JPH0731675A - Apparatus for dissolving solid dialysis chemical and container for the chemical used therefor - Google Patents

Abstract

PURPOSE:To decrease a space of installation to the floor area and to improve workability of taking in and out of a container by arranging a container wherein a solid dialysis chemical is stored so as to direct its opening in the horizontal direction and arranging in lines and placing a plurality of these containers at multistage state in the vertical direction. CONSTITUTION:Containers P and Q each wherein a solid dialysis chemical is quantitatively stored are placed on container holders 10 and 12 in such a way that these opening parts are directed in the horizontal direction and the opening parts are positioned at the same vertical face and are arranged in lines at multi-stages in the vertical direction. A quantitative water feeding means 36 for feeding quantitatively diluting water to the containers P and Q is formed thereby and container connecting means 16 and 18 are successively freely removably connected to the openings of the containers p and Q to perform feeding and discharging or the diluting water and dissolved soln. of the solid dialysis chemical obtd. from the specified containers through the container connecting means 16 and 18 are stored in dissolving tanks 28 and 30. Each of the container connecting means 16 and 18 is moved to the openings of the containers arranged in lines and placed by means of movement-controlling means 20 and 22 respectively.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a device capable of automatically preparing a dialysate having a predetermined concentration from a solid dialyzing drug for use in hemodialysis, and particularly to hygienic and more labor saving of the solid dialyzing drug. The present invention relates to an apparatus for dissolving a solid dialysis drug which can be converted into a solid solution and a container for the solid dialysis drug used therein.

[0002]

2. Description of the Related Art Today, a dialysate preparation drug is commercially available as a concentrated liquid or a powdery or granular solid agent.
It is used as a dialysis solution by appropriately dissolving it in diluted water to adjust the concentration.

As this type of dialysate, bicarbonate type and acetic acid type are used, and in this case, the bicarbonate type dialysate does not contain sodium bicarbonate (hereinafter referred to as agent A). Two kinds of dialysis agents, one containing sodium bicarbonate (hereinafter referred to as agent B), are used. The solid dialysis agent is a bicarbonate dialysis fluid B
Many agents are used.

When a dialysate is prepared from a solid dialysis drug, usually the drug is first dissolved and mixed in water to form a concentrated solution,
This concentrated liquid is supplied to a dialysate adjusting device, and water is further mixed to adjust the dialysate.

However, in a dialysate adjusting device for supplying dialysate to a plurality of dialyzers, a method for dissolving and mixing a solid dialysate in water has conventionally been required every time one dialysis is performed. The amount of water required to make the concentrated liquid is stored in a predetermined tank, and a container containing multiple solid dialysis drugs (often in a transparent bag) is opened manually, and then the drug is placed in the tank. It is general to charge and dissolve and mix by mechanical stirring with a stirrer (stirring blade) or the like provided in the tank.

[0006] Usually, such a dissolving and mixing operation is not carried out in a clean atmosphere such as a clean room, and therefore, there are many occasions where bacteria and dust in the air come into contact with a dialysis drug and a concentrated liquid after dissolution. Also, there are many opportunities for human contact with the container when the container containing the dialysis drug is opened or put in, so there is a problem in terms of hygiene. Also, leaving the concentrated solution after dissolution and mixing for a long time, or by dissolving and mixing and leaving it on the day before use for dialysis, not only in terms of hygiene but also the concentration of the concentrated solution may change. Not desirable. In particular, a concentrated solution of sodium bicarbonate has low stability and is difficult to store, so it is necessary to use it by dissolving it during dialysis.
Therefore, the dissolving and mixing work must be carried out during a busy time period before the start of dialysis, which is a heavy burden on the person engaged in dialysis. Further, even after the dialysis is finished, many operations such as discarding the excess concentrated liquid and cleaning the inside of the tank are required.

From such a point of view, conventionally, a labor-saving sodium bicarbonate continuous dissolution apparatus that continuously and automatically dissolves sodium bicarbonate and does not require manpower has been proposed (Japanese Patent Publication No. No. 55893). This continuous dissolution apparatus supplies sodium bicarbonate by a powder supply means such as a powder feeder and water by a water supply means to a stirring tank, and the powder supply means or the water supply means is supplied depending on the concentration after stirring. By controlling and dispensing sodium bicarbonate or water, a concentrated sodium bicarbonate solution is obtained.

