JPH0753338A - Hair tonic - Google Patents
Hair tonicInfo
- Publication number
- JPH0753338A JPH0753338A JP5198572A JP19857293A JPH0753338A JP H0753338 A JPH0753338 A JP H0753338A JP 5198572 A JP5198572 A JP 5198572A JP 19857293 A JP19857293 A JP 19857293A JP H0753338 A JPH0753338 A JP H0753338A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- parts
- hair
- extract
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001256 tonic effect Effects 0.000 title abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 18
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960003632 minoxidil Drugs 0.000 claims abstract description 15
- 240000000249 Morus alba Species 0.000 claims description 23
- 235000008708 Morus alba Nutrition 0.000 claims description 23
- 244000045947 parasite Species 0.000 claims description 23
- 230000000694 effects Effects 0.000 abstract description 11
- 239000003795 chemical substances by application Substances 0.000 abstract description 8
- 239000006210 lotion Substances 0.000 abstract description 6
- 239000000443 aerosol Substances 0.000 abstract description 4
- 239000006071 cream Substances 0.000 abstract description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract description 2
- 239000002260 anti-inflammatory agent Substances 0.000 abstract description 2
- 229940125715 antihistaminic agent Drugs 0.000 abstract description 2
- 239000000739 antihistaminic agent Substances 0.000 abstract description 2
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 230000003078 antioxidant effect Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000002674 ointment Substances 0.000 abstract description 2
- 150000005846 sugar alcohols Polymers 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 229940124549 vasodilator Drugs 0.000 abstract description 2
- 239000003071 vasodilator agent Substances 0.000 abstract description 2
- 240000001638 Scurrula parasitica Species 0.000 abstract 1
- 239000002981 blocking agent Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000003641 microbiacidal effect Effects 0.000 abstract 1
- 229940124561 microbicide Drugs 0.000 abstract 1
- 239000002855 microbicide agent Substances 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 25
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 24
- 230000003779 hair growth Effects 0.000 description 20
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 11
- -1 etc.) Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000008213 purified water Substances 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 6
- 239000000469 ethanolic extract Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 4
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229940042585 tocopherol acetate Drugs 0.000 description 4
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 3
- 229940043276 diisopropanolamine Drugs 0.000 description 3
- 229960003720 enoxolone Drugs 0.000 description 3
- 230000037308 hair color Effects 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 208000019300 CLIPPERS Diseases 0.000 description 2
- 235000002566 Capsicum Nutrition 0.000 description 2
- 240000008574 Capsicum frutescens Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- 239000001390 capsicum minimum Substances 0.000 description 2
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- 229930007845 β-thujaplicin Natural products 0.000 description 2
- MRAMPOPITCOOIN-VIFPVBQESA-N (2r)-n-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide Chemical compound CCOCCCNC(=O)[C@H](O)C(C)(C)CO MRAMPOPITCOOIN-VIFPVBQESA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- UYZQWKKNVBJVOF-UHFFFAOYSA-N 1-decoxytetradecane Chemical compound CCCCCCCCCCCCCCOCCCCCCCCCC UYZQWKKNVBJVOF-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 238000011735 C3H mouse Methods 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 235000014066 European mistletoe Nutrition 0.000 description 1
- FOGXJPFPZOHSQS-AYVLZSQQSA-N Hydrocortisone butyrate propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)CC)(OC(=O)CCC)[C@@]1(C)C[C@@H]2O FOGXJPFPZOHSQS-AYVLZSQQSA-N 0.000 description 1
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 1
- 244000152640 Rhipsalis cassutha Species 0.000 description 1
- 235000012300 Rhipsalis cassutha Nutrition 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- RZMKWKZIJJNSLQ-UHFFFAOYSA-M carpronium chloride Chemical compound [Cl-].COC(=O)CCC[N+](C)(C)C RZMKWKZIJJNSLQ-UHFFFAOYSA-M 0.000 description 1
- 229950003631 carpronium chloride Drugs 0.000 description 1
- 229940008396 carrot extract Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 1
- 239000001599 crocus sativus l. flower extract Substances 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 229960001067 hydrocortisone acetate Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 229960003517 isothipendyl Drugs 0.000 description 1
- OQJBSDFFQWMKBQ-UHFFFAOYSA-N isothipendyl Chemical compound C1=CN=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 OQJBSDFFQWMKBQ-UHFFFAOYSA-N 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000003915 liquefied petroleum gas Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 238000007433 macroscopic evaluation Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- TXGSOSAONMOPDL-UHFFFAOYSA-N propan-2-yl 3,4,5-trihydroxybenzoate Chemical compound CC(C)OC(=O)C1=CC(O)=C(O)C(O)=C1 TXGSOSAONMOPDL-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229940076591 saffron extract Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、ミノキシジルと桑寄生
（ソウキセイ）の抽出物を併用することにより発毛効果
を増強した育毛剤に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair-growth agent having an enhanced hair-growth effect by using minoxidil and a mulberry parasite extract.
