JPH0635143B2 - Infusion container manufacturing method - Google Patents
Infusion container manufacturing methodInfo
- Publication number
- JPH0635143B2 JPH0635143B2 JP2237988A JP23798890A JPH0635143B2 JP H0635143 B2 JPH0635143 B2 JP H0635143B2 JP 2237988 A JP2237988 A JP 2237988A JP 23798890 A JP23798890 A JP 23798890A JP H0635143 B2 JPH0635143 B2 JP H0635143B2
- Authority
- JP
- Japan
- Prior art keywords
- synthetic resin
- thermoplastic synthetic
- parison
- present
- bag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 238000001802 infusion Methods 0.000 title claims description 6
- 229920003002 synthetic resin Polymers 0.000 claims description 26
- 239000000057 synthetic resin Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 25
- 229920001169 thermoplastic Polymers 0.000 claims description 25
- 239000004416 thermosoftening plastic Substances 0.000 claims description 25
- 238000003860 storage Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 6
- 238000000071 blow moulding Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 description 7
- -1 polypropylene Polymers 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 239000003978 infusion fluid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920005672 polyolefin resin Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
Description
本発明は輸液容器の製造方法に関するものである。更に
詳しくは複数の薬液を臨床で用いられる場合に適当とさ
れる一体化した容器（以下，マルチバツグという）の製
造方法に関するものである。The present invention relates to a method for manufacturing an infusion container. More specifically, the present invention relates to a method for producing an integrated container (hereinafter referred to as multi-bag) that is suitable when a plurality of drug solutions are clinically used.
第３図は現行マルチバツグの説明図である。 一般にマルチバツグは周縁部４で袋状に仕上げられた上
下に継合する２個の液状収納部１，２にアミノ酸又は葡
萄糖などの薬液，すなわち，輸液が各々収納され，これ
を吊下部５を利用してスタンド（図示されてない）など
から患者に輸液を注入するために用いられるものであ
る。 このように使用されるマルチバツグは軟質の熱可塑性合
成樹脂で作られている。そして上下にポート３と３′
（液体を容器に充填したり，容器から排出するとき用い
られる口をポートという）を有し下方のポート３′だけ
から液体収納部１の輸液も液体収納部２の輸液と共に注
入できるように液体流通部６が設けられてある。 この液体流通部６は使用前には流体が連通してはならな
いので熱融着性フイルム７を挿入し，その部分を熱圧着
しておく方法が見受けられるようになった。その場合
は，使用にあたり液体収納部１や２を手で押し熱融着性
フイルム７を剥離させ流体を連通させて使用するもので
ある。FIG. 3 is an explanatory diagram of the current multi-bag. In general, multi-bags are stored in a bag-like shape at the peripheral portion 4 and are joined in two liquid storage parts 1 and 2 that are vertically joined to each other. It is used to inject an infusion solution into a patient from a stand (not shown) or the like. The multi-bag used in this way is made of a soft thermoplastic synthetic resin. And up and down ports 3 and 3 '
A liquid is provided so that the infusion solution in the liquid storage section 1 can be injected together with the infusion solution in the liquid storage section 2 only through the lower port 3 ′ having a port (the port used for filling the liquid in the container or discharging the container). A distribution unit 6 is provided. Since fluid must not be communicated with the liquid circulation portion 6 before use, a method has been found in which the heat-fusible film 7 is inserted and the portion is thermocompression bonded. In that case, in use, the liquid storage parts 1 and 2 are pushed by hand and the heat-fusible film 7 is peeled off to allow the fluid to communicate.
このようなマルチバツグを作るには，フイルムを得るこ
と・バツグ用に裁断すること・製袋のための熱プレス及
び冷プレス・熱融着性フイルムの挿入・ポート投入・ポ
ート部溶着・仕上げのための最終的熱プレス及び冷プレ
ス・薬液充填・ポート部溶着という連綿たる工程を経る
ことになる。 本発明は製袋・薬液充填・ポート部溶着という簡単な工
程だけでマルチバツグを作ることを目的とする。To make such a multi-bag, obtain the film, cut it for the bag, hot press and cold press for bag making, insert the heat-fusible film, insert the port, weld the port, and finish. The final hot press and cold press, chemical filling, and port welding will be repeated. An object of the present invention is to make a multi bag by only simple steps of bag making, filling with a chemical solution, and welding of a port portion.
