JPH07231930A - Blood bag - Google Patents

Abstract

PURPOSE:To provide a blood bag having a blood introducing tube having a blood filtering material provided on the way thereof. CONSTITUTION:A blood filtering material 6 is arranged on the way of a blood introducing tube 3 having a blood collecting needle 5 provided to the leading end thereof and the rear end of the blood introducing tube 3 is connected to a blood bag main body 2. An anticoagulant-containing container is provided on the way of the blood introducing tube 3 through a connection tube and/or a mixing tank of blood and an anticoagulant and the connection tube and/or the mixing tank of blood and the anticoagulant are arranged on the upstream side of the blood filtering material 6. Therefore, a white corpuscle can be removed simultaneously with the collection of blood and the whole blood of a person after the collection of blood can be easily obtained as white corpuscle removed whole blood of a person. Therefore, blood can be stably preserved without being affected by a white corpuscle.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood bag in which a blood filter material is attached in the middle of a blood introducing tube.

[0002]

BACKGROUND ART In order to prevent post-transfusion side effects, GVHD, etc., leukocyte removal from blood products and leukocyte inactivation have been widely studied. JP-A-1
No. 320064 and JP-A-2-271868,
Whole blood collected from a donor is collected in a blood bag, and the whole blood from which white blood cells have been removed is passed through a blood filter material (leukocyte removal filter) placed in the middle of a blood discharge tube connected to the blood bag, and the whole blood is collected in another blood bag. It is disclosed to collect in. In addition, JP-A-4-200550 and JP-A-4-4-2
No. 36959 discloses a blood bag in which a plurality of child bags are attached to a blood bag body (parent bag) via a blood discharge tube and a connecting tube, and a blood filter material is arranged in the middle of the blood discharge tube and the connecting tube. ing.

Recently, it has been reported that white blood cells in whole blood act to preserve blood collected and adversely affect blood preservation. In the above-mentioned blood bag, whole blood collected from the donor is temporarily collected in the main body of the blood bag. Therefore, if whole blood is stored in this state, leukocytes in the whole blood may act and adversely affect blood preservation. Therefore, the inventors of the present invention have earnestly studied to solve the above problems, and arrived at the next invention.

[0004]

[Means for Solving the Problems]

[1] The present invention provides a blood bag in which a blood filter material is arranged in the middle of a blood introduction tube having a blood collection needle attached to its tip, and a blood bag body is attached to the rear end of the blood introduction tube. [2] In the present invention, a container containing an anticoagulant is attached via a connecting tube and / or a mixing tank for blood and an anticoagulant in the middle of a blood introducing tube, and the connecting tube and / or blood and an anticoagulant are attached. The mixing tank was placed upstream of the blood filter material [1]
A blood bag as described is provided. [3] The present invention provides the blood bag according to [2], in which a mixing tank for blood and an anticoagulant and a blood filter material are integrally mounted. [4] The present invention provides a pre-filter material inside the blood filter material, in the middle of the blood introducing tube upstream of the blood filter material, at least at one location selected from the mixing tank of blood and anticoagulant. The attached blood bag according to [1] to [3] is provided.

[0005]

FIG. 1 is a schematic view showing an example of the blood bag of the present invention (FIG. 2 is a sectional view taken along the line AA of FIG. 1). Blood bag 1
Is a bag-shaped blood bag body 2 made of a flexible synthetic resin (hereinafter,
It is configured by mounting a blood introducing tube 3 and a blood discharging tube 4 on the upper end of the "main body 2"), the blood introducing tube 3 is connected to a blood collecting needle 5 at its tip, and a blood filter material 6 is arranged on the way. ing. A blood preservation solution is enclosed in the main body 2.

The blood filter material (leukocyte removal filter) used in the present invention may be any of a porous body, a fiber and a non-woven fabric, but the non-woven fabric is preferable. This non-woven fabric includes PET, PE, PP, nylon, PVC, vinylon, acrylic, polyurethane and the like, but a material having heat resistance of 100 ° C. or higher and capable of high pressure steam sterilization is preferable. Further, the fiber diameter of the non-woven fabric or the like constituting the blood filter material is 10 μm or less, preferably 0.5 to 3 μm. The distribution of these fiber diameters may be uniform or non-uniform (for example, 5 μ at any point and 1 μ at any point), and uniform, uniform, uniform and non-uniform, non-uniform and non-uniform. It may be a mixture of.

For example, as shown in FIG. 2, the blood filter material 6 is formed by stacking a plurality of non-woven fabrics and folding them in two to form a layer, or by forming a bag shape by opening the upper end and closing both ends and the lower end. Flexible synthetic resin sheet 7 and blood introduction tube 3
It is placed in the middle of the blood introduction tube 3 by sandwiching it in between and three-dimensionally sealing it with a high-frequency welder or the like (S is a sealing portion). When the blood filter material 6 is layered, the upper end and both ends are sealed as described above, and when it is bag-shaped, the upper part is sealed as described above. Also blood filter material 6
Can be loaded between the two flexible synthetic resin sheets 7 using a fibrous mass.

