JPH07505634A - 新規オピエート誘導体，タンパクおよびポリペプチドオピエート誘導共役体および標識 - Google Patents
新規オピエート誘導体，タンパクおよびポリペプチドオピエート誘導共役体および標識Info
- Publication number
- JPH07505634A JPH07505634A JP5517657A JP51765793A JPH07505634A JP H07505634 A JPH07505634 A JP H07505634A JP 5517657 A JP5517657 A JP 5517657A JP 51765793 A JP51765793 A JP 51765793A JP H07505634 A JPH07505634 A JP H07505634A
- Authority
- JP
- Japan
- Prior art keywords
- formulas
- tables
- mathematical
- chemical formulas
- chemical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229920001184 polypeptide Polymers 0.000 title claims description 67
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- 102000004169 proteins and genes Human genes 0.000 title claims description 67
- 108090000623 proteins and genes Proteins 0.000 title claims description 67
- 229940127240 opiate Drugs 0.000 title description 33
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- 125000005647 linker group Chemical group 0.000 claims description 36
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- 230000000890 antigenic effect Effects 0.000 claims description 11
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
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- 125000001246 bromo group Chemical group Br* 0.000 description 1
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- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 description 1
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- FJAZVHYPASAQKM-JBAURARKSA-N estrone 3-O-(beta-D-glucuronide) Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CCC4=O)C)CC2=CC=3O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O FJAZVHYPASAQKM-JBAURARKSA-N 0.000 description 1
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- ZTVZLYBCZNMWCF-UHFFFAOYSA-N homocystine Chemical compound [O-]C(=O)C([NH3+])CCSSCCC([NH3+])C([O-])=O ZTVZLYBCZNMWCF-UHFFFAOYSA-N 0.000 description 1
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- HVTICUPFWKNHNG-UHFFFAOYSA-N iodoethane Chemical compound CCI HVTICUPFWKNHNG-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
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- CHWRSCGUEQEHOH-UHFFFAOYSA-N potassium oxide Chemical compound [O-2].[K+].[K+] CHWRSCGUEQEHOH-UHFFFAOYSA-N 0.000 description 1
- 229910001950 potassium oxide Inorganic materials 0.000 description 1
- ZFFFJLDTCLJDHL-UHFFFAOYSA-N pregnanediol glucuronide Natural products C1CC2(C)C3CCC4(C)C(C(O)C)CCC4C3CCC2CC1OC1OC(C(O)=O)C(O)C(O)C1O ZFFFJLDTCLJDHL-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/816—Alkaloids, amphetamines, and barbiturates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Anesthesiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86410792A | 1992-04-06 | 1992-04-06 | |
| US864,107 | 1992-04-06 | ||
| PCT/US1993/003009 WO1993020079A1 (en) | 1992-04-06 | 1993-03-31 | Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07505634A true JPH07505634A (ja) | 1995-06-22 |
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| JP5517657A Pending JPH07505634A (ja) | 1992-04-06 | 1993-03-31 | 新規オピエート誘導体，タンパクおよびポリペプチドオピエート誘導共役体および標識 |
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|---|---|
| US (1) | US5610283A (enExample) |
| EP (1) | EP0635019B1 (enExample) |
| JP (1) | JPH07505634A (enExample) |
| AT (1) | ATE180484T1 (enExample) |
| AU (1) | AU3941893A (enExample) |
| CA (1) | CA2132342A1 (enExample) |
| DE (1) | DE69325096T2 (enExample) |
| WO (1) | WO1993020079A1 (enExample) |
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| WO1999038869A1 (en) | 1998-01-29 | 1999-08-05 | Monash University | Therapeutic compounds |
| US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6262265B1 (en) * | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
| EP2080511A3 (en) * | 2000-08-22 | 2009-09-30 | Shire LLC | Active agent delivery systems and methods for protecting and administering active agents |
| US8394813B2 (en) * | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| EP1709957A3 (en) * | 2001-06-05 | 2007-02-14 | Control Delivery Systems | Sustained-release analgesic compounds |
| US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| CA2467559A1 (en) * | 2001-11-19 | 2003-05-30 | Control Delivery Systems, Inc. | Topical delivery of codrugs |
| GB0130535D0 (en) * | 2001-12-20 | 2002-02-06 | Randox Lab Ltd | Haptens immunogens antibodies and conjugates to oxycodone and its metabolites |
| US7700561B2 (en) | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
| US6991911B2 (en) * | 2003-12-15 | 2006-01-31 | Dade Behring Inc. | Assay for entactogens |
| US7022492B2 (en) * | 2003-12-15 | 2006-04-04 | Dade Behring Inc. | Ecstasy haptens and immunogens |
