CN110201098B - Compound propolis composition for treating dysentery of livestock and poultry as well as preparation method and application thereof - Google Patents
Compound propolis composition for treating dysentery of livestock and poultry as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of animal medicinal preparations, and particularly relates to a compound propolis composition for treating dysentery of livestock and poultry, and further discloses a preparation method and application thereof. The compound propolis composition for treating livestock and poultry dysentery is prepared by taking propolis, nutmeg, cinnamon, dragon's blood, cortex albiziae, diverse wormwood herb, mutton red mutton smell, liquorice, fructus evodiae, tree peony bark, fingered citron and rice sprout as raw materials, and based on compatibility and combination of the traditional Chinese medicines according to the theory of Chinese veterinarian, the compound propolis composition plays a role in treating both symptoms and root causes of livestock and poultry dysentery aiming at pathogenic factors and clinical symptoms.
Description
Technical Field
The invention belongs to the technical field of animal medicinal preparations, and particularly relates to a compound propolis composition for treating dysentery of livestock and poultry, and further discloses a preparation method and application thereof.
Background
Dysentery of livestock and poultry is an intestinal disease caused by virus or bacterial infection, is a general term mainly including diarrhea symptoms caused by various factors such as bacteria, viruses, parasites and the like, and is mainly caused by environmental factors, diet sanitation and the like. The long-term severe diarrhea can cause the animal body to lose a large amount of water, salts, alkaline substances and the like, generate dehydration, salt deficiency and acidosis with different degrees, cause blood to become concentrated, influence the normal circulation of body fluid and finally cause heart failure and death. The smaller the day-old of the livestock and poultry, the higher the morbidity and the higher the mortality, and the mortality is generally between 10 and 30 percent. Dysentery of livestock and poultry can occur all the year round, and is one of the main diseases damaging livestock and poultry breeding. The main clinical symptoms of livestock and poultry dysentery are frequent defecation with frequent diarrhea, thin excrement or purulent blood; or the animal feed contains indigestible feed or other pathological contents, and the animal feed has a small quantity of excrement and symptoms of tenesmus each time, thereby seriously affecting the health condition of the animal body. At present, the disease almost spreads all livestock and poultry breeding countries in the world, and is widely distributed, so that serious economic loss is caused.
At present, a plurality of medicines for treating dysentery diseases exist, and western medicine treatment mainly comprises sterilization, inflammation diminishing and body fluid supplementing, but the problems of unsatisfactory curative effect or medicine residue and the like generally exist. The traditional Chinese medicine considers that the dysentery of livestock and poultry is mainly caused by heat-toxin accumulated in the stomach and intestine, belongs to the interior excess heat syndrome, and the principle of clearing heat and removing toxicity, drying dampness and astringing is adopted for treatment. Therefore, the research and development of a specific medicine for treating dysentery of livestock and poultry without toxic and side effects, drug residues and drug resistance is one of the new problems to be solved by scientific research technicians in the field.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to provide the compound propolis composition for treating dysentery of livestock and poultry, and further provide the preparation method and the application thereof.
In order to solve the technical problems, the compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 15-35 parts of propolis, 15-55 parts of nutmeg, 15-45 parts of cinnamon, 15-65 parts of dragon's blood, 10-50 parts of cortex albiziae, 15-55 parts of artemisia anomala, 15-35 parts of mutton red mutton smell, 15-45 parts of liquorice, 15-45 parts of fructus evodiae, 15-55 parts of tree peony bark, 15-65 parts of fingered citron and 15-65 parts of rice sprout.
Preferably, the compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 25 parts of propolis, 35 parts of nutmeg, 30 parts of cinnamon, 40 parts of dragon's blood, 30 parts of cortex albiziae, 35 parts of artemisia anomala, 25 parts of mutton red mutton smell, 30 parts of liquorice, 30 parts of fructus evodiae, 35 parts of cortex moutan, 40 parts of fingered citron and 40 parts of rice sprout.
