heating unit 23U). Heating (heating) is performed by the warmer, and the heat is transferred to the tube T held by the flat heater to perform heating.

The upper warmer 21U and the lower warmer 21D are connected to the temperature controller TC via the heating line HL, respectively.

(temperature control)

Preferably, the temperature sensor TP is disposed between the winding tube STE and the contact portion CP of the upper warmer 21U to warm the temperature so as to set the temperature.

The shape of the warmer 21 and the heat exchanger 11 are both substantially circular, and if they are overlapped by the upper part and the lower part, since they can almost overlap each other, the heat exchanger 11 (winding tube STE) can be monitored and The temperature of the contact portion CP of the warmer 21 (the upper warmer 21U) maintains the liquid (blood, etc.) at the actual set temperature, and prevents the liquid (blood, etc.) from being excessively warmed.

[warming section 23, 123]

The warming portions 23 and 123 are attached to the warmers 21 and 121 and are portions where heat is generated. Though it is not particularly limited, it can be suitably used for a so-called substantially planar heater (that is, a rubber heater, a ceramic heater, or the like, and a metal wire ML (MLU, MLD) for heating is disposed inside).

Here, since the heating unit 23 is attached to the warmer 21 and the user is installed in the warmer 121, the heating unit 123 is preferably formed in a substantially circular shape in accordance with the shape thereof. The warming portion 123 is formed in a substantially circular shape in accordance with the form of the warmer 121.

Hereinafter, in order to simplify the symbols, the warming units 23 and 123 will be described as the heating unit 23 and will be described.

When the heating unit 23 is formed in substantially the same shape and diameter (size) as the heat exchanger 11 and the warmer 21 when viewed from the upper U side, electric power can be reduced, and unnecessary electric power is not required.

However, even if the shape of the warming portion 23 is not necessarily the same shape as the heat exchanger 11 (substantially circular, substantially circular), for example, it is substantially elliptical or substantially rectangular, the heat exchanger 11 may be formed in the same manner. In the case of a shape (a substantially circular ring shape or a substantially circular shape), the heating is similarly performed, and the heating efficiency is substantially the same as in the case of forming the same shape (a substantially circular ring shape or a substantially circular shape).

The heating unit 23 (the upper warmer 23U and the lower warmer 23D) is attached to the surface of the heat exchanger 11 that is in contact with the warmer 21 (the upper warmer 21U and the lower warmer 21D). The surface of the opposite side, specifically by lamination, can control the warmer 21 at a uniform temperature. Since the warmer 21 and the warming portion 23 have a substantially flat shape, they are in close contact with each other in a layered manner, and the most effective heat transfer (heating operation) can be realized.

Further, as shown in FIG. 5, when it is used in the heat exchange device 1, it is sufficient that the flattening ratio f is at most 70%.

The winding tube STE having a substantially elliptical (flat) cross section is excellent in adhesion to the substantially plate-shaped warmer 21, and the area (contact area) of the contact portion CP is also increased (refer to FIG. 5(A)). In addition, as shown in Fig. 6), since the distance from the center portion LC of the cross section (liquid flow path) of the winding tube STE is shortened, the heating efficiency is improved.

Further, as in the heat exchanger 211 of FIG. 3, only the heat exchanger for winding the tube STE is formed by sandwiching the tube T (liquid outflow port 13) protruding from the center portion C in the warmer 21 (upper plus The groove or the like of the heater 21U) can be disposed on substantially the same plane as the winding tube STE and the liquid inflow port 12.

(temperature control)

As described above, while warming is performed by the warmer 21, the liquid flows from the liquid inflow port 12 to the winding tube STE and the circuit SLT, and is discharged from the liquid outflow port 13.

More specifically, the temperature sensor TP disposed between the winding tube STE and the contact portion CP of the upper heater 21U is heated so that the temperature becomes the set temperature. In this case, since the shapes of the warmer 21 and the heat exchanger 11 are both substantially circular, if the upper and lower portions are overlapped, they almost coincide with each other, and thus the heat exchanger 11 is monitored by winding The temperature of the contact portion CP of the tube STE) and the warmer 21 (the upper warmer 21U) can maintain the liquid (blood, etc.) at the actual set temperature, and can prevent the liquid (blood, etc.) from being excessively warmed. .

