JPH07308393A - Cancer treating apparatus - Google Patents

Abstract

PURPOSE:To achieve higher effect of optical treatment by irradiating lesion effectively with activating light concerning a cancer treating apparatus to be used for the treatment of caner and tumor. CONSTITUTION:This apparatus includes a catheter type insertion body which is provided with a tube 11 with its tip closed whose tip side is inserted into a subject to be treated and an optical fiber 12 to let the tip side be arranged freely slidably in the tube 11.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cancer treatment device used for the treatment of cancer and tumors. More specifically, for example, cancers or tumors that have arisen in sites or organs where resection surgery is considerably difficult, such as pancreatic cancer. The present invention relates to a cancer treatment device used for treatment of lung cancer, brain tumor, cancer of brain stem and spine, cancer near aorta, and the like.

[0002]

2. Description of the Related Art Cancer is one of the most terrifying diseases left for human beings at present, and the elucidation of its root cause and the therapeutic method are in the developing stage. There are three typical treatment methods that are currently effective: surgical resection, radiation therapy, and anticancer drug therapy.
These are the most commonly used.

Of these, the surgical resection method is the most effective curative method and is most often used. However, for a malignant tumor in the deep part of the body where this method cannot be adopted, radiation therapy and anticancer drug therapy are used in combination. Often used. However, these radiotherapy and anticancer drug therapy are often accompanied by strong side effects, and the complete cure rate is considerably lower than that of the surgical resection method, and there is a high risk of recurrence.

Therefore, in recent years, researches on cancer treatment methods by physical therapy without side effects have been vigorously pursued, and typical methods thereof include a heat treatment method and a phototherapy method using a photosensitizer. The heat treatment method is a method of killing cancer cells by overheating or cooling them. For example, even if the cancer cells are kept at a temperature + 5 ° C higher than the body temperature for a certain period of time, the damage to surrounding normal cells is relatively small. It has been reported to have a great therapeutic effect.

On the other hand, in the phototherapy method, when cells having absorbed the photosensitizer are irradiated with activating light having a specific wavelength, the photosensitizer absorbs light energy to generate activated oxygen which destroys the cells. It is based on the mechanism that the photosensitizer is injected, and the excretion rate of the photosensitizer after injection of the photosensitizer is 1/3 or less (about 1/5) in cancer cells as compared with normal cells, which is extremely high. It takes advantage of the fact that it is very low.

The present invention described later is directed to this phototherapy method, and this phototherapy method will be described in detail below. Figure 9
[Fig. 4] is a graph showing the relative concentration of ATX-S10 remaining in cells with respect to the elapsed time from the time of injecting ATX-S10, which is one of the photosensitizers, into the body. Graph PN is the residual concentration in normal cells, and graph PC is the residual concentration in cancer cells.

[0007] After the photosensitizer is directly injected into the affected area or intravenously, the sensitizer is sufficiently injected into the cells in the affected area and its surroundings, and after a suitable waiting time (about 3 hours), normal cells are passed. Has already excreted most of the photosensitizer, whereas a state in which most of the photosensitizer remains in the cancer cells (a state capable of phototherapy) appears. When activated light of a specific wavelength is irradiated in this photo-treatable state, activated oxygen that destroys cells is actively generated in the cancer cells where most of the photosensitizer remains, and most of the photosensitizer is excreted. Activated oxygen is hardly generated in the normal cells, and the cancer cells are selectively killed.

[0008] The duration of the photo-treatable state (phototherapy effective period) after one injection of the photosensitizer starts about 3 hours after the injection of the sensitizer, and the cancer cells excrete most of the sensitizer. About 14
It ends after time. Note that FIG. 9 shows an example of ATX-S10, and the waiting time after injection of the photosensitizer and the phototherapy effective period vary by about one digit depending on the type of the photosensitizer. The main points of this treatment are to keep the affected area evenly exposed to activated light as uniformly as possible within this effective period of light treatment, and to determine the intracellular concentration of activated oxygen that kills the cells, and the normal cell death in normal cells. The rate remains at a very low value within the allowable limit, and the cancer cell mortality rate is 100% within the cancer cell.
The amount of irradiation light is controlled so that the values are close to each other.