FIG. 3 is a schematic view showing another embodiment of the blood bag. The blood bag 21 is provided with a mixed injection part 28 in the middle of a blood introduction tube 23, and a container 30 containing an anticoagulant is connected thereto via a connecting tube 29. It is connected. A needle may be attached to the tip of the connecting tube and connected to the mixed injection section 28, or the connecting tube 29 may be directly connected to the mixed injection section 28.

The blood bag 41 shown in FIG. 4 is provided with a blood and anticoagulant mixing tank 51 in the middle of a blood introducing tube 43, and a container 50 containing the anticoagulant is attached thereto via a connecting tube 49.

The blood bag 61 shown in FIG. 5 has a mixing tank 71 for blood and anticoagulant and a blood filter material 66 integrally mounted and arranged in the middle of a blood introducing tube 69. 6 is shown in FIG.
In the BB cross-sectional view of FIG. 3, the blood filter material 66 is sandwiched between the blood outlet 72 of the mixing tank 71 and the two flexible synthetic resin sheets 67 to three-dimensionally seal (Fig. Inside, S is a seal part). The mixing tank 71 may be an injection-molded product made of a hard synthetic resin, or may be a bag made of two flexible synthetic resin sheets. (The same applies to the mixing tank in FIG. 4).

In the present invention, (1) the inside of the blood filtration material 6, 26, 46, 66, (2) the blood filtration material 6, 2
Blood introduction tubes 3, 2 upstream of 6, 46, 66
In the middle of 3, 43, 63, (3) the pre-filter material can be arranged in at least one place selected from the mixing tanks 51, 71 of blood and anticoagulant. The pre-filter material 80 used in the present invention is a filter material having a fiber diameter of 3 to 60 μ, preferably 5 to 30 μ and a fiber diameter larger than those of the blood filter materials 6, 26 and the like. The material and fiber diameter distribution are the same as those of the blood filtration material. Further, it can be attached to the flexible housing in the form of lumps as well as layers and bags.

For example, in the case of the blood filtration material 6, a layered (may be a lump) pre-filtration material 80 can be arranged inside the blood filtration material 6 as shown in FIG. In addition, the mixing tank 51,
In the case of 71, in the case of an injection molded product made of a hard synthetic resin, as shown in FIG.
When the sheet is made of a flexible synthetic resin sheet, it can be mounted in a layer shape, a bag shape or a lump shape as in the case of the blood filtration material 6.

The blood bag 1 of the present invention (21, 41,
61), the blood drain tube 4 (24, 44, 6)
A plurality of child bags 95, 96, 97 can be attached to 4) via the connecting tube 91 and the connecting tubes 92, 93, 94. A storage solution for red blood cells is enclosed in the child bag 97.

[0014]

EFFECTS OF THE INVENTION Since leukocytes can be removed simultaneously while collecting blood, human whole blood after blood collection can be easily obtained as leukocyte-removed human whole blood. Therefore, when blood is stored, stable blood storage can be performed without being affected by white blood cells. Since the blood filter material 3 is loaded in the flexible housing, the centrifugal operation similar to that of the blood bag can be performed, and the blood leak from the blood filter material and the breakage or damage of the housing can be prevented.

[Brief description of drawings]

FIG. 1 is a schematic view of a blood bag of the present invention.

FIG. 2 is a sectional view taken along line AA of FIG.

FIG. 3 is a schematic view of a blood bag of the present invention.

FIG. 4 is a schematic diagram of a blood bag of the present invention.

FIG. 5 is a schematic view of the blood bag of the present invention.

6 is a sectional view taken along line BB of FIG.

[Explanation of sign]

 1, 21, 41, 61 Blood bag 2, 22, 42, 62 Main body 3, 23, 43, 63 Blood introduction tube 4, 24, 44, 64 Blood discharge tube 5, 25, 45, 65 Blood collection needle 6, 26, 46, 66 Blood filter material 7, 67 Sheet 28 Mixed injection part 29, 49, 69 Connection tube 30, 50, 70 Anticoagulant-containing container 51, 71, Mixing tank 72, Connection tube 80 Pre-filter material 91 Connection pipe 92, 93, 94 Connection tube 95, 96, 97 Child bag

 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Takeshi Inoue 3-28-15 Minamioi, Shinagawa-ku, Tokyo Kawasumi Chemical Industry Co., Ltd.

Claims (4)

[Claims] 1. A blood bag characterized in that a blood filter material is arranged in the middle of a blood introducing tube having a blood collection needle attached to its tip, and a blood bag body is attached to the rear end of the blood introducing tube. 2. A container containing an anticoagulant is attached through a connecting tube and / or a mixing tank for blood and an anticoagulant in the middle of the blood introducing tube to mix the connecting tube and / or blood with an anticoagulant. The tank is arranged upstream of the blood filtration material.
The described blood bag. 3. The blood bag according to claim 2, wherein the blood-anticoagulant mixing tank and the blood filter material are integrally mounted. 4. The pre-filter material is attached inside the blood filter material, in the middle of the blood introducing tube upstream of the blood filter material, at least at one location selected from the mixing tank of blood and anticoagulant. The blood bag according to claim 1.