JPH06225933A - Liquid separator - Google Patents

Abstract

PURPOSE:To provide a liquid separator which enables the withdrawing of liquids in layers easily and accurately from the top or the bottom of a container even without a path formed to withdraw the liquid in the lower layer to the container holding the liquids of a plurality of layers from the top of the container. CONSTITUTION:A roller moves from a side end part of a master back B1 comprising soft material as holding liquids separated into an upper layer S1, an intermediate layer S3 and a lower layer S2 so as to get a part of the back side of the master bag B1 tight on the belly side thereof pressing it and then, stopped at a specified position to form a path for guiding the liquid in the lower layer S2 to a second port Q2 on the side part of the master bag B1. Thereafter, the master bag B1 is pressurized to take out the liquid in the upper layer S1 from at the first port Q1 and the liquid in the lower layer S2 from the second port Q2 to be housed into slave bags B2a and B2b.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid separating device for taking out a liquid for each layer from a flexible container in which a layered separating liquid is sealed such as a blood bag.

[0002]

2. Description of the Related Art Recently, instead of whole blood transfusion, component transfusion in which only necessary components in blood are transfused to a patient or the like, or only plasma is collected from blood for preparation of plasma preparation. Has been done. In order to obtain such blood for component transfusion and plasma preparation, a flexible blood bag, so-called multi-bag, has been used. This blood bag is composed of a blood collection bag (so-called parent bag) for containing blood collected from a donor, and one or more separation bags (so-called child bags) connected to the parent bag via a tube. The blood contained in the parent bag is composed of a plasma layer, a red blood cell layer, and an intermediate layer (a buffy coat layer containing platelets, white blood cells or fat, and other bacteria, and a so-called buffy coat layer). Each of the components in the parent bag that has been centrifugally separated is taken out for each component and is taken into the child bag. In addition, when each component is taken into the child bag, it is necessary to prevent the components from mixing with each other.

Such a blood bag is shown in FIGS.
There is one shown in FIG. Blood bag 10 shown in FIG.
In 0A, a tube is attached to the upper portion of the parent bag 101 that stores the collected blood. Tubes t1 to t3 are connected to this tube via two T-shaped branch tubes, and a tip end of each tube t1 to t3 contains a child bag 102a containing a red blood cell preservation solution, and two empty child bags 102b, 102c is connected.

In order to separate each component from the parent bag 101, first, the abdominal surface of the parent bag 101 containing the blood separated into the three layers of the plasma layer S1, the red blood cell layer S2 and the intermediate layer S3 by centrifugation. The blood plasma component forming the upper layer S1 is transferred to the child bag 102b through the tube t2 by pressurizing. When the transfer of the plasma component is completed, a small amount of the plasma component remaining in the parent bag 101, the component of the intermediate layer, that is, the buffy coat layer, and a part of the red blood cell component of the lower layer are transferred to the child bag 102c via the tube t3. Transfer. When the intermediate layer is removed from the parent bag 101 in this manner, the red blood cell preservation solution contained in the child bag 102a is then transferred through the tube t1 to the parent bag 101.
Transfer inside. The blood bag 100A for separating the components of blood in this manner is practical because the components can be collected from one direction (upper side in this example) of the parent bag 101.

In FIG. 15, tubes t1 and t2 are provided above and below a parent bag 101, and the parent bag 101 separated into the three layers by centrifugation is attached to a liquid separating apparatus. By pressurizing the abdominal surface of the parent bag 101, the plasma layer S1 is released from the upper tube t1.
Is taken out into the child bag 102a, the red blood cell layer S2 is taken out from the lower tube t2 into the child bag 102b, and the intermediate layer S3 is left inside the parent bag 101 (see Japanese Patent Publication No. 63-20144). ). This blood bag 100B is a parent bag 101 in a centrifugally separated state.
Since the desired components are taken out from above and below respectively, the intermediate layer can be efficiently separated and collected from the blood. The reference numeral “103” in FIGS. 14 and 15 is a blood collection needle.

In the blood bag 100C shown in FIG. 16, a seal portion 104 extending to the bottom of the parent bag 101 is formed by heat-sealing both front and back surfaces of the parent bag 101, thereby forming a passage 105 for taking out upwards. It was formed independently inside. Then, the parent bag 101 containing the centrifuged blood is attached to the liquid separation device,
By pressing the abdominal surface of the bag, the first tube t1
From the plasma tube S1 and the red blood cell layer S2 from the second tube t2, leaving the intermediate layer S3 in the parent bag 101 (European Patent Publication No. 048).
4751A1). This blood bag 100C
Is practical because each component can be taken out from above.