[Example 1] (production of heat exchanger 1)

As the winding tube STE, the first embodiment uses the pair The section of the soft polyethylene resin tube of 3.4 mm (inner diameter) × 4.9 mm (outer diameter) is roughly elliptical.

As shown in FIG. 4, the winding tube STE of the first embodiment is sandwiched between metal plates MP (two upper metal plates MPU and lower metal plates MPD) having holes (not shown) formed at four corners. The metal plate MP is tightened by the bolts B and the nut N, and the winding tube STE is sandwiched between the winding tubes STE so as to have a flattening ratio f of 60%, and the heat exchanger 1 is produced by press molding.

The metal plate MP holding the winding tube STE is directly placed in a heating chamber (not shown), and heated at 110 ° C for 90 minutes to heat the side portions S of the tubes T constituting the winding tube STE Spliced and fixed.

(heating test of heat exchange device)

As shown in FIG. 1, the heat exchanger 1 of the first embodiment is disposed in the heat exchanger 21 (see the above description, the heat exchange unit 23 uses a planar rubber heater) to form a heat exchange device. The heat exchange device was subjected to a heating test using water as a liquid to be treated. That is, the following heating test was carried out: while the water was allowed to flow at a normal temperature (inlet side temperature: 24 ° C water) at a flow rate of 20, 50, 80 mL/min, while controlling the heat exchanger 21 at 42 ° C Heating was performed, and the temperature of the inlet (liquid inflow port 12, liquid outflow port 13) was measured. The results are shown in Table 1.

[Comparative Example 1]

As Comparative Example 1, except for use A soft polyvinyl chloride resin pipe having a circular cross section of 3.4 mm (inner diameter) × 4.9 mm (outer diameter) is the same as that of the first embodiment except that the heat exchanger 501 is substantially circular. test. The results are shown in Table 1.

[Table 1]

(examination of results)

According to Table 1, it can be seen that the temperature rise of the heat exchanger 1 in which the flattening ratio f of the cross section of the winding tube STE of Example 1 is 60% is higher than that of the general one which is not processed by using Comparative Example 1. The heat exchanger 501 around the tube STE (circular in cross section, substantially round) is 3 to 4 ° C high. In other words, the tube T having a substantially elliptical cross section in Example 1 has a better heating efficiency than the tube having a substantially true cross section in Comparative Example 1. That is, the temperature after the heating (exit side) has been confirmed, and in the case where the same target value is required, the liquid flow path of the first embodiment can be achieved with a shorter tube.

Furthermore, it is necessary to consider the liquid flowing into the heat exchanger, usually blood, or "liquid flowing into the blood (for example, replenishing solution, dialysate, etc.)". This means that when the temperature of the heating device is set to 42 ° C or higher, there is a possibility of blood denaturation. Therefore, as an absolute limiting factor, it is required to control the temperature of the heating device of 42 ° C or lower.

Further, since the replenishing liquid and the dialysate at normal temperature often flow at a flow rate of 10 to 50 mL/min, in the configuration of the heat exchangers 1 and 11, 111, and 211 of the embodiment, the temperature can be raised to the same temperature as the body temperature. .

[Example 2, Comparative Example 2-3]

The heat exchanger 311 (Fig. 10) according to the fourth embodiment of the present invention and the heat of the comparative example were used. The exchanger 511 (Fig. 11), 611 (Fig. 12), performs a heat exchange test.

(content of heat exchanger)

The heat exchanger 311 of FIG. 10 (the cross section of the tubes FLT and TLT is a true circle) is referred to as Example 2, and the heat exchanger 511 of FIG. 11 (the tube T is wound in a single layer and the cross section is a true circle) is set as a comparison. In Example 2, the heat exchanger 611 of FIG. 12 (the tubes FLT and TLT were double-wound and the cross section was a true circle) was designated as Comparative Example 3.

The test results are shown in Table 2 (Example 2, NO1 to 18), Table 3 (Comparative Example 2-NO1, Comparative Example 3-NO2), and Table 4 (Comparative Example 3, NO1 to 6).