【０００２】[0002]
【従来の技術】従来、ヒトの頭髪の成長を促進または維
持させることに用いられる育毛剤に関しては、種々の技
術が提案されてきている。特に天然物中の成分を発毛成
分とする研究はかなり行われており、桑寄生の抽出物に
発毛効果があることが報告されている（特開昭６２−９
９３１９号）。2. Description of the Related Art Conventionally, various techniques have been proposed for hair-growth agents used for promoting or maintaining the growth of human hair. In particular, a great deal of research has been conducted on hair growth components in natural products, and it has been reported that an extract of mulberry parasite has a hair growth effect (JP-A-62-9).
9319).
【０００３】[0003]
【発明が解決しようとする課題】しかしながら、桑寄生
の抽出物を皮膚に塗布しただけでは、発毛効果が十分で
あるとはいえず、より発毛効果に優れた製剤の開発が望
まれている。However, it cannot be said that the hair-growth effect is sufficient just by applying the mulberry parasite extract to the skin, and it is desired to develop a preparation having a more excellent hair-growth effect. There is.
【０００４】[0004]
【課題を解決するための手段】本発明者らは、桑寄生の
発毛効果をさらに増強する物質を鋭意探索した結果、ミ
ノキシジルと桑寄生の抽出物を併用すると、各々の発毛
効果が相乗的に増強されることを見い出し本発明を完成
した。すなわち本発明の育毛剤は、ミノキシジル０．１
〜２重量％に桑寄生の抽出液を１〜２０重量％配合した
ことを特徴とする。[Means for Solving the Problems] As a result of diligent search for substances that further enhance the hair growth effect of mulberry parasites, the present inventors have found that, when minoxidil and an extract of mulberry parasites are used in combination, each hair growth effect is synergistic. The present invention has been completed by finding out that they are enhanced. That is, the hair restorer of the present invention is minoxidil 0.1.
It is characterized in that mulberry parasite extract is blended in an amount of 1 to 20% by weight in an amount of 2% by weight.
【０００５】本発明に用いる桑寄生の抽出物は、ヤドリ
ギの茎葉（桑寄生）を好ましくは乾燥、粉砕した後、常
温または加温下において溶剤で抽出したものであり、更
に必要に応じて、抽出溶媒を留去したその残分である。
溶剤には、通常用いられる溶剤、たとえばイソプロパノ
ール、エタノール、メタノールおよび水などの水溶性の
溶媒やアセトン、ヘキサンなどの有機溶媒あるいはそれ
らの混液を用いることができる。好ましくはアルコー
ル、アルコールと水の混液である。抽出溶媒の量は生薬
の乾燥重量に対して２〜５倍が望ましい。また、桑寄生
の抽出物の配合量は、抽出液として１〜２０重量％であ
ることが望ましい。The mulberry parasite extract used in the present invention is preferably a mistletoe foliage (mulberry parasite), which is preferably dried and pulverized, and then extracted with a solvent at room temperature or under heating. It is the residue obtained by distilling off the extraction solvent.
As the solvent, a commonly used solvent, for example, a water-soluble solvent such as isopropanol, ethanol, methanol and water, an organic solvent such as acetone and hexane, or a mixed solution thereof can be used. Alcohol or a mixed liquid of alcohol and water is preferable. The amount of the extraction solvent is preferably 2 to 5 times the dry weight of the crude drug. The amount of the mulberry parasite extract blended is preferably 1 to 20% by weight as an extract.
