JPH06298652A - Digestive tube function adjustor, its production and feed containing the same - Google Patents

Abstract

PURPOSE:To obtain an adjustor for regulating human or animal digestive tube function. CONSTITUTION:A digestive tube function adjustor comprises calcium oxide prepared by treating eggshell at high temperature or the calcium oxide and one or more of extracted essences of mugwort, pear and cabbage. A given amount of calcium oxide prepared by treating eggshell at high temperature is mixed with a prescribed amount of one or more of extracted essences of mugwort, pear and cabbage, grinding the mixture to produce the digestive tube function adjustor. A composition comprising the calcium oxide prepared by treating eggshell at a high temperature and one or more of extracted essences of mugwort, pear and cabbage to give a feed containing the digestive tube function adjustor.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a digestive tract function regulator for the purpose of obtaining a regulator or the like for regulating the digestive tract function of humans or animals, a method for producing the same, and a feed containing the same.

[0002]

2. Description of the Related Art It has been proposed that a dried product or an extract of raw pears, mugwort and cabbage is effective as a gastrointestinal function regulator (Japanese Patent Application No. 4-291996).

[0003]

[Problems to be Solved by the Invention] The proposed drug is recognized as effective as a preventive, therapeutic / prophylactic drug, therapeutic drug, functional food and functional feed for diarrhea.

On the other hand, the present invention is intended to further enhance the medicinal effect.

[0005]

According to the present invention, the drug effect is dramatically increased by adding calcium oxide obtained by treating eggshells at a high temperature to the above drug.

That is, the invention of a digestive tract function regulator is a digestion characterized by calcium oxide obtained by treating eggshells at a high temperature or one or more kinds of mugwort, pears or cabbage coexisting with the calcium oxide. It is a tube function regulator.

The invention of the method further comprises mixing a predetermined amount of calcium oxide obtained by treating eggshells at a high temperature with a predetermined amount of one or more kinds of extract of mugwort, pears or cabbage and pulverizing. A method for producing a gastrointestinal function regulator, which comprises:

Next, the invention of a feed is characterized by adding to the feed a composition consisting of calcium oxide obtained by treating eggshells at a high temperature and one or more of mugwort, pears or cabbage. It is a feed containing a function regulator.

The above-mentioned high temperature treatment of eggshells involves
The firing is performed at 00 ° C to 1500 ° C, but 1000 ° C or higher is preferable in order to improve the activity of calcium oxide. However, since the activity does not change even if it is fired at 1300 ° C or higher, it is more preferably 1200 ° C to 1 ° C.
It is 300 ° C. The amount of the tube-regulating function regulator added to the feed is 0.1 mg / Kg to 100 mg / Kg, preferably 1 mg / Kg or more.

The above-mentioned gastrointestinal function regulating agent can be prepared by mixing calcium oxide powder with one or more kinds of mugwort, pears or cabbage. The form of mugwort, pears or cabbage contains the components. It is not particularly limited as long as it is one. For example, raw, dried products and extracts containing active ingredients can be used. When mixing wormwood, pears or cabbage in the form of an extract with the powder of calcium oxide to prepare a powdery gastrointestinal function regulator, the total weight of the extract of wormwood, pears or cabbage (concentrated to 60% of the raw material weight) With respect to 1, the calcium oxide is preferably 0.05 or more, more preferably 0.1 or more.

The gastrointestinal function-regulating agent of the present invention can be used for cattle,
Livestock such as pigs and horses, poultry such as chickens and quails, towns,
The digestive tract function can be regulated safely and effectively for fish such as tai, eel, masu, koi, and goldfish, pets such as dogs and cats, or humans.

Although the dose varies depending on the above-mentioned target animals, it is preferably 0.1 mg to 100 mg per 1 kg of body weight. Even if it exceeds 100 mg, it can be estimated that there are no side effects or other adverse effects, but since there is no change in drug efficacy, 100 mg is the upper limit. The lower limit indicates the case where the medicinal effect is good, and a smaller amount (1/20,
(About 0.05 mg) has a slow regulation function.

The digestive tract in the present invention refers to the organs from the mouth to the anus, and is particularly the stomach, duodenum, small intestine, large intestine and rectum.

The digestive tract function means digestive / absorption and digestive motility such as peristalsis. The gastrointestinal function-regulating agent according to the present invention is useful mainly as a therapeutic or prophylactic agent for diarrhea when acting on the lower gastrointestinal tract such as the large intestine and rectum. Further, when it acts on the upper part of the digestive tract such as stomach and duodenum, it is effective for improving pain, gastric emptying, adjusting wheezing and the like.