The heat exchangers 311, 511, and 611 of Figs. 10 to 12 are each made of a tube made of polyvinyl chloride resin.

The inner and outer diameters of the tubes TLT and FLT of the second embodiment are 3.4 mm (inner diameter) × 4.9 mm (outer diameter) (NO1 to 9, 13 to 15 in Table 2) and 3.6 mm (inner diameter) × 4.8 mm (outer diameter) (NO10 to 12, 16 to 18 in Table 2), tube length (length of winding tube STEW) was evaluated by 3 m (NO1 to 18 in Table 2) .

Further, in Comparative Examples 2 and 3, the following tubes were produced for evaluation: the inner and outer diameters of the tubes were 3.4 mm (inner diameter) × 4.9 mm (outer diameter), and the tube length (the length of the winding tube STE, STEW) was a single layer winding (Comparative Example 2), the length was 2.7 m, and the double winding (Comparative Example 3) ) is 1.5m long.

(heating test and cooling test)

The heat test and the cooling test were carried out using the heat exchangers of the above examples and comparative examples. The test conditions are as follows.

(1) Example 2 of Table 2 and Comparative Example 3 of Table 4, as a liquid to be treated, at room temperature The water (normal temperature water) flows in a treated liquid pipe FLT (hereinafter referred to as a pipe FLT).

As the treatment liquid, water (warmed water) controlled at 42 ° C in the heating test was caused to flow in another treatment liquid pipe TLT (hereinafter simply referred to as pipe TLT). In the cooling test, water (cooling water) cooled to 2 to 4 ° C was allowed to flow.

(2) In Comparative Example 2 of Table 3, water (normal temperature water) at normal temperature was flowed into the tube TLT as a liquid to be treated. Further, in Comparative Example 3 of Table 3, as the liquid to be treated, water (normal temperature water) at normal temperature flows only in one tube FLT, and in the other tube TLT, no liquid flows.

In Comparative Example 2 and Comparative Example 3 of Table 3, the winding tubes STE and STEW were sandwiched from the outside by two heaters (hot plates) to warm them.

(3) In Example 2 of Table 2 and Comparative Example 3 of Table 4, in the heating test and the cooling test, heating and cooling were not performed.

In the second embodiment of Table 2, the liquid to be treated and the treatment liquid flow in the same direction (parallel) as the reverse direction (countercurrent).

(4) In Comparative Example 3 of Table 4, the liquid to be treated and the treatment liquid were caused to flow in the opposite direction (countercurrent).

In the heating test and the cooling test, the temperature at the inlet and the outlet of each liquid (normal temperature water, warm water, cooling water) was measured.

The heat exchange performance as a result of the test was evaluated by the heat exchange coefficient R.

The heat exchange coefficient R is calculated based on the following formula (1) or (2).

(i) When no external heater (hot plate) is used: (Example 2 of Table 2 and Comparative Example 3 of Table 4) R = (Bto-Bti) / (Wt - Bti) (1)

(In the table, Bto: temperature at the outlet side of the liquid to be treated (°C), Bti: temperature at the inlet side of the treatment liquid (°C), and Wt: temperature of the treatment liquid (°C)).

(ii) When using an external heater (hot plate): (Comparative Example 2, 3 of Table 3) R = (Bto-Bti) / (Ht-Bti) (2)

(In the table, Bto: temperature at the outlet side of the liquid to be treated (°C), Bti: temperature at the inlet side of the treated liquid (°C), Ht: surface temperature of the heater (°C)).

(Results and investigation)

The above results are shown in Table 2 (Example 2, NO1 to NO18), Table 3 (Comparative Example 2-NO1, Comparative Example 3-NO2), and Table 4 (Comparative Example 3, NO1 to 6).

(Performance confirmation of Example 2 (Table 2))

According to Table 2, regarding the performance of Example 2, the following <a> to <g> were confirmed.

