JPH0652839U - Simple applicator for biological tissue adhesive - Google Patents

Abstract

(57) [Summary] [Purpose] A living tissue adhesive that can be easily and evenly applied and is excellent in workability when the living tissue adhesive is mixed with sterile gas and applied for the purpose of adhering and closing living tissue. A spraying device is provided. [Constitution] Spray head with aseptic gas supply channel
A pair of syringe bodies (2) filled with (1), a high pressure regulator (5) and a small high pressure gas cylinder (6) are integrated, a spray head and a high pressure regulator are connected by a tube (7), and an air filter (14) is attached. Pass through and supply sterile gas.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention relates to a device for applying a living body adhesive containing animal protein as a main component to humans or animals, and is particularly suitable for treatment of lacerations and burns of the skin, hemostasis or skin transplantation, etc. The present invention relates to a device for spraying a bioadhesive onto a device.

[0002]

[Prior art]

 A biological tissue adhesive containing animal protein as a main component is formed in situ by mixing a solution of a protein with a solution of a coagulation factor that promotes clot formation of the protein. When using this type of biological tissue adhesive, for example, when a solution containing factor XIII and fibrinogen is mixed with a thrombin-containing solution and used for biological tissue attachment, one solution is conventionally applied to the application site. A method of coating this with the other solution, or a method of premixing two solutions in a mixed solution, sucking it into a syringe, and then applying it to a site to be adhered has been adopted.

However, all the above methods have drawbacks. That is, the first method has a problem that the mixing is incomplete due to the solidification of the surface before the two solutions are completely mixed, so that the adhesive strength is lowered, and the second method is Since the solidification of the adhesive occurs immediately when the two solutions are mixed, it is necessary to apply the adhesive to the application site quickly after mixing the two solutions, which requires considerable skill, and even if the application was possible. However, the application site was limited, which was a problem. Therefore, as a method for solving such a problem, in recent years, two different solutions have been previously stored in two syringe bodies, respectively, and the two solutions stored in these syringe bodies have been stored. A method has been proposed in which two solutions are simultaneously poured out and mixed while being mixed (JP-A-64-25843, JP-A-64-40040 and JP-A-62-20853). Japanese Utility Model Publication 62-62674, Japanese Utility Model Publication 62-62675, Japanese Utility Model Publication 62-65972, Japanese Utility Model Publication 62-65973, Japanese Utility Model 3-47609, Japanese Utility Model 1-82049. Bulletin).

For example, in the device of Japanese Utility Model Publication No. 3-47609, the conical portions of two syringe bodies are connected by a collecting head including a conveyor flow path for each component of a biological tissue adhesive, and a plunger is integrated. The solution is ejected from the two syringe bodies to the collecting head at the same time by operating the two syringe bodies, and aseptic gas is supplied from the sterile gas supply channel provided in the collecting head to eject the two liquids injected into the collecting head. It is designed so that it can be sprayed in the form of a mist, and is characterized in that the center line of the spout of the sterile gas supply flow path is arranged so as to intersect at a predetermined position in front, and the adhesive can be applied over a wide range.

However, this is because when the injection operation of the adhesive is interrupted, solidification of the adhesive may occur and the collecting head may need to be replaced, and at the same time, the facility must be protected to ensure sterile gas. It must be introduced from the unit using a long tube or a tube longer than a large high pressure cylinder. At this time, it was feared that long tubes and large cylinders would obstruct the work, prolong the time of the surgery, and sometimes affect the surgical results.

[0006]

[Problems to be solved by the device]

 The present invention has been made in view of the above problems, and the purpose thereof is to be applicable to a large area, and to prevent the adhesive from solidifying due to the interruption of the injection work, and to make it long. An object of the present invention is to provide a compact simple application device for a living tissue adhesive that does not hinder the work with a tube.

[0007]

[Means for solving problems]

 In order to solve the above problems, the present invention integrates two syringe bodies filled with a spray head provided with a sterile gas supply passage, a small high-pressure cylinder and a pressure regulator, and a spray head and a regulator by a tube. It is a simple applicator for biological tissue adhesives, which is connected, downsized, and improved in operability.

The simple applicator for biological tissue adhesives of the present invention is small in size and has improved operability, so that work can be performed in a short time, and at the same time, obstruction of work with a long tube can be overcome. Becomes

[0009]

【Example】

 The present invention will be described with reference to the drawings. FIG. 1 is a plan view of a simple application device for a biological tissue adhesive according to an embodiment of the present invention, FIG. 2 is a side view thereof, and FIG. 3 is an explanatory view thereof.

As shown in FIG. 1, FIG. 2 and FIG. 3, a simple application device for a living tissue adhesive of the present invention is a spray head (1), a set of syringe bodies (2), a syringe holding means (3), an integrated body. Gas pressure from the pressure regulator (5), which is composed of a dynamic high pressure cylinder (6), a pressure regulator (5), a small high pressure cylinder (6) and a connecting tube (7). Is adjusted, gas is introduced into the spray head (1), and sprayed from the spray head narrowed portion (8). The adhesive can be easily applied by pressing the integral operating means (4) of the syringe body (2) filled with the fibrinogen solution and the thrombin solution.

The syringe body (2) is generally made of glass or a transparent synthetic resin material such as polypropylene or polycarbonate, and has a squeezed end for connecting the syringe body (2) to the spray head (1). It is composed of a barrel (9) having a barrel and a slidable plunger (10) inserted in the barrel (9).