When the agent for regulating gastrointestinal function according to the present invention is used as a therapeutic or preventive agent for diarrhea, the etiology is not particularly specified. For example, bacterial diarrhea such as Salmonella enteritis,
Viral diarrhea such as adenovirus, parasite diarrhea such as amoebic dysentery, and food. Toxic diarrhea such as drug addiction,
Allergic diarrhea due to food allergies, functional diarrhea such as cold / neurological diarrhea, and the use of antibiotics (those based on bacterial replacement phenomenon, staphylococcal diarrhea, etc.)
It is effective for diarrhea, digestive and absorption disorders, increased digestive hormones, and chronic diarrhea associated with large bowel disease.

Further, it is effective against bacterial diarrhea such as chicken and pig swine colitis, swine dysentery, etc., viral diarrhea such as TGE and rotavirus, simple diarrhea such as stress and feeding, and aquaculture. Fish is also effective against various diarrhea.

The digestive tract function regulator of the present invention comprising calcium oxide can be expected to have a very large effect when used in a considerable amount (for example, 100 mg / Kg).

The form of the pear used in the present invention is not particularly limited as long as it contains the components, and the fruit is raw or powdered, or an organic solvent, water and an organic solvent. It can be used as an extract containing an active ingredient extracted with a mixture or water.

As the organic solvent, for example, methanol, ethanol, n-propanol, n-butanol, acetone, ethyl acetate, ether, methylene chloride, chloroform, benzene, carbon tetrachloride, petroleum ether, etc. are used. Can be used alone or as a mixture of two or more.

The mugwort, sashimi and cabbage used in the present invention can be used as an extract containing an organic solvent, a mixture of water and an organic solvent or an active ingredient extracted with water.

These extracts are concentrated, diluted,
Alternatively, it is used after removing the solvent, but when reacting with calcium oxide, it is preferable to adjust the water content in consideration of the components in the extract.

For example, 5 parts by weight of water is soaked in 1 part by weight of raw material, and after boiling hot extraction for 30 minutes, the resulting solution is appropriately concentrated to obtain an extract containing 10% by weight of the raw material. And

In addition, the pear extract powder MF (trade name,
Maruzen Pharmaceutical Co., Ltd. Sashiri extract 30%, dextrin 70
% Product) can also be used as a prickly pear extract.

The digestive tract function regulator according to the present invention can be added to feed and given to livestock and the like. Therefore, the present invention includes one or more of pears, mugwort and cabbage,
A feed containing calcium oxide as an essential component and having a gastrointestinal function regulating action.

The amounts of pears and the like and calcium oxide used in the present invention are not particularly limited because they vary depending on the form of administration and the animals to which they are administered.

For example, when a mixture of the prickly pear extract and calcium oxide is administered to livestock such as pigs, the body weight is usually 1
It is recognized that 0.3 mg or more of the pear extract per Kg is effective, and preferably 1 mg or more.

The mixing ratio of sashimi, mugwort and cabbage in the present invention is not particularly limited, but usually 0.25 to 400 parts by weight of the raw sagebrush extract per 1 part by weight of the above sashimi extract. 0.5 to 800 parts by weight, preferably 0.5 to 200 parts by weight of mugwort and 1 to 400 parts by weight of cabbage, in terms of parts and fresh cabbage leaf weight.
More preferably 1 to 100 parts by weight of mugwort and 5 of cabbage.
~ 200 parts by weight. The amount of calcium oxide based on the extract mixture was 0.
05 to 20 parts by weight is preferable, and 0.1 is more preferable.
10 to 10 parts by weight.

By adding the digestive tract function regulator according to the present invention to food, it can be used as a so-called functional food.

Furthermore, when the present invention is administered as a medicine or so-called health food, it can be prepared into tablets, granules, powders, capsules, syrups and the like. These preparations can be molded as they are with calcium oxide, but they are usually used as excipients for preparations,
It can be produced by a commonly used method by mixing with a binder, a lubricant and the like.

It goes without saying that the gastrointestinal function regulator according to the present invention is completely safe in terms of toxicity.

[0031]

Example 1 100 kg of washed and dried egg shell was placed in a furnace and baked at 1200 ° C. for 5 hours to obtain about 50 kg of calcium oxide.

On the other hand, 1.8 kg of fresh mugwort leaves were placed in 9 liters of water and heated on high heat for 30 minutes, then on low heat to 1
The extract is 080g.

Further, 1.8 kg of fresh cabbage leaves are put in 9 liters of water, heated for 30 minutes with high heat and then with low heat to obtain 1080 g.

When 1 kg of calcium oxide, 200 g of pear extract powder MF (described above) were mixed with 450 g each of the extract of mugwort and cabbage,
2 kg of powder was obtained.

When the powder is produced, the temperature rise due to the heat of reaction is 10
Since it was confirmed that the temperature was 0 ° C or lower, the components of the extracted extract remained as it was without being affected by heat.