Also in the sodium bicarbonate continuous dissolution apparatus configured as described above, for example, a container containing sodium bicarbonate necessary for one dialysis is opened, and then a storage container such as a hopper which communicates with the powder supply means. It requires work to put in. In this case, the sodium bicarbonate and the storage container are in contact with the air for a long time, which is a sanitary problem. Further, no proposal has been made for automation or labor saving in cleaning and disinfecting the powder supplying means in this case.

From this point of view, when the applicant first prepares a dialysis solution from powdery or granular solid dialysis drug, the applicant manually operates the container in which the solid dialysis drug is enclosed. Of the solid dialysis drug, which shortens the contact time of the solid dialysis drug with unclean air as much as possible, and can obtain a dialysate of a predetermined concentration automatically with a sanitary and labor-saving device. A melting device was developed and a patent application was filed (Japanese Patent Application Laid-Open No. 5-14648).
No. 7).

That is, the invention according to the above-mentioned patent application supplies the dilution water for dissolving the solid dialysis drug to a container in which a fixed amount of the solid dialysis drug in the form of powder or granules is sealed, respectively, and In a solid dialysis drug dissolving device configured to mix and dissolve a dialysis drug with diluting water and store the solution in a dissolution tank, two containers each containing a fixed amount of the two types of solid dialysis drugs are radiused. Direction and a container transfer means arranged on concentric circles separated by a predetermined distance so as to sequentially transfer the concentric circles in the rotational direction of the concentric axis, and dilution water for the two types of containers at predetermined positions of the container transfer means. And a dissolution tank for storing a solution of the solid dialysis drug dissolved by the fixed quantity water supply means.

[0011] However, the container transfer means arranges the containers in which the two kinds of solid dialysis drugs are quantitatively sealed respectively in a pair on the turntable on concentric circles that are spaced apart by a predetermined distance in the radial direction. Transfers sequentially in the direction of rotation of the concentric shaft. Further, a container connecting means is liquid-tightly connected to the pair of containers at a predetermined position to form a diluting water or solution circulation system through a dissolution tank and required flow passage means. Then, a fixed amount of dilution water is supplied from a part of the flow path means or a dissolution tank, and this is circulated and supplied to the container by the action of a pump device provided in the circulation system so that a solid of a predetermined concentration is contained in the dissolution tank. It is configured to store the solution of the dialysis drug.

[0012]

However, in the previously proposed dissolution apparatus, a large number of containers, each containing a fixed amount of solid dialysis drug, are arranged on the turntable in the same horizontal plane with their mouths facing upward. Therefore, increasing the number of containers accommodated not only increases the installation space for the floor area, but also complicates the container loading and unloading work, and has many inconveniences especially when installed and used in a hospital or the like. .

Therefore, an object of the present invention is to significantly reduce the installation space of the container with respect to the floor area, and to arrange a large number of containers in an aligned manner and to simplify the work of taking them in and out.
An object of the present invention is to provide a device for dissolving a solid dialysis drug, which has good operability.

Further, in the present invention, when a fixed amount of dilution water is sequentially supplied to a large number of containers in which a fixed amount of a solid dialysis drug is sealed, and when a solution having a predetermined concentration is obtained, the connection with each container is made. It is an object of the present invention to provide a container for a solid dialysis drug, which has a novel structure and is suitable for smoothly flowing out a solution from the container.

[0015]

A device for dissolving a solid dialysis drug according to the present invention comprises a container in which a fixed amount of a powdered or granular solid dialysis drug is sealed, and dilution water for dissolving the solid dialysis drug is added to each container. In a solid dialysis drug dissolving device configured to supply and mix and dissolve the solid dialysis drug in the container with dilution water and store the solution in a dissolution tank, a container in which a fixed amount of the solid dialysis drug is enclosed is provided. ,
A container holding means arranged such that its mouth portion is oriented in the horizontal direction, and a plurality of these containers can be arranged and arranged in multiple stages in the vertical direction such that the mouth portions are located on the same vertical plane, and the container. A constant quantity water supply means for supplying a fixed amount of dilution water, a container connecting means for supplying and discharging a dilution water by sequentially detachably connecting to the mouth of the container, and the container connecting means. A dissolution tank for storing a solution of the solid dialysis drug obtained from a predetermined container via the container and a movement control means for sequentially moving the container connecting means with respect to the mouth of the container aligned and mounted on the container holding means are provided. It is characterized by