[0009]

In order to apply the activation light to the affected area, conventionally, an optical fiber was directly inserted into the affected area and the activation light was sent through the optical fiber. However, in this method, (a) since the optical fiber cannot be moved during the treatment, the irradiation region, that is, the treatment range is very narrowly limited. (B) In order to irradiate light from the tip of the optical fiber in all directions, it is necessary to cut the tip of the optical fiber into, for example, a conical shape, which is difficult to process, which makes the optical fiber very expensive. Will end up. (C) In order to repeat the treatment, it is necessary to reinsert the optical fiber each time, which imposes a heavy burden on both the patient and the doctor. (D) Since the treatment range is narrow, it is very difficult to cure a large cancer or tumor. There is a problem. (E) It is necessary to disinfect the optical fiber before the treatment and re-disinfect or dispose of the optical fiber after the treatment. Since the optical fiber usually requires a length of 1 m or more and is a composite material, disinfection and disposal are considerably troublesome. , It is not easy to use.

In view of the above facts, it is an object of the present invention to provide a cancer treatment device at a low cost, which is capable of irradiating the affected area with activating light over a wide area to enhance the effect of a large phototherapy and which is easy to use. To do.

[0011]

A first cancer treatment device of the present invention that achieves the above object is a tube having a closed distal end, the distal end of which is inserted into the body to be treated, and the distal end of which is slidable inside the tube. A catheter type inserter having an optical fiber to be arranged, which emits predetermined activating light, the activating light propagates in the optical fiber, and from the tip of the side of the optical fiber arranged in the tube. A light source that emits activating light to the optical fiber so as to be emitted, and an optical fiber that is arranged in the tube are configured to reciprocate in the longitudinal direction of the tube and to rotate in the tube in the direction of rotation. It is characterized by comprising a drive mechanism for driving the optical fiber so as to perform at least one movement selected from the above.

Here, the above-mentioned "tube with a closed tip"
Means that the tip of the tube itself may be closed, or the tip of the tube may be closed by a plug or the like fitted in the opening at the tip. In the above-mentioned first cancer treatment device of the present invention, the optical fiber is
It is preferable to have a flat surface that is oblique to the longitudinal direction of the optical fiber.

Further, it is preferable that the driving mechanism drives the optical fiber so that the optical fiber periodically reciprocates and / or rotates. The second cancer treatment device of the present invention that achieves the above object is provided with a scatterer that scatters predetermined activation light and has a closed tip, the tip side of which is inserted into the body to be treated, and the tip side of which is a tube. A catheter-type inserter that has an optical fiber that is disposed inside and emits activating light from the tip toward a scatterer; and activating light is emitted, and the activating light propagates in the optical fiber. It is characterized by comprising a light source for injecting activating light into the optical fiber so as to be emitted from the tip of.

In the second cancer treatment device, the scatterer is preferably made of a plastic material containing polyurethane, polyacetal, or nylon 11. Further, the scatterer may also serve as a stopper for closing the tip of the tube, or, the scatterer,
It may be provided inside the tube whose tip is closed.

Further, in the second cancer treatment device, the optical fiber has a flat surface at the tip of the optical fiber in the longitudinal direction of the optical fiber, and the scatterer faces the tip of the optical fiber. It is preferable that the position has a plane extending parallel to the plane of the tip of the optical fiber. Furthermore, the third aspect of the present invention that achieves the above object
The cancer treatment device of (1) has a catheter-type inserter having a tube with a closed tip, the tip side of which is inserted into the body to be treated, and an optical fiber whose tip side is arranged in the tube, and a predetermined activation light. A light source that emits light and makes the activation light enter the optical fiber so that the activation light propagates in the optical fiber and is emitted from the tip of the optical fiber on the side disposed in the tube. The luminous flux density of the emitted light on a spherical surface centered on the center of the tip of the optical fiber is 0.37 times or more of the maximum value. When defined as a region, the tip of the optical fiber is a flat surface having an emission solid angle of 0.12 steradians or more.

