CN108982191B - Magnetic force detection pen, detection platform for magnetic force pen and detection method - Google Patents

Magnetic force detection pen, detection platform for magnetic force pen and detection method Download PDF

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Publication number
CN108982191B
CN108982191B CN201811223382.9A CN201811223382A CN108982191B CN 108982191 B CN108982191 B CN 108982191B CN 201811223382 A CN201811223382 A CN 201811223382A CN 108982191 B CN108982191 B CN 108982191B
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China
Prior art keywords
magnetic force
movable
detection
movable sleeve
tray
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CN201811223382.9A
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CN108982191A (en
Inventor
林志铿
李运涛
谢艺浜
王泽增
林伟年
尤卓波
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Yixin Xiamen Technology Co ltd
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Yixin Xiamen Technology Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising

Abstract

The invention relates to a magnetic force detection pen, which comprises a table body, wherein a tray for placing the magnetic force detection pen is transversely arranged on the table surface of the table body, the magnetic force detection pen contains liquid to be detected and a stirring body for stirring the liquid to be detected, a movable body for driving the stirring body to move by utilizing magnetic force is arranged above the tray, and a photoelectric detection head is arranged below a detection platform; the invention also relates to a detection platform and a detection method for the magnetic force detection pen. The magnetic force detection pen is simple, reasonable and compact in structural design, is matched with the magnetic force detection pen for use, realizes stirring of liquid to be detected by utilizing magnetic force, and is high in automation degree, efficient and convenient.