In the above-mentioned dissolution apparatus, the fixed quantity water supply means is connected to the dissolution tank through an opening / closing valve, and when the fixed quantity of dilution water is supplied to each of the containers, the dissolution tank is connected to the container via pump means. It can be provided together with the flow path means for communicating with the connecting means and further for communicating with the dissolution tank from the container connecting means.

In this case, a concentration meter for detecting the concentration of the solution of the solid dialysis drug can be provided in the flow path means provided together with the fixed quantity water supply means.

Further, the container connecting means is movably arranged along the respective mouth portions of the containers which are aligned and mounted on the container holding means, and the positioning is stopped in order corresponding to the respective mouth portions of the respective containers. It can be provided together with an industrial robot as a movement control means for controlling operation.

Further, the container connecting means may be integrally provided with an opening means for opening a sealing material for sealing the mouth of the container.

A storage tank for storing a solution of solid dialysis drug having a predetermined concentration can be connected to the dissolution tank via an open / close valve.

On the other hand, a container for quantitatively encapsulating a solid dialysis drug in the form of powder or granules has its mouth almost at the lower surface of the container when the mouth is arranged in the container holding means so as to be oriented horizontally. It is characterized in that they are provided at the same position or less.

In this case, the portion serving as the lower surface of the container placed on the container holding means can be configured to incline downward toward the mouth.

[0023]

According to the apparatus for dissolving a solid dialysis drug according to the present invention, a container in which a fixed amount of powdered or granular solid dialysis drug is enclosed is arranged by the container holding means so that the mouth of each container is oriented in the horizontal direction. At the same time, the containers are vertically arranged in multiple stages so that the respective mouths are located on the same vertical plane, and the diluted water is added to the mouths of these respective containers by means of a container connecting means that can be sequentially moved. By connecting to the fixed-quantity water supply means and sequentially storing the dissolution liquid in the dissolution tank while dissolving the solid dialysis drug in the container, the dialysate with a predetermined concentration is automatically and hygienically and labor-saving. It can be easily prepared by the above device.

In this case, when the container holding the solid dialysis drug is arranged so that the mouth portion is oriented horizontally in the container holding means, the mouth portion is located at substantially the same position as the lower surface of the container or less. By providing
It is possible to smoothly achieve the outflow of the solution of the dialysis drug from the container with the dilution water.

[0025]

Embodiments of the apparatus for dissolving a solid dialysis drug and the container for a solid dialysis drug used therein according to the present invention will be described in detail below with reference to the accompanying drawings.

First, the basic principle of the apparatus for dissolving a solid dialysis drug according to the present invention will be described with reference to FIG. That is, in FIG. 1, reference numeral 1 indicates a container in which a powdery or granular solid dialysate preparation agent is quantitatively sealed, and reference numeral 2 stores a solution obtained by dissolving the solid dialysate. 3 shows a dissolution tank. However, in the present invention, dilution water is supplied to the solid dialysis drug in the container 1 to dissolve the solid dialysis drug, and the obtained solution of the dialysis drug is stored in the dissolution tank 2 and mixed and dissolved. A water supply means 3 is provided. In this case, the container 1 and the dissolution tank 2 are connected to each other so as to form a circulation system of dilution water or a dissolution liquid. Therefore, the water supply means 3 is connected so as to supply a predetermined amount of dilution water to the dissolution tank 2 in advance (indicated by a solid line) or directly to supply the dilution water to the container 1 (indicated by a broken line). )be able to.

As an alternative, diluting water is directly supplied from the water supply means 3 to the solid dialysis drug in the container 1 to dissolve the solid dialysis drug, and the obtained solution of the dialysis drug is sequentially introduced into the dissolution tank 2. It is also possible to store and circulate the solution (not shown) (shown by a chain line).