In this third cancer treatment device, the optical fiber is slidably arranged in the tube, and the optical fiber arranged in the tube reciprocates in the longitudinal direction of the tube. As is done, it is preferable to have a drive mechanism that drives the optical fiber. In this case, the driving mechanism preferably drives the optical fiber so that the optical fiber makes periodic reciprocating motion.

In each of the first, second, and third cancer treatment devices, the tube is preferably made of a plastic material containing polyurethane, polyacetal, or nylon 11, and the tube is preferably made of plastic material. It is preferable that the end of the tube on the side of the tip inserted into the body to be treated has a pointed portion whose area of a cut surface orthogonal to the longitudinal direction of the tube decreases as it approaches the tip of the tube.

Further, in any of the first, second and third cancer treatment devices, the light source continuously or stepwise increases the incident light amount of the activation light incident on the optical fiber. It is preferably one.

[0019]

In the first cancer treatment device of the present invention, the optical fiber is slidably provided in the tube. Therefore, once the tube is inserted, the optical fiber can be reciprocated or rotated by the patient. Does not cause pain and the patient is not injured each time the optical fiber is pulled out and inserted, and it is easy to perform the treatment in a plurality of times.
A tube having a diameter of about 0.5 mm to 1.5 mm can be used, and side effects such as bleeding caused by inserting the tube into the affected area are small.

Strict disinfection before the treatment is performed only with the tube, and after the treatment, the tube, which is much cheaper than the optical fiber, can be easily disposed of by incineration or the like, and the usability is very good. Also, when the optical fiber is reciprocated,
It is possible to obtain a wide light irradiation area in the longitudinal direction of the tube, and it is possible to deal with an affected area having a large size.

Further, it is possible to inexpensively cut the tip of the optical fiber at a low cost, and when combined with the rotational movement of the optical fiber, a wide light irradiation area can be obtained around the tube. In addition, by periodically reciprocating or rotating the optical fiber, it is possible to continue activating light over a wide light irradiation area for a long time, and at the same time, the light is directed to a specific part of the tube. Since it does not hit continuously, melting and carbonization of the thin tube due to heat of light irradiation are prevented, and the tube can be used for a long time.

The second cancer treatment device of the present invention is provided with a scatterer in the tube, and is suitable for a small affected area, and can be used even if the optical fiber is not reciprocated or rotated. The tip of the fiber can simply be a light source that emits light in all directions that is most suitable for treatment.
As this scatterer, the same material as the tube, for example, a plastic material containing polyurethane, polyacetal, or nylon 11 can be used, and it is inexpensively formed. This scatterer may also serve as a stopper at the tip of the tube, or the tip of the tube may be originally formed in a shape in which such a scatterer is arranged, and the scatterer may be formed from the tip of the tube with an open mouth. May be inserted into the tube to close the mouth of the tube, or a scatterer may be inserted into the tube from the rear end side of the tube whose tip is closed. When the scatterer is provided, the tip of the light tube does not need to be obliquely cut, and the tip of the optical fiber may be a plane cut perpendicularly to the longitudinal direction of the optical fiber and faces the tip of the scatterer's optical fiber. The side may also be cut into a plane facing the tip of the optical fiber.

Further, in the third cancer treatment device of the present invention, the activating light is emitted from the tip of the optical fiber arranged in the tube so that the activating light spreads over a predetermined solid angle and is emitted. It has a scattering plane. Here, in the third cancer treatment device of the present invention, the luminous flux density of the emitted light on the spherical surface centered on the center of the tip of the optical fiber is 0, which is the maximum value, of the emitted solid angle indicating the spread of the emitted activation light. ．
It is defined as a region of 37 times or more, and the scattering plane at the tip of the optical fiber is defined as a plane that makes this emission solid angle 0.12 steradians or more. This scattering plane is easily defined by rough polishing such as a file. Because it can be obtained at low cost and the activation light spreads to a degree that satisfies this, the activation light is irradiated to a large area of the affected area without the need for a scatterer or the like separate from the optical fiber. This is because the above effect can be achieved.