本発明は、軟質の熱可塑性合成樹脂と該合成樹脂とは異
なる第２の熱可塑性合成樹脂とを共押出しして，内層の
一部に第２の熱可塑性合成樹脂が断続的に存在するよう
にパリソンを形成し，次いで該パリソンをブロー成形し
て，パリソンの軸方向に第２の熱可塑性合成樹脂の存在
部分を継合部とし，該継合部をはさんで２個の液体収納
部を直列に形成すると共に，この２個の液体収納部のそ
れぞれにポートを突設させ，前記継合部を流体が連通し
ないように熱圧着することを特徴とする輸液容器の製造
方法を要旨とする。 本発明を図面を用いて詳しく説明する。 第１図は本発明のパリソンの斜視図であり，第２図は本
発明製造方法の輸液容器の説明図である。本発明におい
て，パリソン本体11は主として軟質の熱可塑性合成樹脂
からなるが，この素材としては，100℃以上の高温での
加熱殺菌処理に耐えるもので医用に現在使用されている
軟質の熱可塑性合成樹脂を指し，ポリ塩化ビニル・ポリ
プロピレン・ポリエチレン・ポリプロピレン−ポリエチ
レンの共重合物などをあげることができる。 本発明において，２個の液体収納部１及び２を作るのは
アミノ酸又は葡萄糖などの薬液をおのおの別々に収納さ
せるためである。また、液体収納部１及び２の継合部13
に対向して，おのおのにポート３と３′を突設させるの
は薬液を投入するためと臨床で使用するときに排出する
ために当然必要とするものである。 本発明において継合部13は，２個の液体収納部１と２に
充填される２種の薬液が臨床で使用されるまでは全く混
じり合わないように，第２図の点線で示す第２の熱可塑
性合成樹脂部を介して流体が連通しないように熱圧着さ
れている。しかし，マルチバツグを臨床で使用する場
合，継合部13を連通させるために液体収納部１や２を手
でおしつけ，第２の熱可塑性合成樹脂部を継合部13の内
部で剥離させ，両薬液が混じり合って使用される。この
ようにマルチバツグの２種の薬液が臨床で使用されるま
では全く混じり合わない，臨床で使用するときに，継合
部13が連通するための接着性は，ほどよいものでなけれ
ばならない。この適度の接着性は剥離方法で評価すれば
30〜250ｇ／cmの値が好ましい。 上記のようなマルチバツグを得るために，本発明におい
て，第２の熱可塑性合成樹脂を断続的にパリソンの内層
に存在させる。該パリソンから２個の液体収納部が上記
第２の熱可塑性合成樹脂の存在部分を継合部13としてパ
リソンの軸方向に直列にブロー成形により作られ，継合
部13を流体が連通しないように熱圧着する。この熱圧着
条件は使用する樹脂により決められるが，例えば，軟質
の熱可塑性合成樹脂をポリエチレンとし，第２の熱可塑
性合成樹脂をポリプロピレンとした場合，温度を180〜2
50℃，時間を３〜５秒が好ましい。 その第２の熱可塑性合成樹脂としては，医療用用途であ
ることを考慮してポリエチレン・ポリプロピレンのよう
なポリオレフイン系樹脂が好ましい。そして上記の適度
の接着性を得るために，本発明においてパリソンの主素
材は軟質の熱可塑性合成樹脂を主とし，それとは異種の
熱可塑性合成樹脂とからなる複合素材とするのである。 本発明のようなマルチバツグにおいて，ポート部にバリ
が生じるタイプのバツグでは第２の熱可塑性合成樹脂が
ポート３や３′をはずれてマルチバツグの液体収納部に
あると袋を形成しなくなり，袋の機能をなさなくなる。
そのため本発明では第１図に点線で示すように第２の熱
可塑性合成樹脂12をパリソンの内層に断続的に存在させ
るのが好ましく，それが無難であるといえる。 また，複合素材のパリソンにおいて第２の熱可塑性合成
樹脂12の投入量は継合部13を連通させたときの口の大き
さと関係し，少なくとも連通部の巾と連通部の長さに相
当するだけがパリソンの内層に断続的に存在する必要が
ある。この断続的に存在させるという間隔は輸液容器の
１個当たりの寸法に合わせればよい。 本発明のように，複合素材のパリソンを共押出しで作る
のは周知の方法でよい。例えば，二つのエクストルダー
を用い，軟質プラスチツクのパリソン本体の押出し中
に，一定の間隔を保って第２の熱可塑性合成樹脂を注入
すると得られる。 なお本発明のマルチバツグは２個の液体収納部を上下に
連ねたもので，これらの継合部13は臨床で使用されるま
では熱融着されたままであるが，この部分にクリツプな
どで熱融着部分の剥離を防止しておくことも好ましいこ
とである。 本発明で以上のように作られたマルチバツグは液体収納
部１と２に薬液が充填され，各ポート部の溶着がなされ
る。必要ならば念入りに継合部13にクランプを付けて使
用までの両薬液間の連通を防止しておくこともある。According to the present invention, a soft thermoplastic synthetic resin and a second thermoplastic synthetic resin different from the synthetic resin are co-extruded so that the second thermoplastic synthetic resin is intermittently present in a part of the inner layer. A parison is formed on the parison, and then the parison is blow-molded so that the portion where the second thermoplastic synthetic resin exists is a joint portion in the axial direction of the parison, and the two liquid storage portions sandwich the joint portion. A method for manufacturing an infusion container is characterized in that the two are formed in series, a port is provided in each of the two liquid storage portions, and the joint portion is thermocompression-bonded so that fluid does not communicate with each other. To do. The present invention will be described in detail with reference to the drawings. FIG. 1 is a perspective view of a parison of the present invention, and FIG. 2 is an explanatory view of an infusion container of the manufacturing method of the present invention. In the present invention, the parison body 11 is mainly made of a soft thermoplastic synthetic