Description

Magnetic force detection pen, detection platform for magnetic force pen and detection method
Technical Field
The invention relates to a magnetic force detection pen, a detection platform for the magnetic force pen and a detection method.
Background
In the existing medical field, environment, animals, plants and other application fields, a common needle is generally adopted for sampling, and the mixing and stirring of the diluent are manually carried out, so that the stirring degree of each sample is different due to the difference of the force, the experimental result is influenced to a certain extent, and finally the sample reacts with the detection reaction part or directly reacts with the detection reaction part, so that a user needs to use a plurality of test instruments, and the used test instruments have single functions, are independent, occupy a large space, consume time and labor, have low working efficiency and have large limitations.
Taking conventional blood detection as an example, in the conventional blood detection, after sample blood is collected, the sample and diluent are required to be mixed uniformly by hand, the mixed sample is added to test paper to react, and then the detection result is judged according to the test paper reaction result, so that the method has a plurality of problems:
(1) In the sample collection process, a special pipetting device is needed to quantitatively suck the sample into the diluent, and the sample is mixed manually, but the operation forces of different people are different, the manual operation time is different, and the mixing degree of the sample and the diluent is different, so that the reaction result of the test paper is affected.
(2) After sample collection, in an open container device, the inspector may contact the sample, presenting biosafety issues;
(3) The traditional detection is to judge the result by adopting color, the judgment of the naked eyes of individuals is different, different people can obtain different results with the same result, and the results cannot be uniformly judged by an instrument.
In the existing detection mode, the body fluid is always mixed with the diluent manually after being collected, and the mixing force and time have an influence on the mixing effect, because of personnel operation difference, the mixing time and force cannot be unified, and the follow-up result can be influenced. Accordingly, there is a lack of a mixing operation of a small volume of sample and a device connected to the detection on the market.
Disclosure of Invention
In view of the defects of the prior art, the technical problem to be solved by the invention is to provide the magnetic force detection pen, the detection platform for the magnetic force pen and the detection method, which are reasonable in structural design, efficient and convenient.
In order to solve the technical problems, the technical scheme of the invention is as follows: the utility model provides a magnetic force detects pen, includes the casing, wear to be equipped with rather than sliding fit's movable sleeve in the casing, the casing is provided with puts the thing chamber at movable sleeve's stroke end, it is provided with sealed diaphragm to put thing chamber towards movable sleeve's opening, movable sleeve's front portion is provided with and is used for putting thing chamber complex collection head, movable sleeve's middle part is provided with the hybrid chamber, movable sleeve's rear portion sliding fit has movable thimble, the front end of collection head is provided with the capillary that is used for gathering sample and top to break sealed diaphragm, the rear end of collection head is provided with the feed liquor passageway of connecting capillary and hybrid chamber, be provided with the stirring body of reciprocating motion under the magnetic force effect in the hybrid chamber, be provided with reaction portion in the casing, be provided with in the movable thimble and connect the liquid passageway of hybrid chamber and reaction portion behind its broken hybrid chamber of bursting.
Preferably, the reaction section includes a test strip.
Preferably, the mixing cavity comprises a piston in sliding fit with the movable sleeve, a mixing cavity is formed between the piston and the movable sleeve, and a concave part which is favorable for the movable thimble to puncture is formed at the tail part of the piston.
Preferably, the shell, the movable sleeve and the movable thimble are coaxially arranged, the reaction part and the movable sleeve are arranged in parallel, the movable thimble and the liquid outlet channel are provided with bending parts, and the movable sleeve and the movable thimble move along the axis.
The utility model provides a magnetic force detects pen and uses testing platform, includes the stage body, transversely be provided with the tray that is used for placing magnetic force and detects the pen on the mesa of stage body, the top of tray is provided with the activity body that utilizes magnetic force to drive stirring body motion, testing platform's below is provided with the photoelectricity and detects the head.
Preferably, at least one of the stirring body and the movable body is a magnet; the stirring body and the movable body are both magnets, or the stirring body is a magnet and the movable body is made of ferromagnetic substances, or the movable body is a magnet and the stirring body is made of ferromagnetic substances.
Preferably, the rack and pinion assembly is arranged on the table body, the rack and pinion assembly comprises a first driving gear and a first driven rack which are meshed with each other, the first driving gear is connected with the first motor, and the first driven rack is connected with the tray and drives the tray to reciprocate in a linear motion.
Preferably, a guide rail is arranged at the side of the tray along the moving direction of the tray, and the tray is in sliding fit with the guide rail.
Preferably, the table body is provided with a driving wheel assembly, and the movable body is eccentrically arranged on the wheel disc of the driving wheel or one of the driven wheels.
The detection method comprises any one of the magnetic force detection pens and any one of the detection platforms for the magnetic force detection pens, and comprises the following steps:
(1) Taking out a movable sleeve of a magnetic force detection pen, completing blood collection by utilizing a capillary tube at the front end of a collection head, storing a collected blood sample in the capillary tube, taking down a limiting block on a shell of the magnetic force detection pen for clamping the movable sleeve, driving the movable sleeve to move towards a storage cavity by utilizing a manual or driving device, enabling the movable sleeve to continuously move after the capillary tube breaks a sealing membrane, enabling diluent in the storage cavity to drive the blood sample to enter a mixing cavity through the capillary tube and a liquid inlet channel and be mixed in the process that the collection head gradually enters the storage cavity, enabling the mixing cavity to gradually increase after a mixed liquid drives a piston to retract, enabling the collection head to completely enter the storage cavity, and stopping moving the movable sleeve;