| US20050130243A1 (en) * | 2003-12-15 | 2005-06-16 | Zheng Yi F. | Assay for entactogens |
| US7037669B2 (en) * | 2004-03-22 | 2006-05-02 | Dade Behring Inc. | Assays for amphetamine and methamphetamine using stereospecific reagents |
| US7115383B2 (en) * | 2004-03-22 | 2006-10-03 | Dade Behring Inc. | Assays for amphetamine and methamphetamine |
| ES2341121T3 (es) * | 2004-10-27 | 2010-06-15 | Mallinckrodt, Inc. | Metodo para la separacion y purificacion de hidrocodona mediante cromotografia preparatoria. |
| US7238791B1 (en) * | 2005-12-16 | 2007-07-03 | Roche Diagnostics Operations, Inc. | 6-monoacetylmorphine derivatives useful in immunoassay |
| JP2009533443A (ja) * | 2006-04-10 | 2009-09-17 | シャイア エルエルシー | 一置換及び二置換のオキシコドン化合物及び組成物 |
| JP2009533459A (ja) * | 2006-04-14 | 2009-09-17 | シャイア エルエルシー | 共有結合する化合物の鎮痛作用の増強と、有害な副作用の減衰と、前記化合物の乱用の予防とのための組成物及び方法 |
| US20080207668A1 (en) * | 2006-10-06 | 2008-08-28 | New River Pharmaceuticals Inc. | Pharmaceutical compositions of hydromorphone for prevention of overdose or abuse |
| NZ700688A (en) | 2009-12-01 | 2016-02-26 | Shire Human Genetic Therapies | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| CN103906527B (zh) | 2011-06-08 | 2020-07-10 | 川斯勒佰尔公司 | Mrna递送的脂质纳米颗粒组合物和方法 |
| CA2895702C (en) * | 2011-12-21 | 2020-03-31 | The Scripps Research Institute | Heroin haptens, immunoconjugates and related uses |
| US20150267192A1 (en) | 2012-06-08 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| EP2968586B1 (en) | 2013-03-14 | 2018-07-25 | Translate Bio, Inc. | Cftr mrna compositions and related methods and uses |
| US9694069B2 (en) * | 2013-03-14 | 2017-07-04 | Alere San Diego, Inc. | 6-acetylmorphine analogs, and methods for their synthesis and use |
| ES2708561T3 (es) | 2013-03-14 | 2019-04-10 | Translate Bio Inc | Métodos para la purificación de ARN mensajero |
| EP4276176A3 (en) | 2013-10-22 | 2024-01-10 | Translate Bio, Inc. | Mrna therapy for argininosuccinate synthetase deficiency |
| EP3060258A1 (en) | 2013-10-22 | 2016-08-31 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
| CA2944800A1 (en) | 2014-04-25 | 2015-10-29 | Shire Human Genetic Therapies, Inc. | Methods for purification of messenger rna |
| JP2019506390A (ja) | 2016-01-21 | 2019-03-07 | ザ スクリプス リサーチ インスティテュート | 合成オピオイドワクチン |
| EA201991747A1 (ru) | 2017-02-27 | 2020-06-04 | Транслейт Био, Инк. | НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR |
| WO2018213476A1 (en) | 2017-05-16 | 2018-11-22 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr |
| WO2019094528A1 (en) | 2017-11-09 | 2019-05-16 | The Scripps Research Institute | An improved heroin vaccine |
| WO2020041793A1 (en) | 2018-08-24 | 2020-02-27 | Translate Bio, Inc. | Methods for purification of messenger rna |
| EP3883592A1 (en) | 2018-11-21 | 2021-09-29 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr |
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| US3852157A (en) * | 1971-05-14 | 1974-12-03 | Syva Corp | Compounds for enzyme amplification assay |
| US3884898A (en) * | 1972-08-18 | 1975-05-20 | Syva Co | Normorphine derivatives bonded to proteins |
| SE404553B (sv) * | 1977-03-04 | 1978-10-09 | Pharmacia Diagnostics Ab | Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner |
| SE427505B (sv) * | 1977-03-04 | 1983-04-11 | Pharmacia Diagnostics Ab | Reagens till anvendning vid immunkemiska bestemningsmetoder |
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4939264A (en) * | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| DE69231382T2 (de) * | 1991-04-12 | 2001-01-25 | Biosite Diagnostics Inc., San Diego | Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden |
-
1993
- 1993-03-31 WO PCT/US1993/003009 patent/WO1993020079A1/en not_active Ceased
- 1993-03-31 JP JP5517657A patent/JPH07505634A/ja active Pending
- 1993-03-31 DE DE69325096T patent/DE69325096T2/de not_active Expired - Fee Related
- 1993-03-31 EP EP93908688A patent/EP0635019B1/en not_active Expired - Lifetime
- 1993-03-31 AU AU39418/93A patent/AU3941893A/en not_active Abandoned
- 1993-03-31 AT AT93908688T patent/ATE180484T1/de active
- 1993-03-31 CA CA002132342A patent/CA2132342A1/en not_active Abandoned
-
1995
- 1995-02-15 US US08/389,969 patent/US5610283A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5610283A (en) | 1997-03-11 |
| EP0635019A1 (en) | 1995-01-25 |
| WO1993020079A1 (en) | 1993-10-14 |
| CA2132342A1 (en) | 1993-10-14 |
| EP0635019A4 (enExample) | 1995-02-01 |
| ATE180484T1 (de) | 1999-06-15 |
| EP0635019B1 (en) | 1999-05-26 |
| AU3941893A (en) | 1993-11-08 |
| DE69325096T2 (de) | 1999-09-30 |
| DE69325096D1 (de) | 1999-07-01 |
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