JPH06336420A - Cosmetic - Google Patents

Abstract

PURPOSE:To prepare a cosmetic capable of extremely effectively preventing the discoloration of proanthocyanidin with time and increasing the commercial value. CONSTITUTION:The cosmetic contains (A) proanthocyanidin and (B) one or more compounds selected from sodium bisulfite, 1-hydroxyethane-1,1-diphosphonic acid, diethylenetriaminepentaacetic acid (salt) and phytic acid as active components.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic containing proanthocyanidins, which prevents coloration.

[0002]

BACKGROUND OF THE INVENTION Proanthocyanidins contained in grape extracts and the like have an active oxygen removing action [J. Agric. Food Che
m., 39: 1549-1552 (1991)], antioxidant action [JP-A-61
-16982, Monthly Food Distribution Technology, 21 (2): 16-19], and that procyanidin, one of its constituents, has a whitening effect (JP-A-2-134309). However, it is also known to be incorporated into cosmetics.

By the way, although proanthocyanidins themselves are white to pale yellow, they gradually color and brown over time. Therefore, when preparing a cosmetic composition containing proanthocyanidins, as is the case with the use of high-purity proanthocyanidins, in particular, a grape extract containing proanthocyanidins suitable as a proanthocyanidin source was used. In this case, during storage and distribution of the cosmetic, it is initially colored in pale yellow, its coloring degree tends to increase with time, and it tends to become brown, and this coloring has the drawback of reducing the commercial value of the cosmetic. there were.

[0004]

Needless to say, cosmetics are excellent in terms of effectiveness and safety, but it is also important that the cosmetics have more stable and beautiful appearance. Therefore, in order to use proanthocyanidins as a blending component of cosmetics, it has been required to develop means for preventing this coloring over time.

[0005]

[Means for Solving the Problems] The inventors of the present invention have been eager to solve the above-mentioned drawbacks of cosmetics containing proanthocyanidin and to obtain cosmetics having excellent stability without coloring over time. I did a research. And as a result, by using a specific compound such as sodium bisulfite,
It has been found that an excellent coloring prevention effect can be obtained. Also,
In particular, it has been found that the use of a weakly acidic to neutral pH range of 4 to 7 can significantly prevent coloring.

The present invention has been completed based on these findings, and the following components (A) and (B) (A) proanthocyanidin (B) sodium bisulfite, 1-hydroxyethane-
The present invention provides a cosmetic composition containing, as an active ingredient, one or more compounds selected from 1,1-diphosphonic acid, diethylenetriaminepentaacetic acid (salt) and phytic acid.

The proanthocyanidin which is the component (A) of the present invention is bark of squeezed lees or seeds of grape fruits, husks of conker, vines, barley, red beans, pine, oak, peaches, etc. And the like are compounds included in the above.

More specifically, the proanthocyanidins are condensed or polymerized with condensed tannins present in various plants as described above, that is, flavan-3-ol or flavan-3,4-diol as a constituent unit. It is a group of compounds (a mixture of oligomers), which are given this name because they produce anthocyanidins such as cyanidin, delphinidin, and pelargonidin by acid treatment.

Therefore, as the proanthocyanidins of the present invention, all of the dimers to the 10-mer of the above-mentioned constitutional units, and further proanthocyanidins such as polymer procyanidins, prodelphinidins and propelargonidins and their stereoisomers are all included. Of these, the following formulas with excellent solubility etc. are included

[Chemical 1] (In the formula, R ₁ is hydrogen or a hydroxyl group, R _{2 to} R ₄ are each independently hydrogen, a hydroxyl group or a methoxyl group, and R ₅ is hydrogen, a galloyl group or a glycopyranosyl group). Or flavan-3,4-
2- to 10-mer, especially 2 to 4-mer proanthocyanidins having a diol as a constitutional unit can be preferably used (see JP-A-61-16982).

As the proanthocyanidins, those obtained by a synthetic method can also be used.

Proanthocyanidins are usually contained in the grape extract extracted from the squeezed lees or seeds of grape fruits in an amount of 10% or more (in terms of solid content) in terms of flavanols. Is the most economical source of proanthocyanidins. In the present invention, this grape extract will be described below as an example of a proanthocyanidin source in the present invention.

The extraction method of the grape extract containing proanthocyanidins is not particularly limited, and the raw material such as squeezed lees of grape fruits or seeds is immersed in an extraction solvent, and this is extracted at room temperature or under heating, Just filter.

Examples of the extraction solvent include water, primary alcohols such as methyl alcohol and ethyl alcohol, liquid polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, lower alkyl esters such as acetic acid ethyl ester, benzene and hexane. Known solvents such as hydrocarbon, ethyl ether, and acetone can be used, and these solvents can be used alone or in combination of two or more. Among them, the preferable extraction solvent includes an aqueous solution of an organic solvent miscible with water, particularly an aqueous solution of ethyl alcohol, methyl alcohol, acetone and the like.