On the other hand, in the liquid separating apparatus, a lower pressure biasing method as shown in FIG. 17 (for example, Japanese Examined Patent Publication No. 55-17, 5) is used by a method of pressurizing a parent bag which has been conventionally centrifuged.
No. 85, etc.) and a parallel pressurizing method as shown in FIG. 18 (see, for example, JP-A-55-155,652). In the former, the parent bag 101 is hung on a hook f provided on the separation stand 106, and the pressure plate 107 whose lower end is rotatably supported pressurizes the abdominal surface of the bag, while the latter is separated. 106
A pressure plate 108 is provided in parallel with the above, and the abdominal surface of the bag is pressed in this parallel state. These include automatic pressurization and manual pressurization, but with the automatic pressurization that has been widely used recently, in either method, the position of the intermediate layer is detected while being detected by an interface sensor (not shown). The pressure plate 107 or 108 pressurizes the bag.

[0008]

However, as in the blood bag 100A shown in FIG. 14, in which three tubes t are provided above the parent bag 101, the plasma layer S1 and the parent bag 101 are removed from the parent bag 101. Take out the intermediate layer S3 that easily sticks to the inner surface of the container, and then add the red blood cell preservation solution to the parent bag 1
Since it is put in 01, the middle layer S3 in the parent bag 101
Is left behind, and the timing of taking out the intermediate layer S3 is difficult, and there is a problem in controllability. In the blood bag 100B shown in FIG. 15 in which the tubes t are provided above and below the parent bag, the component extraction ports are at the top and bottom, so handling the tubes t becomes inconvenient when the bag is attached to the liquid separation device. .

Further, in a blood bag 100C shown in FIG. 16 in which an upper passage is independently formed in the parent bag 101, there is a possibility that the intermediate layer S3 may enter into this passage, so that a complete component is obtained. Since the separation cannot be performed and the front and back surfaces of the parent bag 101 must be heat-sealed to form a seal portion extending to the bottom of the bag, the number of manufacturing processes increases. Furthermore, parent bag 1
When 01 is attached to the separating device, the front and back sides of the attachment are fixed, so the workability when handling the parent bag 101 is poor.

The present invention has been made in order to solve the problems associated with the above-mentioned prior art, and even if the container is not provided with a passage for taking out the liquid of the lower layer from the upper part of the container, It is an object of the present invention to provide a liquid separating device that allows liquid in the lower layer to be easily taken out from the upper part of a container, and that the tube can be handled easily and the separation accuracy is extremely high.

[0011]

According to the present invention for achieving the above object, the components fractionated in at least three layers of an upper layer, an intermediate layer and a lower layer are housed in the upper layer or the upper layer or the lower layer. A container holding part for holding a flexible parent container having a first outlet and a second outlet on one side of a lower layer, and two opposing surfaces of the parent container held by the container holding part A liquid separating device having a container pressing portion made up of a supporting member for supporting one surface and a pressing member for pressing the other surface, the pressing device comprising a pressing means for driving the pressing member, Comprises a roller-type pressing member and a second pressing member provided adjacent to the roller-type pressing member, and while maintaining the roller-type pressing member in three regions of the upper layer, the intermediate layer, and the lower layer, Push laterally from one side wall of the container to the other side wall. While moving for a predetermined distance, across the intermediate layer from between the first outlet and the second outlet, to a predetermined distance before the other end of the parent container to a close distance to the two opposing surfaces of the parent container. And a passage communicating with the second outlet is formed in the parent container by the contact portion.
The pressing member presses the parent container so that the upper layer is the first
The lower layer to the second outlet through the passage and the upper layer to the first outlet, and the lower layer to the first outlet. Exit and the second
When it is on the outlet side, the liquid separating apparatus is characterized in that the upper layer is guided to the second outlet through the passage and the lower layer is guided to the first outlet. Furthermore, the present invention includes a weight measuring unit that constantly measures the weight of the parent container.

