JP3049182B2 - Filter for leukocyte removal - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an improvement in a leukocyte removing filter used for medical equipment such as a blood bag, a blood transfusion set, a blood circuit, and a pheresis circuit.

[0002]

FIG. 7 is a cross-sectional view of a conventional leukocyte removing filter 31 in which a blood filter material 33 made of a nonwoven fabric or a porous filter is used as a two-piece material made of a hard synthetic resin. Of the housing 32, 32 of the
Then, the filter 33 is compressed by welding the end portions 38 of the housings 32 and 32, and the filter 3 is pressed.
Leaks from the three end surfaces are prevented (39 is a welded portion in FIG. 7). However, since the filter 33 is only physically pressed by the housing, if the thickness of the filter 33 is increased or the number of filters 33 is increased, the pressure of the filter 33 is reduced. The airtightness of the filter 33 was reduced, causing blood leak from the end face of the filter 33. When the pressure of the filter 33 is increased, welding of the housings 32 becomes difficult, and the housing 32 after welding is easily damaged by residual stress. Further, since the housing 32 is formed of a hard synthetic resin for crimping the filter 33, impact resistance and chemical resistance are poor, resulting in cracks due to chemicals, and damage due to impacts and drops during transportation. . The inventor of the present invention has made intensive studies in order to solve the above-mentioned problems, and has arrived at the following invention.

[0003]

Means for Solving the Problems [1] According to the present invention, a blood filter material is loaded in a flexible housing having similar thermal and electrical properties to the blood filter material, and A peripheral portion of the material is directly welded to the housing to divide the housing into a blood inflow chamber and an outflow chamber, and to form a blood inflow chamber with a blood inflow port and a blood outflow chamber with a blood outflow chamber. Provided is a filtered leukocyte removal filter. [2] In the present invention, the blood filter material is thermally and electrically connected to the blood filter material.
The upper edge of the blood filter material which is loaded in a flexible housing having similar pneumatic properties, and whose peripheral edge is sealed from the lower side to the side, is attached to the upper edge of the flexible housing. A leukocyte removal filter formed by directly welding and dividing the housing into a blood inflow chamber and a blood outflow chamber, and communicating with a blood inflow port to the blood inflow chamber and a blood outflow port to the blood outflow chamber. provide.

[0004]

1 is a schematic diagram of a leukocyte removal filter 1 of the present invention (FIG. 2 is a cross-sectional view taken along line AA of FIG. 1). It is configured by being loaded into the flexible housing 2. As the blood filter material 3, for example, a fiber described in published patent publication No. 58-54126 or a nonwoven fabric described in published patent publication 60-193468 is used. It is preferable to use a non-woven fabric made of fiber, which has similar thermal and electrical properties to the housing to which these are welded. For example, polyester, polyamide, polypropylene, polyethylene, polyurethane, polyvinyl chloride,
Acrylonitrile, styrene-based elastomer and the like are used. These can be loaded into the flexible housing 2 by sandwiching them between, for example, two flexible sheets and welding the peripheral edge thereof (in FIG. 1, reference numeral 4 denotes a sealing portion).

The housing 2 is preferably made of a flexible synthetic resin, and has similar thermal and electrical properties to the blood filter material. The material used for the housing 2 is soft vinyl chloride, polyurethane, ethylene, or the like. Thermoplastic elastomers such as vinyl acetate copolymers, hydrogenated styrene-butadiene-styrene copolymers, styrene-isoprene-styrene copolymers or hydrogenated products thereof, and thermoplastic elastomers and polyolefins, ethylene-ethyl acrylate And the like. Preferred are soft vinyl chloride, polyurethane, styrene-butadiene-styrene copolymer, styrene-ethylene-butylene-styrene copolymer, and thermoplastic elastomers containing these as main components.

The housing 2 has a blood flow as described later.
Entry member (blood inlets 8, 16, 25, blood transfer tube
10) and blood outflow members (blood outlets 7, 15, 26,
A blood transfer tube 9) is attached. The welding of the housing 2 may be external heating welding by heat sealing, or may be internal welding by a high frequency welder or an ultrasonic welder. In addition, as for the method of welding, the blood filter material and the housing 2 may be simultaneously welded directly by heat sealing, a high frequency welder, and an ultrasonic welder, and only the peripheral portion of the stacked blood filter material 3 is welded first, and thereafter, It may be welded directly to the housing 2.

The blood inlet 8 and the blood outlet 7 are made of a hard synthetic resin by injection molding or extrusion molding, and the flexible sheet is welded between two flexible sheets constituting the housing 2. At the same time, it can be mounted on the housing 2 (in FIG. 2, reference numerals 5 and 6 are welded portions of the mouth). Finally, blood transfer tubes 9 and 10 are attached to the blood inlet 8 and the blood outlet 7, respectively. Further, instead of the blood inlet 8 and the blood outlet 7, the tips of the blood transfer tubes 9, 10 can be directly attached. The housing 2 is divided into a blood inflow chamber 8a and a blood outflow chamber 7a by the blood filter material 3 and is formed such that a blood inflow port 8 communicates with the blood inflow chamber 8a and a blood outflow port 9 communicates with the blood outflow chamber 7a. Have been.

In the embodiment of the present invention, a non-woven fabric made of polyurethane was used as the blood filter material 3 and sealed with a flexible synthetic resin housing. As the flexible synthetic resin, polyvinyl chloride or polyurethane having a Shore A hardness of 90 or less was used (see Table 1).

[0009]

[Table 1]

In Examples 1-4 and Comparative Examples 1-3, 200 g
Was dropped from a height of 1000 mm to check for cracks in the housing. From the results in Table 2, no damage was observed in the leukocyte removal filter of the present invention.