【０００６】ミノキシジルと桑寄生の抽出物を含有する
育毛剤は、通常の皮膚適用外用剤、例えば、ローション
剤、トニック剤、クリーム剤、軟膏剤、エアゾール剤な
どの基剤に配合し、常法に従って製造することができ
る。これらの製剤には、血管拡張剤（塩化カルプロニウ
ム、ニコチン酸ベンジル、センブリ抽出物、オタネニン
ジンエキス、ビタミンＥアセテート、トウガラシチンキ
など）、副腎皮質ホルモン（酢酸ヒドロコルチゾン、酪
酸プロピオン酸ヒドロコルチゾンなど）、抗ヒスタミン
剤（塩酸ジフェンヒドラミン、塩酸イソチペンジルな
ど）、抗炎症剤（グリチルレチン酸、グアイアズレンな
ど）、角質溶解剤（尿素、サリチル酸など）、殺菌剤
（グルコン酸クロルヘキシジン、イソプロピルメチルフ
ェノール、第４級アンモニウム塩、ヒノキチオールな
ど）、保湿剤（ヒアルロン酸ナトリウム、グリセリン、
コンドロイチン硫酸、冬虫夏草抽出物、サフラン抽出物
など）、油分（ミリスチン酸イソプロピル、レシチン、
スクワランなど）、界面活性剤（ポリオキシエチレンソ
ルビタン脂肪酸エステル、ソルビタン脂肪酸エステル、
ポリオキシエチレン脂肪酸エステル、グリセリン脂肪酸
エステルなど）、多価アルコール（プロピレングリコー
ル、グリセリン、マクロゴールなど）、抗酸化剤（ジブ
チルヒドロキシトルエン、イソプロピルガレートな
ど）、金属イオン封鎖剤（エチレンジアミンテトラアセ
テートまたはその塩など）、清涼化剤（メントール、カ
ンフルなど）、色素、香料を本発明をそこなわない限り
配合することができる。[0006] A hair-growing agent containing minoxidil and an extract of mulberry parasite is compounded in a usual external preparation for skin application, for example, a base such as lotion, tonic agent, cream, ointment or aerosol, and the usual method is used. Can be manufactured according to. These preparations include vasodilators (carpronium chloride, benzyl nicotinate, cembly extract, ginseng extract, vitamin E acetate, capsicum tincture, etc.), corticosteroids (hydrocortisone acetate, hydrocortisone butyrate propionate, etc.), antihistamines (hydrochloric acid hydrochloride). Diphenhydramine, isothipendyl hydrochloride, etc.), anti-inflammatory agents (glycyrrhetinic acid, guaizulene, etc.), keratolytic agents (urea, salicylic acid, etc.), bactericides (chlorhexidine gluconate, isopropylmethylphenol, quaternary ammonium salts, hinokitiol, etc.), moisturizing Agent (sodium hyaluronate, glycerin,
Chondroitin sulfate, Cordyceps sinensis extract, saffron extract, etc.), oil (isopropyl myristate, lecithin,
Squalane, etc., surfactants (polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester,
Polyoxyethylene fatty acid ester, glycerin fatty acid ester, etc.), polyhydric alcohol (propylene glycol, glycerin, macrogol, etc.), antioxidant (dibutylhydroxytoluene, isopropyl gallate, etc.), sequestering agent (ethylenediamine tetraacetate or its salt) Etc.), a cooling agent (menthol, camphor, etc.), a coloring agent, and a flavoring agent can be blended unless the present invention is impaired.
【０００７】本発明の育毛剤は、１日１〜数回、適量を
頭皮に塗布して使用する。The hair restorer of the present invention is applied to the scalp in an appropriate amount once to several times a day for use.
【発明の効果】本発明により、発毛効果に優れた育毛剤
を提供することが可能となった。Industrial Applicability According to the present invention, it is possible to provide a hair-growth agent having an excellent hair-growth effect.