Thus, according to the present invention, the conventional means for quantitatively supplying the dialysis drug to the dissolution tank is omitted, and the dilution water is directly supplied to the solid dialysis drug enclosure. The dialysis drug in the container can be collected in a dissolution tank to prepare a solution of the dialysis drug having a predetermined concentration simply and hygienically.

FIG. 2 is a schematic system diagram showing an embodiment of the apparatus for dissolving a solid dialysis drug according to the present invention. In addition, in the present embodiment, for example, it can be applied as a dissolution apparatus for a solid bicarbonate dialysate drug for preparing a dialysate from two agents A and B. In this case, A enclosed in the containers P and Q
The composition of each of the agent and the agent B is a solid dialysis drug composed of a plurality of compositions or a single composition (the agent B is commercially available only for sodium bicarbonate).

In FIG. 2, reference numerals 10 and 12 indicate container holding means for accommodating and mounting the containers P and Q, respectively, in which two kinds of solid dialysis drugs are enclosed, in a multi-stage manner. However, the container holding means 10 and 12 store the containers P and Q in a single storage case 14 as shown in FIG. 3, for example.
The mouth portions are arranged so as to be oriented in the horizontal direction, and the containers P and Q are arranged so as to be vertically arranged in multiple stages so that the mouth portions are located on the same vertical plane.

Container connection means 16 and 18 for supplying dilution water are provided to the containers P and Q arranged and placed by the container holding means 10 and 12, respectively. The container connecting means 16 and 18 are arranged so as to be movable along the respective mouths of the corresponding containers P and Q, and control operations are performed so as to sequentially perform positioning and stop corresponding to the respective mouths of the containers P and Q. It is configured to be operated by the movement control means 20 and 22 which are, for example, industrial robots.

However, the containers P and Q used in this embodiment are made of, for example, a polyethylene container which is formed into a cylindrical shape by a blow molding method, and the circular mouth portion is sealed with the same polyethylene film to solidify the inside. It consists of a fixed amount of dialysis drug. Further, when opening the containers P and Q, in order to prevent the drug inside the containers from coming into contact with the atmosphere as much as possible, the container connecting means 16 and 18 are configured to be opened when or after being connected to the containers. It is preferable. Therefore, the container connecting means 16 and 18 connected to the mouths of the containers P and Q are integrally provided with an unsealing means for unsealing the sealing material that seals the mouths. Then, at the time of connecting to the containers P and Q, one end portion of the flow path means 24 and 26, which communicates with the inside of the container through a seal member and supplies and discharges dilution water, is connected to the container connecting means 16 and 18. Install.

Dissolution tanks 28 and 30 are provided corresponding to the container connection means 16 and 18, respectively, and the dissolution tanks 28 and 30 and the container connection means 16 and 18 are connected to each other by flow path means 24 and 26. Then, each of the containers P,
A circulating system for dilution water or solution for Q is constructed.
In this case, circulation pump devices 32 and 34 are provided in a part of the flow path means 24 and 26. Also, the flow path means 24,
A fixed quantity water supply means 36 for supplying dilution water of the solid dialysis drug is connected to a part of 26 or the dissolution tanks 28 and 30 via opening / closing valves 38 and 40.

Concentration meters 42 and 44, which are electric conductivity meters and the like for detecting the concentration of the solution, are provided in a part of the flow path means 24 and 26 constituting the solution circulation system. You can

In addition, in the dissolution tanks 28 and 30, on-off valves are respectively provided at portions of discharge pipes 46 and 48 for discharging the dissolved solution obtained by dissolving the stored solid dialysis drug with dilution water. Storage tank 5 via 50, 52
4, 56 are connected in communication with each other to store the dilute solutions of the two types of solid dialysis drugs having the predetermined concentrations respectively obtained in the dissolution tanks 28, 30 and appropriately store them in a dialysate supply device (not shown). It is configured to supply and prepare a dialysate having a predetermined concentration.