<a> Confirm that the performance corresponding to the flow rate of the treatment liquid (warm water) is poor

According to the results of NO1 to NO3, it can be seen that even if the flow rate (flow rate) of the treatment liquid (warm water) is varied in the range of 100 to 300 mL/min, the heat exchange coefficient is still in the range of 0.46 to 0.47, and there is substantially no difference. , stable heat exchange performance can be obtained.

<b>Review of the flow direction of the treatment liquid (warm water)

According to the results of NO2 and NO4, it can be known that in the case of some micro-backflow, the heat exchange coefficient is large, and the heat exchange performance is better than that of the parallel flow. Furthermore, it can be known that even if it is cocurrent, the heat exchange performance is sufficient.

<c> Confirm the performance corresponding to the flow rate of the liquid to be treated

According to the results of NO5 and NO6, it is confirmed that when the flow rate (flow rate) of the liquid to be treated is small (slow), the heat exchange coefficient is large and the heat exchange performance is good.

<d> Confirm the performance corresponding to the set temperature of the treatment liquid (warm water)

According to the comparison results of NO7, 8, and 9 and NO2, 5, and 6, it can be seen that if there is a difference of 5 ° C, there is no difference in heat exchange coefficient, and stable heat exchange performance can be obtained, but if the treatment liquid is high temperature Since it is likely to cause protein denaturation, it is preferably set to 45 °C.

<e>Performance confirmation corresponding to the difference in pipe diameter (wall thickness)

According to NO11, 12 and NO5, 6, it can be seen that when the wall thickness is small, the heat exchange coefficient is large and the heat exchange performance is good in the range of 0.3 to 0.5.

<f>Performance confirmation and influencing factors in the case of cooling

According to NO13 to 15, it can be seen that when the flow rate (flow rate) of the liquid to be treated is small (slow), the heat exchange coefficient is large and the heat exchange performance is good.

<g>Performance confirmation corresponding to the difference in pipe diameter (wall thickness) in the case of cooling

According to NO13 to 15 and NO16 to 18, it is found that when the wall thickness is small, the heat exchange coefficient is large and the heat exchange performance is good in the range of 0.3 to 0.5.

(heating performance test) (comparison of example 2 and comparative example 3)

According to the comparison results of Table 2 (Example 2/NO2) and Table 4 (Comparative Example 3/NO1), the heat exchange coefficient (0.47) of Example 2 was about 2.4 times the heat exchange coefficient (0.20) of Comparative Example 3.

According to the comparison results of Table 2 (Example 2/NO5, NO6) and Table 4 (Comparative Example 3/NO2, NO3), the heat exchange coefficient (0.31, 0.21) of Example 2 was the heat exchange coefficient of Comparative Example 3 (0.16). About 0.1 times that of 0.10).

(Cooling performance test) (Comparative Example 2 with Comparative Example 3)

According to Table 2 (Example 2/NO13 to N15) and Table 4 (Comparative Example 3/NO4 to NO6) As a result of the comparison, the heat exchange coefficient (0.40, 0.26, 0.16) of Example 2 was about 2.2 to 2.7 times the heat exchange coefficient (0.18, 0.11, 0.06) of Comparative Example 3.

(to sum up)

From the above results, it was found that the heat exchange coefficient of Example 2 was about 2 to 2.7 times that of Comparative Example 3, and the heat exchange performance was excellent.

Comparative Example 3 (heat exchanger 611) has poor heat exchange performance (low heat exchange coefficient) because "the liquid to be treated (normal temperature water)" and "treatment liquid (warm water or cooling water)" are only part of the way. Adjacent (all liquid flow paths are not adjacent at side S). Further, as in the results of Comparative Example 3/NO2 of Table 2, the heat exchanger 611 had a heat exchange coefficient of 0.37 even when an external heater was used in combination.

According to the results of NO1 to NO4 of Table 2, the heat exchange coefficient of Example 2 (heat exchanger 311) of the present invention can be known, and a comparative example with Table 3 using an external heater can be obtained even without using an external heater. 2 (heat exchange coefficient: 0.49) is substantially equivalent, or inferior to the heat exchange performance (heat exchange coefficient: 0.45 to 0.47).

As described in the above paragraph [0046], if the heat exchange devices 51 and 201 of the heat insulating material 51 and the heat exchanger 21 (or the cooling device) are used in combination, it is expected to obtain further improved heat exchange performance.

