JPH04118215A - Manufacture of transfusion container - Google Patents
Manufacture of transfusion containerInfo
- Publication number
- JPH04118215A JPH04118215A JP2237988A JP23798890A JPH04118215A JP H04118215 A JPH04118215 A JP H04118215A JP 2237988 A JP2237988 A JP 2237988A JP 23798890 A JP23798890 A JP 23798890A JP H04118215 A JPH04118215 A JP H04118215A
- Authority
- JP
- Japan
- Prior art keywords
- synthetic resin
- thermoplastic synthetic
- parison
- present
- liquid storage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 34
- 239000000057 synthetic resin Substances 0.000 claims abstract description 34
- 229920001169 thermoplastic Polymers 0.000 claims abstract description 32
- 239000004416 thermosoftening plastic Substances 0.000 claims abstract description 32
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 239000012530 fluid Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 7
- 238000000071 blow moulding Methods 0.000 claims abstract description 4
- 238000003860 storage Methods 0.000 claims description 19
- 238000001802 infusion Methods 0.000 claims description 9
- 238000004891 communication Methods 0.000 claims description 7
- -1 polypropylene Polymers 0.000 abstract description 10
- 239000004698 Polyethylene Substances 0.000 abstract description 6
- 229920000573 polyethylene Polymers 0.000 abstract description 6
- 239000004743 Polypropylene Substances 0.000 abstract description 5
- 229920001155 polypropylene Polymers 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 3
- 229920000915 polyvinyl chloride Polymers 0.000 abstract description 2
- 239000004800 polyvinyl chloride Substances 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 229920001577 copolymer Polymers 0.000 abstract 1
- 229920005992 thermoplastic resin Polymers 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000003466 welding Methods 0.000 description 4
- 239000002131 composite material Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007731 hot pressing Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920005672 polyolefin resin Polymers 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Abstract
Description
本発明は輸液容器の製造方法に関するものである。更に
詳しくは複数の薬液を臨床で用いられる場合に適当とさ
れる一体化した容器（以下、マルチバッグという）の製
造方法に関するものである。The present invention relates to a method of manufacturing an infusion container. More specifically, the present invention relates to a method for manufacturing an integrated container (hereinafter referred to as a multi-bag) suitable for clinical use of multiple drug solutions.
第３図は現行マルチバッグの説明図である。
一般にマルチバッグは周縁部４で袋状に仕上げられた上
下に継合する２個の液体収納部１，２にアミノ酸又は葡
＠糖などの薬液、すなわち、輸液が各々収納され、これ
を吊下部５を利用してスタンド（図示されてない）など
から患者に輸液を注入するために用いられるものである
。
このように使用されるマルチバッグは軟質の熱可塑性合
成樹脂で作られている。そして上下にポート３と３゛（
液体を容器に充填したり、容器から排出するとき用いら
れる口をポートという）を有し下方のポート３”だけか
ら液体収納部１の輸液も液体収納部２の輸液と共に注入
できるように液体流通部６が設けられである。
この液体流通部６は使用前には流体が連通してはならな
いので熱融着性フィルム７を挿入し、その部分を熱圧着
しておく方法が見受けられるようになった。その場合は
、使用にあたり液体収納部ｌや２を手で押し熱融着性フ
ィルム７を剥離させ流体を連通させて使用するものであ
る。FIG. 3 is an explanatory diagram of the current multi-bag. In general, a multi-bag has two liquid storage parts 1 and 2 that are finished in a bag shape at the peripheral edge 4 and are joined at the top and bottom, each containing a medicinal solution such as amino acid or grape@sugar, that is, an infusion solution, and these are stored in a hanging part. 5 is used to inject infusion into a patient from a stand (not shown) or the like. The multibags used in this way are made of soft thermoplastic synthetic resin. And ports 3 and 3 on the top and bottom (
The opening used when filling or discharging liquid from the container is called a port), and the liquid is distributed so that the infusion in the liquid storage part 1 can be injected together with the infusion in the liquid storage part 2 only from the lower port 3''. A portion 6 is provided in the liquid distribution portion 6. Since fluid must not be in communication with this liquid distribution portion 6 before use, there is a method of inserting a heat-fusible film 7 and bonding that portion with heat. In that case, the liquid storage parts 1 and 2 are pressed by hand to peel off the heat-fusible film 7 and allow fluid to communicate with each other.