As the grape extract, the extract obtained by extracting as described above may be used as it is, or may be further concentrated if necessary. In addition, these extracts can be purified by a conventional method, for example, countercurrent distribution method, liquid chromatography and the like, and then used.

The content of the component (A) (proanthocyanidin) in the cosmetic composition of the present invention is, in terms of flavanols,
Usually, 0.0001 to 5% by weight (hereinafter simply referred to as "%") (preferably as a dry solid content of the grape extract of 0.001).
0001 to 10%, more preferably 0.01 to 5%). When the extract is used, the concentration of the extract is not limited as long as the content of the dry solid as a solute is within the above range.

The component (B) of the present invention is a compound selected from sodium bisulfite, 1-hydroxyethane-1,1-diphosphonic acid, diethylenetriaminepentaacetic acid (salt) and phytic acid, and other similar compounds. The use of compounds does not give good results.

Of the component (B), examples of the salt of diethylenetriaminepentaacetic acid include its pentasodium salt and its calcium trisodium salt.

The amount of the component (B) blended in the cosmetic composition varies depending on the amount of the component (A) blended, but in the case of sodium bisulfite, it is generally 0.0001-2.
0%, 0.001 to 2.0% in the case of phytic acid, and 0.001 in the case of 1-hydroxyethane-1,1-diphosphonic acid or diethylenetriaminepentaacetic acid (salt).
It is about 1.5%.

The cosmetic composition of the present invention can be produced by mixing the above-mentioned essential components (A) and (B) according to a conventional method, and can be used as a milky lotion, cream, lotion, pack, ointment, dispersion. It can be in the form of liquids, granules, detergents and the like.

In addition to the above-mentioned essential components, the cosmetic composition of the present invention also contains, as necessary, aqueous components, powders, surfactants, oils, humectants, alcohols, etc. which are used in ordinary cosmetic compositions.
A pH adjuster, an antiseptic, a dye, an antioxidant, a thickener, a fragrance and the like can be appropriately added.

The pH of this cosmetic composition is not particularly limited, but it is preferable to set it from a weakly acidic to neutral pH range of 4 to 7 in order to further enhance the coloring prevention effect.

[0022]

EXAMPLES The present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 Production of grape extract: 30% by weight of 20 parts by weight of grape seeds
80 parts by weight of (v / v) ethanol was added, and the mixture was extracted at room temperature for 2 weeks with occasional stirring and filtered to obtain a crude extract. This is concentrated under reduced pressure to 1/10 volume, 5 times volume of ethanol is added to the concentrated solution, and filtered. The filtrate was concentrated under reduced pressure and ultrafiltered to obtain a grape extract [1 as dry solid content.
5.0% (W / V), proanthocyanidin content in terms of flavanols 53% (per dry solid content)].

Reference Example 2 Production of grape extract: 50 parts by weight of grape juice dregs, 50 parts by weight
80% by weight of ethanol (% / v / v) was added, and after extraction at room temperature for 10 days, this was filtered to obtain a grape extract [0.95% (w / v) as dry solid, flavanol as proanthocyanidins. Contained 48% (per dry solid content)].

Reference Example 3 Production of grape extract: 8 to 20 parts by weight of ground grape seeds
80% by weight of 0% (v / v) ethanol was added, and the mixture was extracted at room temperature for 3 days and then filtered to obtain a grape extract [2.4% (w / v) as dry solid content, proanthocyanidins. 66% (based on dry solid content) in terms of flavanols].

Reference Example 4 Production of grape extract: 80 parts by weight of hot water was added to 20 parts by weight of crushed grape juice dregs, and the mixture was extracted at 60 to 70 ° C. for 5 hours and then filtered to obtain a grape extract. [3.4% (W / V) as dry solid content, containing 26% (per dry solid content) of proanthocyanidin in terms of flavanol].

Test Example Coloring Prevention Effect Test: A cosmetic was prepared with a composition containing the following various test substances and used as a sample for the coloring prevention effect test. The coloring prevention effect test was carried out by leaving each sample in a constant temperature bath at 40 ° C. for 1 month and then setting the coloring degree of each sample to 400 n.
It was judged by measuring the absorbance of m. The reference value was the value of absorbance measured on the day of preparation. The results are shown in Table 1.

(Composition) Content (%) (1) Polyoxyethylene oleyl ether (20E.O.) 0.2 (2) Ethanol 15.0 (3) Preservative 0.2 (4) Grape Extract ^* 1.0 (5) Test substance (Table 1) (6) Residual amount of purified water * Prepared in Reference Example 1

(Production Method) (1) to (3) are dissolved. Dissolve (4) to (6). Mix while stirring and adjust the pH with a pH adjuster.
Adjusted to 6.5.

