JPH0263470A - Liquid treating device - Google Patents

Abstract

PURPOSE:To recover the whole of remaining liquid, e.g., a blood making agent, by a method wherein a gas communicating part capable of communicating the inside of a housing to the outside thereof is provided, and a liquid outflow port is shut out by a passage cutoff means capable of opening the liquid outflow port during a use. CONSTITUTION:When liquid, e.g., physiological salt water or blood, is caused to flow in a liquid treating device through a liquid inflow port 2, air in the liquid treating device is replaced with liquid. The replaced air is discharged through a gas communicating part 6 to the outside of a liquid treating device 1. Further, liquid is caused to flow in through the liquid inflow port 2, and a pass cutoff means 7 is opened. The liquid treating device 1 starts treatment of liquid by means of a head. With an on-off means 7' opened, air in the liquid treating device 1 is discharged through the gas communicating part 6 and replaced with liquid. With the on-off means 7' closed, gas is prevented from entering the liquid treating device 1 through the gas communicating part 6 during treatment. Further, remaining liquid, e.g., blood, is all discharged under gravity to the outside of a housing 4 by forcing air to flow in from the outside with the on-off means 7' opened.

Description

[Detailed description of the invention] [Industrial application field 1 The present invention relates to a liquid processing device for liquids such as blood.

[Prior Art] Conventionally, when component transfusion is performed for a patient who requires only red blood cells, a concentrated red blood cell (CRC) obtained by one normal centrifugation operation has been transfused. However, this concentrated red blood cell solution contains a large amount of white blood cells and platelets, so it is not desirable to transfuse concentrated red blood cell solution to patients who only need red blood cells. A filtration method has been adopted as one method to do so. A liquid processing device such as a blood filter that performs this filtration includes a member for filtering a large amount of white blood cells and platelets as described above, that is, a fluid processing section, in a housing provided with a fluid inlet and a liquid outlet. It will be stored.

When carrying out the filtration method using such a liquid processing device, air mixed in the liquid processing device will have an adverse effect on the patient's body. The air inside the liquid treatment device must be completely removed.The operation to remove the air inside the liquid treatment device is performed as follows. While filling physiological saline or red blood cell concentrate through the liquid inlet, remove the air inside the liquid processor. During this process, tap or invert the liquid handler to prevent air from accumulating in the liquid handler, then fill the liquid handler with saline or red blood cell concentrate to completely eliminate air. do.

After completely eliminating the air in the liquid treatment device, the red blood cell concentrate in the liquid treatment device is filtered to remove white blood cells and platelets. A small amount of red blood cell concentrate remained in the liquid handler after filtration.

[Problems to be Solved by the Invention] However, in the conventional liquid treatment device, in order to completely exclude air from inside the liquid treatment device, it is necessary to perform the above-mentioned operation. Therefore, when preparing a large amount of blood products using a liquid processor at a blood center or hospital, or when using a liquid processor at a patient's bedside, the air venting operation described above is complicated. This was time-consuming and, in the worst case scenario, there was a risk that the air would not be completely removed from the liquid treatment device.

In addition, some amount of concentrated red blood cell liquid remaining in the liquid processing device,
Because it was difficult to recover, it was discarded as is, and the valuable red blood cell concentrate could not be recovered in its entirety.

Therefore, the present invention was made in view of the above circumstances, and
It is an object of the present invention to provide a liquid processing device 23 which can easily and completely perform an air removal operation before preparing a liquid such as a blood product, and which can recover the entire amount of the liquid such as a blood product remaining after processing.

[Means for Solving the Problems] In order to solve the above problems, the liquid treatment device of the present invention includes a housing provided with a liquid inlet and a liquid outlet, a liquid treatment section housed in the housing, and the liquid treatment device of the present invention. A gas communication portion is provided in the housing and allows gas to communicate between the inside and the outside of the housing, and the liquid outlet is blocked by a passage blocking means that can be opened during use.

Further, a housing including a liquid inlet and a liquid outlet;
a liquid processing section housed in the housing; and a gas communication section provided in the housing to enable gas communication between the inside and outside of the housing, the gas communication section being opened when necessary; Opening/closing means are provided which can be closed when unnecessary.

Further, the one passage blocking means is provided with a blocking member that can be broken and separated during use.

Further, it is preferable that the gas communication section includes a filter that allows gas to pass through but does not allow liquid to pass through.

Furthermore, it is preferable that the gas communication section includes a filter that allows gas to pass through but does not allow bacteria to pass through.

