JPH07502727A - 接着分子に対する抗体を用いた同種移植片拒絶の防止 - Google Patents
接着分子に対する抗体を用いた同種移植片拒絶の防止Info
- Publication number
- JPH07502727A JPH07502727A JP5507007A JP50700793A JPH07502727A JP H07502727 A JPH07502727 A JP H07502727A JP 5507007 A JP5507007 A JP 5507007A JP 50700793 A JP50700793 A JP 50700793A JP H07502727 A JPH07502727 A JP H07502727A
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- antibody
- ligand
- specific
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76804491A | 1991-10-01 | 1991-10-01 | |
US768,044 | 1991-10-01 | ||
PCT/US1992/008279 WO1993006864A1 (fr) | 1991-10-01 | 1992-09-29 | Prevention du rejet d'une allogreffe a l'aide d'anticorps contre des molecules d'adhesion |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH07502727A true JPH07502727A (ja) | 1995-03-23 |
Family
ID=25081356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5507007A Pending JPH07502727A (ja) | 1991-10-01 | 1992-09-29 | 接着分子に対する抗体を用いた同種移植片拒絶の防止 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0610298A1 (fr) |
JP (1) | JPH07502727A (fr) |
AU (1) | AU667487B2 (fr) |
CA (1) | CA2120500A1 (fr) |
HU (1) | HUT69725A (fr) |
MX (1) | MX9205637A (fr) |
WO (1) | WO1993006864A1 (fr) |
ZA (1) | ZA927503B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6764681B2 (en) | 1991-10-07 | 2004-07-20 | Biogen, Inc. | Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction |
WO1993015764A1 (fr) * | 1992-02-12 | 1993-08-19 | Biogen, Inc. | Traitement de l'inflammation intestinale |
DE69315847T2 (de) * | 1992-08-21 | 1998-06-25 | Genentech Inc | Verfahren zur behandlung einer durch lfa-1 vermittelten störung |
US5817515A (en) * | 1993-12-23 | 1998-10-06 | Icos Corporation | Human B2 integrin alpha subunit antibodies |
US6670321B1 (en) * | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
AU2001230920A1 (en) * | 2000-01-14 | 2001-07-24 | Genentech Inc. | Diagnosis and treatment of hepatic inflammatory disorders by inhibiting the binding of lfa-1 to icam-1 |
US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
CA2454618C (fr) | 2001-07-24 | 2012-04-03 | Biogen Idec Ma, Inc. | Methodes de traitement ou de prevention de troubles sclereux par l'usage d'agents se liant a cd2 |
WO2005115436A1 (fr) | 2004-05-07 | 2005-12-08 | Astellas Us Llc | Polypeptide lfa-3 soluble destine a traiter de troubles viraux |
AU2005254980A1 (en) | 2004-06-09 | 2005-12-29 | Genentech, Inc. | Method of treating granuloma annulare or sarcoid |
WO2008140484A2 (fr) | 2006-11-09 | 2008-11-20 | Xdx, Inc. | Procédés pour diagnostiquer et surveiller l'état d'un lupus érythémateux systémique |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE114972T1 (de) * | 1987-11-02 | 1994-12-15 | Baylor College Medicine | Verwendung von icam-1 oder ihre funktionelle derivate zur behandlung unspezifischer entzündungen. |
EP0365837B1 (fr) * | 1988-09-28 | 1995-08-02 | Dana Farber Cancer Institute | Molécules d'adhésion intercellulaire et leurs ligands de liaison |
JPH04501565A (ja) * | 1988-11-14 | 1992-03-19 | ブリガム・アンド・ウイメンズ・ホスピタル | Elam―1に特異的な抗体およびその用途 |
EP0387701B1 (fr) * | 1989-03-09 | 1992-08-12 | Boehringer Ingelheim Pharmaceuticals Inc. | Utilisation des molécules d'adhésion intercellulaire et leurs ligands de liaison dans le traitement de l'asthme |
WO1990013316A1 (fr) * | 1989-04-28 | 1990-11-15 | Baylor College Of Medicine | Dissemination de cellules infectees par l'hiv-1 |
US5011778A (en) * | 1989-05-23 | 1991-04-30 | Otsuka Pharmaceutical Co., Ltd. | Monoclonal antibodies directed to IL-1 activated endothelial cells and medicaments employing the monoclonal antibodies |
GB9009549D0 (en) * | 1990-04-27 | 1990-06-20 | Celltech Ltd | Recombinant antibody and method |
GB9009548D0 (en) * | 1990-04-27 | 1990-06-20 | Celltech Ltd | Chimeric antibody and method |
-
1992
- 1992-09-29 AU AU27829/92A patent/AU667487B2/en not_active Ceased
- 1992-09-29 WO PCT/US1992/008279 patent/WO1993006864A1/fr not_active Application Discontinuation
- 1992-09-29 JP JP5507007A patent/JPH07502727A/ja active Pending
- 1992-09-29 CA CA002120500A patent/CA2120500A1/fr not_active Abandoned
- 1992-09-29 HU HU9400930A patent/HUT69725A/hu unknown
- 1992-09-29 EP EP92922110A patent/EP0610298A1/fr not_active Withdrawn
- 1992-09-30 ZA ZA927503A patent/ZA927503B/xx unknown
- 1992-10-01 MX MX9205637A patent/MX9205637A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX9205637A (es) | 1993-05-01 |
AU2782992A (en) | 1993-05-03 |
EP0610298A1 (fr) | 1994-08-17 |
HUT69725A (en) | 1995-09-28 |
AU667487B2 (en) | 1996-03-28 |
CA2120500A1 (fr) | 1993-04-15 |
WO1993006864A1 (fr) | 1993-04-15 |
ZA927503B (en) | 1993-05-03 |
HU9400930D0 (en) | 1994-06-28 |
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