JPH06238001A - Biological adhesive sprayer - Google Patents

Abstract

PURPOSE:To provide a biological adhesive sprayer, by which an adhesive can be applied easily and uniformly and the absolute quantity of gas applied to the diseased part is decreased to reduce the contamination of the diseased part to the utmost. CONSTITUTION:A biological adhesive sprayer comprises a pair of syringe bodies including a barrel 5 and a plunger 7, a pair of doglegged nozzles 2, a syringe holding means 3, an integral operating means 4 and an adhesive spray tube 10, wherein the adhesive spray tube 10 includes a connecting end 16 connected to a compressor and an adhesive spray port 11, the adhesive spray port 11 includes an opening part 12, a constriction part 13 and a reduced diameter part 14, and the opening part 10 is provided with an adhesive injection hole 15 close to the constriction part 13.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a device for applying a biomedical adhesive containing animal protein as a main component to humans or animals, and particularly to treatment of skin scratches and burns, hemostasis,
The present invention relates to a device for spraying a biomedical adhesive onto a diseased part of a living body, which is suitable for skin transplantation and the like.

[0002]

Bioadhesives containing animal protein as a main component are formed in situ by mixing a solution of a protein with a solution of a coagulation factor that promotes clot formation of the protein. When using a bioadhesive of this type, for example, when a solution containing Factor XIII and fibrinogen is mixed with a thrombin-containing solution and applied to a laceration site to be adhered or protected, one solution is conventionally used. Is applied to the application site and the other solution is applied to the application site, or two solutions are premixed in a mixing container, sucked into a syringe, and then applied to the site to be adhered. ing.

However, all of the above methods have drawbacks. That is, the first method is problematic because the solidification of the surfaces of the solutions occurs before the two solutions are completely mixed, resulting in incomplete mixing, resulting in a decrease in adhesive strength. The method is that solidification of the adhesive occurs immediately after mixing the two solutions,
After mixing the two solutions, the adhesive had to be quickly applied to the application site, which required considerable skill, and even if it could be applied, the field of application was limited, which was a problem.

Therefore, as a method of solving such a problem, two different solutions are preliminarily stored in two syringe bodies respectively, and the two solutions stored in these syringe bodies are simultaneously poured out to obtain two solutions. Various methods of applying the solution while mixing it have been proposed (Japanese Patent Laid-Open No. 64-64-
25843, JP-A-64-40040, JP-A-62-62674, JP-A-62-62675.
Japanese Utility Model Publication No. 62-65972, Japanese Utility Model Publication No. 62-65972.
65973, Japanese Utility Model Publication No. 3-47609, Japanese Utility Model Publication No. 64-20853, and Japanese Utility Model Publication No. 1-82049). Among these proposals, the invention of Japanese Patent Laid-Open No. 64-25843 and the invention of Japanese Utility Model Publication No. 3-47609 are sprays suitable for application to a wide area such as scratches and burns on the skin, wide-ranging hemostasis, and skin transplantation. It has a means.

The idea of Japanese Utility Model Publication No. 3-47609 is 2
The conical parts of one syringe body are connected by a collecting head containing a conveyor flow path for each component of the bioadhesive, so that the plungers are actuated together to eject the solution from the two syringe bodies simultaneously into the collecting head. In addition, the sterile gas is supplied from the sterile gas supply passage provided in the collecting head so that the two liquids ejected to the collecting head can be atomized. It is characterized in that the center line of the outlet portion is arranged so as to intersect at a predetermined front position. Also, Japanese Patent Laid-Open No. 64-2
In the invention of Japanese Patent No. 5843, a pair of syringe bodies are integrated by a syringe holding means, and an integral actuating means is attached to a plunger so that two liquids can be simultaneously ejected, and a tip of one syringe body is sprayed, It is characterized in that the tip of the other syringe body is attached with a flat nozzle at the tip so that one solution can be applied by the nozzle while the other solution is sprayed.

