JPH07225230A - Inspection equipment with specimen collecting equipment - Google Patents

Abstract

PURPOSE:To enable collection of a specimen adjustment of diluent and inspection reaction with simple and clean operations by forming a vessel wherein a specimen collecting part provided in series with a tube of a structure where a reaction part and diluent absorption part can be separated is so taken in as to be tightly fixed to the diluent absorption part. CONSTITUTION:With a cup 12 of an inspection equipment held with a hand, a specimen collecting part 4 is pushed into a specimen (for example, stool), and just after a required specimen is collected, the collecting part 4 is inserted into a vessel mouth 6 of a vessel 11 in which dissolving liquid or diluent is contained, so that the mouth part 6 is capped over a specimen diluent absorption part 3, and then engaged with a cap 12 for fixing. By this operation, the thin film of a lid 14 of the vessel 11 is broken, and the collected specimen is mixed with the diluent or dissolving liquid 10. Then, after the inspection equipment is inverted, it is held in horizontal posture so that required diluent is sent to a reaction test paper 3 in a reaction part 1 by way of an absorbing body 7 from an intake opening 5, and reaction completion indicated on the test paper 3 and inspection result mark are confirmed (8, 9). As required, the reaction part 1 is detached, and sent to a specified inspection organization.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention makes it possible to collect and preserve specimens and perform diagnostic tests in a single container in clinical tests, mass screenings, general in vitro self-tests, etc.
The present invention relates to a biochemical and immunological reaction test instrument in which these tests are simple and accurate.

[0002]

A spatula, a match stick, a toothpick, a cotton swab, and various other plastic molded products are used as a sample collecting device for clinical examination. Specimens collected by these instruments should be transferred to an empty container as they are, or transported to a laboratory, or placed in a container containing a separately prepared dissolving or diluting solution and diluted, and the diluted specimen liquid should be sent to the laboratory. Transporting. However, due to leakage or the like, not only the reaction side is adversely affected, but also sanitary problems often occur. In addition, in order to take out this diluted sample solution at a laboratory, remove the lid of this container, or open it by cutting or punching a hole with a needle to obtain a sample diluent through the filtering section, Alternatively, a method of obtaining a sample diluting liquid by transferring it to another container through a filter paper has been used, but there is a problem that the inspection work is complicated.

Further, conventionally, in order to collect a small amount or a small amount of a fixed amount of a sample, a groove or an uneven portion is formed in a part of a molded instrument, and the fixed amount is filled by filling the part with the sample. To ensure accuracy, the excess sample is squeezed with the edge of the container or paper, but at that time it may drop even the sample that is essential, and it adheres to the outside of the container. If it was too unsanitary. In addition, in the test performed by diluting the sample with the dissolution liquid, a method is also known in which the sample collection device is attached to the dissolution liquid container as a lid, and when the sample is collected, the sample collection device is extracted from the container and used. At the time of extraction, the lysate in the core leaks out and the sample does not reach the specified dilution, or the sample cannot be collected sufficiently because the sample collection part is already wet with the lysate, or the sample is collected in the lysate. Since the device is fixed, there is a problem that the sample sticks to the sample collecting part and is difficult to dissolve in the solution.

Further, there is a work of transferring the above-mentioned dissolution liquid or dilution liquid to a reaction container, a reaction plate or the like at the inspection stage, but at that time, a titration error or cross-contamination is likely to occur, and a pretreatment work therefor is required. In many cases, the inspection work is complicated. In particular, in the in vitro self-diagnosis test,
Unless these problems are solved, the accuracy of diagnosis will be impaired. In addition, in a large number of simultaneous tests called mass screening, the general person handles his or her own sample, so that particularly simple, accurate and particularly hygienic at the time of returning are required, but in the above conventional method, in response to these requests , Was completely unsatisfied.

[0005]

SUMMARY OF THE INVENTION The present invention has been made in view of such a point, and is a test with a sample collecting instrument capable of performing all of sample collection, sample diluent adjustment, and test reaction. The purpose is to provide a device. Another object of the present invention is to provide a test device with a sample collecting device that can quantitatively send a sample diluent to a test means such as a reaction test strip.

[0006]

The structure of the present invention in accordance with the above object is a reaction part which can confirm the inspection result and the end of the reaction, and which has a reaction means such as a reaction test paper inside and a reaction part. A test instrument comprising a tubular body configured to be separable into a sample diluent absorbing part containing an absorber for sending the sample diluent to the means, and a sample collecting part connected to the tubular body. When,
It is characterized in that it comprises a container for accommodating a dissolving liquid or a diluting liquid, accommodating the sample collecting part, and tightly fixing the sample diluting liquid absorbing part.