このようなマルチバッグを作るには３ フィルムを得る
こと・バッグ用に裁断すること・製袋のための熱プレス
及び冷プレス・熱融着性フィルムの挿入・ポート投入・
ポート部溶着・仕上げのための最終的熱プレス及び冷プ
レス・薬液充填・ボート部溶着という連綿たる工程を経
ることになる。
本発明は製袋・薬液充填・ポート部溶着という簡単な工
程だけでマルチバッグを作ることを目的とする。To make such a multi-bag, there are 3 steps: Obtaining the film, cutting it into bags, hot pressing and cold pressing for bag making, inserting the heat-adhesive film, inserting the port,
It goes through a continuous process of final hot pressing and cold pressing for port welding and finishing, chemical filling, and boat welding. The object of the present invention is to make a multi-bag using only the simple steps of bag making, filling of a chemical solution, and welding of a port part.
【課題を解決するための手段及び作用】本発明は、軟質
の熱可塑性合成樹脂と該合成樹脂とは異なる第２の熱可
塑性合成樹脂とを共押出しして、内層の一部に第２の熱
可塑性合成樹脂が断続的に存在するようにパリソンを形
成し１次いで該パリソンをブロー成形して、パリソンの
軸方向に第２の熱可塑性合成樹脂の存在部分を継合部と
し、該継合部をはさんで２個の液体収納部を直列に形成
すると共に、この２個の液体収納部のそれぞれにポート
を突設させ、前記継合部を流体が連通しないように熱圧
着することを特徴とする輸液容器の製造方法を要旨とす
る。
本発明を図面を用いて詳しく説明する。
第１図は本発明のパリソンの斜視図であり、第２図は本
発明製造方法の輸液容器の説明図である。
本発明において、パリソン本体１１は主として軟質の熱
可塑性合成樹脂からなるが、この素材としては、１００
°Ｃ以上の高温での加熱殺菌処理に耐えるもので医用に
現在使用されている軟質の熱可塑性合成樹脂を指し、ポ
リ塩化ビニル・ポリプロピレン・ポリエチレン・ポリプ
ロピレン−ポリエチレンの共重合物などをあげることが
できる。
本発明において、２個の液体収納部１及び２を作るのは
アミノ酸又は葡萄糖などの薬液をおのおの別々に収納さ
せるためである。また、液体収納部１及び２の継合部１
３に対向して、おのおのにポート３と３゛を突設させる
のは薬液を投入するためと臨床で使用するときに排出す
るために当然必要とするものである。
本発明において継合部１３は、２個の液体収納部ｌと２
に充填される２種の薬液が臨床で使用されるまでは全く
混じり合わないように、第２図の点線で示す第２の熱可
塑性合成樹脂部を介して流体が連通しないように熱圧着
されている。しかしマルチバッグを臨床で使用する場合
、継合部１３を連通させるために液体収納部１や２を手
でおしっけ、第２の熱可塑性合成樹脂部を継合部１３の
内部で剥離させ１両薬液が混じり合って使用される。
このようにマルチバッグの２種の薬液が臨床で使用され
るまでは全（混じり合わないで、臨床で使用するときに
、継合部１３が連通するための接着性は、はどよいもの
でなければならない。この適度の接着性は剥離方法で評
価すれば３０〜２５０ｇ／ｃｍの値が好ましい。
上記のようなマルチバッグを得るために１本発明におい
て、第２の熱可塑性合成樹脂を断続的にパリソンの内層
に存在させる。該パリソンがら２個の液体収納部が上記
第２の熱可塑性合成樹脂の存在部分を継合部１３として
パリソンの軸方向に直列にブロー成形により作られ、継
合部１３を流体が連通しないように熱圧着する。二〇熱
圧着条件は使用する樹脂により決められるが９例えば、
軟質の熱可塑性合成樹脂をポリエチレンとし、第２の熱
可塑性合成樹脂をポリプロピレンとした場合。
温度を１８０〜２５０°Ｃ２時間を３〜５秒が好ましい
。
その第２の熱可塑性合成樹脂としては、医療用用途であ
ることを考慮してポリエチレン・ポリプロピレンのよう
なポリオレフィン系樹脂が好ましい。そして上記の適度
の接着性を得るために１本発明においてパリソンの主素
材は軟質の熱可塑性合成樹脂を主とし、それとは異種の
熱可塑性合成樹脂とからなる複合素材とするのである。
本発明のようなマルチバッグにおいて、ポート部にハリ
が生しるタイプのバッグでは第２の熱可塑性合成樹脂が
ポート３や３′をはずれてマルチバッグの液体収納部に
あると袋を形成しなくなり。
袋の機能をなさなくなる。そのため本発明では第１図に
点線で示すように第２の熱可塑性合成樹脂１２をパリソ
ンの内層に断続的に存在させるのが好ましく、それが無
難であるといえる。
また、複合素材のパリソンにおいて第２の熱可塑性合成
樹脂１２の投入量は継合部１３を連通させたときの口の
大きさと関係し、少なくとも連通部の巾と連通部の長さ
に相当するだけがパリソンの内層に断続的に存在する必
要がある。この断続的に存在させるという間隔は輸液容
器の１個当たりの寸法に合わせればよい。
本発明のように、複合素材のパリソンを共押出しで作る
のは周知の方法でよい。例えば、二つのエクストルーダ
を用い、軟質プラスチックのパリソン本体の押出し中に
、一定の間隔を保って第２の熱可塑性合成樹脂を注入す
ると得られる。
なお本発明のマルチバッグは２個の液体収納部を上下に
連ねたもので、これらの継合部１３は臨床で使用される
までは熱融着されたままであるが。
この部分にクリップなどで熱融着部分の剥離を防止して
おくことも好ましいことである。
本発明で以上のように作られたマルチハングは液体収納
部１と２に薬液が充填され、各ボート部の溶着がなされ
る。必要なれば倉入りに継合部１３にクランプを付けて
使用までの百薬液間の連通を防止しておくこともある。[Means and effects for solving the problems] The present invention involves co-extruding a soft thermoplastic synthetic resin and a second thermoplastic synthetic resin different from the synthetic resin, so that a part of the inner layer is coated with the second thermoplastic synthetic resin. A parison is formed so that the thermoplastic synthetic resin is present intermittently, and then the parison is blow molded, and the portion where the second thermoplastic synthetic resin is present in the axial direction of the parison is used as a joint, and the joint is formed. Two liquid storage parts are formed in series across the two liquid storage parts, and a port is provided protruding from each of the two liquid storage parts, and the joint part is thermocompression bonded to prevent fluid communication. This article summarizes the manufacturing method of the characteristic infusion container. The present invention will be explained in detail using the drawings. FIG. 1 is a perspective view of a parison of the present invention, and FIG. 2 is an explanatory diagram of an infusion container of the manufacturing method of the present invention. In the present invention, the parison main body 11 is mainly made of a soft thermoplastic synthetic resin, but this material is made of 100%
Refers to soft thermoplastic synthetic resins that can withstand heat sterilization at temperatures above °C and are currently used for medical purposes, including polyvinyl chloride, polypropylene, polyethylene, and polypropylene-polyethylene copolymers. can. In the present invention, the two liquid storage parts 1 and 2 are created in order to separately store medicinal solutions such as amino acids or glucose. In addition, the joint part 1 of the liquid storage parts 1 and 2