(2) The magnetic detection pen is characterized in that a first motor on a detection platform for the magnetic detection pen is operated in the forward direction to drive the tray to gradually extend out, the magnetic detection pen which collects blood samples and completes mixing is arranged on the tray, the first motor is operated in the reverse direction to drive the tray to retract and move to a preset position, the first motor stops operating, a second motor is operated to drive a movable body to rotate, the movable body is driven to move in the magnetic detection pen in a reciprocating manner under the left and right directions of magnetic force, liquid to be detected is stirred until the liquid to be detected is uniformly mixed, the second motor stops operating, the first motor continues to operate in the reverse direction, a lug is arranged on the platform, a movable thimble on the magnetic detection pen moves towards a mixing cavity and breaks the mixing cavity in a propping manner on the lug, and a liquid outlet channel introduces the mixed liquid uniformly stirred in the mixing cavity into the detection test paper to complete reaction;
(3) The first motor works positively to drive the tray to extend gradually, and the photoelectric detection head transmits detected information to the background server for discrimination processing to finish detection.
Compared with the prior art, the invention has the following beneficial effects: the magnetic force detection pen is simple, reasonable and compact in structural design, is matched with the magnetic force detection pen for use, realizes stirring of liquid to be detected by utilizing magnetic force, can control stirring force and stirring times, is high in automation degree, can eliminate differences among samples caused by different stirring force and stirring times, and is high in detection precision, efficient and convenient.
The invention will be described in further detail with reference to the drawings and the detailed description.
Drawings
Fig. 1 is a schematic view of a first state of a magnetic pen according to an embodiment of the present invention.
Fig. 2 is a schematic view of a second state of the magnetic pen according to the embodiment of the invention.
Fig. 3 is a schematic view illustrating a third state of the configuration of the magnetic pen according to the embodiment of the present invention.
Fig. 4 is a schematic top view illustrating a structure of a magnetic pen detection platform according to an embodiment of the present invention.
Fig. 5 is a schematic bottom view illustrating a structure of a magnetic pen detection platform according to an embodiment of the present invention.
In the figure:
1-shell, 2-movable sleeve, 3-object placing cavity, 4-sealing membrane, 5-collecting head, 6-mixing cavity, 7-movable thimble, 8-capillary, 9-liquid inlet channel, 10-stirring body, 11-liquid outlet channel, 12-test paper, 13-piston and 14-limiting block;
15-a table body, 16-a tray, 17-a movable body, 18-a photoelectric detection head, 19-a gear rack assembly, 191-a first driving gear, 192-a first driven rack, 193-a first motor, 20-a guide rail, 21-a double gear assembly, 211-a second driving gear, 212-a second driven gear, 213-a second motor and 22-a bracket.
Detailed Description
In order to make the above features and advantages of the present invention more comprehensible, embodiments accompanied with figures are described in detail below.
As shown in fig. 1-3, a magnetic force detection pen comprises a housing 1, wherein a movable sleeve 2 in sliding fit with the housing 1 is arranged in the housing 1, a storage cavity 3 is arranged at the stroke tail end of the movable sleeve 2 in the housing 1, a sealing membrane 4 is arranged at an opening of the storage cavity 3 towards the movable sleeve 2, a collecting head 5 for gradually sealing fit with the storage cavity 3 is arranged at the front part of the movable sleeve 2, a mixing cavity 6 is arranged at the middle part of the movable sleeve 2, a movable thimble 7 is in sliding fit with the rear part of the movable sleeve 2, a capillary tube 8 for collecting samples and propping up the sealing membrane 4 is arranged at the front end of the collecting head 5, a liquid inlet channel 9 for connecting the capillary tube 8 with the mixing cavity 6 is arranged at the rear end of the collecting head 5, a stirring body 10 in reciprocating movement under the action of magnetic force is arranged in the mixing cavity 6, a reaction part is arranged in the housing 1, and a liquid outlet channel 11 for connecting the mixing cavity 6 with the reaction part is arranged in the movable thimble 7 after the movable thimble breaks up the mixing cavity 6; the collecting head 5 plays a sealing role in the process of gradually entering the storage cavity 3, so that the diluent can drive the sample in the capillary 8 to enter the mixing cavity 6 through the liquid inlet channel 9 without leaking out from the side; the sample may be a liquid or a powdered solid.
In the embodiment of the present invention, the reaction part includes a test paper 12; the test strip 12 may be a PH test strip, or may be another type of test strip according to practical needs, and may be a colloidal gold test strip, a latex test strip, a fluorescent quantitative test strip, a dry chemical test strip, a chemical test strip, or the like, which is not limited thereto.
In the embodiment of the present invention, the diluent is placed in the storage cavity 3.
In the embodiment of the present invention, the sealing membrane 4 is a sealing membrane, and the sealing membrane may be made of a plastic film, an aluminum film or a tin film, but is not limited thereto.
In the embodiment of the invention, the mixing cavity 6 comprises a piston 13 in sliding fit with the movable sleeve 2, and the mixing cavity 6 is enclosed between the piston 13 and the movable sleeve 2.
In the embodiment of the present invention, the tail of the piston 13 is provided with a concave portion that is beneficial for the movable thimble 7 to puncture, and the piston 13 is made of rubber, silica gel or plastic, but is not limited thereto.
In the embodiment of the present invention, the stirring body 10 is spherical and is an iron bead, a coated iron bead or a magnetic bead.