[Example 3-4, Comparative Example 4] (modulation of heat exchanger)

As the winding tube STE, the tube length is 2.6 m, and the example 3 is used. The cross section of the tube of 3.4 mm (inner diameter) × 4.9 mm (outer diameter) is roughly elliptical, and the example 4 and the comparative example 4 are used. 3.4 mm (inside diameter) × 4.9 mm (outer diameter) tube (circular cross section, substantially round).

As shown in Fig. 9, the winding tube STE of the third embodiment is sandwiched between metal plates MP (two upper metal plates MPU and lower metal plate MPD) having holes (not shown) at four corners. The metal plate MP is fastened by the bolt B and the nut N, and the winding tube STE is sandwiched so as to have a flatness f of 60%, and press forming is performed.

The metal plate MP holding the winding tube STE is directly placed in a heating chamber (not shown), and heated at 110 ° C for 90 minutes to heat the side portions S of the tubes T constituting the winding tube STE Spliced and fixed.

The third embodiment is a heat exchanger 11 (a winding tube (having a substantially elliptical cross section)), and the temperature is measured at a contact portion between the warmer (substantially circular ring shape) and the heat exchanger.

Embodiment 4 is a heat exchanger 511 (winding tube (a cross section is substantially circular)), and temperature measurement Set to "contact point between the heater (substantially circular ring) and the heat exchanger".

In Comparative Example 4, the heat exchanger 511 "winding tube (having a substantially circular cross section)" was used, and the temperature was measured on the surface of the warmer (substantially circular ring shape) (non-contact portion with the heat exchanger).

(heating test)

The heating test was carried out as follows: The heat exchangers 11 and 511 of Example 3, Example 4, and Comparative Example 4 were placed on the warmer 21 (on the lower D side of the upper warmer 21U, as shown in Fig. 1). A groove is formed in the side S direction, and a thermocouple as the temperature sensor TS is embedded in the groove. The heating portion 23 uses a flat ruthenium rubber heater to make the normal temperature water as the liquid to be treated. (inlet side temperature: 24 ° C water) and warm water (inlet side temperature: 34 ° C water), each flowing at a flow rate of 20, 50, 80 mL / min, while controlling at 42 ° C by a rubber heater The warmer 21 performs heating, and measures the temperature of the inlet (the liquid inlet 12 to be treated, the liquid outlet 13) as the water of the liquid to be treated. The results are shown in Tables 5 and 6.

(result) (temperature of heat exchanger 11)

(i) When the water to be treated is normal temperature (inlet side temperature: water at 24 ° C): It can be known that Example 3 is increased by 7.9 to 14.8 ° C, and Example 4 is increased by 4.8 to 11.0 ° C, compared with comparison. In the case of the rising temperature of Example 4 of 1.1 to 3.5 ° C, the temperature became higher.

(ii) In the case of warm water (inlet side temperature: water at 34 ° C), it can be known that Example 3 is increased by 4.5 to 7.0 ° C, and Example 4 is increased by 2.8 to 5.9 ° C compared to the above-mentioned normal temperature (inlet side temperature: In the case of water at 24 ° C, the rise temperature of the comparative example was 1.1 to 3.5 ° C, and the temperature became relatively high.

From this, it can be understood that in Example 3 and Example 4, compared with Comparative Example 4, the heating can be concentrated only on the heat exchanger 11, and the heating efficiency can be improved.

Further, in the winding tube of Example 3 (having a substantially elliptical cross section), the heating efficiency can be further improved as compared with the winding tube (cross section: substantially circular) of the fourth embodiment.

Thereby, the temperature after heating (exit side) can be known, and when the same target value is required, Example 3 and Example 4 can be compared with Comparative Example 4, and the liquid flow path of the shorter tube can be used. Achieved.

In other words, it can be seen that Example 3 and Example 4 have better heating efficiency than Comparative Example 4, and the temperature after heating (outlet side), when the same target value is required, Example 3 and implementation In Example 4, compared to Comparative Example 4, a liquid flow path of a shorter tube was achieved.