[0006]

However, the bio-adhesive sprayer disclosed in Japanese Utility Model Publication No. 3-47609 is of a type that sprays using a pressurized sterile gas from a compressor. Depending on the viscosity, it may not be possible to spray unless the pressure is raised to about 1.5 to 2 kg, and if the gas pressure is increased, the absolute amount of gas hitting the affected area will increase, so that bacteria etc. around the affected area will scatter. There is a possibility that the affected area may be contaminated, which is a problem. Also,
The bioadhesive sprayer disclosed in JP-A-64-25843 is
There are drawbacks in that it is difficult to apply a uniform adhesive and it takes time to apply. The present invention has been made in view of the above circumstances, and provides a bio-adhesive sprayer in which an adhesive can be easily and uniformly applied, and the absolute amount of gas hitting the affected area is reduced to minimize the risk of contamination of the affected area. The purpose is to do.

[0007]

In order to solve the above-mentioned problems, the present invention provides a pair of syringe bodies each comprising a barrel having a narrowed end and a slidable plunger inserted into the barrel, and a pair of syringes. Means for holding and fixing the body, means for integrally operating the pair of plungers, a pair of bent nozzles respectively attached to the narrowed ends of the syringe body, and a connection to the compressor at both ends thereof The adhesive spray port includes a pair of adhesive spray pipes having an end and an adhesive spray port, and a side wall of which has an adhesive injection hole into which the tip of the nozzle can be substantially airtightly inserted. However, the inner diameter of the adhesive spray tube is reduced and connected to a narrowed portion having a uniform inner diameter, and then the inner diameter is suddenly expanded and opened to the outside, and the adhesive injection hole is The narrowed portion in the enlarged opening It employs a bioadhesive spray device thus provided in contact. The ratio d / d 'of the inner diameter d upstream of the reduced diameter portion of the adhesive spray tube and the inner diameter d'of the narrowed portion is preferably 5 or more. Further, according to the present invention, a tubular body having a connecting end to a compressor and an adhesive spray port at both ends thereof, and an adhesive injection hole into which a tip of the nozzle can be substantially airtightly inserted is formed in a side wall thereof. The adhesive spray port has a configuration in which the inner diameter of the adhesive spray tube is reduced and connected to a narrowed portion having a uniform inner diameter, and then the inner diameter is suddenly expanded to open to the outside. However, a bioadhesive spray tube is used in which the adhesive injection hole is provided in the enlarged diameter opening portion in the vicinity of the narrowed portion.

[0008]

According to the above construction, since the pressured gas in the air chamber passes through the narrowed portion of the adhesive spray pipe to increase the pressure and flow velocity, the gas is suddenly expanded in diameter. As the pressure decreases, the gas is jetted at the same flow velocity as the passage speed of the narrowed portion while diffusing according to the shape of the opening of the adhesive spray tube due to its viscosity. Therefore, a suction force and a radial gas flow are generated by the negative pressure in the expanded diameter opening, and the two solutions injected from the nozzle are diffused by the gas and atomized while being mixed with each other. In this case, since the gas flow velocity is accelerated in the narrowed portion, the amount of gas ejected to obtain the gas flow velocity required for spraying is reduced. Therefore, since the absolute amount of the gas blown to the affected area is also reduced, the risk of contamination of the affected area by bacteria or the like around the affected area is reduced.

[0009]

Embodiments of the present invention will now be described with reference to the drawings. 1 is a schematic explanatory view of a bioadhesive spraying device of the present invention, FIG. 2 is a plan view of a portion of the bioadhesive spraying device of the present invention excluding an adhesive spray pipe, and FIG. 3 is a bioadhesive of the present invention. FIG. 4 is a cross-sectional view of the adhesive spray pipe of the spray device, and FIG. 4 is a diagram showing the relationship between the nozzle of FIG. 1 and the adhesive spray pipe. 1 to 3
As shown in FIG. 1, the bioadhesive spraying device of the present invention includes a pair of syringe bodies 1 including a barrel 5 and a plunger 7, a pair of nozzles 2 that are usually bent in a dogleg shape, a syringe holding means 3, and an integrated body. The adhesive spray pipe 10 has a connection end 16 with a compressor and an adhesive spray port 11, and the adhesive spray port 11 is an opening. The opening 12 is provided with an adhesive injection hole 15 in the vicinity of the narrowed portion 13, which is composed of the portion 12, the narrowed portion 13 and the reduced diameter portion 14.