In this third cancer treatment device, the optical fiber is slidably arranged in the tube, and when the optical fiber is reciprocated, a wider light irradiation area can be obtained, and a large affected area can be dealt with. . Further, by making this reciprocating motion a periodic motion, it is possible to uniformly irradiate activation light onto a wide light irradiation region. Incidentally, the above first and second
And in any of the third cancer treatment device, by using polyurethane, polyacetal, or nylon 11 as the main raw material of the tube, it has the light transmittance required for this treatment device, and the flexible structure does not damage the human body, Furthermore, a tube that is not toxic to the human body is realized. Further, in the case of polyacetal, there is also an advantage that it is hard to be carbonized even when irradiated with strong light. In the case of nylon 11, a cheap and robust tube can be formed.

By making the tip of the tube sharp, it becomes easy to insert the tube into the affected area. In addition, as shown in FIG. 9, since the concentration of the photosensitizer in normal cells continues to decrease even during the effective period of phototherapy, activation of normal photocells is not affected by irradiation with strong activating light. Oxygen is less likely to be generated, and therefore, over time, irradiation with stronger activation light can further enhance the therapeutic effect.

In each of the first, second and third cancer treatment devices of the present invention, a tube and an optical fiber which can obtain a wide light irradiation area and can be used for a long time can be provided at low cost. Only inexpensive tubes that can be incinerated are used as disposables for each patient or treatment, which is excellent in terms of usability and hygiene management.

[0027]

EXAMPLES Examples of the present invention will be described below. FIG. 1 is a schematic configuration diagram showing an embodiment of the cancer treatment device of the present invention. The cancer treatment device 10 is provided with a disposable type tube 11, and a tip portion 11a thereof is inserted into an affected part having a cancer or a tumor in a patient's body. This tube 11 is made of polyacetal, for example,
The outer diameter is about 1 mm.

The cancer treatment device 10 includes an optical fiber 1
2 are provided, wound around the first reel 13 and the second reel 14, and fixed to the first reel 13 and the second reel 14 by fixing tools 13a and 14a, respectively. The tip portion 12a of the optical fiber 12 on the second reel 14 side is inserted into the tube 11,
1 reaches the tip 11a. Optical fiber 1
The second incident end 12b is connected to the laser light source 15. The laser light source 15 emits laser light having a wavelength used as activation light, and the laser light source 15 emits laser light having a wavelength used as the activation light.
It is incident on the optical fiber 12 from 2b. The laser light source 15 is capable of emitting a variable amount of laser light, and the amount of light is changed with the passage of time by a control circuit (not shown). Details will be described later. The laser light entering the optical fiber 12 propagates inside the optical fiber 12 and is emitted from the tip inserted into the tube 11.

The first reel 13 is connected to the shaft 16a of the torque motor 16, and by the torque motor 16,
It is urged in the direction of arrow A shown. A rod 17 having a male screw engraved thereon is fixed to the second reel 14. The rod 17 is screwed with a fixed bearing 18 and a shaft 20a of the reversible motor 20 is coupled via a coupling 19. Is connected with. The fixed bearing 18 is fixed to a base or the like (not shown). The reversible motor 20 is a motor that can rotate both forward and backward, and a guide member (not shown) prevents rotation of the motor body and guides the entire motor to move back and forth (left and right in FIG. 1). Has been done.

When the reversible motor 20 rotates forward, the rod 17
Rotates forward, and since the rod 17 is screwed with the fixed bearing 18, it moves forward together with the reversible motor 20 and moves the second reel 14 forward while rotating it. At this time, the second reel 14 pulls the optical fiber 12 wound around the first reel 13 to wind the optical fiber 12 around the second reel 14, while pushing the tip 12 a of the optical fiber 12 into the tube 11. While the optical fiber 12 is
Rotate in the positive direction around the longitudinal direction of the axis. When the reversible motor 20 rotates in the reverse direction, the rod 17 retreats while rotating in the reverse direction, and the part of the optical fiber 12 that has been wound around the second reel 14 is rewound and wound around the first reel 13. The tip portion 12a of the optical fiber 12 moves in the direction of being pulled out of the tube 11 while rotating in the opposite direction. A control circuit (not shown) that controls the reversible motor 20 is provided with a timer, and the reversible motor 20 repeats normal rotation and reverse rotation each time the timer times out, whereby the tip portion 12a of the optical fiber 12 becomes a tube. 1
The periodic reciprocating motion and the rotating motion are repeated within 1.