(industrial availability)

In the medical heat exchanger according to the present invention, the tube is wound, and a substantially S-shaped circuit (SLTE) is formed in the substantially central portion (C), and a substantially spiral winding is formed on the outer circumference of the circuit (SL). The tube (STE), the liquid inflow port (12) and the liquid outflow port (13) are arranged in one direction of the substantially identical or substantially opposite side portions (S), the above-mentioned circuit (SLTE), the above-mentioned winding tube (STE) The liquid inflow port (12) and the liquid outflow port (13) are disposed on substantially the same plane. Here, the winding tube STE has a substantially elliptical cross section, and the flattening ratio of the substantially elliptical shape is 30 to 70%, and the side portions S adjacent to the respective tubes T constituting the winding tube (STE) are formed. It is fixed by heat fusion. According to the above configuration, since the heat exchanger of the present invention is disposed in the middle of the extracorporeal circuit, the heated liquid taken from the blood or the like circulating in the patient can be efficiently heated to circulate in the body of the patient. Therefore, as a heat exchanger for medical use, there is a great possibility of industrial use.

1‧‧‧Hot exchange unit

11‧‧‧ heat exchanger

12‧‧‧Liquid flow inlet

13‧‧‧Liquid outlet

21‧‧‧Heat exchanger

22D‧‧‧lower ontology

22U‧‧‧ upper body

C‧‧‧ Central Department

DE‧‧ End

PE‧‧‧ base end

S1‧‧‧1st side

S2‧‧‧2nd side

SLTE‧‧‧ loop

STE‧‧‧ winding tube

Claims (16)