[0012]

[Function] At least three layers of the upper layer, the intermediate layer and the lower layer are provided inside.
A flexible parent container containing the fractionated components in one layer and having a first outlet and a second outlet on one side of the upper layer or the lower layer is attached to the container holder. And
A roller-type pressing member moves a predetermined distance while laterally pressing from one side wall of the parent container toward the other side wall while maintaining the three regions of the upper layer, the intermediate layer, and the lower layer. . Thus, a contact portion is formed on the two opposing surfaces of the parent container, between the first outlet and the second outlet, across the intermediate layer, and before the predetermined distance from the other end of the parent container, and The contact portion forms a passage communicating with the second outlet in the parent container. Next, by the second pressing member,
When the parent container is pressed and the upper layer is on the side of the first outlet and the second outlet, the lower layer is guided to the second outlet through the passage and the upper layer is Taken to the first exit. In addition, the lower layer has the first outlet and the second layer.
, The upper layer is led to the second outlet and the lower layer is led to the first outlet through the passage.

[0013]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described below with reference to the drawings. 1 is a schematic perspective view of a liquid separating apparatus according to an embodiment of the present invention, FIG. 2 is a schematic plan view showing an example of a blood bag, FIG. 3 is a sectional view taken along line 3-3 of FIG. 1, and FIG. , Figure 1
5 is an enlarged perspective view of a pressing unit and a pressure plate, FIG. 6 is an explanatory view showing a pressing operation of the container pressing unit, and FIG. 7 is an unlocked state of the container pressing unit. FIG.

In FIG. 1, a liquid separating apparatus 10 takes out from a centrifugally separated parent bag (parent container) B1 for each component blood, and a container holding portion 11 holding the parent bag B1 and tubes t1 and t2. Clamping member 12 for selectively clamping the liquid and liquid contained in the parent bag B1
A pressing unit 51 that divides into two regions and forms a passage for leading the liquid in the lower layer to the second port (corresponding to the second outlet), and container pressurization that pressurizes the parent bag B1 held in the container holding unit 11. Unit 13 and the pressing unit 51
And a control unit C for controlling the container pressurizing unit 13 and the like.

The blood bag B is made of a flexible synthetic resin, and as shown in FIG. 2, a blood collecting bag for containing blood collected from a donor, a so-called parent bag B1, and a tube t in the parent bag B1. It has a plurality of separation bags, so-called child bags B2a and B2b, which are communicated with each other through. As shown in the figure, the parent bag B1 is formed with a first port Q1 and a second port Q2 (corresponding to a first outlet and a second outlet), and a tube t1 is formed at the first port Q1. Child bag B2a through the second port Q2
A child bag B2b is connected to the container via a tube t2. When the blood in the parent bag B1 is centrifuged, the plasma layer S
1, the erythrocyte layer S2 and the intermediate layer S3 are separated, but it is the plasma layer S1 and the erythrocyte layer S2 that are used. These component bloods are taken out from the parent bag B1 and the child bag B2.
It is taken in by a and B2b.

The pressing unit 51, as shown in FIG.
It is provided inside a case 50 attached to the front side of the body case 14. This pressing unit 51 is shown in FIG.
As shown in FIG. 5, a pressing portion 52 for pressing the abdominal surface side and the rear surface side of the parent bag B1 so as to closely contact each other, and the pressing portion 5
Two rollers (roller-type pressing member) 5 provided in 2
Roller opening / closing means 65 for moving the 3a and 53b close to and away from each other, and roller moving means 70 for moving the pressing portion 52 toward and away from the parent bag B1 from the side.
Have and.

The pressing portion 22 has two rollers 53, which have a motor for rotating itself therein and which are vertically arranged.
It has a and 53b. The upper ends of the rollers 53a and 53b are rotatably connected to one ends of an upper first lever 55a and an upper second lever 55b, which are rotatably connected to each other by a pin 54.
The lower end of 53b has a lower first lever 58a and a lower second lever 5 rotatably connected to each other by a pin 57.
It is rotatably connected to one end of 8b. The other ends of the upper first lever 55a and the lower first lever 58a are fixedly supported by a column 60a arranged vertically, and similarly, the other ends of the upper second lever 55b and the lower second lever 58b are column It is fixedly supported by 60b. In addition, spring members 56 and 59 are provided that provide a biasing force such that the tip ends of the first lever and the second lever open. Therefore, although the rollers 53a and 53b are normally separated from each other, the roller 5 is opened by the roller opening / closing means 65.
The liquid contained in the parent bag B1 is divided into two areas by bringing 3a and 53b close to each other and part of the ventral side and the back side of the parent bag B1 are in close contact with each other. A passage for guiding the liquid of the lower layer S2 can be formed in the second port.