The invention also discloses a method for preparing the compound propolis composition, which is characterized by comprising the step of uniformly mixing the propolis, nutmeg, cinnamon, dragon's blood, cortex albiziae, diverse wormwood herb, mutton red mutton smell, liquorice, fructus evodiae, tree peony bark, finger citron and rice sprout according to selected parts by weight.
The method for preparing the compound propolis composition comprises the following steps:
(1) respectively taking each raw material component, carrying out superfine grinding, and then sieving with a 600-sand 800-mesh sieve for later use;
(2) respectively taking the propolis, the nutmeg, the cinnamon, the dragon's blood, the cortex albiziae and the herba artemisiae anomala according to the selected weight parts, and mixing for 5-10 minutes until the propolis, the nutmeg, the cinnamon, the dragon's blood, the cortex albiziae and the herba artemisiae anomala are uniform;
(3) respectively taking the mutton red mutton smells, the liquorice, the fructus evodiae, the cortex moutan, the fingered citron and the rice sprout according to the selected weight parts, and mixing for 5-10 minutes until the materials are uniform;
(4) and (3) mixing the mixtures prepared in the steps (2) and (3), and continuously mixing for 10-15 minutes until the mixture is uniform, thus obtaining the product.
The invention also discloses application of the compound propolis composition in preparing a veterinary drug preparation for treating dysentery of livestock and poultry.
The invention also discloses a veterinary drug preparation prepared by adding conventional auxiliary materials into the compound propolis composition for treating livestock dysentery according to a conventional process.
The veterinary drug preparation comprises powder, granules, tablets and capsules.
The invention also discloses a method for preparing the veterinary drug preparation, which comprises the step of preparing the propolis composition according to the method, and adding conventional auxiliary materials to prepare the veterinary drug preparation with the required dosage form according to a conventional process.
The invention also discloses application of the propolis composition or the veterinary drug preparation in preparing livestock and poultry feed.
The invention also discloses a feed for treating dysentery of livestock and poultry, which comprises the propolis composition or the veterinary drug preparation.
The compound propolis composition for treating dysentery of livestock and poultry is prepared by taking propolis, nutmeg, cinnamon, dragon's blood, cortex albiziae, diverse wormwood herb, mutton red mutton smell, liquorice, fructus evodiae, tree peony bark, fingered citron and rice sprout as raw materials,
propolis is bitter, pungent and cold in taste, and has effects of invigorating spleen and stomach channels, resisting bacteria, relieving inflammation, relieving pain, relieving itching, promoting tissue regeneration, enhancing immunity, resisting anaphylaxis oxidation, stopping bleeding, and protecting gastrointestinal mucosa;
nutmeg, pungent in flavor and warm in nature, has the functions of astringing intestines to stop diarrhea, warming middle-jiao and promoting qi circulation, and enters spleen, stomach and large intestine channels; can be used for treating deficiency-cold of spleen and stomach, chronic diarrhea, abdominal distention and pain, etc.;
cinnamon, pungent and sweet in flavor, strong in nature and hot in nature, has the functions of tonifying fire, supporting yang, warming middle-jiao and dispelling cold, and enters spleen, kidney, heart and liver channels; can be used for treating deficiency cold of spleen and stomach, cold pain, kidney yang deficiency, wind cold arthralgia, sexual impotence, and cold womb;
dragon's blood, sweet in taste, salty, neutral in nature, enter heart, liver meridian, have effects of removing blood stasis and relieving pain, stopping bleeding and promoting granulation; can be used for treating traumatic injury, abdominal pain due to blood stasis, traumatic hemorrhage, and unhealed skin and external diseases;