【０００８】[0008]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳細に説明する。EXAMPLES The present invention will be described in detail below based on examples and comparative examples.
【０００９】実施例１ エタノール６５重量部にプロピレングリコール５重量
部、ミノキシジル０．５重量部、桑寄生の７０％エタノ
ール抽出液（桑寄生１重量部に７０％エタノール５重量
部を加え、室温で１週間抽出した後、濾紙で濾過して得
た濾液である。以下、実施例２、３及び試験例において
同じ。）５重量部及び精製水２４．５重量部を加えて撹
拌溶解し、ローションタイプの育毛剤を調整した。Example 1 65 parts by weight of ethanol, 5 parts by weight of propylene glycol, 0.5 parts by weight of minoxidil, 70% ethanol extract of mulberry parasite (1 part by weight of mulberry parasite was added with 5 parts by weight of 70% ethanol, and the mixture was stirred at room temperature). This is a filtrate obtained by extracting for one week and then filtering with a filter paper. The same applies to Examples 2 and 3 and Test Example below.) 5 parts by weight and 24.5 parts by weight of purified water are added, and the mixture is stirred and dissolved to obtain a lotion. The type of hair restorer was adjusted.
【００１０】実施例２ 精製水４７．７重量部にカルボキシビニルポリマー０．
４重量部を撹拌しながら分散させた。これに、エタノー
ル４０重量部、プロピレングリコール１重量部、グリセ
リン５重量部、ミノキシジル０．５重量部、桑寄生の７
０％エタノール抽出液５重量部、ジイソプロパノールア
ミン０．４重量部を撹拌溶解させた液を添加し、撹拌混
合してゲルタイプの育毛剤を調製した。Example 2 47.7 parts by weight of purified water were mixed with 0.
4 parts by weight were dispersed with stirring. 40 parts by weight of ethanol, 1 part by weight of propylene glycol, 5 parts by weight of glycerin, 0.5 part by weight of minoxidil, and 7 parts of mulberry parasite
A solution in which 5 parts by weight of 0% ethanol extract and 0.4 parts by weight of diisopropanolamine were dissolved by stirring was added and mixed by stirring to prepare a gel type hair restorer.
【００１１】実施例３ ポリオキシエチレン（２０）ソルビタンモノステアレー
ト５重量部、ソルビタンモノステアレート３重量部、セ
タノール２重量部、ステアリルアルコール２重量部、流
動パラフィン１０重量部、ビタミンＥアセテート０．２
重量部を加温しながら混合溶解した。別に、ミノキシジ
ル１重量部、桑寄生の７０％エタノール抽出液３重量
部、パントテニールエチルエーテル０．５重量部、パラ
オキシ安息香酸メチル０．１重量部、プロピレングリコ
ール１０重量部、精製水６３．２重量部を加温しながら
撹拌溶解した液を加え、撹拌混合しながら室温まで冷却
し、クリームタイプの育毛剤を調製した。Example 3 Polyoxyethylene (20) sorbitan monostearate 5 parts by weight, sorbitan monostearate 3 parts by weight, cetanol 2 parts by weight, stearyl alcohol 2 parts by weight, liquid paraffin 10 parts by weight, vitamin E acetate 0. Two
Part by weight was mixed and dissolved while heating. Separately, 1 part by weight of minoxidil, 3 parts by weight of 70% ethanol extract of mulberry parasite, 0.5 part by weight of pantotenyl ethyl ether, 0.1 part by weight of methyl paraoxybenzoate, 10 parts by weight of propylene glycol, 63.2 of purified water. A solution in which the parts by weight was stirred and dissolved was added, and the mixture was stirred and cooled to room temperature to prepare a cream type hair restorer.