The roller opening / closing means 65 has a V-shaped body 66 having a V-shaped groove at the tip thereof.
An advancing / retreating rod 67 is connected to the end of the, and a solenoid (pressing means) 68 for advancing / retreating the advancing / retreating rod 67 is provided. Then, the slopes 66a of the V-shaped groove of the V-shaped body 66 are pressed against the support columns 60a and 60b to bring the support columns 60a and 60b close to each other, so that the rollers 53a and 53.
It is designed to be close to b. The roller opening / closing means 65 is supported on the substrate 71 by a supporting member (not shown). Further, the roller moving means 70 has a substrate 71 that supports the pressing portion 22, and the substrate 7
A connecting rod (not shown) provided at the bottom of
2 is connected, and a solenoid (pressing means) 73 for moving the advancing / retreating rod 72 forward / backward is provided. This allows
The pressing portion 52 can be moved toward and away from the parent bag B1 from the side and stopped at a predetermined position. still,
The structure for moving the rollers 53a and 53b close to and away from each other is not limited to the above, and can be changed as appropriate. The drive source for the roller opening / closing means 65 and the roller moving means 70 is not limited to a solenoid, and a motor or cylinder may be used. Good.

As shown in FIGS. 1 and 3, the container pressurizing unit 13 is provided in a housing 15 installed in the front portion of the main body case 14, and a front wall 15 a of the housing 15 holds the container. A portion 11 is provided so as to project, and a through hole 17 formed in the parent bag B1 is hooked on the container holding portion 11 to suspend the parent bag B1.

Inside the housing 15 of the container pressurizing unit 13, as shown in FIG. 3, a container pressurizing unit 18 for applying pressure from the abdominal surface side and the rear surface side of the parent bag B1 suspended by the container holding unit 11 is provided. Has been. The container pressing portion 18 includes a first pressing plate (supporting member) 19 that abuts on the ventral side of the parent bag B1 and pressurizes it, and a second pressing plate 19 that abuts on the back side of the parent bag B1.
The pressing plate (second pressing member) 20 and the direction in which the second pressing plate 20 presses the parent bag B1, that is, the first pressing member 20
Spring member 2 that applies pressure toward the pressure plate 19 side
1 and.

In this embodiment, the first pressure plate 19 is
It is configured by a door body that opens and closes the front surface portion of the housing 15. The door body is preferably made of a transparent material such as acrylic resin so that the state of the parent bag B1 inside can be seen.

On the other hand, the second pressure plate 20 is provided inside the housing 15 so as to face the first pressure plate 19, and as shown in FIG. A first link 22 is rotatably connected to the side by a pin 22a, and a rear end of the first link 22 is rotatably supported by a support shaft 23 attached to the housing 15. The ends of 24 are connected. The third link 25 is attached to the end of the second link 24, and the end of the third link 25 is in contact with the pressing member 26. The pressure member 26 is connected to the door body via a link mechanism 27, presses the third link 25 via the link mechanism 27 with the opening of the door body, and causes the second pressure plate 20 to be a spring member. It is designed to retreat against the resilience of 21. That is, the door body is used as one member of the container pressing unit 18 without providing an independent pressing plate.
The reason why the pressure plate 19 is also used is to reduce the number of parts and to simplify the configuration, and the second pressure plate 20 is retracted by utilizing the opening / closing force of the door body so that the door body is opened. This is for the container pressurizing unit 18 to be ready for pressurization. As a result, when the door is opened, the parent bag B is immediately released.
You will be ready to pressurize 1.

When the operation of forming the passage for guiding the liquid of the lower layer S2 to the second port formed in the parent bag B1 by the pressing unit 51 is finished, the second pressure plate 2
The lock state of 0 is released. That is, a cam member (not shown) provided on the roller moving means 70 of the pressing unit 51 pushes down the push rod 30 against the elastic force of the spring member 31. The push rod 30 has a tapered portion 30a formed at the tip thereof.
a is engaged with a pin 33 attached to the claw portion 32. The claw portion 32 is biased in one direction around the pin 34 by a spring member (not shown) or the like, and the support shaft 2
3, which is engaged with and locked by the ratchet wheel 35 attached to 3, the push rod 30 pushes the pin 33 to retract the pawl portion 32 which is engaged with the ratchet wheel 35.
The above-mentioned second link 24 attached to the support shaft 23.
Is unlocked so that it can be freely rotated, and the spring member 21 causes the second pressure plate 20 to move to the parent bag B1.
To pressurize. Needless to say, a motor, a cylinder or the like can be used as a drive source for pressurizing. As described above, according to this embodiment, the roller 5
The pressing member 91 is composed of 3 and the second pressure plate,
The pressing member 91 and the first pressure plate 19 that supports the pressing of the pressing member 91 constitute a container pressing portion 90.