cortex Albizziae, sweet in taste and neutral in nature, enters liver, heart and lung channels, and has the functions of soothing nerves, relieving depression, promoting blood circulation and relieving swelling; can be used for treating restlessness, traumatic injury, skin ulcer, furunculosis, etc.;
herba Artemisiae Anomalae, bitter in taste, cold in nature, neutral in nature, and entering liver, heart and spleen channels, has the functions of clearing summer heat, promoting diuresis, promoting blood circulation, removing blood stasis and relieving pain; can be used for treating sunstroke, enteritis, dysentery, rheumatalgia, traumatic injury, and traumatic hemorrhage;
the mutton smell is pungent, warm in nature, and has the functions of warming the middle-jiao, invigorating the spleen, tonifying yang and promoting estrus; can be used for treating short breath, asthenia, cough, white scour of piglets, bone atrophy, sexual impotence, and infertility;
the liquorice is sweet in taste and neutral in nature, enters lung, heart and spleen channels, and has the functions of tonifying spleen and qi, eliminating phlegm and stopping cough, regulating the middle warmer and relieving urgency, detoxifying, harmonizing the effects of various medicines, and relieving toxicity and pungency of the medicines; can be used for treating weakness of spleen and stomach, cough, asthma, and poisoning;
the evodia rutaecarpa, pungent, bitter and hot in taste, enters liver, spleen, stomach and kidney meridians and has the functions of warming middle energizer, relieving pain, regulating qi and arresting vomiting; can be used for treating deficiency-cold of spleen and stomach, cold intestine diarrhea, and cold stomach with salivation;
cortex moutan, being bitter, pungent and slightly cold in nature, has the functions of clearing heat and cooling blood, and promoting blood circulation to remove blood stasis, and enters heart, liver and kidney meridians; it can be used for treating warm toxic macula, epistaxis blood, hematochezia, hematuria, traumatic injury, carbuncle, swelling, and skin ulcer;
the fingered citron is bitter, pungent, sour and warm in taste, enters lung, liver, spleen and stomach channels, and has the functions of soothing liver, regulating qi, harmonizing stomach, relieving pain and helping digestion; can be used for treating qi stagnation of spleen and stomach, abdominal distention and pain, anorexia, dyspepsia, etc.;
the rice sprout is sweet in taste and warm in nature, has the functions of promoting digestion, regulating the middle warmer, tonifying spleen and stimulating appetite, and enters spleen and stomach channels; it can be used for treating weakness of spleen and stomach, indigestion, and abdominal distention.
The propolis composition is based on the compatibility and combination of the traditional Chinese medicines according to the Chinese veterinary theory, and plays a role in treating both principal and secondary aspects of diseases aiming at pathogenic factors and clinical symptoms of livestock and poultry dysentery. The traditional Chinese medicine composition disclosed by the invention has the advantages of no pollution, no toxic or side effect, no medicine residue, no drug resistance, very obvious curative effect, wide material taking range and low cost. The propolis composition disclosed by the invention is reasonable in formula and simple in preparation method, and raw material components are mixed more uniformly step by step; and the bioavailability is high through superfine grinding.
According to the propolis composition, the twelve traditional Chinese medicines are preferably selected according to the traditional theory of Chinese veterinarian, and are made into pure traditional Chinese medicine powder according to the preferable proportion.
Detailed Description
Example 1
The compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 150kg of propolis, 150kg of nutmeg, 150kg of cinnamon, 150kg of dragon's blood, 100kg of cortex albiziae, 150kg of diverse wormwood herb, 150kg of mutton red mutton smell, 150kg of liquorice, 150kg of fructus evodiae, 150kg of cortex moutan, 150kg of fingered citron and 150kg of rice sprout.
