JPH065611Y2 - Reflection spectrum standard - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to a reflection spectrum standard used for a measurement performance standard test of a reflected light spectrum analyzer.

[Prior Art] A reflected light spectrum analyzer is a device developed for the purpose of measuring the amount of hemoglobin (Hb) and oxygen saturation (SO ₂ ) in blood in a blood vessel without damaging a living body. 4 and 5
The basic configuration and measurement principle are shown in the figure.

FIG. 1 shows a tissue spectrum measurement probe in which a light-transmitting optical fiber 2 and a light-receiving optical fiber 3 are bundled in a parallel state and the outer circumference is covered with a coating layer 4. The optical fibers 2 and 3 in the rear portion of the probe 1 are bundled into independent optical fibers, and a light source 5 and a lens 6 are provided on the incident end side of the optical fiber 2. Further, an analyzer 9 including a spectroscope 7 and an image sensor array 8 is connected to the emission end side of 3.

In this device, the measurement end 10 of the probe 1 is connected to the measurement target tissue 1
The light from the light source 5 is irradiated onto the tissue via 6 and 2 by contacting with 1, and the reflected light from the tissue is received at 3. And
This reflected light is taken into 9 and spectrally analyzed, and the spectrum analysis result is displayed by the CRT or graphic printer of FIG.

[Problems to be solved by the device]

Since the above-mentioned reflected light spectrum analyzer measures the amount of Hb and SO ₂ in the living body as described above, it is desirable to carry out the measurement performance standard in a form suitable for the living body measurement. This is because the measurement error in actual measurement becomes large due to the difference in the measurement conditions when the value is evaluated by comparing it with the reference value obtained by the theoretical formula or the like.

However, a standard test method or standard test apparatus that can meet such demand has not yet been developed.

Therefore, this invention intends to provide a standard device that enables highly reliable performance standardization suitable for biometric measurement.

[Means for Solving the Problems]

The standard device of this invention is a transparent glass plate in which a space crossing the optical path of irradiation light from the surface is provided in the middle of the thickness direction and carboxyhemoglobin is filled and sealed in this space, and a transparent glass plate is laminated on the back surface of this glass plate for transmission. A white plate that reflects light is used to standardize the measurement performance of the above-mentioned reflected light spectrum analyzer based on the reflection spectrum in the carboxyhemoglobin-filled portion of this instrument.

[Action]

When carbon monoxide is added to hemoglobin, Hb has a high affinity for CO, and the two bind to form carboxyhemoglobin (HbCO) that can be stored for a long time. Since the HbCO is contained in the standard device of the present invention, the reflection spectrum obtained at the HbCO filling part has almost the same measurement condition as that in the actual measurement of the living body, and the spectrum is always constant.

Therefore, the above-mentioned problems can be eliminated by standardizing the performance of the analyzer based on this reflected light spectrum.

〔Example〕

 1 to 3 show one embodiment of the present invention.

Reference numeral 21 in FIG. 1 denotes a substrate glass 21a and a cover glass 21.
b is a glass plate, and this glass plate has 21a
The recessed portion provided in 21 is airtightly closed by 21b to create a space 22 that crosses the optical path of the measurement light 12.

Reference numeral 23 is a white plate attached to the back surface of the glass plate 21 for reflecting the measurement light 12, and 24 and 25 are inlets and air vents communicating from 22 to the outside.

Reference numeral 26 is HbCO which is evacuated from the space 22 and filled therein. After the HbCO is filled, the openings of 24 and 25 are hermetically sealed with an adhesive 27 or the like.

Here, although the space 22 shown in FIG. 2 has a circular shape in plan view,
This shape may be arbitrarily determined.

Further, as shown in FIG. 3, a fixture 28 of the measuring probe 1 may be attached to the standard device 20 composed of the above.

In this standard device, the measuring end 10 of the probe 1 is brought into close contact with the surface of 21 at the filling portion of 26, and the light from the light source 5 described in FIG. 4 is emitted from the optical fiber 2. Then, the reflected light is received by the optical fiber 3 and analyzed to check whether the analysis result matches that of HbCO. If they match, the device is normal, and if they do not match, the accuracy is poor and accuracy adjustment is required.

〔effect〕

As described above, the standard device of the present invention has a measurement condition that is almost the same as that of the biometric measurement and can always obtain a constant reflection spectrum. Therefore, the measurement performance of the reflection spectrum analyzer is actually measured based on this standard value. It is possible to evaluate easily and in a reliable form in conformity with the above, and it is possible to mass-produce a device having a constant performance and to perform a simple inspection for deterioration with time of the device.

[Brief description of drawings]

FIG. 1 is a sectional view showing an example of the standard device of the present invention, and FIG.
FIG. 4 is a plan view thereof, FIG. 3 is a front view of another embodiment, FIG. 4 is a conceptual diagram showing the basic configuration and measurement principle of a reflected light spectrum analyzer, and FIG. 5 is a block diagram of the device of FIG. is there. 20 ... Standard device, 21 ... Glass plate, 22 ... Space, 23 ... White plate, 26 ... HbCO.

Claims (1)

[Scope of utility model registration request] 1. A transparent glass plate in which a space traversing the optical path of irradiation light from the surface is provided midway in the thickness direction and carboxyhemoglobin is filled and sealed in the space, and a transparent glass plate is laminated on the back surface of the glass plate to transmit transmitted light. It is composed of a white plate to reflect,
A reflection spectrum standard instrument for standardizing the measurement performance of a reflected light spectrum analyzer for measuring the amount of hemoglobin and oxygen saturation of living tissue based on the reflection spectrum in the carboxyhemoglobin filled part of this instrument.