[0011]

[Table 2]

FIG. 3 is a schematic view of the leukocyte removal filter 11 of the present invention (FIG. 4 is a view taken in the direction of arrow A in FIG. 3). The leukocyte removal filter 1 comprises a blood filter material 13 and a housing 12. It is constituted by loading in. The blood filter material 3 is in the form of a flat plate (including a single layer and a laminate). For example, the peripheral portion is sandwiched between two flexible sheets, and the periphery thereof is heat-sealed, a high-frequency welder, an ultrasonic welder, or the like. (See FIG. 3, reference numeral 14 denotes a sealing portion).

Thus, the inside of the housing 12 is partitioned by the blood filter material 13 into a blood inflow chamber 18 and a blood inflow chamber 17.
The blood inlet 16 and the blood outlet 15 are formed so as to communicate with the respective chambers 17 and 18. Blood inlet 16, outlet 1
Reference numeral 5 denotes a hole formed in the flexible sheet constituting the housing 12 which is formed by injection molding, or a flexible tube-shaped member may be connected to the holed flexible sheet. .

The selection and sealing of the materials of the blood filter material 3 and the housing 12 can be performed in the same manner as in the leukocyte removal filter device 1 described above.

In the embodiments of the present invention, the materials shown in Tables 3 and 4 are used for the filter material, the number of sheets, the basis weight, the housing material, the sealing method and the like. Examples 6 to 10
An airtightness test, an impact resistance test, and a leak test were performed using the leukocyte removal filter described in (1). Table 5 shows the results. From the results in Table 5, good results were obtained in all Examples.

[0016]

[Table 3]

[0017]

[Table 4]

[0018]

[Table 5]

FIG. 5 is a schematic view of a leukocyte removing filter 21 of the present invention (FIG. 6 is a longitudinal sectional view of FIG. 5). The leukocyte removing filter 21 has a housing with a blood outlet 26 welded to the bottom. 2
2 and blood inlet 25 mounted on top of housing 22
It is composed of The blood filter material 23 is formed in a hook-bell shape, and the peripheral edge portion is sealed from the lower portion to the side portion by welding, the upper edge portion is opened, and the upper edge portion is directly connected to the upper edge portion of the housing 22. It is welded (24 in FIG. 5 is a peripheral sealing portion). The housing 22 is divided into a blood inflow chamber 28 and a blood outflow chamber 27, and is formed so that a blood inflow port 25 communicates with the blood inflow chamber 28 and a blood outflow port 26 communicates with the blood outflow port 27. In the leukocyte removal filter 21, since the outer periphery of the blood filter material 23 is mounted in a suspended state without being simultaneously sealed with the outer periphery of the housing 22, the filter area becomes larger and the filter speed becomes faster. Housing 2
The same material as that of the leukocyte removal filter 1 is used for the material 2 and the blood filter material 23.

Further, the leukocyte removing filters 1 and 1 of the present invention.
1, 21 can be subjected to high-pressure steam sterilization.

[0021]

By sealing the blood filter material with the flexible housing, it is possible to prevent the housing from being damaged due to an impact or drop during transportation. Further, even if the blood bag is centrifuged at the same time, damage to the housing and damage to the blood bag can be prevented. Further, since the peripheral portion of the blood filter material is welded, even if the blood filter material becomes thicker or the number of sheets to be stacked increases, the airtightness does not deteriorate and blood leak does not occur.

[Brief description of the drawings]

FIG. 1 is a schematic diagram of a leukocyte removal filter according to the present invention.

FIG. 2 is a sectional view taken along line AA of FIG. 1;

FIG. 3 is a cross-sectional view of a leukocyte removal filter according to the present invention.

FIG. 4 is a view taken in the direction of arrow A in FIG. 1;

FIG. 5 is a schematic diagram of a leukocyte removal filter according to the present invention.

6 is a longitudinal sectional view of FIG.

FIG. 7 is a cross-sectional view of a conventional leukocyte removal filter.

DESCRIPTION OF SYMBOLS 1 Leukocyte removal filter 2 Housing 3 Blood filter material 4 Sealing part 5 Mouth welding part 6 Mouth welding part 7 Blood outflow port 8 Blood inflow port 7a Blood outflow chamber 8a Blood inflow chamber Reference Signs List 9 blood transfer tube 10 blood transfer tube 11 leukocyte removal filter 12 housing 13 blood filter material 14 sealing portion 15 blood outflow port 16 blood inflow port 17 blood outflow chamber 18 blood inflow chamber 21 leukocyte removal filter Reference Signs List 22 Housing 23 Blood filter material 24 Peripheral sealing portion 25 Blood inlet 26 Blood outlet 27 Blood outflow chamber 28 Blood inflow chamber

Claims (2)

(57) [Claims] 1. A blood filter material is thermally and electrically connected to the blood filter material.
The blood filter material is loaded in a flexible housing having similar properties, the peripheral portion of the blood filter material is directly welded to the housing, and the housing is divided into a blood inflow chamber and an outflow chamber, and a blood inflow chamber is formed. A leukocyte removal filter, wherein a blood outlet is connected to a blood inlet and a blood outlet chamber. 2. The method according to claim 1, wherein the blood filter material is thermally and electrically connected to the blood filter material.
The upper edge of the blood filter material is loaded in a flexible housing having similar properties , and the upper edge of the blood filter material is sealed directly on the upper edge of the flexible housing from the bottom to the side. do it,
A filter for leukocyte removal, wherein the housing is divided into a blood inflow chamber and a blood outflow chamber, and a blood inflow port is connected to the blood inflow chamber and a blood outflow port is connected to the blood outflow chamber.