The compound propolis composition for treating dysentery of livestock and poultry is prepared by the following steps:
(1) according to the prescription of the raw material medicine, various components are respectively subjected to superfine grinding and then sieved by a 700-mesh sieve;
(2) weighing propolis, nutmeg, cinnamon, dragon's blood, cortex albiziae and herba artemisiae anomalae according to the weight, and mixing for 5-10 minutes until the mixture is uniform;
(3) weighing mutton red, liquorice, fructus evodiae, cortex moutan, fingered citron and rice sprout according to the weight, and mixing for 5-10 minutes until the materials are uniform;
(4) and (3) combining the compositions prepared in the steps (2) and (3), and continuously mixing for 10-15 minutes until the compositions are uniform.
Example 2
The compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 250kg of propolis, 350kg of nutmeg, 300kg of cinnamon, 400kg of dragon's blood, 300kg of cortex albiziae, 350kg of diverse wormwood herb, 250kg of mutton red mutton smell, 300kg of liquorice, 300kg of fructus evodiae, 350kg of cortex moutan, 400kg of fingered citron and 400kg of rice sprout.
The preparation method of the compound propolis composition for treating dysentery of livestock and poultry is the same as that in example 1.
Example 3
The compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 350kg of propolis, 550kg of nutmeg, 450kg of cinnamon, 650kg of dragon's blood, 500kg of cortex albiziae, 550kg of diverse wormwood herb, 350kg of mutton red mutton smell, 450kg of liquorice, 450kg of fructus evodiae, 550kg of cortex moutan, 650kg of fingered citron and 650kg of rice sprout.
The preparation method of the compound propolis composition for treating dysentery of livestock and poultry is the same as that in example 1.
Example 4
The compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 150kg of propolis, 550kg of nutmeg, 150kg of cinnamon, 650kg of dragon's blood, 100kg of cortex albiziae, 550kg of diverse wormwood herb, 150kg of mutton red mutton smell, 450kg of liquorice, 150kg of fructus evodiae, 550kg of cortex moutan, 150kg of fingered citron and 650kg of rice sprout.
The preparation method of the compound propolis composition for treating dysentery of livestock and poultry is the same as that in example 1.
Example 5
The compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 350kg of propolis, 150kg of nutmeg, 450kg of cinnamon, 150kg of dragon's blood, 500kg of cortex albiziae, 150kg of diverse wormwood herb, 350kg of mutton red mutton smell, 150kg of liquorice, 450kg of fructus evodiae, 150kg of cortex moutan, 650kg of fingered citron and 150kg of rice sprout.
The preparation method of the compound propolis composition for treating dysentery of livestock and poultry is the same as that in example 1.
Example 6
The compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 200kg of propolis, 450kg of nutmeg, 220kg of cinnamon, 520kg of dragon's blood, 200kg of cortex albiziae, 450kg of diverse wormwood herb, 200kg of mutton red mutton smell, 380kg of liquorice, 220kg of fructus evodiae, 450kg of cortex moutan, 275kg of fingered citron and 525kg of rice sprout.
The preparation method of the compound propolis composition for treating dysentery of livestock and poultry is the same as that in example 1.
Example 7
The compound propolis composition for treating dysentery of livestock and poultry comprises the following raw material medicaments: 300kg of propolis, 250kg of nutmeg, 380kg of cinnamon, 275kg of dragon's blood, 400kg of cortex albiziae, 250kg of diverse wormwood herb, 300kg of mutton red mutton smell, 220kg of liquorice, 380kg of fructus evodiae, 250kg of cortex moutan, 525kg of fingered citron and 275kg of rice sprout.
The preparation method of the compound propolis composition for treating dysentery of livestock and poultry is the same as that in example 1.
Examples of the experiments
Experimental example 1
The clinical experimental animal adopts pullorum disease as a representative to carry out the test of livestock and poultry dysentery, and the sick broiler chicken with 20 days old and weight of 0.9kg-1.0kg and confirmed pullorum disease in a laboratory is selected.
The sick chickens are separately fed, fed with complete feed and randomly divided into 3 groups, each group comprises 100 chickens, the feeding environment of the 3 groups is completely the same, and the experimental time is 5 days; the blank control group is not treated, and the drug control group uses diarrhea and dysentery recovery powder according to the instruction; the Chinese medicinal composition of the invention is prepared by feeding the product (the composition prepared in the example 2 of the invention) to sick poultry and the like.