【００１２】実施例４ ミノキシジル０．５重量部、桑寄生の無水エタノール抽
出液（桑寄生１重量部に無水エタノール３重量部を加
え、室温で１週間抽出した後、濾紙で濾過して得た濾液
である。以下実施例５、６において同じ。）８重量
部、、ヒノキチオール０．１重量部、センブリエキス
０．１重量部、ニンジンエキス０．１重量部、グリチル
レチン酸０．２重量部、ビタミンＥアセテート０．０２
重量部、プラセンタエキス０．１重量部、Ｌ−メントー
ル０．２重量部、１，３−ブタンジオール５重量部、ポ
リオキシエチレン（６０）硬化ヒマシ油０．４重量部、
ミリスチン酸オクチルドデシル１重量部、グリセリルモ
ノイソステアレート１重量部、エタノール６５重量部、
精製水１８．３重量部を撹拌溶解してローションタイプ
の育毛剤を調製した。Example 4 0.5 part by weight of minoxidil and an anhydrous ethanol extract of mulberry parasite (1 part by weight of mulberry parasite were added with 3 parts by weight of absolute ethanol, and the mixture was extracted at room temperature for 1 week, and then filtered through a filter paper to obtain. The same applies to the following Examples 5 and 6.) 8 parts by weight, hinokitiol 0.1 part by weight, assembly extract 0.1 part by weight, carrot extract 0.1 part by weight, glycyrrhetinic acid 0.2 part by weight, Vitamin E acetate 0.02
Parts by weight, placenta extract 0.1 parts by weight, L-menthol 0.2 parts by weight, 1,3-butanediol 5 parts by weight, polyoxyethylene (60) hydrogenated castor oil 0.4 parts by weight,
Octyldodecyl myristate 1 part by weight, glyceryl monoisostearate 1 part by weight, ethanol 65 parts by weight,
A lotion type hair restorer was prepared by stirring and dissolving 18.3 parts by weight of purified water.
【００１３】実施例５ ミノキシジル０．５重量部、桑寄生の無水エタノール抽
出液５重量部、プロピレングリコール５重量部、ポリオ
キシエチレン（２０）モノオレエート５重量部、エタノ
ール５０重量部、精製水３０．５重量部を撹拌溶解し
た。この液をエアゾール缶に入れ、液化石油ガス４重量
部を加圧充填し、エアゾールタイプの育毛剤を調製し
た。Example 5 Minoxidil 0.5 part by weight, mulberry parasite anhydrous ethanol extract 5 parts by weight, propylene glycol 5 parts by weight, polyoxyethylene (20) monooleate 5 parts by weight, ethanol 50 parts by weight, purified water 30. 5 parts by weight were dissolved by stirring. This liquid was put in an aerosol can and pressurized with 4 parts by weight of liquefied petroleum gas to prepare an aerosol type hair restorer.
【００１４】実施例６ 精製水４８．７重量部にカルボキシビニルポリマー０．
４重量部を撹拌しながら分散させた。これに、エタノー
ル４０重量部、プロピレングリコール５重量部、ミノキ
シジル０．５重量部、桑寄生の無水エタノール抽出液５
重量部、ジイソプロパノールアミン０．４重量部を撹拌
溶解させた液を添加し、撹拌混合してゲルタイプの育毛
剤を調製した。Example 6 To 48.7 parts by weight of purified water was added carboxyvinyl polymer 0.
4 parts by weight were dispersed with stirring. To this, 40 parts by weight of ethanol, 5 parts by weight of propylene glycol, 0.5 parts by weight of minoxidil, 5 parts of anhydrous ethanol extract of mulberry parasite
A solution in which 0.4 parts by weight of diisopropanolamine and 0.4 part by weight of diisopropanolamine were dissolved by stirring was added and mixed by stirring to prepare a gel-type hair restorer.
【００１５】実施例７ ミノキシジル０．５重量部、桑寄生のイソプロピルアル
コール抽出液（桑寄生１重量部にイソプロピルアルコー
ル５重量部を加え、室温で１週間抽出したのち、濾紙で
濾過して得た濾液である。以下、実施例８において同
じ。）４重量部、１，３−ブタンジオール２重量部、プ
ロピレングリコール４重量部、ポリオキシエチレン（２
０）ポリオキシプロピレン（６）デシルテトラデシルエ
ーテル３重量部、エタノール５５重量部、精製水３１．
５重量部を撹拌溶解し、ローションタイプの育毛剤を調
製した。Example 7 0.5 part by weight of minoxidil and an isopropyl alcohol extract solution of mulberry parasite (1 part by weight of mulberry parasite was added with 5 parts by weight of isopropyl alcohol, and the mixture was extracted at room temperature for 1 week and then filtered through a filter paper to obtain. This is the filtrate. The same applies to Example 8 below.) 4 parts by weight, 1,3-butanediol 2 parts by weight, propylene glycol 4 parts by weight, polyoxyethylene (2
0) Polyoxypropylene (6) decyl tetradecyl ether 3 parts by weight, ethanol 55 parts by weight, purified water 31.
