JPH07505908A - Ｎｍｄａ受容体のアロステリックモジュレーター - Google Patents
Ｎｍｄａ受容体のアロステリックモジュレーターInfo
- Publication number
- JPH07505908A JPH07505908A JP6509297A JP50929794A JPH07505908A JP H07505908 A JPH07505908 A JP H07505908A JP 6509297 A JP6509297 A JP 6509297A JP 50929794 A JP50929794 A JP 50929794A JP H07505908 A JPH07505908 A JP H07505908A
- Authority
- JP
- Japan
- Prior art keywords
- section
- seq
- con
- nmda
- polyamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- YBAFDPFAUTYYRW-UHFFFAOYSA-N N-L-alpha-glutamyl-L-leucine Natural products CC(C)CC(C(O)=O)NC(=O)C(N)CCC(O)=O YBAFDPFAUTYYRW-UHFFFAOYSA-N 0.000 description 1
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- 125000003368 amide group Chemical group 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 239000007640 basal medium Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
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- 239000007853 buffer solution Substances 0.000 description 1
- 230000009460 calcium influx Effects 0.000 description 1
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- 150000001718 carbodiimides Chemical class 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
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- 238000005119 centrifugation Methods 0.000 description 1
- 210000001638 cerebellum Anatomy 0.000 description 1
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- 108050003126 conotoxin Proteins 0.000 description 1
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- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 229960003077 cycloserine Drugs 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
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- 239000012847 fine chemical Substances 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
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- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 description 1
- 239000002431 glycine receptor agonist Substances 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
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- LBOJYSIDWZQNJS-UHFFFAOYSA-N neurogard Chemical compound C12=CC=CC=C2C2(C)C3=CC=CC=C3CC1N2 LBOJYSIDWZQNJS-UHFFFAOYSA-N 0.000 description 1
- 230000001962 neuropharmacologic effect Effects 0.000 description 1
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- 239000004090 neuroprotective agent Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95281892A | 1992-09-28 | 1992-09-28 | |
| US952,818 | 1992-09-28 | ||
| PCT/US1993/009295 WO1994007914A1 (fr) | 1992-09-28 | 1993-09-28 | Modulateurs allosteriques du recepteur de nmda |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07505908A true JPH07505908A (ja) | 1995-06-29 |
Family
ID=25493263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6509297A Pending JPH07505908A (ja) | 1992-09-28 | 1993-09-27 | Ｎｍｄａ受容体のアロステリックモジュレーター |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5830998A (fr) |
| EP (1) | EP0625988B1 (fr) |
| JP (1) | JPH07505908A (fr) |
| AU (1) | AU680448B2 (fr) |
| CA (1) | CA2124566A1 (fr) |
| DE (1) | DE69332605T2 (fr) |
| ES (1) | ES2188596T3 (fr) |
| WO (1) | WO1994007914A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854217A (en) | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
| US6277825B1 (en) * | 1996-07-22 | 2001-08-21 | University Of Utah Research Foundation | Use of conantokins for treating pain |
| US6515103B1 (en) | 1996-07-22 | 2003-02-04 | University Of Utah Research Foundation | Conantokins |
| WO1998003189A1 (fr) * | 1996-07-22 | 1998-01-29 | Cognetix, Inc. | Utilisation de conantokines |
| US5844077A (en) * | 1997-04-28 | 1998-12-01 | Cytotherapeutics, Inc. | Use of conantokins for producing analgesia or for neuroprotection |
| US6624288B1 (en) * | 1997-12-16 | 2003-09-23 | Cognetix, Inc. | Gamma-conopeptides |
| WO1999040436A1 (fr) * | 1998-02-10 | 1999-08-12 | University Of Utah Research Foundation | PROCEDES POUR LA PURIFICATION ET LA DETERMINATION D'UNE CONUS η-CARBOXYLASE |
| CA2386555A1 (fr) * | 1999-09-10 | 2001-03-15 | University Of Utah Research Foundation | Gamma-carboxyglutamate renfermant des conopeptides |
| US6399574B1 (en) | 2000-03-22 | 2002-06-04 | University Of Utah Research Foundation | Use of conantokins |
| AU2001296389A1 (en) * | 2000-09-29 | 2002-04-08 | Cognetix, Inc. | Stable peptide formulations |
| AU2002248553A1 (en) * | 2001-03-07 | 2002-09-24 | Cognetix, Inc | Linear y-carboxyglutamate rich conotoxins |
| NZ531785A (en) * | 2001-08-20 | 2007-03-30 | Maiken Nedergaard | Treatment of glial tumors with ionotropic glutamate receptor antagonists |
| EP1298581A1 (fr) * | 2001-09-27 | 2003-04-02 | C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa | Procédé et dispositif pour calculer les valeurs des neurones d'un réseau neuronal |