A heat exchanger (11, 111) for a liquid heat exchanger (11, 111), characterized in that the heat exchanger is composed of a tube having a liquid inlet and an outlet, and is substantially at the center. (C), a substantially S-shaped circuit (SLTE) is formed by the tube, and a substantially spiral winding tube (STE) is formed on the outer circumference of the circuit (SLTE), the liquid inlet (12) and the liquid The outflow port (13) is disposed at an adjacent or separate position in a direction substantially the same as one direction of the side portion (S) of the heat exchanger, or in a direction toward the side (S) and The other side (S) has a direction substantially opposite to each other and is disposed at a separate position, the above-mentioned circuit (SLTE), the winding tube (STE), the liquid inflow port (12), and the liquid outflow port (13) Disposed on substantially the same plane, the cross section of the winding tube (STE) is formed into a substantially elliptical shape, and the flattening ratio of the substantially ellipse is in the range of 30 to 70%, constituting each of the winding tubes (STE) The adjacent side portions (S) of the tube (T) are fixed by heat welding. A heat exchanger (211) is a heat exchanger (211) for a liquid, characterized in that the heat exchanger (211) is composed of a tube having a liquid inlet and an outlet, and is substantially at the center ( On the outer circumference of C), the substantially spiral winding tube (STE) is formed by the tube, and the liquid inflow port (12) and the liquid outflow port (13) are oriented toward the side of the heat exchanger (211) One direction of the portion (S) is substantially the same direction, disposed at an adjacent or separate position, or in a direction substantially opposite to one direction of the side portion (S) and one direction of the other side portion (S). Configured in separate locations, The winding tube (STE), the liquid inflow port (12), and the liquid outflow port (13) are disposed on substantially the same plane, and the cross section of the winding tube (STE) is formed in a substantially elliptical shape. The flatness ratio of the ellipse is in the range of 30 to 70%, and the side portions (S) adjacent to the respective tubes (T) constituting the winding tube (STE) are fixed by heat welding. A heat exchanger (311), characterized in that in a heat exchanger (311) for liquid, a pair of composite pipes (TW) are formed, and the pair of composite pipes (TW) are used as a heat medium. Forming a plurality of tubes each having a liquid inlet and an outlet for the liquid to be treated, and the side (S) of the treated liquid tube (BLT) and the processing liquid tube (TLT) The coiled tube (STEW) in which the composite tube (TW) is wound into a substantially spiral shape is formed on the outer periphery of the substantially central portion (C), and the liquid to be treated is in the composite tube (TW). The inflow port (32) and the treatment liquid outflow port (43) are disposed adjacent to each other in a direction substantially the same as one direction toward the heat exchanger side portion (S), the liquid outflow port (33) and the treatment liquid inflow port (42) is disposed adjacent to each other in substantially the same direction as one direction of the side portion (S), the liquid inflow port (32) and the treatment liquid outflow port (43), and the liquid outflow port (33) and the treatment liquid The inflow port (42) is disposed apart in one direction of the same side portion (S), or along one direction of the side portion (S) and the other side portion (S) Disposed in one direction, the winding tube (STEW), the liquid inflow port (32), the processing liquid outflow port (43), the liquid outflow port (33), and the processing liquid inflow port (42) are disposed substantially the same. on flat surface. A heat exchange device (1) is a heat exchange device (1) for performing heat exchange of liquid, characterized in that it has: a heat exchanger (21) having a heat exchange portion; and claim 1 Or a heat exchanger (11, 111, 211) for fluids as described in 2; the heat exchanger (21) has a substantially plate-like upper body (22U) and a lower body (22D), the upper body (22U) and the lower portion The main body (22D) is provided with a substantially planar heat exchange portion (23) including a heat source on a surface opposite to the contact surface of the heat exchanger (11, 111, 211), and the upper body (22U) The heat exchanger (11, 111, 211) is disposed between the lower body (22D) and the lower body (22D). A heat exchange device (101) is a heat exchange device (101) for performing heat exchange between liquids, comprising: a heat insulating material (51); and the liquid heat exchanger according to claim 3 ( 311); the heat insulating material (51) has a substantially plate-shaped upper body (52U) and a lower body (52D), and the heat exchanger is disposed between the upper body (52U) and the lower body (52D) 311). A heat exchange device (201) is a heat exchange device (201) for performing heat exchange between liquids, comprising: the heat exchanger (21); and the heat exchanger (311) described in claim 3 The heat exchanger (21) has a substantially plate-shaped upper body (22U) and a lower body (22D), and the upper body (22U) and the lower body (22D) are in contact with the heat exchanger (311) The substantially opposite surface is provided with a substantially planar heat exchange portion (23), and the heat exchanger (311) is disposed between the upper body (22U) and the lower body (22D). A heat exchange method for performing heat exchange between a liquid to be treated and a liquid to be treated, The heat exchanger (311) having the winding tube (STEW) described in the claim 3 is used, and the steps (1) to (3) are as follows: (1) the liquid to be treated a step of introducing the liquid to be treated into the liquid pipe (BLT) from the liquid inlet (32), and flowing the liquid to be treated to the liquid outlet (33); (2) using the temperature-adjusted