[0030] ** Does not contain test substance.

As is clear from these results, only the component (B) was extremely effective in preventing the coloration of the proanthocyanidin-containing cosmetic composition.

Example 1 Cosmetic water: (composition) (A) Content (%) Polyoxyethylene oleyl ether (20E.O.) 0.2 Ethanol 15.0 Perfume Appropriate preservative 0 .2 (B) Grape extract ^* 2.0 Sodium bisulfite 0.1 Malic acid 0.02 Sodium malate 0.04 Purified water balance * Prepared in Reference Example 2.

(Production Method) 1. Mix (A) until uniformly dispersed. 2. Mix (B) until uniformly dispersed. 3. Add (A) to (B) with stirring. The pH of the obtained lotion was 6.5.

Example 2 Emulsion: (Composition) (A) Content (%) Polyethylene glycol monostearate (40E.O.) 1.0 Glyceryl monostearate 0.5 Behenyl alcohol 0.5 Liquid paraffin 5.0 Beeswax 1.0 Olive oil 5.0 (B) Grape extract ^* 0.1 1-Hydroxyethane-1,1-diphosphonic acid 0.5 Carboxyvinyl polymer 0.1 Triethanolamine 0.1 Glycerin 5.0 0 Preservative 0.5 Fragrance Suitable amount Purified water balance * Prepared in Reference Example 3.

(Production Method) 1. Heat and mix (A) until uniformly dispersed. 2. Heat and mix (B) until uniformly dispersed. 3. Both (A) and (B) are kept at a high temperature, and (A) is added thereto while stirring (B). After cooling and defoaming, filling is performed. The pH of the obtained emulsion was 6.5.

Example 3 Beauty Solution: (Composition) (A) Amount (%) Polyoxyethylene hydrogenated castor oil (80E.O.) 0.2 Ethanol 5.0 Glycerin 5.0 Perfume Suitable Amount Preservative 0.2 (B) Grape extract ^* 0.5 Diethylenetriaminepentaacetic acid 1.0 Carboxyvinyl polymer 0.15 Polyvinylpyrrolidone 0.1 Triethanolamine 0.15 Water residual amount * In Reference Example 2 Prepared.

(Production Method) 1. Mix (A) until uniformly dispersed. 2. Mix (B) until uniformly dispersed. 3. While stirring, add (A) to (B), degas and then fill to make a product. The pH of the obtained beauty essence is 6.
It was 0.

Example 4 Cream: (composition) (A)% Sodium acylmethyl taurine 0.5 Sorbitan trioleate 2.0 Behenyl alcohol 3.0 Squalane 10.0 Paraffin wax 3.0 Octyl oleate Dodecyl 7.0 (B) Grape extract ^* 1.0 Phytic acid 0.3 1,3-Butanediol 5.0 Preservative 0.5 Fragrance Suitable amount Purified water balance * Prepared in Reference Example 4 thing.

(Production Method) 1. Heat and mix (A) until uniformly dispersed. 2. Heat and mix (B) until uniformly dispersed. 3. (A) and (B) are both kept at a high temperature, (A) is added while stirring (B), and after cooling and defoaming, filling is performed.
The pH of the obtained cream was 6.0.

The cosmetics of Examples 1 to 4 obtained as described above were not colored by the grape extract even after 3 months, and were stable over time, and the effect of the grape extract was high. It was effective.

[0041]

The cosmetics of the present invention can very effectively prevent the coloring of a grape extract containing proanthocyanidins with time and enhance the commercial value thereof. that's all

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification number Office reference number FI Technical indication location A61K 7/00 J 9051-4C K 9051-4C W 9051-4C (72) Inventor Kimura Kimura 48-18 Sakaemachi, Kita-ku, Tokyo Inside Kose Research Institute (72) Inventor Toshiaki Ariga 339 Noda, Noda, Chiba Prefecture Kikkoman Corporation (72) Inventor Katsumi Yuasa 339 Noda, Noda, Chiba Prefecture Kikkoman Corporation Within

Claims (3)

[Claims] 1. The following components (A) and (B) (A) proanthocyanidin, (B) sodium bisulfite, 1-hydroxyethane-
A cosmetic comprising, as an active ingredient, one or more compounds selected from 1,1-diphosphonic acid, diethylenetriaminepentaacetic acid (salt) and phytic acid. 2. The cosmetic according to claim 1, which has a pH of 4 to 7. 3. The cosmetic according to claim 1, wherein the proanthocyanidin is contained in the grape extract.