Here, the tip portion 1 of the optical fiber 12 is used.
2a shows an example in which both reciprocating motion and rotary motion are given. For example, if the fixed bearing is removed and the reversible motor 20 is fixed, the tip portion 12a of the optical fiber 12 will perform only rotary motion. The fixed bearing 18 is removed, and the shaft 20 of the reversible motor 20 is replaced with the coupling 19.
If the rod 17 and the shaft 20a of the reversible motor 20 are connected via a gear structure or the like that converts the rotational movement of a into a linear movement, only the reciprocating movement in the longitudinal direction of the tube is given to the tip portion 12a of the optical fiber 12. You can also

In using the cancer treatment device 10 shown in FIG. 1, a photosensitizer is injected into the affected area and a tube 11 is inserted into the affected area.
, The distal end 12 of the optical fiber 12 is inserted into the tube, and the operation is started after waiting a predetermined waiting time. FIG. 2 is a partially enlarged view showing the distal end portion 11 a of the tube 11 inserted into the affected area 30 and the distal end portion 12 a of the optical fiber 12 inserted into the tube 11.

The distal end 11c of the distal end 11a of the tube 11 is closed so that body fluid does not enter inside, and the distal end 12a of the optical fiber 12 inserted into the distal end 11a of the tube 11 has a further distal end. It has a front end face 12c that is obliquely cut as shown. The laser light propagating inside the optical fiber 12 has a tip surface 12c.
Is reflected by the tube 12 and emitted from the side surface of the tube 12,
It is irradiated to 0.

FIG. 3 is a diagram showing changes in the irradiation area of the laser light due to the movement of the optical fiber 12. In the state of FIG. 3 (A), when the laser beam is applied to the partial region 30a of the affected area 30 and the distal end portion 12a of the optical fiber 12 moves in the direction of being pulled out from the tube 11 while rotating,
As shown in (B), another partial region 30b of the affected area 30 is irradiated with laser light, and the distal end portion 12a of the optical fiber 12 is further rotated and moved, resulting in the state of FIG.
Laser light is irradiated onto another partial region 30c of 0. In this manner, the distal end portion 12a of the optical fiber 12 reciprocates and rotates in the tube 11 to cause the affected part 30
The laser light is evenly and repeatedly applied over the entire area of.

FIG. 4 is a view showing a state in which the two tubes 11 are inserted into the affected area 30 and the heat pipe 40 is further inserted. When the size of the affected area 30 is large, a plurality of tubes 11 are inserted as shown in the figure, laser light is emitted from the plurality of optical fibers 12, and the entire area of the affected area 30 is irradiated with laser light in one treatment. You may do it. Further, when the laser beam continues to be irradiated, the affected area 30 has heat, and when it is desired to reduce the heat, the heat pipe 40 may be inserted into the affected area 30 as shown in the figure to cool the affected area 30. Alternatively, the affected area 30 may be further heated by the heat pipe 40, and the above-mentioned heat treatment method may be used in combination with the light treatment method.

FIG. 5 is a partially enlarged view showing the distal end portions of the tube and the optical fiber of another embodiment of the cancer treatment device according to the present invention. The tip 11c of the tube 11 has an open mouth, and the scatterer 21 is fitted and fixed in the mouth, and plays a role of a plug for closing the mouth. Both the scatterer 21 and the tube 11 are made of polyacetal. In addition, the optical fiber 1 is provided inside the tube 11.
2 is plugged in. It is preferable that the optical fiber 12 can be inserted into and removed from the tube 11, but at the time of treatment,
The optical fiber 12 is arranged at a predetermined position inside the tube 11 and is not moved or rotated.