warm water as the treatment liquid or Cooling water, introducing the treatment liquid from the treatment liquid inlet (42) into the treatment liquid treatment liquid pipe (TLT), and flowing the treatment liquid to the treatment liquid discharge port (43); and (3) via a step of heat-exchange the liquid to be treated and the liquid to be treated on the wall surface of the liquid pipe (BLT) and the processing liquid pipe (TLT); and heating or cooling the liquid to be treated by the processing liquid The heat exchange of the liquid to be treated described above is carried out. A heat exchange method characterized by using the heat exchange device (101, 201) described in claim 5 or 6, and including the steps (1) to (3) described in claim 7, by treating the liquid, The liquid to be treated is heated or cooled, whereby heat exchange of the liquid to be treated is performed. A heat exchange device (1001, 1101) is a heat exchange device (1001, 1101) for performing heat exchange between liquids, characterized in that it has a heat exchanger (11, 111, 211, 511) for circulating the liquid. And a warmer (21, 121) having a heating portion; the heat exchanger (11, 111, 211, 511) and the warmer (21, 121), both having a side from the upper (U) side The observed shape is substantially circular or substantially circular, and the diameter of the heat exchanger (11, 111, 211, 511) is formed to be substantially the same as the diameter of the warmer (21, 121). The heaters (21, 121) are mounted on the surface opposite to the heat exchanger (11, 111, 211, 511) on the surface opposite to the heat exchanger (11, 111, 211, 511), and are provided with substantially planar heating portions (23, 123). A temperature sensor (TS) is disposed between the above-mentioned warmer (21, 121) and a contact portion (CP) of the heat exchanger (11, 111, 211, 511), and a temperature controller (TC) is disposed The temperature sensor (TS) is connected to the set temperature of the liquid flowing through the heat exchanger (11, 111, 211, 511) at the position of the contact portion (CP). The heat exchange device (1001, 1101) of claim 9, wherein the heat exchanger (11, 111, 211, 511) is constituted by a tube having an inlet and an outlet of the liquid, by the tube, A substantially spiral winding tube (STE) is formed on an outer circumference of the substantially central portion (C), and the liquid inflow port is disposed in one direction of a side portion (S) substantially the same as or substantially opposite to the heat exchanger. (12) and the liquid outflow port (13), the winding tube (STE), the liquid inflow port (12), and the liquid outflow port (13) are disposed on substantially the same plane. The heat exchange device (1001, 1101) of claim 9, wherein the warmer (21, 121) has a heat exchanger (11, 111, 211, 511) that can be clamped from both sides. a pair of upper warmers (21U, 121U) and lower warmers (21D, 121D), and the above heat exchangers (21U, 121U) and lower warmers (21D, 121D) (11, 111, 211, 511) The surface to be contacted is the opposite side surface, and the upper heating portion (23U, 123U) and the lower heating portion (23D, 123D) are attached. The heat exchange device (1001, 1101) according to any one of claims 9 to 11, wherein the heat exchanger (11, 1101, 511) having the heat exchanger (11, 111, 211, 511) and the heater (21, 121) are fixed (31), The outer casing (31) has a pair of upper casings (31U) and a lower casing (31D), and the heat exchangers (11, 111, 211, 511) and the warmers (21, 121) are disposed in the casing (31), according to the upper casing (31U), the upper heating unit (23U, 123U), the upper heater (21U, 121U), the heat exchanger (11, 111, 211, 511), the lower heating unit (23D) The 123D), the lower warmer (22D, 122D), and the lower casing (31D) are arranged in an overlapping manner. A heat exchanger (11, 111, 211) for use in the heat exchange device (1001, 1101) recited in claim 10, characterized in that the heat exchanger (1001, 1101) is heat exchanger (11) 111, 211) and the cross section of the winding tube (STE) is formed into a substantially elliptical shape, and the flattening ratio of the substantially elliptical shape is 70%. A heat exchanger (511) for use in the heat exchange device (1001, 1101) recited in claim 10, characterized by an upper warmer (21U, 121U) and a lower warmer (21D, 121D) The heat exchanger (511) of the heat exchanger (1001, 1101) and the heat exchanger (511) formed of a substantially circular winding tube (STE) is pressurized. The cross section of the winding tube (STE) was formed into a substantially elliptical shape, and the flattening ratio of the substantially elliptical shape was 70%. A warmer (21, 121) is installed in a heat exchanger (11, 111, 211, 511) having a substantially circular shape, and is characterized in that the warmer (21, 121) is from the upper part. The form observed on the (U) side has a substantially circular ring shape or a substantially circular shape, and the diameter is formed into a heat exchanger (11, 111, 211, 511 having a substantially circular shape as viewed from the upper (U) side. The diameters are substantially the same, and the warmers (21, 121) are in contact with the heat exchangers (11, 111, 211, 511) The surface on the opposite side is a substantially planar heating portion (23, 123), and a temperature is placed at a position (CP) of the heat exchanger (11, 111, 211, 511). Sensor (TS). The warmer (21, 121) of claim 15, wherein the upper heat exchanger (11, 111, 211, 511) is clamped from both sides, and has a pair of upper heaters (21U, 121U) and a lower warmer (21D, 121D), and the upper heat exchanger (21U, 121U) and the lower warmer (21D, 121D) and the above heat exchanger (11, 111, 211, 511) The surface to be contacted is the opposite side surface, and the upper heating portion (23U, 123U) and the lower heating portion (23D, 123D) are attached to the contact portion with the heat exchanger (11, 111, 211, 511) ( The position of the CP) is equipped with a temperature sensor (TS).