The upper part of the main body case is shown in FIG.
As shown in FIG. 4, the clamp member 12 for individually blocking and releasing the flow of the constituent blood flowing through the two tubes t1 and t2 extending from one end of the parent bag B1.
Is provided. The clamp member 12 includes a first clamp member 40a that opens and blocks a tube t1 through which a blood plasma component flows, a second clamp member 40b that opens and blocks a tube t2 through which a red blood cell component flows, and these clamp members 40a. , 40b actuating solenoid 4
1a, 41b, and the interruption-release control by a signal from the control unit C issued according to the position of the intermediate layer S3 of the centrifuged blood, the weight of the parent bag B1, and the pressurization time. It is supposed to be done. Then, the component blood that has flowed out through this tube t is
It is stored in the child bags B2a and B2b installed in the tray 42 formed on the upper part of the tray.

The position of the intermediate layer S3 is detected by the interface detecting member 43 provided on the second pressure plate 20. A photo sensor is generally used as the interface detection member 43, and the interface is detected by the difference in the light absorption rate of each of the three layers described above. The signal from the interface detection member 43 is controlled by Input to part C.

The weight of the parent bag B1 is measured by the weight measuring section G.
Is constituted by a weight sensor 44 provided below the container pressurizing unit 13. In order to measure the weight of the parent bag B1, the total weight of the container pressing unit 13 is calculated based on the total weight of the container pressing unit 13, the housing 15 and the first and second pressing plates 19,
It is calculated by subtracting the tare of 20 or the like. The total weight of the container pressing unit 13 is detected by a weight sensor 44 provided below the container pressing unit 13. The weight sensor 44 can be configured by, for example, a block 45 provided so as to support the housing 15 of the container pressing unit 13 and having a strain gauge attached to a side surface thereof. In the figure, reference numeral "46" is a scale stopper.

The tray 42 for accommodating the child bags B2a and B2b is closed by an upper lid 47, and the packing 4 around the tray is closed.
It is hermetically sealed by 8. Therefore, the pump P
By depressurizing the inside of the tray with the guide tube 49, it is possible to facilitate the inflow of the component blood from the parent bag B1 to the child bag B2.

The pressurizing time is detected by the timer 51 provided on the control panel 50 provided on the front surface of the main body case 14, and the signal from the timer 51 is also input to the control section.

Next, the operation of accommodating each component of blood contained in the parent bag B1 in the separated state in the child bags B2a and B2b by the device of the embodiment will be described.
First, as shown in FIG. 1, with the first pressure plate 19 opened, the through hole 17 of the parent bag B1 is inserted into the container holding portion 11.
And put on the parent bag B1 at the same time
The tubes t1 and t2 extended from 1 are fitted into the clamp members 40a and 40b, respectively. At the same time, the child bags B2a and B2b are placed in the tray 42, and then the upper lid 4
Close 3. The blood in the parent bag B1 has already been separated by a centrifuge into an upper layer, an intermediate layer and a lower layer.

When the blood bag B has been set in the housing 15 in this way, the first pressure plate 19 serving as a door is closed. Next, the start switch 87 of the control unit C shown in FIG. 4 is turned on. Both clamp members 40
The solenoids a and b are closed by the solenoids 41a and 41b. When the start switch 87 is turned on, the timer 51 is first set and the weight of the parent bag B1 is measured. The weight of the parent bag B1 is calculated by subtracting the tare of the housing 15 and the first and second pressure plates 19 and 20 from the total weight of the container pressure unit 13.
That is, the weight is detected by subtracting the weight of the tare of the container pressurizing unit 13, which is input to the control unit C in advance, from the weight of the container pressurizing unit 13 detected by the weight sensor 44. Here, if the weight of the parent bag B1 is not the predetermined weight, the parent bag B1 is removed as non-conforming,
When the weight is a predetermined weight and it is determined that the weight is suitable, the pressing unit 51 operates. As shown in FIG. 5, the solenoid 68 is actuated to push out the advancing / retreating rod 67, and the slope 66a of the V-shaped groove of the V-shaped body provided at the tip of the advancing / retreating rod 67 is pressed against the columns 60a and 60b. Prop 60
The a and 60b gradually approach each other so as to be caught in the V-shaped groove of the V-shaped body. Therefore, the rollers 53a and 53b provided at the other end on the side opposite to the columns 60a and 60b come close to and closely contact with each other. In this state, the motor provided inside the rollers 53a and 53b causes the rollers to rotate in the direction A of FIG.
The solenoid 73 is operated to push out the advancing / retreating rod 67, and the pressing portion 52 supported by the base plate 71 is approached from the side of the parent bag B1. Therefore, as shown in FIG. 8, while the two rollers 53a and 53b sequentially press a part of the abdominal surface side and the back surface side of the parent bag B1 from the side end portion of the parent bag B1 in close contact with each other (FIG. 8). (A)) That is, the rollers 53a and 53b move and stop at a predetermined position while squeezing (FIG. 8 (B)). As a result, the liquid contained in the parent bag B1 is divided into two regions, and the lower layer S2 is formed in the second port formed in the parent bag B1.
The passage 81 for guiding the liquid can be formed.