In the embodiment of the present invention, the casing 1, the movable sleeve 2 and the movable thimble 7 are coaxially disposed, the reaction portion is disposed parallel to the movable sleeve 2, and the movable thimble 7 and the liquid outlet channel 11 each have a bending portion, for example, a U-shape, a branched shape, etc., but not limited thereto; the movable sleeve 2 and the movable thimble 7 both move along the axis; the shell 1 is provided with a through hole between the outlet of the liquid outlet channel 11 and the reaction part, as the mixed liquid flows out along the liquid outlet channel 11 after the movable thimble 7 breaks the piston 13, the through hole is long and narrow, the width of the through hole is larger than or equal to the size of the outlet of the liquid outlet channel 11, the length of the through hole is larger than or equal to the distance from the breaking piston 13 to the stopping movement of the movable thimble 7, and the end point of the through hole coincides with the end point of the stopping movement of the outlet of the liquid outlet channel 11, so that the mixed liquid can be introduced into the reaction part or drop into the reaction part under the action of gravity, and the reaction is completed.
In the embodiment of the present invention, the housing 1 is detachably provided with a stopper 14 for clamping the movable sleeve 2.
As shown in fig. 4-5, a detection platform for a magnetic pen comprises a platform body 15, a tray 16 for placing a magnetic detection pen 2 is transversely arranged on the table surface of the platform body 15, a movable body 17 for driving a stirring body 10 to move by magnetic force is arranged above the tray 16, and a photoelectric detection head 18 is arranged below the detection platform.
In the embodiment of the present invention, at least one of the stirring body 10 and the movable body 17 is a magnet; the stirring body 10 and the movable body 17 are both magnets, or the stirring body 10 is a magnet, the movable body 17 is made of ferromagnetic substance, or the movable body 17 is a magnet, and the stirring body 10 is made of ferromagnetic substance.
In the embodiment of the present invention, the rack and pinion assembly 19 is disposed on the table body 15, and the rack and pinion assembly 19 includes a first driving gear 191 and a first driving gear 192 that are meshed with each other, where the first driving gear 191 is coupled to the first motor 193, and the first driving gear 192 is coupled to the tray 16 and drives the tray to reciprocate linearly.
In the embodiment of the present invention, a guide rail 20 is disposed at the side of the tray 16 along the moving direction thereof, and the tray 16 is slidably engaged with the guide rail 20.
In the embodiment of the invention, the table body 15 is provided with a driving wheel assembly, and the movable body 17 is eccentrically arranged on a wheel disc of the driving wheel or one of the driven wheels; the driving wheel assembly may be a double gear assembly 21, a sprocket chain assembly or a belt pulley assembly, etc., but is not limited thereto, and the double gear assembly 21 is exemplified in the present invention.
In the embodiment of the present invention, the table body 15 is provided with a double gear assembly 21, the double gear assembly 21 includes a second driving gear 211 and a second driven gear 212 that are meshed with each other, the second driving gear 211 is coupled with a second motor 213, and the movable body 17 is eccentrically disposed on a gear disc of the second driven gear 212.
In the embodiment of the present invention, the second driven gear 212 is mounted on the table surface via the support 22.
In an embodiment of the present invention, a detection method includes the following steps, taking blood collection as an example:
(1) Taking out the movable sleeve 2 in the magnetic force detection pen, completing blood collection by utilizing the capillary tube 8 at the front end of the collection head 5, storing the collected blood sample in the capillary tube 8, taking down the limiting block 14, driving the movable sleeve 2 to move towards the storage cavity 3 by utilizing a manual or driving device, enabling the movable sleeve 2 to continue to move after the capillary tube 8 breaks the sealing membrane 4, driving the blood sample in the storage cavity 3 to enter the mixing cavity 6 together through the capillary tube 8 and the liquid inlet channel 9 and mixing in the process that the collection head 5 gradually enters the storage cavity 3, and gradually increasing the mixing cavity 6 after driving the piston to retract by the mixed liquid, enabling the collection head 5 to completely enter the storage cavity 3, and stopping the movement of the movable sleeve 2;
(2) The first motor 193 on the detection platform for the magnetic force detection pen works forward to drive the tray 16 to extend gradually, and the magnetic force detection pen 2 which collects blood samples and completes mixing is placed on the tray 16; the first motor 193 works reversely to drive the tray 16 to retract and move to a preset position, and the first motor 193 stops working; the second motor 213 works to drive the movable body 17 to rotate, and drive the stirring body 10 to reciprocate in the magnetic force detection pen 2 under the left and right magnetic force, so as to stir the liquid to be detected until the liquid to be detected is uniformly mixed, and the second motor 213 stops working; the first motor 193 continues to work reversely, the platform 15 is provided with a bump, the movable thimble 7 on the magnetic force detection pen 2 moves towards the mixing cavity 6 and breaks the mixing cavity 6 on the bump, and the liquid outlet channel 11 introduces the mixed liquid uniformly stirred in the mixing cavity 6 into the detection test paper 12 to complete the reaction;
(3) The first motor 193 works forward to drive the tray 16 to gradually extend, a window which is favorable for observing the test paper 12 is arranged at the bottom of the tray 16, and in the process that the tray 16 gradually extends, the test paper 12 passes through a photoelectric detection head, and the photoelectric detection head transmits detected information to a background server for discrimination processing to finish detection; the photoelectric detection head and the background server are both existing devices, and the photoelectric detection head may include a color code sensor or other sensors that are beneficial to collecting information on the test paper 12, which is not limited thereto.
The present invention is not limited to the above-described preferred embodiments, and any person can obtain other various types of magnetometric detection pens, detection platforms for magnetometric pens, and detection methods under the teaching of the present invention. All equivalent changes and modifications made according to the claims of the present invention shall fall within the scope of the present invention.