| EP1476178A4 (fr) * | 2002-02-14 | 2009-08-26 | Bayer Pharmaceuticals Corp | Strategies de formulation dans la stabilisation de peptides dans des solvants organiques et a l'etat seche |
| WO2010093070A1 (fr) * | 2009-02-12 | 2010-08-19 | 서울대학교산학협력단 | Composition pharmaceutique contenant un antagoniste d'ampar privé de glu-r2, convenant à la prévention ou au traitement de maladies psychiatriques |
| CN102167730A (zh) * | 2011-01-29 | 2011-08-31 | 浙江大学 | 芋螺毒素类似物Glu-Con-G[1-13]、设计合成方法及用途 |
| WO2017109756A2 (fr) * | 2015-12-22 | 2017-06-29 | Universidad Nacional De Colombia | Peptides synthétiques modulateurs du récepteur nmda |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1417736A (fr) * | 1963-12-17 | 1965-11-12 | Asahi Chemical Ind | Procédé pour réaliser la synthèse de l'alpha-aminoglutaronitrile, de l'acide dl-glutamique, et de leurs dérivés alcoylés |
| US3658968A (en) * | 1970-06-11 | 1972-04-25 | Merck & Co Inc | Composition and method of treatment |
| US3769424A (en) * | 1970-10-01 | 1973-10-30 | Merck & Co Inc | Composition and method of treating dopamine deficiency in brain tissue |
| ATE70535T1 (de) * | 1986-02-13 | 1992-01-15 | Ciba Geigy Ag | Ungesaettigte aminosaeuren. |
| US5175344A (en) * | 1986-02-13 | 1992-12-29 | Ciba-Geigy Corporation | Unsaturated amino acids |
| US5051413A (en) * | 1986-02-13 | 1991-09-24 | Ciba-Geigy Corporation | Unsaturated amino acids |
| US4806543A (en) * | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
| CA1305177C (fr) * | 1987-06-30 | 1992-07-14 | Yasufumi Ohfune | Carboxypropylglycine et procede pour sa production |
| US4904681A (en) * | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
| US5242947A (en) * | 1988-02-10 | 1993-09-07 | New York University | Use of polyamines as ionic-channel regulating agents |
| JP2757960B2 (ja) * | 1988-10-17 | 1998-05-25 | サントリー株式会社 | （２Ｒ，３Ｓ，４Ｓ）−α−（カルボキシシクロプロピル）グリシン |
| US5049555A (en) * | 1988-12-19 | 1991-09-17 | Nova Pharmaceutical Corporation | Antagonists of specific excitatory amino acid receptors as neuroprotectants and anxiolytics |
| US5061721A (en) * | 1989-03-15 | 1991-10-29 | G. D. Searle & Co. | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
| JP2780115B2 (ja) * | 1989-07-24 | 1998-07-30 | 旭化成工業株式会社 | 虚血性脳細胞障害に対する細胞保護剤 |
| US6017957A (en) * | 1989-08-08 | 2000-01-25 | The United States Of America As Represented By The Department Of Health And Human Services | Partial agonists of the strychnine insensitive glycine modulatory site of the N-methyl-D-aspartate receptor complex as neuropsychopharmacological agents |
| WO1991002523A1 (fr) * | 1989-08-17 | 1991-03-07 | The Children's Medical Center Corporation | Agonistes et antagonistes de l'amino acide glutamatergique |
| US5189020A (en) * | 1989-11-22 | 1993-02-23 | Neurex Corporation | Method of reducing neuronal damage using omega conotoxin peptides |
| US5051403A (en) * | 1989-11-22 | 1991-09-24 | Neurex Corporation | Method of treating ischemia-related neuronal damage |
| DK101290D0 (da) * | 1990-04-24 | 1990-04-24 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| US5086072A (en) * | 1990-06-18 | 1992-02-04 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex |
| GB9109007D0 (en) * | 1991-04-26 | 1991-06-12 | Merck Sharp & Dohme | Therapeutic method |
| EP0518818A3 (en) * | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
| JP3218038B2 (ja) * | 1991-09-09 | 2001-10-15 | ワーナー−ランバート・コンパニー | 尿酸排泄促進剤およびｅａａ拮抗剤の組合せのための医薬組成物 |
| WO1993010145A1 (fr) * | 1991-11-12 | 1993-05-27 | Neurex Corporation | Compositions pour le traitement retarde de lesions neuronales associees a l'ischemie |
-
1993
- 1993-09-27 JP JP6509297A patent/JPH07505908A/ja active Pending
- 1993-09-28 ES ES93923173T patent/ES2188596T3/es not_active Expired - Lifetime
- 1993-09-28 EP EP93923173A patent/EP0625988B1/fr not_active Expired - Lifetime
- 1993-09-28 CA CA002124566A patent/CA2124566A1/fr not_active Abandoned
- 1993-09-28 AU AU52945/93A patent/AU680448B2/en not_active Ceased
- 1993-09-28 WO PCT/US1993/009295 patent/WO1994007914A1/fr active IP Right Grant
- 1993-09-28 DE DE69332605T patent/DE69332605T2/de not_active Expired - Fee Related
-
1994
- 1994-10-14 US US08/323,436 patent/US5830998A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994007914A1 (fr) | 1994-04-14 |
| EP0625988A4 (fr) | 1998-03-04 |
| CA2124566A1 (fr) | 1994-04-14 |
| US5830998A (en) | 1998-11-03 |
| EP0625988A1 (fr) | 1994-11-30 |
| ES2188596T3 (es) | 2003-07-01 |
| DE69332605D1 (de) | 2003-02-06 |
| AU680448B2 (en) | 1997-07-31 |
| AU5294593A (en) | 1994-04-26 |
| DE69332605T2 (de) | 2003-05-08 |
| EP0625988B1 (fr) | 2003-01-02 |
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