As shown in FIG. 2, a pair of syringe bodies 1 each comprising a barrel 5 and a slidable plunger 7 inserted in the barrel 5 are held and fixed by a syringe holding means 3, and the plunger 7 is fixed. An integral actuating means 4 for pushing a pair of plungers 7 at the same time is attached to the ends of the. The nozzle 2 is attached to the tip 6 of the tip of the syringe body 1. The parts other than the nozzle 2 and the adhesive spray tube 10 can be the same as the invention of Japanese Patent Application Laid-Open No. 64-25843, which was filed by one of the applicants of the present applicant, and therefore a more detailed description is omitted. .

The nozzle 2 is, as shown in FIGS. 1 and 2,
Needle base 8 for mounting on the tip 6 of the syringe body 1 and needle tube 9 inserted into the adhesive injection hole 15 of the adhesive spray tube 10.
The needle tube 9 is bent into an L shape. As a material for forming the needle tube 9, a metal or a synthetic resin can be used and is not particularly limited as long as it does not adversely affect the living body and the adhesive, but is usually polyethylene, polypropylene, ethylene-propylene copolymer, Synthetic resins such as polycarbonate and polyester, and metals such as stainless steel (SUS316L and the like) are preferably used. A brim 18 may be provided at the tip of the nozzle 2 to keep the insertion depth of the nozzle 2 into the adhesive injection hole 15 constant.

The adhesive spray pipe 10 has, at both ends thereof, a connecting end 16 for connecting to a compressor (not shown) and an adhesive spray port 11 for winding the adhesive and spraying it. Although it is a tubular body, it is usually, but not limited to, formed of a soft vinyl chloride resin or a flexible resin such as polyethylene, polyester, or polypropylene. And, if necessary, the adhesive spray port 1 downstream of the connection end 16
A sterilizing filter 17 for removing bacteria and the like in the air is provided at an appropriate position apart from 1. The adhesive spray port 11 includes a reduced diameter portion 14 in which the inner diameter of the adhesive spray tube 10 is reduced, a narrowed portion 13 having a uniform inner diameter continuous with the reduced diameter portion 14, and the narrowed portion 13. It consists of an opening 12 that is continuous and steeply expanded in diameter and opens to the outside.
The adhesive spray pipe 10 is provided in the opening 12 close to the narrowed portion 13.
An adhesive injection hole 15 is formed perpendicularly to the axis of.

The narrowed portion 13 of the adhesive spray port 11 accelerates the flow velocity of gas by narrowing the flow of gas (usually air) sent from the compressor, and as a result,
This is a portion for making the pressure in the pipe smaller than the atmospheric pressure (negative pressure) to assist the injection of the adhesive from the adhesive injection hole 15, and the inner diameter d ′ thereof is the inner diameter of the pipe upstream of the reduced diameter portion 14. d
And d / d 'is preferably 5 or more. d
If / d 'is less than 5, it is difficult to obtain a sufficient flow velocity of the gas, and depending on the pressure of the gas pumped by the compressor, the internal pressure of the pipe in the narrowed portion 13 may not be a negative pressure. .

