JPH0725838A - Orally administering agent for preventing or recovering fatigue - Google Patents

Abstract

PURPOSE:To reform bitter taste of orally administering agent containing L- valine, L-leucine and L-isoleucine which are branched chain amino acids as active ingredients. CONSTITUTION:This orally administering agent for preventing and recovering fatigue is characterized by including L-body of valine, leucine and isoleucine as active ingredients and adding one or more kinds of D-bodies of these amino acids, tryptophan and threonine thereto so as to reform the bitter taste. This orally administering agent may be a one the bitter taste of which is supplementally reformed by a bitter taste-reforming auxiliary.

Description

Detailed Description of the Invention

[0001]

The present invention relates to a branched chain amino acid L-
The present invention relates to an agent for preventing or relieving fatigue for oral administration, which contains the body as an active ingredient and has a corrected bitterness.

[0002]

2. Description of the Related Art It is known that when L-forms of branched chain amino acids such as valine, leucine and isoleucine are used in combination, a muscular activity enhancing action is observed. And these L
-The administration of amino acids in combination in the form of so-called amino acid infusions has already been practiced.

Considering the above-mentioned action of the branched chain amino acid L-form, it is expected that the oral administration of these can easily prevent or recover from fatigue, but in reality, Not the branched chain amino acid L-
An oral administration agent for preventing or recovering from fatigue, which contains the body as an active ingredient, is far from practical use.

The main reason for this is that the L-form of the branched chain amino acid has an inherent bitterness that remains in the tongue forever.

[0005]

SUMMARY OF THE INVENTION Under the background of the prior art described in the preceding paragraph, the object of the present invention is to prevent the fatigue which is excellent in the bitterness inherent in the L-form of branched chain amino acids. An object is to provide an oral administration agent for recovery.

[0006]

Means for Solving the Problems The present inventor has conducted a study by screening various corrective agents for bitterness in order to solve the above-mentioned problems. As a result, the branched chain amino acids, tryptophan and threonine D- It was found that the body has a function of correcting the bitterness of the L-body of the branched chain amino acid. And based on this, the present invention was completed.

That is, the present invention contains L-forms of valine, leucine and isoleucine as active ingredients, and one or more of these D-forms of amino acids, tryptophan and threonine are added to correct the bitterness thereof. The present invention relates to an orally administered agent for preventing or relieving fatigue, which is characterized by

The present invention will be described below in detail.

In the orally-administered agent of the present invention, three kinds of branched chain amino acids of L-valine, L-leucine and L-isoleucine are used in combination as an active ingredient. There is no special limitation on the usage rate, and it can be the same as for infusion. For example, L to isoleucine 1 by weight is L.
-Valine 0.2-2 and L-leucine 0.5-5.

As mentioned above, the branched chain amino acid D-
The body and the D-form of tryptophan and threonine have an action of correcting the bitterness of the L-form of the branched chain amino acid. That is, the bitterness of the mixture of L-valine, L-leucine and L-isoleucine is D-valine, D-leucine, D-isoleucine, D-tryptophan and D-
It can be corrected using at least one of the five D-amino acids of threonine.

The amount of branched chain D-amino acid, D-tryptophan and D-threonine to be used to correct the bitterness of a branched chain L-amino acid is, in essence, a mixture of given branched chain L-amino acids. It is an amount sufficient to correct the bitterness of, and this can be easily determined by a person skilled in the art by a simple sensory test.
In the case of 0.5 parts by weight of D-valine for 1 of this mixture.
By using the above, the bitterness of the mixture can be masked to a satisfactory level.