[0036]

Example 2 1.5 kg of calcium oxide obtained in the same manner as in Example 1 was mixed with an extract of equal amount of mugwort, sashimi and cabbage and water (concentrated to 60% of the raw material weight) 2:
1.6 kg of the extract mixed in the ratio of 3: 1 was mixed and left overnight at room temperature to obtain 3 kg of powder.

[0037]

Test Example 1 SLC: SD Male rats (4 weeks old, body weight 100-150 g) each containing the above-mentioned 3 types of CaO are shown in Table 1.
10, 30, 100 mg / Kg, or physiological saline was orally administered as a control, and 30 minutes later, 1 ml of castor oil was orally administered, and the antidiarrhea represented by the following formula 1 was calculated from these values. The antidiarrheal effect was judged by the index. The measured values and the antidiarrheal index are shown in Table 1.

[0038]

[Equation 1]

[0039]

[Table 1]

As shown in Table 1, all CaOs were confirmed to have antidiarrheal effect, but eggshell-derived CaO had the strongest antidiarrheal effect, and especially in the 100 mg / Kg administration group, diarrhea was completely eliminated within 2 hours. Did not develop.

[0041]

Test Example 2 Eggshell-derived CaO or a mixture of eggshell-derived CaO and YTK was orally administered to 4 SLC: SD male rats (4 weeks old, body weight: 100 to 150 g).
(The amount of YTK extract in each sample of the compounded preparation is 10 mg /
The amount of CaO contained in each sample adjusted to Kg is
3.3, 6.7, 10, 10, 13.3 mg / Kg) Or, as a control, orally, a saline solution is orally administered, and 30
One minute later, 1 ml of castor oil was orally administered, and the antidiarrheal index represented by the following formula 1 was used to judge from these values whether antidiarrheal was effective. The measured values and the antidiarrheal index are shown in Table 1.

Liquid formulation in which each heat-extracted extract of mugwort (Y), pear (T), and cabbage (K) was mixed in a ratio of 2: 3: 1 (each heat-extracted extract has a dry weight of about 65%) CaO. Prescription formulation An extract (liquid) adsorbed on egg shell-derived CaO at the following compounding ratio and dried. (1) CaO 25%: YTK 75% (1: 3) (2) CaO 40%: YTK 60% (2: 3) (3) CaO 50%: YTK 50% (1: 1) (4) CaO 56 %: YTK 44% (14:11) Therefore, the amount of CaO in each self-administered sample was 10 mg of YTK.
/ Kg, (1) 3.3 mg / Kg, (2) 6.7, respectively
It becomes mg / Kg, (3) 10 mg / Kg, and (4) 12.7 mg / Kg.

[0043]

[Equation 2]

[0044]

[Table 2]

As shown in Table 2, the CaO-YTK blended preparations were found to have a dramatic enhancement of the antidiarrheal effect as compared with each of them alone.

[0046]

EFFECTS OF THE INVENTION According to the present invention, it has been confirmed that a remarkable effect can be obtained as compared with the case of using one or more kinds of pear, mugwort, and cabbage which have been conventionally proposed.

Further, according to the production method of the present invention, there are various effects such that the powdery regulator can be produced easily and easily, and the molding and the like upon administration to animals are easy.

The feed of the present invention has the effect of promptly inhibiting symptoms such as diarrhea without the need for administration of a special drug.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI Technical display location A61K 35/78 W 7822-4C ACR C 7822-4C // (A61K 33/08 35:78) 7822 −4C (72) Inventor Masatoshi Fujimoto 2-5-4 Tokodai, Tsukuba, Ibaraki Prefecture (72) Inventor Nori Ueki 6-6-29 Akatsuka, Itabashi-ku, Tokyo (72) Masashi Shirane Nishimochi, Matsue City, Shimane Prefecture 1071 Tamachi

Claims (5)

[Claims] 1. A digestive tract function regulator comprising calcium oxide obtained by treating egg shells at a high temperature. 2. A digestive tract function regulator, comprising calcium oxide obtained by treating egg shells at a high temperature and one or more kinds of mugwort, pears or cabbage. 3. A predetermined amount of calcium oxide obtained by subjecting an eggshell to a high temperature treatment, and a predetermined amount of one or more kinds of extract of mugwort, pears or cabbage, and powdered. A method for producing a digestive tract function regulator. 4. A digestive tract function regulator, comprising a calcium oxide obtained by treating eggshells at a high temperature, and a composition comprising one or more of mugwort, pears or cabbage added to a feed. feed. 5. The digestive tract function regulator and the method for producing a digestive tract function regulator according to any one of claims 1, 2, 3 and 4, wherein the egg shell is calcined at 1200 ° C to 1300 ° C. Or feed.