Claims (5)

1. The detection method is characterized by comprising a magnetic force detection pen and a detection platform for the magnetic force detection pen;
the magnetic force detection pen comprises a shell, a movable sleeve in sliding fit with the movable sleeve is arranged in the shell in a penetrating manner, a storage cavity is formed in the tail end of the stroke of the movable sleeve, a sealing diaphragm is arranged in the storage cavity towards an opening of the movable sleeve, a collecting head matched with the storage cavity is arranged at the front part of the movable sleeve, a mixing cavity is arranged in the middle of the movable sleeve, a movable thimble is in sliding fit with the rear part of the movable sleeve, a capillary tube used for collecting a sample and propping the sealing diaphragm is arranged at the front end of the collecting head, a liquid inlet channel used for connecting the capillary tube and the mixing cavity is arranged at the rear end of the collecting head, a stirring body capable of reciprocating under the action of magnetic force is arranged in the mixing cavity, a reaction part is arranged in the shell, and a liquid outlet channel used for connecting the mixing cavity and the reaction part after the movable thimble is propped against the mixing cavity is arranged in the movable thimble;
the shell, the movable sleeve and the movable thimble are coaxially arranged, the reaction part is parallel to the movable sleeve, the movable thimble and the liquid outlet channel are provided with bending parts, and the movable sleeve and the movable thimble move along the axis;
the shell is provided with a through hole between the outlet of the liquid outlet channel and the reaction part, the through hole is long and narrow, the width of the through hole is larger than or equal to the size of the outlet of the liquid outlet channel, the length of the through hole is larger than or equal to the running distance from the bursting piston to the stopping movement of the movable thimble, and the end point of the through hole coincides with the end point of the stopping movement of the outlet of the liquid outlet channel;
the detection platform for the magnetic force detection pen comprises a platform body, a tray for placing the magnetic force detection pen is transversely arranged on the table top of the platform body, a movable body for driving the stirring body to move by utilizing magnetic force is arranged above the tray, and a photoelectric detection head is arranged below the detection platform;
the rack and pinion assembly comprises a first driving gear and a first driven rack which are meshed with each other, the first driving gear is connected with a first motor, and the first driven rack is connected with the tray and drives the tray to reciprocate linearly;
the table body is provided with a driving wheel assembly, and the driving wheel assembly is a double-gear assembly; the double-gear assembly comprises a second driving gear and a second driven gear which are meshed with each other, the second driving gear is connected with a second motor, and the movable body is eccentrically arranged on a gear disc of the second driven gear;
the detection method comprises the following steps:
(1) Taking out a movable sleeve of a magnetic force detection pen, completing blood collection by utilizing a capillary tube at the front end of a collection head, storing a collected blood sample in the capillary tube, taking down a limiting block on a shell of the magnetic force detection pen for clamping the movable sleeve, driving the movable sleeve to move towards a storage cavity by utilizing a manual or driving device, enabling the movable sleeve to continuously move after the capillary tube breaks a sealing membrane, enabling diluent in the storage cavity to drive the blood sample to enter a mixing cavity through the capillary tube and a liquid inlet channel and be mixed in the process that the collection head gradually enters the storage cavity, enabling the mixing cavity to gradually increase after a mixed liquid drives a piston to retract, enabling the collection head to completely enter the storage cavity, and stopping moving the movable sleeve;
(2) The magnetic force detection pen is characterized in that a first motor on a detection platform for the magnetic force detection pen is driven to work positively, the tray is driven to extend gradually, the magnetic force detection pen which collects blood samples and completes mixing is arranged on the tray, the first motor is driven to work reversely, the tray is driven to retract and move to a preset position, the first motor stops working, a second motor is driven to rotate, a stirring body is driven to reciprocate in the magnetic force detection pen under the action of magnetic force, liquid to be detected is stirred until the liquid to be detected is uniformly mixed, the second motor stops working, the first motor continues to work reversely, a lug is arranged on the platform body, a movable thimble on the magnetic force detection pen enables the movable thimble to move towards a mixing cavity and push the mixing cavity on the lug, and a liquid outlet channel introduces the mixed liquid uniformly stirred in the mixing cavity into the detection test paper to complete reaction;
(3) The first motor works positively to drive the tray to extend gradually, and the photoelectric detection head transmits detected information to the background server for discrimination processing to finish detection.
2. The method of claim 1, wherein: the reaction part comprises detection test paper.
3. The method of claim 1, wherein: the mixing cavity comprises a piston which is in sliding fit with the movable sleeve, a mixing cavity is formed between the piston and the movable sleeve, and a concave part which is beneficial to the penetration of the movable thimble is formed at the tail part of the piston.
4. The method of claim 1, wherein: at least one of the stirring body and the movable body is a magnet; the stirring body and the movable body are both magnets, or the stirring body is a magnet and the movable body is made of ferromagnetic substances, or the movable body is a magnet and the stirring body is made of ferromagnetic substances.
5. The method of claim 1, wherein: the side of tray is provided with the guide rail along its direction of motion, tray and guide rail sliding fit.
CN201811223382.9A 2018-10-19 2018-10-19 Magnetic force detection pen, detection platform for magnetic force pen and detection method Active CN108982191B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112666095B (en) * 2020-12-29 2023-04-21 上海理工大学 Urine component analysis device based on color code sensor