Note that points to be noted regarding the correction of bitterness according to the present invention will be added. It is the degree of correction of the bitterness of branched chain L-amino acids by branched chain D-amino acids, D-tryptophan or / and D-threonine. According to the invention, the bitterness of a mixture of branched L-amino acids is completely corrected, i.e. not necessarily completely masked, with the branched D-amino acids, D-tryptophan or / and D-threonine alone. That is. The bitterness of the branched chain L-amino acid is compared with the branched chain D-amino acid,
Partially straightened with D-tryptophan or / and D-threonine, and even completely with one or more of the bitterness supplementary correctors electrolytes, acids, sweeteners, alanine and glycine. Good. Of course, branched chain D-amino acids, D-tryptophan or / and D-
It is perfectly acceptable to completely correct the bitterness with threonine alone and use such an auxiliary corrective agent to adjust the taste of the orally-administered agent of the present invention. However, conversely,
Even if an attempt is made to correct the bitterness of a branched chain L-amino acid with only such an auxiliary bitterness corrective agent without using any branched chain D-amino acid, D-tryptophan or / and D-threonine, the bitterness is effectively obtained. Cannot be masked well.

When the D-form of a branched chain amino acid is used for correcting bitterness according to the present invention, the D-form need not be in the pure D-form, but may be in the DL-form. Of course good things. The L-form of the branched chain amino acid has a bitter taste, but the D-form generally has no bitterness and has a sweet taste, and DL
-The body also has a sweet taste, in particular DL-valine is the sweetest and cheapest of the branched chain amino acids, so the branched chain D- of the present invention.
Preferred for use as an amino acid. Of the DL-valine thus used, the L-valine of the present invention is of course the L-valine of the present invention. Further, the D-form of tryptophan has a very strong sweetness, and the D-form of tryptophan according to the present invention can be used in the form of DL-tryptophan for correcting bitterness. Overall, DL-tryptophan is most preferred for the bitterness correction according to the present invention because it effectively and effectively corrects the L-form of the branched chain amino acids. As is well known, in the living body, a part of the D-amino acid is converted into the corresponding keto acid and metabolized, or further converted into the L-body by transamination and utilized in the living body. is there.

As the auxiliary bitterness corrector which can be used in addition to one or more of the branched chain D-amino acids, D-tryptophan and D-threonine, as described above, electrolytes, acids and sweeteners can be used. , Natural juice, alanine and glycine. As described above, these bitterness correction aids can be used not only for correcting bitterness but also for adjusting the taste of the orally-administered agent of the present invention. And
Examples of the electrolyte include sodium chloride, potassium chloride, sodium hydrogen carbonate, and the like, and as the acid,
Edible acids such as citric acid, gluconic acid, succinic acid, fumaric acid, malic acid, ascorbic acid can be mentioned, and sweeteners can include various natural and artificial sweeteners. Specifically, glucose, fructose, sucrose, xylose, maltose, trehalose, sorbitol, xylitol,
Aspartame, extract of sweetener components of herbs such as licorice,
Examples of the extract of the sweet component of stevia and natural fruit juice include lemon, orange, grape, apple, pineapple, grapefruit, tomato and the like. Among these, some of which have an acid and a natural sweetener serve as an energy source in the living body, so that the orally-administered agent of the present invention containing such a bitterness correction aid is particularly suitable for administration on an empty stomach. Also becomes. It is well known that the amino acids alanine and glycine both have a sweet taste and are a source of energy for muscles.

There is no particular limitation on the amount of such a bitterness-supplementary corrector used, and the bitterness of the branched chain L-amino acid, which is the active ingredient of the orally administered drug of the present invention, can be changed to the branched chain D-. This is an amount sufficient to mask the amino acid, D-tryptophan and D-threonine in combination with one or more thereof, or an amount sufficient to adjust the taste of the orally-administered agent of the present invention. Those skilled in the art can easily make a determination by a simple sensory test.

The oral preparation of the present invention contains other nutrients,
For example, vitamins may be added appropriately,
This is the same as in so-called health drinks.