[0007]

Embodiments of the present invention will now be described with reference to the drawings. FIG. 1 is a front view of a test device with a sample collecting device of the present invention, FIG. 2 is a front view of a test device of the present invention, and FIG. 3 is a front view of a container containing a dissolving liquid or a diluting liquid of the present invention. is there. As shown in FIGS. 2 and 4, the inspection instrument 16 of the present invention connects the specimen collecting unit 4 to the tubular body 18 having a closed tip through a partition wall 19.

The tubular body 18 is formed by connecting the two tubular bodies of the reaction part 1 and the sample diluent absorbing part 3 in a separable manner by a connecting means such as screwing or fitting. A reaction completion confirmation window 8 and an inspection result confirmation window 9 are opened in the reaction section 1, and a reaction test paper 13 is provided inside. A reaction test paper is usually used as the inspection means, but any other inspection means may be used as long as the inspection result can be determined by the sample diluent. The diluting liquid absorbing section 3 has a sample diluting liquid intake port 5 opened therein, and an absorber 7 for sending the sample diluting liquid to the reaction test paper 13 is provided inside. Absorber 7
Is formed of a material, such as a sponge body or filter paper, which the sample diluent can permeate and send to the reaction test paper 13.
The intake port 5 is sized to ensure a volume for receiving the sample diluent necessary for the reaction.

Around the outer periphery of the diluent absorbing part 3, a cap 12 serving as a lid for a container 11 containing a solution or a diluent.
Are fitted and fixed. As shown in FIG. 3, the container 11 containing the dissolving liquid or the diluting liquid contains the dissolving liquid or the diluting liquid 10 therein, and the container mouth portion 6 has the container lid 1
4 is fixed. Although the container 11 containing the dissolving liquid or the diluting liquid is formed as a separate body from the inspection instrument 16 in the above-described embodiment, the sample collecting unit 4 should not come into contact with the dissolving liquid or the diluting liquid 10. , For example, the sample collecting unit 4 is housed in a bag-like body, or the dissolving or diluting liquid 10 is used.
If it is not accommodated, it may be formed integrally as shown in FIG. Although the container lid 14 is formed of a thin film that easily breaks in the sample collecting unit 4 in the above-described embodiment, this is not necessarily the case. For example, a lid that is screwed or fitted into the container mouth 6 may be used. Further, in the case of an integrated product as shown in FIG. 1, the container lid body 14 is of course unnecessary.

In the above embodiment, the container mouth portion 6 is fitted onto the diluent absorbing portion 3 and fitted onto the cap 12 so as to be tightly fixed to the specimen diluent absorbing portion 3. ing. In the above-described embodiment, the sample collecting unit 4 is made of a material such as sponge which is hard when dried but swells when wet with the solution or diluent, and when the sample is collected, it has fine pores on its surface. After the sample is captured by and stored in the container 11, the sample is released by swelling with the solution or diluent. However, this does not necessarily have to be the case. For example, the sample collecting portion 4 is made of a water-impermeable material, and a concave portion is formed on the lower surface, or a groove or an uneven portion is formed on the outer periphery, and the concave portion is formed. However, it is possible to collect a sample by using a groove or an uneven portion.

In the above embodiment, the reaction part 1 is provided with a reaction completion confirmation window 8 and an inspection result confirmation window 9, but the reaction part 1 is formed of a transparent material to confirm the completion of the reaction. If the inspection result can be confirmed, other means may be used. However, if such an opening is not provided, it is necessary to provide an air vent hole so that the solution or diluent 10 can reach the reaction test paper 13 smoothly. FIG. 5 shows another embodiment of the present invention, in which the partition wall 19 is not provided and the absorbent body 7 and the sample collecting section 4 are closely attached to each other. In this case, the sample collecting unit 4 is formed of a water-permeable material such as a material that is hard in the dry state but swells when wet with the dissolving liquid or the diluting liquid as in the above-described embodiment, or the sample collecting unit 4 is used. It is necessary to form 4 into a cylindrical body or to form an opening so that the sample diluting liquid is sent from the sample collecting unit 4 to the absorber 7.

[0012]

Next, the operation of the present invention configured as described above will be described with reference to an example of a fecal occult blood reaction container used for mass screening for colorectal cancer. First, holding the cap 12 of the inspection device 16 of the present invention shown in FIG. 2 by hand, the sample collecting section 4 is pushed into the sample (feces in this example) several times and stirred.
The extra sample can be collected by wiping it with paper or the like. Immediately after the sample collection, the sample collection part 4 is inserted into the container mouth part 6 of the container 11, the container mouth part 6 is used as the diluent absorbing part 3, and the cap 12 is fitted to the container 11 into the sample diluent absorbing part 3. Close and fit tightly. By this operation,
The thin film of the lid 14 is broken, and the collected sample is mixed in the dissolving liquid or the diluting liquid 10.