[For production]

According to the above configuration, when a liquid such as physiological saline or blood flows into the liquid treatment device from the liquid inlet, the air in the liquid treatment device is replaced by the liquid. This replaced air is discharged from the gas communication section to the outside of the liquid treatment device. Further, liquid is allowed to flow in from the liquid inlet, and after confirming that the air in the liquid processing device has been completely replaced by the liquid, the two-path blocking means is opened. The liquid processor starts processing the liquid using the head.

In addition, since the gas communication section is provided with an opening/closing means that opens when necessary and closes when not necessary, the opening/closing means is used when a liquid such as physiological saline is allowed to flow into the liquid treatment device from the liquid inlet. Open it to exhaust the air in the liquid treatment device from the gas communication section and replace it with liquid. In addition, when processing (removal of components, filtration) liquid such as blood, close the opening/closing means to prevent gas from entering the liquid processing device from the gas communication part during processing. When the opening/closing means is opened to let in air from the outside, the entire amount of liquid such as blood remaining in the housing after being processed by the device is discharged out of the housing by gravity.

rExample 1 Hereinafter, embodiments of the present invention will be described in detail based on the drawings.

FIG. 1 is a partially sectional front view of the liquid treatment device of the present invention;
2 is a sectional view taken along line 11-II in FIG. 1, and FIG. 3 is a sectional view taken along line II-m in FIG. 1. In the drawings, 1 indicates a liquid treatment device. 1 is a housing 4 having a liquid inlet 2 and a liquid outlet 3; a liquid processing unit 5 housed in the housing 4; It consists of a gas communication section 6 that allows for this, and a blocking member (passage blocking means) 7 that is provided at the liquid outlet 3 and that can be opened during use.

The housing 4 may have any shape, but 1
In this embodiment, it has a rectangular shape, and includes a partition plate part 8 which is located approximately in the center in FIG. It is divided into three parts with filter plate parts 10 and 10 having the same shape. As described above, the partition plate portion 8 of the housing 4 is provided with a liquid inlet 2 through which liquid such as blood flows in, and a liquid outlet 3 through which a filtrate flows out after removing substances in the liquid. Furthermore, plane portions 98, 9a are formed on the peripheries of both surfaces 9, 9 of this partition plate portion 8. This plane part 9
A plurality of protrusions 9b, . These protrusions 9b...
... communicates with the liquid inlet 2 and connects the liquid processing section 5.
and the first member 11.1+ form a liquid circulation space A as shown in FIG. Through this liquid circulation space A, fluid such as blood is evenly supplied to the first members 11 and 11 of the liquid processing section 5, respectively. Furthermore, first and second filter media 1 are disposed in the filter plate portion 10.1 of the housing 4.
A convex portion 13.13 for supporting the liquid processing section 5 consisting of 1 and 12 is formed, and the convex portion 13.13 creates a gap between the filter plate portion lO and the second member 12 as shown in FIG. A filtrate circulation space B is formed as a passage for the filtrate.

Since the first filter medium 11 is applied to the front and reduces clogging, it has a coarse mesh, that is, it is made of a material with an apparent lower density than the second filter medium 12, such as polyester. Nonwoven fabric, nylon nonwoven fabric, etc. are used.

Further, the second filter medium 12 must be sufficiently capable of removing substances to be removed from the blood, such as white blood cells, and this second member 12 must be able to remove substances to be removed from the blood, such as white blood cells. For example, a porous material made of synthetic resin or a nonwoven fabric made of ultrafine fibers is used.

The gas communication section 6 is provided on the upper end surface of the housing 4 and includes a nozzle 14 made of transparent resin and formed in a cylindrical shape, and a hydrophobic porous material 1lI fitted into the nozzle 14. (Filter) Consists of 15.15. The height of the nozzle I4 is formed to be slightly lower than the liquid inlet 2, so that the housing 4 can be completely filled with liquid. This porous membrane l5
15 does not allow liquids such as blood components to pass through.

Any material may be used as long as it allows gas such as air to pass therethrough, such as polypropylene, fluororesin, etc. Therefore, even if liquid is introduced through the liquid inlet 2, only gas is removed from the housing 4.

Also, the porous membrane 15.15 advantageously allows gases to pass through but not bacteria, so that bacteria do not enter the housing 4.

The blocking member 7 includes a vibrator portion 7a that is provided in the liquid outlet 3 and communicates with the housing 4, and a breaking portion 7b that is connected to the pipe portion 7a and has a sealed tip and is easy to break. It consists of When necessary, the breaking portion 7b of the blocking member 7 is broken, and the liquid outlet 3 is opened.