The daily dose is as follows: feeding or drinking 460kg of the propolis composition according to 100g of the propolis composition and 250kg of the mixed materials for 2-3 times every day for 5 days; can be absorbed by gastrointestinal tract after oral administration to treat diseases.
The calculation method comprises the following steps:
mortality rate ═ number of dead animals/number of test animals × 100%;
the cure rate is the number of cured animals/the number of experimental animals multiplied by 100 percent;
the symptom rate at the end was ═ number of symptomatic animals/number of test animals × 100%.
The evaluation standard of curative effect is as follows:
and (3) curing: the clinical symptoms of pullorum disease such as normal spirit, normal drinking water, normal respiration, normal feces, normal body temperature and the like disappear, and pathogenic microorganism salmonella and the like are not found through laboratory detection.
Symptoms at the end: clinical symptoms did not improve or even worsen.
The results of each experimental group are recorded at the end of the experiment as shown in table 1 below.
TABLE 1 comparison of the present composition with other drugs for pullorum disease
The results of the clinical experiments are analyzed by group statistics, and the composition group has extremely obvious difference (P is less than 0.01) compared with the diarrhea curing powder group in the aspect of cure rate.
Experimental example 2
Clinical experimental animals adopt piglet white diarrhea as a representative to carry out the test of livestock and poultry dysentery, and sick piglets which are 20-25 days old and have the weight of 6.5-8.5 kg and are diagnosed as piglet white diarrhea in a laboratory are selected.
The sick piglets are separately fed, fed with complete feed and randomly divided into 3 groups, wherein each group has 30 piglets, the feeding environments of the 3 groups are completely the same, and the experiment is carried out for 5 days; the blank control group is not treated, and the drug control group uses the piglet white diarrhea powder according to the instruction; the traditional Chinese medicine composition can be used for feeding sick piglets and the like with the product (the composition prepared in the embodiment 2 of the invention).
The daily dose is as follows: the weight of the pig is 0.2-0.45g per kilogram of body weight, and the pig is fed with the feed for 3 times a day for 5 days continuously; can be absorbed by gastrointestinal tract after oral administration to treat diseases.
The calculation method comprises the following steps:
mortality rate ═ number of dead animals/number of test animals × 100%;
the cure rate is the number of cured animals/the number of experimental animals multiplied by 100 percent;
the symptom rate at the end was ═ number of symptomatic animals/number of test animals × 100%.
The evaluation standard of curative effect is as follows:
and (3) curing: normal spirit, normal drinking and eating, normal breathing, normal feces, normal body temperature and other clinical symptoms of white scour of piglets disappear, and pathogenic microorganism escherichia coli and the like are not found in the feces of sick pigs through laboratory experiments.
Symptoms at the end: clinical symptoms did not improve or even worsen.
The results of each experimental group are recorded at the end of the experiment as shown in table 2 below.
TABLE 2 comparison of the present composition with other drugs for treating white scour of piglets
| Numbering | Group of | The mortality rate is% | The cure rate is% | The rate of symptoms at the end% |
| Ⅰ | Blank control group | 20 | 0 | 80 |
| Ⅱ | Powder for treating white scour of piglets | 10 | 73.3 | 16.3 |
| Ⅲ | The Chinese medicinal composition of the invention | 3.3 | 83.3 | 13.4 |
According to the results of the clinical experiments, compared with the piglet white diarrhea powder group, the composition group has very obvious difference in the aspect of cure rate (P is less than 0.01).
Safety test
60 healthy AA broiler chickens of 20 days old are selected, and the feed or water is mixed for 5 days according to the amount 5 times of the recommended dose of the composition prepared according to the embodiment 2 of the invention, during the administration period, the healthy broiler chickens have no any adverse or abnormal behavior, the drinking water is normally taken, and the weight gain is not obviously different from that of a blank control group (namely, the healthy non-administration medicine).