Protruding ports 3 and 3' are provided opposite to the ports 3 and 3', respectively, because they are necessary for injecting the drug solution and for discharging it during clinical use. In the present invention, the joint part 13 connects two liquid storage parts l and 2.
In order to prevent the two types of medicinal solutions filled in the container from mixing at all until they are used clinically, the container is thermocompressed to prevent fluid communication through the second thermoplastic synthetic resin part shown by the dotted line in Figure 2. ing. However, when the multi-bag is used clinically, in order to connect the joint part 13, the liquid storage parts 1 and 2 are manually flushed, and the second thermoplastic synthetic resin part is peeled off inside the joint part 13. Both chemicals are used together. In this way, until the two types of drug solutions in the multi-bag are used clinically, they should not be mixed together, but when used clinically, the adhesiveness for the joint 13 to communicate is not very good. This appropriate adhesiveness is preferably 30 to 250 g/cm when evaluated by a peeling method.In order to obtain the above multi-bag, in the present invention, the second thermoplastic synthetic resin is Two liquid storage parts are made from the parison by blow molding in series in the axial direction of the parison, with the part where the second thermoplastic synthetic resin is present as the joint part 13. The joining part 13 is thermocompression bonded so that fluid does not communicate with it.20 The thermocompression bonding conditions are determined by the resin used, but 9 For example,
When the soft thermoplastic synthetic resin is polyethylene and the second thermoplastic synthetic resin is polypropylene. Preferably, the temperature is 180-250°C for 2 hours and 3-5 seconds. As the second thermoplastic synthetic resin, a polyolefin resin such as polyethylene or polypropylene is preferable considering the medical use. In order to obtain the above-mentioned appropriate adhesion, the main material of the parison in the present invention is a composite material consisting mainly of a soft thermoplastic synthetic resin and a different type of thermoplastic synthetic resin. In the multi-bag according to the present invention, if the port part is firm, the second thermoplastic synthetic resin will form a bag if it leaves port 3 or 3' and is placed in the liquid storage part of the multi-bag. Gone. The bag will no longer function. Therefore, in the present invention, it is preferable that the second thermoplastic synthetic resin 12 is intermittently present in the inner layer of the parison as shown by dotted lines in FIG. 1, and this can be said to be safe. Furthermore, in the parison made of composite material, the amount of the second thermoplastic synthetic resin 12 to be added is related to the size of the opening when the joint parts 13 are communicated, and corresponds to at least the width of the communication part and the length of the communication part. only need to be present intermittently in the inner layer of the parison. The interval of this intermittent presence may be adjusted to the size of each infusion container. As in the present invention, a composite parison may be produced by coextrusion using any well-known method. For example, this can be obtained by injecting a second thermoplastic synthetic resin at regular intervals during extrusion of a soft plastic parison body using two extruders. Note that the multi-bag of the present invention has two liquid storage sections arranged one above the other, and the joint section 13 of these remains heat-sealed until clinical use. It is also preferable to use a clip or the like to prevent the heat-sealed portion from peeling off. In the multi-hung manufactured as described above according to the present invention, the liquid storage parts 1 and 2 are filled with a chemical solution, and each boat part is welded. If necessary, a clamp may be attached to the joint 13 in the storage to prevent communication between the liquids until use.