The orally-administered agent of the present invention may be in the form of a mere mixture of powdered components, or may be in the form of granules or the like by using a suitable excipient if desired or necessary. Alternatively, it may be in the form of a solution such as an aqueous solution (so-called drink agent), and may be put in the distribution in such a form. In the case of a mere mixture of powdered ingredients or in the case of granules, it is dissolved in water, fruit juice or the like and taken as a solution. The drink preparation of the present invention is a branched chain D-amino acid, D-tryptophan and D- Since one or more kinds of threonine are blended, the bitterness of the branched chain L-amino acid is corrected, which is convenient for taking. Conventionally, a drink agent in which the bitterness of a branched chain L-amino acid is corrected with fruit juice is known, but in this drink agent, a large amount of fruit juice is simply used to correct the bitterness of a branched chain L-amino acid. No special measures were taken to correct the bitterness just by diluting it. As a result, in order to ingest a desired amount of branched chain L-amino acid, it is unavoidable that a large amount of such a drink must be taken.

It goes without saying that the orally-administered agent of the present invention can be taken when physical fatigue is felt during muscle exercise such as sports to recover the fatigue, but it is necessary to take the oral administration after taking it in advance. You can also prevent fatigue by playing sports.

[0019]

EXAMPLES The present invention will be further described below with reference to examples.

Example 1 (Masking effect of D-form (1)) DL-valine was added to a solution prepared by dissolving 7 g of L-isoleucine and 11 g of L-leucine in 1000 ml of distilled water in various amounts shown in Table 1 below. It melt | dissolved and created 7 types of solutions.

[0021]

[Table 1]

The bitterness of the 7 kinds of solutions was subjected to a sensory test by a panel consisting of 10 people. 1 (control) has a fairly strong bitterness, whereas solution N
O. No. 2 had a slightly bitter taste, and the solution NO. No. 3 is slightly bitter, and the solution NO. No. 4 felt sweetness in bittersweet, and the solution No. 5 has a little bitterness in the sweetness,
NO. 6 and NO. 7 was evaluated as having no bitter taste (above, 7 or more out of 10 panelists agreed with the evaluation).

Example 2 (Combination with Supplementary Corrective Agent (Part 1)) L-isoleucine 7 g, L-leucine 11 g and DL
-D in a solution of 20 g of valine dissolved in 1000 ml of distilled water (substantially the same composition as solution No. 3 in Example 1)
Three kinds of solutions were prepared by dissolving L-alanine and glycine in various amounts shown in Table 2 below.

[0024]

[Table 2]

As a result of the same sensory test as in Example 1, the solution NO. 3 has a bittersweet bitterness, whereas solution NO. No. 8 felt a bittersweet taste and sweetness at the same time. 9 felt a bittersweet in the stronger sweetness, and the solution NO. No. 10 was evaluated as having little bitterness and having a sweet taste.

As is clear from this example, the branched chain L-
The bitterness of amino acids can be partially corrected by the branched chain D-amino acids and further completely corrected by using other amino acids (alanine and glycine) which are bitterness correction aids.

Example 3 (Additional Use with Other Supplementary Corrective Agents (Part 1)) L-isoleucine 7 g, L-leucine 11 g and DL
-Valine 20 g, DL-alanine 8 g and glycine 6
g in 1000 ml of distilled water (almost the same composition as solution No. 9 in Example 2) was added to other bitterness correction aids malic acid and citric acid (above, acidulant),
Maltose, glucose and aspartame (above, sweetener) were dissolved in various amounts shown in Table 3 below to prepare 10 kinds of solutions.

[0028]

[Table 3]

The results of the same sensory tests as in Example 1 are shown in Table 4 below.

[0030]

[Table 4]

As is clear from this example, the branched chain L-
The bitterness of amino acids can be corrected not only by using other auxiliary amino acids in addition to other amino acids, but also by correcting them.
The taste of the orally-administered agent of the present invention can be adjusted.

Considering the above results, the solution NO. A further suitable amount of electrolyte (NaCl and K
Succeeded in adding 4 drops of an aqueous solution of a 4: 1 mixture with Cl) and natural juice (drops of 100% lemon juice) and then adding a few drops of lemon flavor to make the taste even easier to drink. did.

Example 4 (Masking effect of D-form (2)) DL- was added to a solution prepared by dissolving 5 g of L-isoleucine, 8 g of L-leucine and 7 g of L-valine in 1000 ml of distilled water.
Tryptophan was dissolved in various amounts shown in Table 5 below to prepare four kinds of solutions.