A lotion type hair restorer was prepared by dissolving 5 parts by weight with stirring.
【００１６】実施例８ ミノキシジル０．５重量部、桑寄生のイソプロピルアル
コール抽出液５重量部、パントテニールエチルエーテル
０．５重量部、エチニルエストラジオール０．０００８
重量部、グリチルレチン酸０．２重量部、ビタミンＥア
セテート０．０２重量部、トウガラシチンキ０．５重量
部、グリセリルモノイソステアレート１重量部、プロピ
レングリコール５重量部、ポリオキシエチレン（２０）
ソルビタンモノオレエート１．５重量部、エタノール７
０重量部、精製水１５．７７９２重量部を撹拌溶解し、
ローションタイプの育毛剤を調製した。Example 8 0.5 part by weight of minoxidil, 5 parts by weight of an isopropyl alcohol extract containing mulberry parasite, 0.5 part by weight of pantothenyl ethyl ether, and 0.0008 of ethinyl estradiol.
Parts by weight, glycyrrhetinic acid 0.2 parts by weight, vitamin E acetate 0.02 parts by weight, capsicum tincture 0.5 parts by weight, glyceryl monoisostearate 1 part by weight, propylene glycol 5 parts by weight, polyoxyethylene (20)
Sorbitan monooleate 1.5 parts by weight, ethanol 7
0 parts by weight and 15.7792 parts by weight of purified water are dissolved by stirring,
A lotion type hair restorer was prepared.
【００１７】試験例１ 発毛効果試験 前記実施例１の調製方法に準じ、表１に示す処方で試料
１〜８及び対照試料１を調製し、Ｃ３Ｈ系マウス（雄
性、７週齢）１０匹を１群とし、各群の動物について、
その背部の２ｃｍ×３ｃｍの範囲をバリカンで除毛し、
試験に供した。Test Example 1 Hair growth effect test Samples 1 to 8 and control sample 1 were prepared according to the formulation shown in Table 1 according to the preparation method of Example 1, and 10 C3H mice (male, 7 weeks old) were prepared. As one group, for each group of animals,
Remove hair with a hair clipper in the area of 2 cm x 3 cm on the back,
It was submitted to the test.
【００１８】[0018]
【表１】 [Table 1]
【００１９】試料１〜８及び対照試料１の各々につい
て、それぞれ別個の群の供試動物を割り当て、その除毛
部に１日１回、０．２ｍｌ塗布した。試料塗布１０日後
及び２０日後の被験部の毛の成長の程度を肉眼により下
記の６段階で評価した。その結果を表２に示す。For each of Samples 1 to 8 and Control Sample 1, test animals of different groups were assigned, and 0.2 ml of the test animals were applied to the hair-removed area once a day. The degree of hair growth in the test area 10 days and 20 days after application of the sample was visually evaluated by the following 6 grades. The results are shown in Table 2.