Then, the inspection device 17 with the sample collecting device is inverted and slowly placed horizontally, so that the required amount of the sample diluent is filled in the intake port 5 and transmitted through the absorber 7 to the reaction test paper 13. Reach The reaction completion mark displayed on the test paper 13 is confirmed in the reaction completion confirmation window 8 of the reaction section 1, and the inspection result mark displayed on the test paper 13 is confirmed from the inspection result confirmation window 9. If necessary, the reaction part 1 may be removed, placed in a separately prepared sealable bag, and sent to a predetermined inspection agency. In the case of an inspection that does not necessarily require a fixed amount of the sample diluent, it is not necessary to determine the capacity of the intake port 5, so simply invert the container and allow the sample diluent to sufficiently permeate the absorber 7. , Upright. The inspection device with a sample collection device 17 of the present invention can change all materials and shapes of the sample collection part 4 as necessary to collect all clinical samples such as blood, feces, urine, other body fluids, mucous membranes and cells. It can be collected and applied to these biochemical and immunological tests.

[0014]

[Effects] As described above, according to the present invention, it is possible to perform a reaction with a fresh sample easily and easily even by a non-specialist by extremely simple and hygienic operation, and also when sending it to a laboratory. Since only the reaction part needs to be sent, it does not cause any hygiene problems due to leakage of filth caused by transportation, and greatly simplifies the inspection work. Remarkably remarkable effect.

[0015]

[Brief description of drawings]

FIG. 1 is a front view showing an embodiment of the present invention.

FIG. 2 is a front view of the inspection instrument of the present invention.

FIG. 3 is a front view of a container containing a dissolving liquid or a diluting liquid of the present invention.

FIG. 4 is a cross-sectional view of the inspection device of the present invention.

FIG. 5 is a cross-sectional view showing another example of the inspection tool of the present invention.

[Explanation of symbols]

 1 Reaction Part 3 Specimen Diluent Absorption Part 4 Specimen Sampling Part 5 Specimen Diluent Intake Port 7 Absorber 8 Reaction End Confirmation Window 9 Test Result Confirmation Window 10 Dissolved Liquid or Diluted Liquid 11 Container Containing Dissolved Liquid or Diluted Liquid 12 Cap 13 Reaction Test Paper (Inspection Means) 14 Container Lid 16 Inspection Instrument 18 Cylindrical Body

Claims (6)

[Claims] 1. A test result and a reaction completion can be confirmed.
A reaction part having a test means such as a reaction test paper inside, and a cylindrical body configured to be separable into a sample diluent absorbing part having an absorber for sending a sample diluent to the checking means, An inspection instrument having a sample collecting part connected to the tubular body and a dissolving or diluting liquid are stored, the sample collecting part is stored, and the sample diluting liquid absorbing part is tightly fixed. An inspection instrument with a sample collection instrument, characterized in that it comprises a container for obtaining. 2. The sample collecting part is made of a material that is hard when dried but swells when wet with the solution or diluent.
The test according to claim 1, wherein the sample is captured by the micropores on the surface when the sample is collected, and swelled by the dissolution liquid or the diluent after the sample is stored in the container to release the sample. Equipment. 3. The inspection instrument according to claim 1, wherein a grasping portion and a cap serving as a lid of the container are fixed to the outer periphery of the tubular body. 4. The sample collecting section and the absorber are connected to each other,
The test instrument according to claim 2, wherein the specimen diluting liquid is configured to be absorbed from the specimen collecting unit to the absorbing unit. 5. A partition is provided between the sample collecting section and the absorber, and a sample or a diluent diluting liquid intake port is opened in the sample diluting liquid absorbing section, and the sample diluting liquid is
The inspection instrument according to claim 1, wherein the inspection instrument is configured to be capable of being quantitatively taken in from the taking-in port. 6. A sample is collected by holding a cap fixed to the cylindrical body, and then the sample collecting section is stored in a container containing the dissolving solution or the diluting solution, and the container is sealed in the cylindrical body. The sample is discharged into a predetermined solution or diluent, and then the test device is inverted to fill the sample inlet with the sample diluent, and then the test device is placed horizontally to allow the test reaction. A biochemical and immunological reaction test method using the test device according to claim 5.