Moreover, in the case of this embodiment, since the pressing is performed by the roller, as shown in FIG.
Can be prevented from being pushed by the movement of the roller and wrapping around to the opposite side of the roller on the left side in the figure. Therefore, the accuracy of component separation is greatly improved.

As shown in FIG. 8, the rollers 53a,
Since the lower end of 53b is located above the lower end of the parent bag B1, the formed passage 81 communicates with the lower layer S2. As described above, in order to secure the communication portion between the passage 81 and the lower layer S2, the lower end portions of the rollers 53a and 53b are preferably located above the lower end portion of the parent bag B1. However, since the position where the intermediate layer S3 is formed is not constant, when the lower end positions of the rollers 53a and 53b are positioned on the upper side, the liquid of the lower layer S2 passes through the passage 81 to the second position.
When the liquid in the intermediate layer S3 is discharged from the port,
It will flow in. Therefore, it is preferable that the lower end portions of the rollers 53a and 53b be located as low as possible within a range in which a communication portion between the passage 81 and the lower layer S2 can be secured. Further, in the case of the present embodiment, two rollers are provided in the pressing portion 52, and the rollers are moved while being pressed by the rollers from both the abdominal surface side and the back surface side of the parent bag B1. As shown in the drawing, the escape 82 when the roller 53b enters is provided in a part of the lateral side of the first pressure plate 19. The number of rollers is not limited to two,
It may be one. In this case, as shown in FIG. 9, the roller 83 may be pressed against the first pressure plate 19 and moved while being pressed.

A lower layer S is provided on one side of the parent bag B1.
When the passage 81 for guiding the second liquid to the second port is formed,
Next, the container pressurizing unit 13 is activated to pressurize the parent bag B1. The pressurization is performed by a cam member (not shown) provided on the roller moving means 70 of the pressing unit 51.
Is pushed down against the elastic force of the spring member 31, the tip tapered portion 30a of the push rod 30 engages with the pin 33 of the claw portion 32, and the engagement between the claw portion 32 and the gear 35 is released. The above-mentioned second link 24 attached to the support shaft 23
The second pressure plate 20 presses the parent bag B1 by the spring member 21 so that the lock can be freely rotated. The parent bag B1 is squeezed between the first pressure plate 19 and the second pressure plate 20 from the abdominal surface side and the back surface side. In this squeezed state, the door body is made of a transparent body. , Visible to the operator.

Further, the vacuum pump P also starts its operation to reduce the pressure in the tray 42. In this way, the component blood is smoothly delivered to the child bags B2a and B2b. When the pressurization of the parent bag B1 is started, both clamp members 40a and 40b are appropriately opened and closed, and the plasma layer S1 or the red blood cell layer S2 in the parent bag B1 is passed through the tube t to the child bags B2a and B2b, respectively. Sent. However,
During this pressurization, the position of the intermediate layer S3 of the parent bag B1, the pressure in the tray 42, and the weight of the parent bag B1 are constantly detected.

The position of the middle layer S3 of the parent bag B1 is the first
It is detected by the interface detection member 43 provided on the pressure plate 19. The measured value of the interface detection member 43 is ± a from the initial value X0 (here, + a indicates that the position of the intermediate layer S3 is displaced upward, and -a indicates that the position of the intermediate layer S3 is displaced downward. (Indicating that the clamps are engaged) within a predetermined range, the open / closed state of both clamp members 40a, 40b is continued. However, for example, the middle layer S3 of the parent bag B1
When the position exceeds + a, the outflow amount of the upper plasma layer S1 is large, so that the tube t through which the plasma layer S1 flows
The clamp member 40a is closed. Conversely, the parent bag B1
When the position of the intermediate layer S3 of the above exceeds -a, the outflow amount of the red blood cell layer S2 below is large, so that the clamp member 40b of the tube t through which the red blood cell layer S2 flows is closed. In this manner, the component blood is allowed to flow out while controlling the middle layer S3 so that it is always at the middle position in the parent bag B1.