FIG. 4 shows an embodiment of a container that can be preferably used in the dissolution apparatus for the solid dialysis drug in this embodiment described above. However, the container 60 shown in (a) of FIG. 4 is made of a polyethylene container formed into a cylindrical shape by a blow molding method, and a circular mouth portion 62 at one end of the container 60 allows the container 60 to move horizontally as shown in the drawing. It is provided so as to be positioned substantially at the same position as the lower surface of the container 60 when arranged so as to be oriented. With such a configuration, the flow path means 24a, 24b or 26 for connecting the container connecting means 16 or 18 and communicating therewith.
When the dilution water is supplied and discharged via a and 26b, the outflow of the solution of the solid dialysis drug in the container 60 can be smoothly achieved.

The container 60 shown in FIG. 4 (b) is a polyethylene container molded in a rectangular shape by the blow molding method. In this case, the circular mouth portion 62 is set in the same manner as in the above-described embodiment, and particularly, the lower surface of the container 60 is provided with the mouth portion 6.
It is configured to incline downward toward 2.
With such a configuration, it is possible to smoothly achieve the outflow of the solution of the solid dialysis drug in the container 60, as in the above embodiment.

Next, the operation of the apparatus of the embodiment shown in FIG. 2 will be described.

First, two kinds of containers P and Q are arranged and arranged in multiple stages at predetermined positions on the container holding means 10 and 12, respectively. In this case, the mouths of the containers P and Q are arranged such that the sealing material can be opened.

Therefore, first, the movement control means 20 and 22 are operated to position the container connecting means 16 and 18 with respect to the predetermined containers P and Q, respectively, and liquid-tightly set at the mouths of the containers P and Q. To do. Next, the on-off valves 38 and 40 are opened, a fixed amount of dilution water is supplied from the fixed amount water supply means 36 into the dissolution tanks 28 and 30, respectively, and the on-off valves 38 and 40 are closed. After that, the pump device 3 provided in the flow path means 24, 26
2, 34 are driven to supply the dilution water in the dissolution tanks 28, 30 into the containers P, Q, respectively. In this way, the solid dialysis drug in the containers P and Q can be sequentially discharged while being dissolved in the dilution water, and the dialysis drug solution having a predetermined concentration can be stored in the dissolution tanks 28 and 30.

In the step of dissolving the dialysis drug, for example, a timer or the like can be used to set a constant operation time. The dissolving liquids stored in the dissolving tanks 28 and 30 are automatically stirred and mixed by circulating them between the containers P and Q by the pump devices 32 and 34, respectively.

In this way, the melting tanks 28,
The dissolved solution of the dialysis drug having a predetermined concentration stored in 30 is provided with open / close valves 50 and 52 provided in discharge pipes 46 and 48, respectively.
Are opened and stored in storage tanks 54 and 56, respectively. Then, the solution of the dialysate having a predetermined concentration stored in the storage tanks 54 and 56 can be appropriately supplied to the dialysate supply device to prepare a dialysate composed of predetermined components.

Although the preferred embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments, and various design changes can be made without departing from the spirit of the present invention. Of course.

For example, in the above-mentioned embodiment, the case where the fixed amount water supply means is directly connected to the dissolution tank is shown.
The fixed amount water supply means may be connected and arranged at any position of the flow path means. Further, the flow path means should be configured such that the fixed quantity water supply means is directly connected to the container without removing the pump device to form a circulation system and the solution of the solid dialysis drug is unilaterally collected from this container to the dissolution tank. You can also

[0045]

As is apparent from the above-mentioned embodiments, according to the present invention, the container in which the solid dialysis drug is enclosed is arranged by the container holding means so that its mouth is oriented in the horizontal direction, and the plurality of these containers are arranged. By arranging the containers of (1) and (2) in multiple stages in the vertical direction so that their mouths are located on the same vertical surface, the installation space for the floor area can be extremely reduced, and the workability of loading and unloading the containers can be significantly improved. .

Also, the container connecting means is arranged movably along the respective mouth portions of the containers with respect to the containers arranged in line on the container holding means so as to correspond to the mouth portions of the respective containers in sequence. The operation can be smoothly performed by the movement control means such as an industrial robot that controls the positioning so as to stop the positioning.

In this way, according to the device of the present invention, the handling is simple and the solid dialysis drug in the container is automatically dissolved to store the solution having a predetermined concentration in the dissolution tank.
It is possible to easily prepare a dialysate containing a predetermined component having a predetermined concentration. Therefore, it is possible to completely omit manual work such as opening of the container and introduction of the drug, and also shortening the time in which the dialysis drug is brought into contact with the outside air, which is extremely hygienic for dissolving and mixing the solid dialysis drug. Can be achieved.