本発明によれば、マルチバッグの製造方法が製袋・薬液
充填・ポート部溶着だけの工程であるので、従来の製造
方法に比し簡単な工程だけでマルチバッグを作ることに
なる。According to the present invention, since the method for manufacturing a multi-bag includes only the steps of bag making, filling of a chemical solution, and welding of the port portion, the multi-bag can be manufactured using only simpler steps compared to conventional manufacturing methods.
第１図は本発明のパリソンの斜視図であり、第２図は本
発明で製造されろく輸液容器の説明図である。
第３図は現行マルチバッグの説明図である。
１及び２−液体収納部、３と３“−ボート、４・−周縁
部、５−吊下部、６−液体流通部、７−熱融着性フィル
ム、１１−パリソン本体、１２−第２の熱可塑性合成樹
脂、１３−継合部。
特許出願人 株式会社二ソショー
第
図
第
図FIG. 1 is a perspective view of a parison according to the present invention, and FIG. 2 is an explanatory diagram of an infusion container manufactured according to the present invention. FIG. 3 is an explanatory diagram of the current multi-bag. 1 and 2 - liquid storage section, 3 and 3" - boat, 4 - peripheral section, 5 - hanging section, 6 - liquid circulation section, 7 - heat-fusible film, 11 - parison body, 12 - second Thermoplastic synthetic resin, 13-joint part. Patent applicant: Nisosho Co., Ltd.
Claims (1)
第２の熱可塑性合成樹脂とを共押出しして、内層の一部
に第２の熱可塑性合成樹脂が断続的に存在するようにパ
リソンを形成し、次いで該パリソンをブロー成形して、
パリソンの軸方向に第２の熱可塑性合成樹脂の存在部分
を継合部とし、該継合部をはさんで２個の液体収納部を
直列に形成すると共に、この２個の液体収納部のそれぞ
れにポートを突設させ、前記継合部を流体が連通しない
ように熱圧着することを特徴とする輸液容器の製造方法
。(1) A soft thermoplastic synthetic resin and a second thermoplastic synthetic resin different from the synthetic resin are coextruded so that the second thermoplastic synthetic resin is intermittently present in a part of the inner layer. forming a parison and then blow molding the parison;
The part where the second thermoplastic synthetic resin exists in the axial direction of the parison is used as a joint part, and two liquid storage parts are formed in series across the joint part, and the two liquid storage parts are A method for manufacturing an infusion container, characterized in that ports are provided in each of the containers and the joints are thermocompression bonded to prevent fluid communication.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2237988A JPH0635143B2 (en) | 1990-09-07 | 1990-09-07 | Infusion container manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2237988A JPH0635143B2 (en) | 1990-09-07 | 1990-09-07 | Infusion container manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04118215A true JPH04118215A (en) | 1992-04-20 |
| JPH0635143B2 JPH0635143B2 (en) | 1994-05-11 |
Family
ID=17023454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2237988A Expired - Lifetime JPH0635143B2 (en) | 1990-09-07 | 1990-09-07 | Infusion container manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0635143B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103350484A (en) * | 2013-07-04 | 2013-10-16 | 成都市联余精密机械有限公司 | Integrated preform injection mould for PP large volume parenteral stationary ring |
-
1990
- 1990-09-07 JP JP2237988A patent/JPH0635143B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103350484A (en) * | 2013-07-04 | 2013-10-16 | 成都市联余精密机械有限公司 | Integrated preform injection mould for PP large volume parenteral stationary ring |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0635143B2 (en) | 1994-05-11 |
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