resin, and as this material, a soft thermoplastic synthetic material that can withstand heat sterilization treatment at a high temperature of 100 ° C. or higher and is currently used for medical purposes is used. This refers to resin, and examples include polyvinyl chloride, polypropylene, polyethylene, and polypropylene-polyethylene copolymers. In the present invention, the reason why the two liquid storage parts 1 and 2 are made is to store the chemical liquid such as amino acid or glucose individually. In addition, the joint portion 13 of the liquid storage portions 1 and 2
It is of course necessary to project the ports 3 and 3 ′ facing each other in order to inject the drug solution and to discharge the drug solution in clinical use. In the present invention, the joint portion 13 is the second portion shown by the dotted line in FIG. 2 so that the two kinds of liquid medicines filled in the two liquid storage portions 1 and 2 do not mix at all until clinical use. The thermocompression bonding is performed so that the fluid does not communicate via the thermoplastic synthetic resin part. However, when the multi bag is used clinically, the liquid storage parts 1 and 2 are squeezed by hand in order to connect the joint part 13, and the second thermoplastic synthetic resin part is peeled off inside the joint part 13, Used as a mixture of chemicals. As described above, the two multi-bug drug solutions do not mix at all until clinically used, and the adhesiveness for the joint portion 13 to communicate with each other when used clinically must be moderate. If this proper adhesiveness is evaluated by the peeling method,
Values between 30 and 250 g / cm are preferred. In order to obtain the multi-bag as described above, in the present invention, the second thermoplastic synthetic resin is intermittently present in the inner layer of the parison. Two liquid storage parts are made from the parison by blow molding in series in the axial direction of the parison with the existing portion of the second thermoplastic synthetic resin as the joining part 13 so that the fluid does not communicate with the joining part 13. Thermocompression bonding to. The thermocompression bonding conditions are determined by the resin used. For example, when the soft thermoplastic synthetic resin is polyethylene and the second thermoplastic synthetic resin is polypropylene, the temperature is 180 to 2
50 [deg.] C. and the time is preferably 3 to 5 seconds. As the second thermoplastic synthetic resin, a polyolefin resin such as polyethylene / polypropylene is preferable in view of its medical use. In order to obtain the above-mentioned appropriate adhesiveness, the main material of the parison in the present invention is mainly a soft thermoplastic synthetic resin, and a composite material made of a thermoplastic synthetic resin different from the soft thermoplastic synthetic resin. In the multi-bag like the present invention, in the type of bag in which burrs are generated in the port portion, if the second thermoplastic synthetic resin leaves the ports 3 and 3'and is in the liquid storing portion of the multi-bag, the bag is not formed, and It loses its function.