The opening 14 of the adhesive spray port 11 is steeply expanded from the narrowed portion 13, and an adhesive injection hole 15 is formed in the wall of the pipe in the vicinity of the narrowed portion 13. The inclination of the expanded diameter portion 13 is usually 3 with respect to the axis of the adhesive spray tube 10.
It is 0 to 60 degrees, and if it is too small, the adhesive adheres to the tube wall and it becomes difficult to spray, and if it is too large, it becomes difficult to form the adhesive injection hole 15. The adhesive injection hole 15 is formed to have a diameter equal to or slightly smaller than the outer diameter of the nozzle 2, and when the adhesive spray pipe 10 is made of a flexible resin, the tip of the nozzle 2 due to its flexibility. Can be inserted in a substantially airtight manner. When the adhesive spray tube 10 is made of hard synthetic resin or metal, a seal member may be attached to the adhesive injection hole 15. Adhesive injection hole 1 of nozzle 2
The insertion depth into the nozzle 5 is preferably such that the tip of the nozzle 2 is near the extension of the inner wall of the narrowed portion 13. This is because turbulent flow is likely to occur above this and adhesive tends to adhere to the tube wall below this (which is also the reason why the adhesive injection hole 15 is not provided in the narrowed portion 13).

Next, the use of the bioadhesive spraying device of the present invention will be described. As shown in FIG. 1, a pair of syringe bodies 1 each filled with an adhesive component (not shown), a pair of nozzles 2 mounted on a tip 6 of the syringe body 1, and a syringe holding means 3 are shown. The bio-adhesive administration tool A including the integral actuating means 4 is prepared, and the nozzle 2 is inserted into the adhesive injection hole 15 of the adhesive spray pipe 10 connected to the compressor. Then, while feeding gas into the adhesive spray tube 10 by a compressor, the bioadhesive administration tool A
When the plunger 7 is pushed to inject the adhesive from the nozzle 2 into the opening 12 of the adhesive spray pipe 10, the adhesive component mixes with the gas to form a mist, and the mist-like adhesive components are mixed with each other. It is sprayed radially.

[0016]

As is apparent from the above description, by using the bioadhesive spraying device of the present invention, the adhesive can be applied easily and uniformly. Since the spray can be performed with the minimum amount, it is possible to obtain an effect that the affected area is not contaminated due to the contamination around the affected area.

[Brief description of drawings]

FIG. 1 is a schematic explanatory view of a bioadhesive spraying device of the present invention.

FIG. 2 is a plan view of a portion excluding an adhesive spray pipe.

FIG. 3 is a cross-sectional view of an adhesive spray tube.

FIG. 4 is a diagram showing a relationship between the nozzle of FIG. 1 and an adhesive spray pipe.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Syringe body 2 Nozzle 3 Syringe holding means 4 Integrated operation means 10 Adhesive spray pipe 11 Adhesive spray port 13 Constriction part 15 Adhesive injection hole

Claims (3)

[Claims] 1. A pair of syringe bodies consisting of a barrel having a narrowed end and a slidable plunger inserted into the barrel, a means for holding and fixing the pair of syringe bodies, and the pair of plungers are integrated. A pair of bent nozzles respectively attached to the narrowed ends of the syringe body, and a connecting end to a compressor and an adhesive spray port at both ends of the nozzle, and the side wall of the nozzle. The tip consists of a pair of adhesive spray pipes having an adhesive injection hole that can be substantially airtightly inserted, and the adhesive spray port has an inner diameter reduced by reducing the inner diameter of the adhesive spray pipe. After being connected to a uniform narrowed portion, the inner diameter is suddenly expanded to open to the outside, and the adhesive injection hole is provided in the expanded opening in the vicinity of the narrowed portion. A bioadhesive spraying device that is formed. 2. The inner diameter d upstream of the reduced diameter portion of the adhesive spray pipe.
The ratio of the inner diameter d ′ of the narrowed portion to d / d ′ ≧ 5.
The bioadhesive spraying device according to item 1. 3. A pipe body having a connecting end to a compressor and an adhesive spray port at both ends thereof, and an adhesive injection hole into which a tip end of the nozzle can be substantially airtightly inserted is formed in a side wall thereof. The adhesive spray port has a configuration in which the inner diameter of the adhesive spray pipe is reduced and connected to a narrowed portion having a uniform inner diameter, and then the inner diameter is suddenly expanded to open to the outside. An adhesive spray tube is provided in which the adhesive injection hole is provided in the enlarged diameter opening portion in the vicinity of the narrowed portion.