10 healthy pigs of 70 days old are selected and fed with 5 times of the recommended dose of the composition prepared according to the example 2 for 10 days, during the administration period, the healthy pigs have no adverse or abnormal behavior, the drinking water and the eating are normal, and the weight gain is not different from that of a blank control group (namely, the healthy pigs do not contain the medicine).
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (10)
1. The compound propolis composition for treating dysentery of livestock and poultry is characterized by comprising the following raw material medicaments: 15-35 parts of propolis, 15-55 parts of nutmeg, 15-45 parts of cinnamon, 15-65 parts of dragon's blood, 10-50 parts of cortex albiziae, 15-55 parts of artemisia anomala, 15-35 parts of mutton red mutton smell, 15-45 parts of liquorice, 15-45 parts of fructus evodiae, 15-55 parts of tree peony bark, 15-65 parts of fingered citron and 15-65 parts of rice sprout.
2. The compound propolis composition for treating dysentery of livestock and poultry according to claim 1, which is characterized by comprising the following raw material medicaments: 25 parts of propolis, 35 parts of nutmeg, 30 parts of cinnamon, 40 parts of dragon's blood, 30 parts of cortex albiziae, 35 parts of artemisia anomala, 25 parts of mutton red mutton smell, 30 parts of liquorice, 30 parts of fructus evodiae, 35 parts of cortex moutan, 40 parts of fingered citron and 40 parts of rice sprout.
3. A method for preparing the compound propolis composition of claim 1 or 2, which is characterized by comprising the step of uniformly mixing the propolis, nutmeg, cinnamon, dragon's blood, cortex albiziae, artemisia anomala, mutton danty, liquorice, fructus evodiae, cortex moutan, fingered citron and rice sprout according to selected parts by weight.
4. The method for preparing the compound propolis composition according to claim 3, which is characterized by comprising the following steps:
(1) respectively taking each raw material component, carrying out superfine grinding, and then sieving with a 600-sand 800-mesh sieve for later use;
(2) respectively taking the propolis, the nutmeg, the cinnamon, the dragon's blood, the cortex albiziae and the herba artemisiae anomala according to the selected weight parts, and mixing for 5-10 minutes until the propolis, the nutmeg, the cinnamon, the dragon's blood, the cortex albiziae and the herba artemisiae anomala are uniform;
(3) respectively taking the mutton red mutton smells, the liquorice, the fructus evodiae, the cortex moutan, the fingered citron and the rice sprout according to the selected weight parts, and mixing for 5-10 minutes until the materials are uniform;
(4) and (3) mixing the mixtures prepared in the steps (2) and (3), and continuously mixing for 10-15 minutes until the mixture is uniform, thus obtaining the product.
5. Use of the compound propolis composition of claim 1 or 2 for preparing veterinary drug preparations for treating dysentery of livestock and poultry.
6. The veterinary drug preparation is prepared by adding conventional auxiliary materials into the compound propolis composition for treating dysentery of livestock and poultry according to the claim 1 or 2 and adopting a conventional process.
7. The veterinary drug formulation according to claim 6, comprising powders, granules, tablets, capsules.
8. The method for preparing the veterinary drug preparation as claimed in claim 6 or 7, which is characterized by comprising the step of preparing the propolis composition according to the method as claimed in claim 3 or 4, adding conventional auxiliary materials, and preparing the veterinary drug preparation in a required dosage form according to a conventional process.
9. Use of the propolis composition according to claim 1 or 2 or the veterinary drug formulation according to claim 6 or 7 for the preparation of livestock feed.
10. A feed for treating dysentery of livestock and poultry, comprising the propolis composition of claim 1 or 2, or the veterinary drug formulation of claim 6 or 7.
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