The present embodiment is provided with a weight measuring unit for constantly measuring the weight of the parent bag B1 so that when the remaining weight in the parent bag B1 reaches a predetermined weight, the parent bag B1
The pressing against is stopped, and both clamp members 40a, 40b
Is blocked and the outflow of component blood is stopped. Since the pressure detection in the tray 42 is for smoothing outflow of the component blood to the child bag B2, when the pressure in the tray 42 does not reach a predetermined decompression, a pressure error is detected in the parent bag B1. Pressurization is stopped. The time of pressurization performed in this manner is detected by the timer 51 provided on the control panel 50 provided on the front surface of the main body case 14 and input to the control unit.

When each component blood is taken out from the parent bag B1 to the child bag B2 in this manner, both clamp members 40a and 40b are closed, and the rollers 53a and 53b provided in the pressing unit 51 are separated from each other. Case 50
Move in and stop at the initial position. In addition, the vacuum pump P,
Also stop weight measurement. In this state, the tubes t1 and t
2 is closed with a clip etc., the door is opened, and the parent bag B1
The child bags B2a and B2b are removed from the liquid separation device.

Here, in this embodiment, when the door is opened, the second pressure plate 20 is retracted, and the container pressure unit 18 is in a pressure-ready state, that is, when the door is opened, the parent bag is immediately opened. You will be ready to pressurize B1. As the door is opened, the third link 2 is moved through the link mechanism 27.
5 is pressed, the second pressure plate 20 is retracted against the elastic force of the spring member 21, and the ratchet wheel 35 and the claw portion 32 are
And are engaged and locked.

The present invention is not limited to the above-mentioned embodiments, but can be modified and used as appropriate within the scope of the claims. For example, in the above-described embodiment, the blood bag is used to separately collect each component blood, but the present invention is not limited to this and can be used to separately collect various liquids. Further, as shown in FIG. 10, the parent bag B1 has a seal portion 84 formed only near the top of the bag by heat-sealing the front and back surfaces thereof, thereby forming a passage for taking out upward from the top of the bag. It is also possible to use the one independently formed only in the vicinity, or, as shown in FIG. 11, a fragmentary seal portion in which the abdominal surface side and the back surface side of the portion to which the roller is pressed and brought into close contact are heat-sealed or the like. You may use what formed 85. Further, as shown in FIG. 12, the first port Q1 to which the tubes t1 and t2 are connected.
Alternatively, the parent bag B1 may be held by the container holding portion 11 with the second port Q2 positioned on the lower side. In this case, the communication part of the passage 81 by the roller 53 becomes the parent bag B.
1 will be formed above 1, and the components of the upper layer S1 will be taken out from below. Further, FIG. 13 is a view of the vicinity of the parent bag B1 as seen from above. In this way, a pressing method for driving both the pressing members 86 on both sides of the parent bag B1 to pressurize the parent bag B1 is adopted. Alternatively, the lower pressure bias method shown in FIG. 17, the parallel pressurization method shown in FIG. 18, or the upper pressure bias method not shown may be used. Furthermore, although automatic pressurization is adopted in the embodiment, manual pressurization may be used.

[0040]

As described above, according to the present invention, while the roller type pressing member maintains the three regions of the upper layer, the intermediate layer and the lower layer, the roller type pressing member can be removed from the side wall at one end of the parent container. It moves a predetermined distance while being pressed laterally toward the side wall at the other end. Thus, a contact portion is formed on the two opposing surfaces of the parent container, between the first outlet and the second outlet, across the intermediate layer, and before the predetermined distance from the other end of the parent container, and The contact portion forms a passage communicating with the second outlet in the parent container. Next, by the second pressing member,
When the parent container is pressed and the upper layer is on the side of the first outlet and the second outlet, the lower layer is guided to the second outlet through the passage and the upper layer is Taken to the first exit. In addition, the lower layer has the first outlet and the second layer.
, The upper layer is led to the second outlet and the lower layer is led to the first outlet through the passage. Therefore, it is not necessary to form a passage in the container in advance, and all the outlets for extracting a plurality of fluids can be attached to the top or the bottom of the parent container, so that each component of the fluid can be taken out from one direction and the handling is easy. It will be extremely easy.