The spray head (1) uses a small high-pressure cylinder (6) as a gas source, and the gas adjusted by the high-pressure regulator (5) is discharged to a portion discharged from the spray head constriction (8). It has the function of supplying the fibrinogen solution and thrombin solution through the inner tube (11) and applying them in the form of a mist.However, it is not limited to this, and usually soft vinyl chloride resin, polyethylene, polyester, or polypropylene can be used. It is made of flexible resin.

The syringe holding means (3) integrally holds and fixes the pair of syringe bodies (2) and the pressure regulator (5), and various shapes are conceivable. 2 and 3 are examples thereof. This has two parallel grooves formed on one surface corresponding to the shape of the outer wall of the barrel. The depth of the groove is larger than the radius of the barrel cross section, so the inlet of the groove becomes narrower. The groove wall holds the barrel exactly when the barrel is fitted into the groove. Furthermore, this syringe holding means (3) can fix the high pressure regulator (5) on the one hand. The high pressure regulator (5) fixed part has a shape that is slightly larger than the outer shape of the high pressure regulator (5), the tip of which is curved slightly inward, and the high pressure regulator (5) is attached to this. It is desirable that it does not fall off when it is inserted, and that it is inclined slightly outward so that it does not interfere with the application and it is easy to hold during application.

The integral manual means (4) fixes the plunge portions of the two plungers (10) so that the plunger (10) can move integrally within the barrel (9). There are various shapes. FIGS. 2 and 3 show an example thereof. Two parallel grooves for inserting the rod of the plunger (10) and a holding plate perpendicular to these grooves are integrally formed. . The shape of the groove is formed to be substantially the same as the groove of the syringe holding means so that the rod is fitted and held in the groove. A gap is formed between the groove and the holding plate so as to correspond to the plunge portion of the plunger.

A synthetic resin is generally used as a material for forming the syringe holding means (3) and the integral operating means (4), and for example, polyethylene, polypropylene, acrylonitrile butadiene styrene copolymer, polycarbonate or the like is suitable. Can be used.

The high-pressure regulator (5) is small in size and has no problem in performance as long as it can be adjusted in the range of 0.5 to 4.0 atm. If one example is shown here, it is possible to use the gas feeder “NR-14” manufactured by Nippon Carbonate Gas Co., Ltd.

The small high-pressure gas cylinder (6) used as a gas source can be attached to the high-pressure regulator (5) and is a gas cylinder that holds a sufficient amount of gas for applying the adhesive. There is no problem in use. As an example, it is possible to use a miniature cartridge "XS-95-CN4" manufactured by Nippon Carbonate Gas Co., Ltd.

The tube (7) connecting the spray head (1) and the high-pressure regulator (5) is resistant to the pressure of gas sufficient for applying the adhesive. It is enough, and it is useful to provide a cock (13) on the way to open and close the gas flow path. Further, it is necessary to install a filter (14) for sterilizing gas on the spray head (1) side of the tube (7). The tube (7) is generally made of vinyl chloride, the cock (13) is, for example, "N-roll (manufactured by Yanase Sangyo Co., Ltd.)", and the air filter (14) is, for example, "Mylex". FG (manufactured by Nippon Millipore) "is used.

A method of using the biological tissue adhesive simple coating device of the present invention will be described. In using the simple device for applying a biological tissue adhesive of the present invention, first, for example, a fibrinogen solution is stored in one of the syringes (2) and the same amount of the thrombin solution is stored in the other syringe (2). As shown in (3), the syringe body is fixed to the syringe holding means (3), and then the high pressure regulator (5) is fixed to the syringe holding means (3). The spray head (1) is fitted into a set of syringe bodies (2), the tube (7) is connected to the spray head (1) and the high pressure regulator (5), and the high pressure regulator is connected. Connect (5) and small high-pressure cylinder (6). After that, the pressure of the gas to be discharged is adjusted by the knob of the high-pressure regulator (5), the cock (13) is released, and the gas is discharged. After that, the fibrinogen solution and the thrombin solution can be simultaneously atomized and applied by gently pressing the integral actuating means (4) with the thumb. At times, it is possible to apply both solutions separately in the form of mist without using the integrated actuating means (4).

[0020]

[Effect of device]

 As will be apparent from the above description, the following advantages can be obtained by using the biological tissue adhesive simple application device of the present invention. (1) Since the coating operation can be performed with one hand, operability is enhanced. (2) Since a long tube for introducing gas is not required, work safety is improved and work efficiency is improved.

[Brief description of drawings]

FIG. 1 is a plan view of the present invention.

[Figure 2] Side view

FIG. 3 Exploded explanatory diagram

[Explanation of symbols]

 1 Spray Head 2 Syringe Body 3 Syringe Holding Means 4 Integrated Actuating Means 5 High Pressure Regulator 6 Small High Pressure Gas Cylinder 7 Tube 8 Spray Head Squeezing Part 9 Barrel 10 Plunger 11 Inner Tube 12 High Pressure Regulator Fixed Part 13 Cock 14 Air Filter

Claims (2)

[Scope of utility model registration request] 1. A simple application for a living tissue adhesive using a small high-pressure gas cylinder, which is used when a living tissue adhesive is mixed with sterile gas and applied for the purpose of adhering or closing living tissue of human or animal. Equipment. 2. A pair of syringe bodies with a spray head provided with a sterile gas supply channel, a high-pressure regulator and a small high-pressure gas cylinder are integrated, and the spray head and the high-pressure regulator are connected by a tube and passed through an air filter. Aseptic gas is supplied, The simple application device for biological tissue adhesives of Claim 1 characterized by the above-mentioned.