Therefore, in the present invention, it is preferable that the second thermoplastic synthetic resin 12 is intermittently present in the inner layer of the parison as shown by the dotted line in FIG. 1, which is safe. Further, in the parison of the composite material, the amount of the second thermoplastic synthetic resin 12 charged is related to the size of the mouth when the joint portion 13 is communicated, and at least corresponds to the width of the communication portion and the length of the communication portion. Only the parison needs to be present in the inner layers of the parison intermittently. The interval of intermittently present may be adjusted to the size of each infusion container. Coextrusion of the composite parison, as in the present invention, may be accomplished by well known methods. For example, it can be obtained by using two extruders and injecting a second thermoplastic synthetic resin at a constant interval during extrusion of a soft plastic parison body. In the multi-bag of the present invention, two liquid storage parts are connected in a vertical direction, and the joint part 13 remains heat-sealed until clinically used, but this part is heated by a clip or the like. It is also preferable to prevent peeling of the fused portion. In the multi-bag constructed as described above in the present invention, the liquid storage portions 1 and 2 are filled with the chemical liquid, and the respective port portions are welded. If necessary, a clamp may be carefully attached to the joint portion 13 to prevent communication between the two chemicals until use.
本発明によれば，マルチバツグの製造方法が製袋・薬液
充填・ポート部溶着だけの工程であるので，従来の製造
方法に比し簡単な工程だけでマルチバツグを作ることに
なる。According to the present invention, since the manufacturing method of the multi-bag is only the steps of bag making, filling with the chemical liquid, and welding of the port portion, the multi-bag is manufactured by a simpler process than the conventional manufacturing method.
第１図は本発明のパリソンの斜視図であり，第２図は本
発明で製造されるく輸液容器の説明図である。 第３図は現行マルチバツグの説明図である。 １及び２……液体収納部，３と３′……ポート，４……
周縁部，５……吊下部，６……液体流通部，７……熱融
着性フイルム，11……パリソン本体，12……第２の熱可
塑性合成樹脂，13……継合部。FIG. 1 is a perspective view of a parison of the present invention, and FIG. 2 is an explanatory view of a transfusion container manufactured by the present invention. FIG. 3 is an explanatory diagram of the current multi-bag. 1 and 2 ... Liquid storage part, 3 and 3 '... Port, 4 ...
Peripheral part, 5 ... Suspended part, 6 ... Liquid distribution part, 7 ... Heat-fusible film, 11 ... Parison body, 12 ... Second thermoplastic synthetic resin, 13 ... Joint part.
Claims (1)
異なる第２の熱可塑性合成樹脂とを共押出しして，内層
の一部に第２の熱可塑性合成樹脂が断続的に存在するよ
うにパリソンを形成し，次いで該パリソンをブロー成形
して，パリソンの軸方向に第２の熱可塑性合成樹脂の存
在部分を継合部とし，該継合部をはさんで２個の液体収
納部を直列に形成すると共に，この２個の液体収納部の
それぞれにポートを突設させ，前記継合部を流体が連通
しないように熱圧着することを特徴とする輸液容器の製
造方法。1. A soft thermoplastic synthetic resin and a second thermoplastic synthetic resin different from the synthetic resin are coextruded, and the second thermoplastic synthetic resin is intermittently present in a part of the inner layer. And then blow-molding the parison to form a joint in the axial direction of the parison as a joint, and store two liquids sandwiching the joint. A method for manufacturing an infusion container, characterized in that the parts are formed in series, and a port is provided on each of the two liquid storage parts so that the joint part is thermocompression-bonded so that fluid does not communicate with each other.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2237988A JPH0635143B2 (en) | 1990-09-07 | 1990-09-07 | Infusion container manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2237988A JPH0635143B2 (en) | 1990-09-07 | 1990-09-07 | Infusion container manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04118215A JPH04118215A (en) | 1992-04-20 |
| JPH0635143B2 true JPH0635143B2 (en) | 1994-05-11 |
Family
ID=17023454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2237988A Expired - Lifetime JPH0635143B2 (en) | 1990-09-07 | 1990-09-07 | Infusion container manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0635143B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103350484B (en) * | 2013-07-04 | 2015-06-10 | 成都市联余精密机械有限公司 | Integrated preform injection mould for PP large volume parenteral stationary ring |
-
1990
- 1990-09-07 JP JP2237988A patent/JPH0635143B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04118215A (en) | 1992-04-20 |
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