Further, since the roller type pressing member advances while pressing the parent container, the upper layer and the intermediate layer are pushed by the movement of the roller type pressing member, and the intermediate layer wraps around the passage formed by the roller type pressing member. Can be prevented. Therefore, the accuracy of component separation is greatly improved.

Furthermore, when the parent container is attached to the separating device,
Since either side may be turned upside down, the workability in handling the parent container is extremely high.

[Brief description of drawings]

FIG. 1 is a schematic perspective view of a liquid separation device according to an embodiment of the present invention,

FIG. 2 is a plan view showing an example of a blood bag,

FIG. 3 is a sectional view taken along line 3-3 of FIG.

4 is a horizontal cross-sectional view showing the main part of FIG.

FIG. 5 is an enlarged perspective view of a pressing unit and a pressing plate.

FIG. 6 is an explanatory view showing a pressurizing operation of the container pressurizing unit,

FIG. 7 is an explanatory view showing an unlocked state of the container pressing unit,

FIG. 8 is a schematic front view and a plan sectional view showing a pressing operation by a roller.

FIG. 9 is a plan sectional view showing a pressing operation by another roller.

FIG. 10 is a front view showing an embodiment of a parent bag.

FIG. 11 is a front view showing an embodiment of a parent bag.

FIG. 12 is a schematic front view and a plan sectional view showing a state in which a parent bag held by another holding method is pressed by rollers.

FIG. 13 is a plan view showing another method of pressurizing the bag.

FIG. 14 is a front view showing an example of a conventional blood bag,

FIG. 15 is a schematic front view showing another example of a conventional blood bag,

FIG. 16 is a schematic front view showing still another example of a conventional blood bag,

FIG. 17 is a schematic explanatory view showing an example of a conventional liquid separation device.

FIG. 18 is a schematic explanatory view showing another example of a conventional liquid separation device.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 11 ... Container holding part, 12 ... Clamping member, 13 ... Container pressing unit, 14 ... Main body case, 18 ... Container pressing part, 19 ... 1st pressing plate (supporting member), 20 ... 2nd pressing plate ( Second pressing member) 51 ... Pressing unit 53 ... Roller (roller type pressing member) 68, 73 ... Solenoid (pressing means) 81 ... Passage B ... Bag, B1 ... Parent bag (parent container), B2a, B2b ... Child bag , Q1 ... first port (first outlet), Q2 ... second port (second outlet), S1 ... upper layer, S2 ... lower layer, S3 ... intermediate layer, t1, t2 ... tube,

─────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] March 18, 1993

[Procedure Amendment 1]

[Document name to be corrected] Drawing

[Correction target item name] All drawings

[Correction method] Change

[Correction content]

[Figure 1]

[Fig. 2]

[Figure 9]

[Figure 10]

FIG. 11

[Figure 3]

[Figure 4]

[Figure 5]

[Figure 6]

[Figure 7]

[Fig. 13]

FIG. 14

FIG. 17

FIG. 18

[Figure 8]

[Fig. 12]

FIG. 15

FIG. 16

Claims (1)

[Claims] 1. A composition containing fractionated components in at least three layers of an upper layer, an intermediate layer and a lower layer, wherein the first outlet and the second layer are provided on one side of the upper layer or the lower layer. A container holding part for holding a flexible parent container provided with an outlet, a support member for supporting one of two facing surfaces of the parent container held by the container holding part, and the other face A liquid separating apparatus having a container pressing portion formed of a pressing member that presses the pressing member, the pressing device driving the pressing member, the pressing member being provided adjacent to the roller-type pressing member. A second pressing member, wherein the roller-type pressing member is laterally moved from one side wall to the other side wall of the parent container while maintaining the three regions of the upper layer, the intermediate layer and the lower layer. While pressing it, move it for a predetermined distance, and A contact portion is formed on two opposite surfaces of the parent container across the intermediate layer from a space between the second outlets and a predetermined distance before the other end of the parent container, and the inside of the parent container is formed by the contact portion. A passage communicating with the second outlet is formed, the second pressing member presses the parent container, and when the upper layer is on the side of the first outlet and the second outlet, Directing the lower layer to the second outlet through a passage,
Directing the upper layer to the first outlet and, if the lower layer is on the side of the first outlet and the second outlet, guiding the upper layer to the second outlet through the passage;
A liquid separation device, characterized in that the lower layer is guided to the first outlet.