The liquid treatment device 1 of the present invention is incorporated into a circuit as shown in FIG. 4, for example, when attempting to remove white blood cells from blood. A blood bag 20 containing blood from which white blood cells are to be removed and a saline bag 21 containing physiological saline.
is located above the liquid treatment device l, and the cleanser 2
2.23, which are connected to the liquid inlet 2 of the liquid treatment device 1 by means of liquid guide tubes 24 and 25, each having a
A physiological saline collection bag 26 and a blood collection bag 27 for collecting blood from which white blood cells have been removed are located below the liquid outlet 3 of the liquid processing device 1. and 27 is Kremme 28.2
9 are connected to the liquid outlet 3 by liquid guide tubes 30, 31, respectively.

Next, we will describe an operation for removing white blood cells from blood using the liquid processing device 1 configured as described above. First, the leukocyte separation operation involves opening the drain 22 and transporting the blood in the blood bag 20 through the liquid guide tube 24. Blood entering the liquid treatment device 1 from the liquid inlet 2 of the liquid treatment device 1 enters the housing 4 and replaces the air within the housing 4.

The replaced air is also exhausted to the outside through the gas communication section 6.

Furthermore, blood is allowed to flow in, filling the inside of the housing 4 with blood, and the air inside the housing 4 is completely eliminated. This state can be easily confirmed because the nozzle 14 is transparent. Furthermore, even if too much blood is allowed to flow through the porous membrane 15 fitted into the nozzle 14, only the air inside the housing 4 is removed and the blood does not flow outside. Bend the outflow port 3, break the breakage part 7b of the blocking member 7, open the blocking member 7, and clean the cleaner 2.
By opening 9, the head starts removing white blood cells from the blood.

That is, blood entering from the liquid inlet 2 is supplied into a plurality of liquid circulation spaces A respectively constituted by the plurality of protrusions 9b in contact with the first filter medium 11, and is supplied to the filter media 11 on the average. Then, the blood is passed through the first filter medium 11, which is a pre-filter, by the head.
and further passes through the second filter medium 12 which is the main filter.
During this process, white blood cells are captured and a highly pure red blood cell product is produced. This red blood cell preparation is collected from the liquid outlet 3 through the liquid guide tube 31 into the blood collection bag 27 .

When the blood has finished flowing from the blood bag 20, the drain 22 is closed. Next, the drain 23 is further opened to collect the blood remaining in the liquid processor 1. Pour the saline solution into the liquid processor 1.
Blood remaining inside is pushed out and collected into a blood collection bag 27. As soon as we finished collecting the blood, Kremme 29
is closed, the drain 28 is opened, and the physiological saline used for blood collection is collected into the physiological saline collection bag 26, thereby completing the leukocyte separation operation.

5 to 7 show other embodiments of the present invention,
The difference from the embodiment shown in FIGS. 1 to 4 is that the gas communication part 6 is provided at the upper part of the front and rear sides of the housing 4,
Furthermore, a removable seal (opening/closing means) 7° is attached to the gas communication part 6.
It is in that it is provided. That is, the gas communication section 6 has holes 10a and 10a formed in the filter plate l port and IO, respectively.
Further, a hydrophobic porous membrane (filter) 15, 15 is fitted into these holes 10a, 10a.Other configurations include the embodiments shown in FIGS. 1 to 4. Since it is the same as that shown in FIG.

The liquid processor 1 in this embodiment is incorporated into a circuit as shown in FIG. 7, for example, when attempting to remove white blood cells from blood. A blood bag 20 containing blood from which white blood cells are to be removed is positioned above the liquid treatment device 1, and is connected to the liquid inlet 2 of the liquid treatment device 1 by a liquid guide tube 24 equipped with a drain 22. It is connected to the. On the other hand, a blood collection bag 27 for collecting blood from which white blood cells have been removed is located below the liquid outlet 3 of the liquid processing device 1. It is connected to the liquid outlet 3 by a liquid duplex 31 .

Next, we will discuss the operation for removing white blood cells from blood using the liquid treatment device 1 having the above configuration.
The 13th work is a creme 22 with the sticker 7° pasted.
．． 29 is opened, the blood in the blood bag 20 flows through the liquid guide tube 24 to the liquid processor 1, and the head starts removing white blood cells from the blood. That is, Figures 1 to 4
Similar to the embodiment shown, the blood entering from the liquid inlet 2 is
These plurality of protrusions 9b in contact with the first filter medium 11...
The liquid is supplied into a plurality of liquid circulation spaces A respectively constituted by..., and uniformly supplied to the first filter medium 11. Then, the blood is passed through the first filter, which is a pre-filter, by the head.
The main filter, the second filter, passes through the filter medium 11 of
The white blood cells are captured at this time and become a highly pure red blood cell preparation. This red blood cell preparation is transferred from the liquid outlet 3 to the red blood cell collection bag 27 via the liquid guide tube 31.
will be collected.