[0034]

[Table 5]

The result of the same sensory test as in Example 1 was that the solution NO. No. 21 has a fairly strong bitterness, whereas solution No. No. 22 has sweetness, but it has a stronger bitterness, and the solution NO. No. 23 has a slight bitterness in the sweetness, and the solution NO. No. 24 was fairly sweet, and a bitterness remained, but sweetness remained forever.

Example 5 (Combination with Supplementary Correction Agent (Part 2)) 5 g of L-isoleucine, 8 g of L-leucine, 7 g of L-valine and 0.5 g of DL-tryptophan were added to 10 parts of distilled water.
A solution dissolved in 00 ml (solution NO.
DL-alanine and glycine were dissolved in various amounts shown in Table 6 below to prepare three kinds of solutions.

[0037]

[Table 6]

The result of the same sensory test as in Example 1 was that the solution NO. As described above, the solution No. 22 has sweetness, but has a stronger bitterness. No. 25 first felt bitterness and then a slight sweetness. 26
Feels slightly bitter in sweetness, and NO. No. 27 was evaluated as being sweet and having little bitterness.

It can be seen that the clarification from Example 2 regarding other amino acids which are auxiliary bitterness correctors is also supported by this example.

Example 6 (Combination with Other Supplementary Corrective Agents (Part 2)) L-isoleucine 5 g, L-leucine 8 g, L-valine 7 g, DL-tryptophan 0.5 g, DL-alanine 2 g and glycine. A solution of 1 g in 1000 ml of distilled water (almost the same composition as solution No. 25 in Example 5) was malic acid as an acidulant, and maltose, glucose and aspartame as sweeteners in various amounts shown in Table 7 below. It melt | dissolved and created two types of solutions.

[0041]

[Table 7]

As a result of the same sensory test as in Example 1, the solution NO. No. 25 felt bitterness first and then a slight sweetness, whereas solution No. 28
Does not feel any bitterness, feels a slightly rich sweetness and sourness, and solution NO. No. 29 was evaluated as having no bitterness and having a refreshing sweetness and sourness.

It can be seen that the clarification from Example 3 regarding the combined use with other supplementary corrective agents is also supported by this example.

Example 7 (Monitor Test) (a) From 9 am in fine weather, four adult men were asked to play tennis in a doubles 6 game preemptive manner in a brute force manner. After the play, everyone complained of fatigue, and this feeling of fatigue remained after 30 minutes.

After 7 days, each person should be kept in the same physical condition as possible the previous time, and asked to play tennis in the same manner as the last time. Immediately after the play, the solution N in Example 3 was obtained.
O. 2 taste-adjusting solutions (drinks) with the same composition as 20
After drinking 30 ml each, after 30 minutes, most of the fatigue had recovered ... 2 people recovered fairly, but still felt tired ... 1 person, and tiredness remained 1 person ,
Met.

(B) Seven days later, 100 ml of the same drug as the previous time was given to the same four adult men immediately before the play.
And during the game, when each person was free to drink the same 100 ml of the same drink, after 30 minutes from the end of the play there was almost no feeling of fatigue ... 3 players, and some feeling of fatigue remained. ...... It was one person.

It can be easily understood from the above (a) that the orally-administered agent of the present invention has a fatigue recovery effect, and (b) has a fatigue prevention effect.

[0048]

INDUSTRIAL APPLICABILITY The present invention provides an orally-administered agent (particularly a drink agent) in which the bitterness of a branched chain L-amino acid is corrected and which is used for preventing or recovering muscle fatigue.

Claims (2)

[Claims] 1. An L-form of valine, leucine and isoleucine is contained as an active ingredient, and at least one of these D-forms of amino acids, tryptophan and threonine is added to correct the bitterness thereof. An orally-administered agent for prevention or recovery of characteristic fatigue. 2. An electrolyte further for correcting bitterness,
The oral administration agent for the prevention or recovery of fatigue according to claim 1, wherein one or more of an acid, a sweetener, natural fruit juice, alanine and glycine is supplementarily added.