【００２０】※肉眼評価における判断基準 ０：発毛が全く認められない １：発毛している ２：硬毛が生えそろっている ３：硬毛が正常の約５０％生えている ４：硬毛が正常の約７５％生えている ５：硬毛が正常の約１００％生えている* Judgment criteria in macroscopic evaluation 0: Hair growth is not recognized at all 1: Hair growth is present 2: Hair bristles are growing 3: Hair bristles are about 50% of normal growth 4: Hard Hair grows about 75% of normal 5: Terminal hair grows about 100% of normal
【００２１】[0021]
【表２】 [Table 2]
【００２２】また、供試動物の毛の色は黒色で、除毛部
の皮膚の色は灰色であり、その毛の成長と共に灰色から
黒色に色調が変化することから、毛の色の黒さの程度を
下記のように測定し、毛の成長を評価した。すなわち、
分光色差計（高速分光色差計ＣＭＳ−１２００型、村上
色彩技術研究所社製）を使用し、Ｌ*ａ*ｂ*表色系に基
づく除毛直後の被験部のＬ*値ａ*値ｂ*値と試料塗布１
０日後及び２０日後の被験部のΔＬ*，Δａ*、Δｂ*を
算出し、The hair color of the test animal is black and the skin color of the hair-removing part is gray. Since the color tone changes from gray to black as the hair grows, the black color of the hair is black. Was measured as described below to evaluate hair growth. That is,
Using a spectrocolorimeter (high-speed spectrophotometer CMS-1200 model, manufactured by Murakami Color Research Laboratory Co., Ltd.), L * value a * value b of the test part immediately after hair removal based on the L * a * b * color system. * Value and sample application 1
Calculate ΔL * , Δa * , Δb * of the test part after 0 day and 20 days,
【００２３】[0023]
【数１】 [Equation 1]
【００２４】の式から色差ΔＥ*ａｂを求め、その１群
の平均値で毛の色の黒さを示した。なお、試料塗布２０
日後に、被験部の２ｃｍ×３ｃｍの範囲の毛をバリカン
で刈り取り、その重量を測定して、各々の試料による毛
の成長量（ｍｇ）とした。これと前記の式から得た色差
ΔＥ*ａｂとの関係を図１に示す。この図より毛の成長
と毛の色の黒さが比例関係にあることは明らかである。
以上の結果から明らかなように、本発明のミノキシジル
および桑寄生の抽出物を含有する育毛剤の発毛効果は著
しく、本発明の発毛効果の有効性が認められた。The color difference ΔE * ab was obtained from the equation, and the blackness of the hair color was shown by the average value of the first group. Sample application 20
After the day, hair in the area of 2 cm × 3 cm in the test area was cut with a hair clipper, and the weight thereof was measured to be the growth amount (mg) of hair by each sample. The relationship between this and the color difference ΔE * ab obtained from the above equation is shown in FIG. From this figure, it is clear that hair growth and hair color black are in a proportional relationship.
As is clear from the above results, the hair-growth effect of the hair-growing agent containing the minoxidil and the mulberry parasite extract of the present invention is remarkable, and the effectiveness of the hair-growth effect of the present invention was confirmed.
【図１】毛の成長量と色差ΔＥ*ａｂの関係を示すグラ
フである。FIG. 1 is a graph showing the relationship between the amount of hair growth and the color difference ΔE * ab.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 漆崎 文男 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Fumio Urushizaki 3-24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd.
Claims (1)
してなる育毛剤。1. A hair restorer comprising minoxidil and an extract of mulberry parasite.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5198572A JPH0753338A (en) | 1993-08-10 | 1993-08-10 | Hair tonic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5198572A JPH0753338A (en) | 1993-08-10 | 1993-08-10 | Hair tonic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0753338A true JPH0753338A (en) | 1995-02-28 |
Family
ID=16393417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5198572A Pending JPH0753338A (en) | 1993-08-10 | 1993-08-10 | Hair tonic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0753338A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07215826A (en) * | 1993-12-07 | 1995-08-15 | Taisho Pharmaceut Co Ltd | Hair tonic |
| US6265412B1 (en) * | 1998-05-26 | 2001-07-24 | Taisho Pharmaceutical Co., Ltd. | Minoxidil compositions for external use |
| JP2007008965A (en) * | 2006-10-23 | 2007-01-18 | Pola Chem Ind Inc | Hair growing agent |
-
1993
- 1993-08-10 JP JP5198572A patent/JPH0753338A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07215826A (en) * | 1993-12-07 | 1995-08-15 | Taisho Pharmaceut Co Ltd | Hair tonic |
| US6265412B1 (en) * | 1998-05-26 | 2001-07-24 | Taisho Pharmaceutical Co., Ltd. | Minoxidil compositions for external use |
| JP2007008965A (en) * | 2006-10-23 | 2007-01-18 | Pola Chem Ind Inc | Hair growing agent |
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