The front end surface 12c of the optical fiber 12 is cut vertically, and the rear end surface 21a of the scatterer 21 is also formed so as to face the front end surface 12c of the optical fiber 12. A part of the laser light emitted from 12c is reflected by the rear end face 21a of the scatterer 21 and is emitted from the tube 11, and the other part is scattered.
1 through the inside of the tube 11 to the side surface of the tube 11 or the scatterer 21.
Is ejected from the tip of. With such a simple structure, an omnidirectional light source that emits laser light from this tip in almost all directions is realized. This light source is capable of irradiating laser light in all directions with a tube inserted in the affected area and an optical fiber inserted in the tube and being stationary, and is particularly effective when the size of the affected area is small. .

FIG. 6 is a view showing the distal end portion of the optical fiber and how the emitted light spreads in another embodiment of the cancer treatment device according to the present invention. Tip surface 12c of optical fiber 12
Is cut vertically, but its tip face 12c is roughly ground with a file, and the laser beam emitted from the tip face 12c has a diameter D of a light flux at a position 10 cm ahead of the tip face 12c. It is spread and ejected so that ≧ 2 cm.

In this way, the optical fiber 12 whose tip surface 12c is processed so that the laser beam spreads and is emitted is inserted into the tube, and when the affected area is small, it is left stationary.
In the case of a large affected area, the affected area is irradiated with laser light while reciprocating in the tube. FIG. 7 is an enlarged view showing the tip of the tube. In FIG. 7 (A), the tip of the tube 11 having a closed tip is processed into a needle-like pointed shape, and in FIG. 7 (B), the plug 22 is fitted into the tube 11 having an open mouth. The tip including the stopper is processed into a needle-like pointed shape. Incidentally, the alternate long and short dash line in FIG. 7B shows the shape before processing. Tube 11 like this
The tube 11 can be smoothly inserted into the affected area by sharpening the tip of the tube.

The tip of the tube 11 is not required to be sharpened in a conical shape, and it is sufficient to use a cheap processing method such as a simple diagonal cut or a triangular pyramid cut. FIG. 8 is a graph showing an example of a temporal change in the light amount of the laser light emitted from the laser light source 15 (see FIG. 1).

Since the photosensitizer still remains in normal cells to some extent in the initial period within the phototherapy effective period shown in FIG. 9,
The light is emitted with a weak light intensity, and the light intensity is increased as time passes and the photosensitizer is excreted from normal cells. By doing this, while minimizing the damage to normal cells,
The maximum therapeutic effect can be achieved. In addition, in each of the above-described embodiments, the tube 11 and the scatterer 21 are described as being made of polyacetal, but the tube 11 and the scatterer 2 are described.
1 may be made of polyurethane or nylon 11, and may be made of other materials.

[0042]

As described above, according to the present invention,
Effectively irradiating the affected area with activating light can enhance the effect of phototherapy, and also the burden on the patient is small, and the tube can be disposable, so a cancer treatment device with excellent safety and hygiene is realized. To do.

[Brief description of drawings]

FIG. 1 is a schematic configuration diagram showing an embodiment of a cancer treatment device of the present invention.

FIG. 2 is a partially enlarged view showing a tip portion of a tube inserted into an affected area and a tip portion of an optical fiber inserted through the tube.

FIG. 3 is a diagram showing a change in an irradiation area of laser light due to movement of an optical fiber.

FIG. 4 is a diagram showing a state in which two tubes are inserted in the affected area and a heat pipe is inserted in the affected area.

FIG. 5 is a partially enlarged view showing the tube and the tip of the optical fiber of another embodiment of the cancer treatment device of the present invention.

FIG. 6 is a view showing the distal end portion of the optical fiber and how the emitted light spreads in another embodiment of the cancer treatment device of the present invention.

FIG. 7 is a view showing a tip portion of a tube.

FIG. 8 is a graph showing a change over time in the amount of laser light emitted from a laser light source.

FIG. 9 is a graph showing an example of the relative concentration of the photosensitizer remaining in the cells with respect to the elapsed time starting from the time when the photosensitizer was injected into the body.