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JPH07225230A (en) * 1994-02-09 1995-08-22 Katsutsune Sato Inspection equipment with specimen collecting equipment
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CN106680477A (en) * 2017-02-14 2017-05-17 杭州诺辉健康科技有限公司 Excrement sampling and occult blood detection integrated device
CN209311170U (en) * 2018-10-19 2019-08-27 医芯(厦门)科技有限公司 Magnetic force detects pen

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Publication number Priority date Publication date Assignee Title
JPH07194957A (en) * 1994-01-06 1995-08-01 Taitetsuku Kk Magnetic stirrer rotating on its own axis and while making revolution
JPH07225230A (en) * 1994-02-09 1995-08-22 Katsutsune Sato Inspection equipment with specimen collecting equipment
CN202793874U (en) * 2012-08-23 2013-03-13 浙江世纪康大医疗科技有限公司 Sample sealed stirring mechanism
JP2013079983A (en) * 2013-02-04 2013-05-02 Seiko Epson Corp Inspection container, inspection device, and inspection method
CN106680477A (en) * 2017-02-14 2017-05-17 杭州诺辉健康科技有限公司 Excrement sampling and occult blood detection integrated device
CN209311170U (en) * 2018-10-19 2019-08-27 医芯(厦门)科技有限公司 Magnetic force detects pen

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