[Brief description of drawings]

FIG. 1 is a schematic system diagram showing the basic principle of a dissolution apparatus for a solid dialysis drug according to the present invention.

FIG. 2 is a schematic system diagram showing one embodiment of a dissolution apparatus for a solid dialysis drug according to the present invention.

3 is an explanatory diagram showing an outline of container holding means of the solid dialysis drug dissolving device shown in FIG. 2. FIG.

FIG. 4 shows a container for a solid dialysis drug used in a device for dissolving a solid dialysis drug according to the present invention, in which (a) is a perspective view showing an embodiment of the container and (b) is another container. It is a perspective view showing an example of.

[Explanation of symbols]

 1 Container 2 Dissolution Tank 3 Water Supply Means 10 and 12 Container Holding Means 14 Storage Cases 16 and 18 Container Connection Means 20 and 22 Movement Control Means 24 and 26 Flow Path Means 28 and 30 Dissolution Tanks 32 and 34 Circulation Pump Device 36 Constant Water Supply Means 38, 40 Open / close valve 42, 44 Concentration meter 46, 48 Discharge pipe 50, 52 Open / close valve 54, 56 Storage tank 60 Container 62 Mouth P, Q Container

Claims (8)

[Claims] 1. A container in which a fixed amount of powdered or granular solid dialysis drug is sealed is supplied with dilution water for dissolving the solid dialysis drug, and the solid dialysis drug in the container is mixed and dissolved with dilution water. In the dissolution device for the solid dialysis drug, which is configured to store this solution in the dissolution tank, the containers each containing a fixed amount of the solid dialysis drug are arranged such that their mouths are oriented in the horizontal direction. Container holding means configured so that a plurality of containers can be aligned and mounted in multiple stages in the vertical direction so that the mouth portions are located on the same vertical plane, and a fixed amount water supply means for supplying a fixed amount of dilution water to the container. A container connecting means for sequentially supplying and discharging diluent water by detachably connecting to the mouth of the container, and a solid dialysate obtained from a predetermined container via the container connecting means And a movement control means for sequentially moving the container connecting means with respect to the mouth of the container aligned and mounted on the container holding means. . 2. The fixed quantity water supply means is connected to the dissolution tank via an opening / closing valve and communicates with the container connection means via a pump means from the dissolution tank when supplying the fixed quantity of dilution water to each of the containers. 2. The apparatus for dissolving a solid dialysis drug according to claim 1, which is provided with a flow path means which is connected to the dissolution tank and is connected to the dissolution tank from the container connection means. 3. The apparatus for dissolving a solid dialysis drug according to claim 2, wherein the flow path means provided together with the quantitative water supply means is provided with a concentration meter for detecting the concentration of the solution of the solid dialysis drug. 4. The container connecting means is movably arranged along the respective mouth portions of the containers which are aligned and mounted on the container holding means, and is controlled so as to sequentially position and stop corresponding to the respective mouth portions of the respective containers. The apparatus for dissolving a solid dialysis drug according to claim 1, wherein the apparatus is provided with an industrial robot as a movement control means that operates. 5. The apparatus for dissolving a solid dialysis drug according to claim 1, wherein the container connecting means is integrally provided with an unsealing means for unsealing a sealing material for sealing the mouth of the container. 6. The apparatus for dissolving a solid dialysis drug according to claim 1, wherein a storage tank for storing a solution of a solid dialysis drug having a predetermined concentration is connected to the dissolution tank via an on-off valve. 7. A container for quantitatively encapsulating a solid dialysis drug in the form of powder or granules, wherein when the container holding means is arranged such that the mouth portion is oriented horizontally, the mouth portion is substantially at the lower surface position of the container. The container for the solid dialysis drug used in the dissolution apparatus according to claim 1, wherein the container is provided so as to be located at the same position or less. 8. The container for a solid dialysis drug according to claim 7, wherein a portion serving as a lower surface of the container placed on the container holding means is configured to be inclined downward toward the mouth portion.