Even after the blood has been drained from the blood bag 20, a small amount of blood remains in the liquid processor 1, that is, the filtered red blood cell preparations in the filtrate distribution space B and the liquid guiding tube 31 remain. Then, when the seal 7' is removed from the gas communication portion 6 and air is admitted, the red blood cell preparation falls due to gravity and is collected in the blood collection bag 27, completing the leukocyte separation operation.

[Effects of the Invention] As detailed above, the liquid treatment device of the present invention includes a housing provided with a liquid inlet and a liquid outlet, a liquid treatment section housed in the housing, and a liquid treatment device provided in the housing. The housing includes a gas communication portion that allows gas to communicate between the inside and the outside of the housing, and the liquid outlet is blocked by a passage blocking means that can be opened during use, so that no flow from the liquid inlet into the liquid processing device is provided. When liquid is introduced into the liquid treatment device, the air in the liquid treatment device is replaced by the liquid. This M-exchanged air is discharged from the gas communication section to the outside of the liquid treatment device.

Further, the liquid is allowed to flow in from the liquid inlet, and after confirming that the air in the liquid processing device has been completely replaced by the liquid, the passage blocking means is opened. The liquid processor starts processing the liquid using the head. Therefore, there is an effect that the air in the liquid treatment device can be easily and completely removed without requiring complicated operations or labor.

In addition, if the gas communication section is provided with an opening/closing means that opens when necessary and closes when unnecessary, by closing the opening/closing means during processing by the liquid processor, gas from the gas communication section can be prevented. Intrusion can be prevented, and when the opening/closing means is opened to let air in from the outside, almost all liquids such as blood remaining in the housing after processing are discharged outside the housing and remain inside the housing. becomes extremely small. Therefore, about 100% of liquid such as Ltfft Ifn liquid
% can be used effectively.

In addition, if the passage blocking means is a blocking member that can be broken and separated, there is no need to close the liquid guide tube connected to the liquid outlet with a clamp or the like, and the air venting operation becomes easier.

Furthermore, if the gas communication section is configured with a filter that allows gas to pass through but does not allow liquid to pass through, it is possible to supply liquid from the two bags to the liquid processing device without worrying about the liquid leaking from the gas communication section. be able to,
This makes the air purge operation easier.

Furthermore, if the gas communication section is configured with a filter that allows gas to pass through but does not allow bacteria to pass through, bacteria will not enter the liquid such as blood, and a sterile liquid can be obtained.

[Brief explanation of the drawing]

The drawings show embodiments of the present invention, and FIG. 1 is a partially sectional front view of the liquid treatment device of the present invention, FIG. 2 is a sectional view taken along line II-DI in FIG. 1, and FIG. The figure is the DI of Figure 1.
4 is a circuit diagram incorporating the liquid treatment device of the present invention, FIG. 5 is a circular front view of FIG. 1 showing another embodiment of the present invention, and FIG. 6 is a sectional view taken along line -III. is Vl-Vl in Figure 5
FIG. 7 is a cross-sectional view taken along the line, and FIG. 4 is a circular circuit diagram showing another embodiment of the present invention. l...Liquid treatment device 2...Liquid inlet 3...Liquid outlet 4...Housing 5---Liquid processing section 6.・−・−・Gas communication part 7・・・・・・Blocking member (passage blocking means) 7°−
...Seal (opening/closing means)

Claims (5)

[Claims] (1) A housing provided with a liquid inlet and a liquid outlet, a liquid processing section housed within the housing, and a gas communication provided in the housing and allowing gas communication between the inside and outside of the housing. , wherein the liquid outlet is blocked by a passage blocking means that can be opened during use. (2) A housing provided with a liquid inlet and a liquid outlet, a liquid processing section housed within the housing, and a gas communication provided in the housing and allowing gas communication between the inside and outside of the housing. A liquid treatment device comprising: a gas communication section, and the gas communication section is provided with an opening/closing means that can be opened when necessary and closed when unnecessary. (3) The liquid treatment device according to claim (1), wherein the passage blocking means includes a blocking member that can be broken and separated. (4) The liquid treatment device according to claim 1, (2), or (3), wherein the gas communication portion includes a filter that allows gas to pass through but not liquid. (5) Claims (1), (2), wherein the gas communication section is provided with a filter that allows gas to pass through but does not allow bacteria to pass through.
The liquid treatment device according to (3) or (4).