[Explanation of symbols]

 10 Cancer treatment device 11 Tube 11a Tube tip 12 Optical fiber 12a Optical fiber tip 12b Optical fiber entrance end 12c Optical fiber tip face 13,14 Reel 15 Laser light source 16 Torque motor 17 Rod 20 Reversible motor 21 Scatterer 22 stopper 30 affected area 40 heat pipe

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Tatsu Hirano 1126-1 Nono-shi, Hamamatsu-shi, Shizuoka Prefecture 1126 Hamamatsu Photonics Co., Ltd. (72) Noboru Yamaguchi Isogodai, Isogo-ku, Yokohama 11-15-203

Claims (14)

[Claims] 1. A catheter-type inserter having a tube with a closed tip, the tip side of which is inserted into a body to be treated, and an optical fiber, the tip side of which is slidably arranged in the tube, and a predetermined activation. The activating light is emitted into the optical fiber, and the activating light propagates in the optical fiber, and the activating light is incident on the optical fiber so that the activating light is emitted from the tip of the side of the optical fiber disposed in the tube. At least one movement selected from reciprocating movement in the longitudinal direction of the tube and rotational movement having the rotation axis as the rotation axis in the tube. A cancer treatment device comprising a drive mechanism for driving the optical fiber so as to perform the following. 2. The cancer treatment device according to claim 1, wherein the optical fiber has a flat surface at an end of the optical fiber, the flat surface being inclined with respect to a longitudinal direction of the optical fiber. 3. The driving mechanism drives the optical fiber so that the optical fiber makes periodic reciprocating motions and / or rotating motions.
The described cancer treatment device. 4. A tube having a scatterer that scatters predetermined activation light and having a closed tip, the tip side of which is inserted into the body to be treated, and the tip side of which is disposed in the tube and which is directed from the tip to the scatterer. And a catheter type inserter that emits the activating light, and emits the activating light, and the activating light propagates in the optical fiber and is emitted from the tip of the optical fiber. Thus, a cancer treatment device comprising a light source for making the activation light incident on the optical fiber. 5. The cancer treatment device according to claim 4, wherein the scatterer is made of a plastic material containing polyurethane, polyacetal, or nylon 11. 6. The cancer treatment device according to claim 4, wherein the scatterer also serves as a stopper that closes the tip of the tube. 7. The cancer treatment device according to claim 4, wherein the scatterer is provided inside the tube whose tip is closed. 8. The optical fiber has a flat surface facing the longitudinal direction of the optical fiber at the tip of the optical fiber, and the scatterer is located at a position facing the tip of the optical fiber. The cancer treatment device according to claim 4, wherein the cancer treatment device has a flat surface extending in parallel with. 9. A catheter-type inserter having a tube with a closed tip, the tip side of which is inserted into a body to be treated, and an optical fiber whose tip side is arranged in the tube, and a predetermined activation light is emitted. And a light source for injecting the activation light into the optical fiber so that the activation light propagates in the optical fiber and is emitted from the tip of the optical fiber on the side disposed in the tube. A region where the luminous flux density of the emitted light on the spherical surface centered on the center of the optical fiber tip is 0.37 times or more of the maximum value, the emission solid angle indicating the spread of the light emitted from the tip of the optical fiber. , The tip of the optical fiber is
A cancer treatment device characterized by being a plane having an exit solid angle of 0.12 steradians or more. 10. The optical fiber is slidably arranged in the tube, and the optical fiber arranged in the tube reciprocates in the longitudinal direction of the tube. 10. The cancer treatment device according to claim 9, further comprising a drive mechanism for driving the optical fiber. 11. The cancer treatment device according to claim 10, wherein the drive mechanism drives the optical fiber so that the optical fiber reciprocates periodically. 12. The cancer treatment device according to claim 1, 4 or 9, wherein the tube is made of a plastic material containing polyurethane, polyacetal or nylon 11. 13. The area of a cutting surface orthogonal to the longitudinal direction of the tube decreases as the tube approaches the distal end of the tube inserted into the body to be treated, as it approaches the distal end of the tube. The cancer treatment device according to claim 1, 4 or 9, wherein the cancer treatment device has a pointed portion. 14. The light source is for increasing the incident light amount of the activation light incident on the optical fiber continuously or stepwise with the passage of time. The described cancer treatment device.