JPH0640837U - Dispensing device - Google Patents

Abstract

(57) [Summary] [Purpose] A dispensing device that maintains a constant temperature from sample aspiration to the end of dispensing, has a simple structure, is inexpensive, and can accurately respond to a small amount of reagent. I will provide a. [Structure] A probe 1 having a fine hole formed therein is inserted into a preheating pipe 2 for meat pressure, the preheating pipe 2 has an end partly disposed in a heating part 5 and the other end part connected to a pump 6. The pipe line 3 is connected, and the pump 6 is further connected to a pipe 7 for introducing wash water.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention relates to a sample dispensing device used in a biochemical automatic analyzer such as a blood coagulation device, and particularly to a dispensing device capable of dispensing a sample while being heated to a constant temperature.

[0002]

[Prior art]

 Blood coagulation time measurement is used to diagnose the presence or absence of disease.As a measurement method, plasma in blood, which is a coagulation component, is separated, and various reagents are added according to the measurement items until coagulation. Measure the time of. When performing such biochemical analysis of blood, an automatic analyzer is used, and samples and reagents are automatically sucked and distributed to a large number of sample containers arranged in a rack. A dispensing device is used when aspirating and dispensing reagents and samples. Conventional dispensers have a structure in which a thin tube is wound in the form of a coil in front of a probe for aspirating and discharging, and a heater is placed in a coil and preheated to a constant temperature. is there.

[0003]

[Problems to be solved by the device]

 In the conventional dispenser as described above, the probe portion up to the heater is not heated, and the sample remaining in the air portion when ejecting the air sucked during sample suction pops up and scatters. There was a problem of causing defects. In addition, a sample that was kept in a constant temperature at a constant temperature also changed (decreased) in temperature when it passed through the probe part and was affected by the probe part and the outside air. In particular, the conventional dispenser has a problem that it is difficult to cope with the miniaturization of the reagent (50 μl to 100 μl). The present invention has been made in view of such problems, and its purpose is to maintain a constant temperature from the sample aspiration to the end of dispensing, and the structure is simple and inexpensive, and even for a small amount of reagent. Is to provide a dispensing device that can respond accurately.

[0004]

[Means for Solving the Problems]

 That is, in this invention, in order to solve the above-mentioned problems, a dispensing device inserts a probe penetrating and penetrating a fine hole into a preheating pipe of meat pressure, and arranges a middle part at a heating portion at the end of the preheating pipe. The other end is connected to a pipe connected to a pump, and the pump is connected to a wash water introducing pipe.

[0005]

[Action]

 The operation when the dispensing device is used as the above means will be described with reference to FIG. 1 which constitutes the dispensing device. First, when the probe 1 is washed, the valve 8 of the pipe line 7 is opened, and pressurized water is introduced into the pipe line 3 and the probe 1 by the pump (syringe pump) 6 for washing. At this time, the washing water is warmed in the heating section 5, and the warmed washing water cleans the pipeline 3 and the probe 1. During this cleaning, the preheating pipe 2 is also heated and warmed. In that state, the sample is sucked and held, and the sample is also warmed and discharged by its preheating.

[0006]

【Example】

 Hereinafter, a specific embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a configuration diagram including a partial vertical sectional view of a dispensing device of the present invention. Reference numeral 1 is a probe, which is an elongated and usually stainless steel pipe. Reference numeral 2 is a thick preheating pipe which is also made of stainless steel, and the probe 1 is inserted into the inner diameter portion of the probe 1 so that a certain length of the probe 1 is projected from the tip end portion. In this case, as a specific size, the outer diameter of the probe 1 is 1.48Φmm, the inner diameter is 1.12Φmm, and the preheating pipe 2 has an outer diameter of 6.35Φmm, an inner diameter of 1.60Φmm, and a long length. The height is about 100 mm. In order to integrally form the probe 1 and the preheating pipe 2, a fine hole (inner diameter is about 1.12 Φ mm) is bored in the thick pipe 2 and the tip end is thinned to form a probe. Is also good.

A pipe line 3 is connected from the upper end of the probe 1, a part of the pipe line 3 is formed in a coil shape, and the pipe line 3 is arranged in a heating unit 5 and further to a pump (eg, syringe pump) 6. It is connected. A pipe line 7 having a valve 8 is connected to the syringe pump 6 so that pressurized water is introduced as washing water. When cleaning the inside of the probe 1, the valve 8 is opened and pressurized water is introduced to clean the inside of the probe 1 and the pipe line 3.

Next, the heating part 5 in which the midway portion of the coiled pipe line 3 is arranged is for heating the cleaning water for cleaning the inside of the probe 1 and the pipe line 3 as described above. Warm water 9 is put in the water tank 10 and heated by the heater 4. It is also possible to control the temperature by using a temperature sensor (not shown) together with the heater 4. The heating unit 5 may be a heating block instead of the water tank 10 containing hot water.

The configuration of the dispensing device of the present invention is as described above. Next, its operation will be described. First, in order to wash the probe 1, the valve 8 of the pipe line 7 is opened, and pressurized water is introduced into the pipe line 3 and the probe 1 by the syringe pump 6 for washing. At this time, the washing water is warmed in the heating unit 5, and the warmed washing water cleans the conduit 3 and the probe 1. The preheating pipe 2 is also heated and warmed during this cleaning. In that state, the sample is sucked and held, and the sample is also warmed and discharged by its preheating. In an actual test, when 100 ml of the cold storage reagent of about 10 ° C is dispensed at 37 ° C, if the heating part 5 is heated to about 40 ° C including the heat radiation loss from the outer surface of the probe 1, it is 37 ° C. It was possible to dispense into the sample.

[0010]

[Effect of device]

 Since the dispensing device of the present invention has the structure described in detail above, it can be a simple and inexpensive probe without forming a complicated heating part around the probe. Also, since the heating is done at the tip of the probe, it is possible to reduce the influence of cooling by the outside air during dispensing. Furthermore, it will be possible to accurately respond to a small amount of reagent.

[Brief description of drawings]

FIG. 1 is a configuration diagram including a partial vertical cross-sectional view of a dispensing device of the present invention.

[Explanation of symbols]

 1 Probe 2 Preheating Pipe 3 Pipe 4 Heater 5 Heating Section 6 Syringe Pump 7 Pipe 8 Valve 9 Hot Water

Claims (1)

[Scope of utility model registration request] 1. A pipe line in which a probe penetrating through a fine hole is fitted into a preheating pipe of meat pressure, the preheating pipe end is provided with a heating part in the middle, and the other end is connected to a pump. A pipetting device, wherein the pipe is connected to the pump and a washing water introducing pipe is connected to the pump.