JPH06157248A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic, having strong hair tonic action and capable of significantly manifesting effects such as prevention of depilation and promotion of hair growth. CONSTITUTION:This hair tonic is characterized by including dantrolene expressed by the formula as an active ingredient therein. The dantrolene is blended in an amount of usually about 0.0001-10wt.%, preferably 0.001-5wt.% based on the total amount of the hair tonic. The hair tonic can be produced according to a well-known method. That is, since the dantrolene is usually powdery, it is dissolved in ethanol, etc., regulated so as to provide a prescribed concentration, as necessary, blended with other ingredients and additives, etc., and then treated according to a conventional method. Thereby, this hair tonic can be prepared as any form applicable to the scalp such as a liquid, an emulsion or an ointment, e.g. a hair tonic, a lotion or a hair cream.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent, and more particularly to a hair nourishing agent which is used in the fields of pharmaceuticals, quasi-drugs and cosmetics and has excellent hair-preventing action such as hair loss prevention and hair growth effect.

[0002]

2. Description of the Related Art Conventionally, hair nourishing cosmetics containing various chemicals have been known in order to remove or reduce the causes of baldness and hair loss.
For example, the herbaceous extract and acetylcholine derivative for the purpose of improving the blood flow to the hair root, female hormone agents such as estradiol as an anti-male hormone, and hinokitiol for the purpose of improving scalp metabolism have been added as hair nourishing ingredients. Hair cosmetics are used for the prevention and treatment of alopecia. However, the mechanism of hair loss and hair growth is very complicated, and just as with conventional hair nourishing cosmetics, it is sufficient to prevent the hair loss by only combining Sengburi extract, etc. for promoting blood circulation and deactivating male hormones. The current situation is that the hair growth effect is not obtained.

On the other hand, the dantrolene represented by the formula (I) is used as a peripheral muscle relaxant (Yano E. et a
l. Masui to Sosei 27, Suppl. 25: 113-118 (1991), Dh
illon DSet al. Drug Dev Res 25, 2: 161-169 (199
2)), its hair nourishing effect has not been reported yet.

[0004]

[Chemical 2]

An object of the present invention is to provide a hair nourishing agent capable of sufficiently exhibiting a hair loss preventing effect and a hair growth promoting effect by incorporating a novel hair nourishing component.

[0006]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present invention removes hair by incorporating dantrolene, which has been conventionally used as a peripheral muscle relaxant, as a hair-feeding component. It was found that an effect of preventing the hair growth and an effect of promoting hair growth were obtained, and the present invention was completed.

That is, the gist of the present invention is the formula (I):

[0008]

[Chemical 3]

The present invention provides a hair nourishing agent characterized by containing dantrolene as an active ingredient.

The dantrolene used in the present invention is a substance known as a peripheral muscle relaxant as described above, and is easily commercially available (for example, manufactured by Sigma). In addition, it can be easily synthesized by a known method (Ellis KO
et al., J. Pharm. