JPH07508719A - 抗−肥満薬 - Google Patents
抗−肥満薬Info
- Publication number
- JPH07508719A JPH07508719A JP5518907A JP51890793A JPH07508719A JP H07508719 A JPH07508719 A JP H07508719A JP 5518907 A JP5518907 A JP 5518907A JP 51890793 A JP51890793 A JP 51890793A JP H07508719 A JPH07508719 A JP H07508719A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- general formula
- obesity
- following general
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Claims (8)
- 1.医薬的に許容できるキャリヤー及び活性成分として、下記一般式(I): R4−(CH2)n−CO−N(R1)−CH(R2)−CO(R2)(I)〔 式中、R1はH又はCH2を表わし;R2は天然に存在するアミノ酸の側鎖を表 わし;R3はOH1OCH2CH3及びNH2を表わし;nは6〜18であり; そして R4はCH3又は下記一般式(II):R2−CO−CH(R2)−N(R1) −CO−(II)(式中、R1,R2及びR3は上記の通りである)で表わされ る基を表わす〕で表わされる化合物を含んで成る肥満の処理のための医薬組成物 。
- 2.活性成分として、N−パルミトイルサルコシン、N,N′−セパコイルビス −グリシン、N,N′−セパコイルビスe− アスパラジン、N,N′−セパコ イルビスd−アスパラデン、N,N′−セパコイルビスサルコシン、N,N′− セパコイルビスーサルコシン−エチルエステル及びN,N′−セパコイルビスー フェニルアラニンから成る群のメンパーである化合物を含んで成る請求の範囲第 1項記載の医薬組成物。
- 3.請求の範囲第1項記載の式Iの化合物を含んで成る肥満を予防するためのダ イエット補充物。
- 4.請求の範囲第1項記載の式Iの化合物の有効量を必要な対象に投与すること を含んで成る肥満の処理方法。
- 5.肥満の処理のための医薬組成物の調製への請求の範囲第1又は2項記載の式 Iの化合物の使用。
- 6.下記一般式(I): R4−(CH2)n−CO−N(R1)−CH(R2)−CO(R2)(I)〔 式中、R1はH又はCH3を表わし;R2は天然に存在するアミノ酸の側鎖を表 わし;R2はOH,OCH2CH3及びNH2を表わし;nは6〜18であり; そして R4はCH2又は下記一般式(II):R2−CO−CH(R2)−N(R1) −CO−(II)(式中、R1,R2及びR3は上記の通りである)で表わされ る基を表わす〕で表わされる化合物。
- 7.医薬的に許容できるキャリヤー及び活性成分として、請求の範囲第6項記載 の化合物を含んで成る医薬組成物。
- 8.下記一般式(I): R4−(CH2)n−CO−N(R1)−CH(R2)−CO(R3)(I)〔 式中、R1はH又はCH2を表わし;R2は天然に存在するアミノ酸の側鎖を表 わし;R2はOH,OCH2CH2及びNH2を表わし;nは6〜18であり; そして R4はCH3又は下記一般式(II):R3−CO−CH(R2)−N(R1) −CO−(II)(式中、R1,R2及びR3は上記の通りである)で表わされ る基を表わす〕で表わされる化合物の肥満を攻撃するだめへの使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL10170892A IL101708A (en) | 1992-04-28 | 1992-04-28 | Anti-fattening drugs comprising amino acid derivatives |
IL101708 | 1992-04-28 | ||
PCT/EP1993/001014 WO1993021913A1 (en) | 1992-04-28 | 1993-04-27 | Anti-obesity drugs |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH07508719A true JPH07508719A (ja) | 1995-09-28 |
JP3666667B2 JP3666667B2 (ja) | 2005-06-29 |
Family
ID=11063576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51890793A Expired - Fee Related JP3666667B2 (ja) | 1992-04-28 | 1993-04-27 | 抗−肥満薬 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0637958B1 (ja) |
JP (1) | JP3666667B2 (ja) |
AT (1) | ATE150967T1 (ja) |
AU (1) | AU4062693A (ja) |
CA (1) | CA2134560C (ja) |
DE (1) | DE69309457T2 (ja) |
DK (1) | DK0637958T3 (ja) |
IL (1) | IL101708A (ja) |
WO (1) | WO1993021913A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008508215A (ja) * | 2004-07-30 | 2008-03-21 | マイコス イタリアーナ ディ コミーニ ミロ アンド チ. エッセ.ア.エッセ | アミノ酸及び植物タンパク加水分解物でのジカルボン酸のn−アシル化誘導体ならびに化粧品及び医薬におけるそれらの使用 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1271267B (it) * | 1994-12-14 | 1997-05-27 | Valle Francesco Della | Ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi |
EP1455774B1 (en) * | 2001-11-26 | 2006-03-01 | Lean-Ex Ltd. | Pharmaceutical composition for treating obesity |
WO2004031214A1 (ja) * | 2002-10-07 | 2004-04-15 | National Institute Of Advanced Industrial Science And Technology | 分子配向の揃った球状微粒子、それを用いた球状マイクロカプセル及びそれらの製造方法 |
WO2007013062A1 (en) * | 2005-07-25 | 2007-02-01 | Lean-Ex Ltd. | Composition and method for weight maintenance |
CN104649926B (zh) * | 2013-11-25 | 2018-08-17 | 刘现梅 | 一种n,n’-癸二酰基二天门冬氨酸及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2234399A1 (de) * | 1972-07-17 | 1974-01-31 | Thomae Gmbh Dr K | Hautschutzmittel |
DE3423166A1 (de) * | 1984-06-22 | 1986-01-02 | Epis S.A., Zug | Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
-
1992
- 1992-04-28 IL IL10170892A patent/IL101708A/en active IP Right Grant
-
1993
- 1993-04-27 WO PCT/EP1993/001014 patent/WO1993021913A1/en active IP Right Grant
- 1993-04-27 AU AU40626/93A patent/AU4062693A/en not_active Abandoned
- 1993-04-27 JP JP51890793A patent/JP3666667B2/ja not_active Expired - Fee Related
- 1993-04-27 DE DE69309457T patent/DE69309457T2/de not_active Expired - Fee Related
- 1993-04-27 DK DK93909847.1T patent/DK0637958T3/da active
- 1993-04-27 EP EP93909847A patent/EP0637958B1/en not_active Expired - Lifetime
- 1993-04-27 AT AT93909847T patent/ATE150967T1/de not_active IP Right Cessation
- 1993-04-27 CA CA002134560A patent/CA2134560C/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008508215A (ja) * | 2004-07-30 | 2008-03-21 | マイコス イタリアーナ ディ コミーニ ミロ アンド チ. エッセ.ア.エッセ | アミノ酸及び植物タンパク加水分解物でのジカルボン酸のn−アシル化誘導体ならびに化粧品及び医薬におけるそれらの使用 |
Also Published As
Publication number | Publication date |
---|---|
ATE150967T1 (de) | 1997-04-15 |
DK0637958T3 (da) | 1997-10-13 |
CA2134560A1 (en) | 1993-11-11 |
IL101708A0 (en) | 1992-12-30 |
AU4062693A (en) | 1993-11-29 |
EP0637958B1 (en) | 1997-04-02 |
EP0637958A1 (en) | 1995-02-15 |
DE69309457T2 (de) | 1997-11-06 |
IL101708A (en) | 1996-08-04 |
CA2134560C (en) | 2002-03-19 |
DE69309457D1 (de) | 1997-05-07 |
JP3666667B2 (ja) | 2005-06-29 |
WO1993021913A1 (en) | 1993-11-11 |
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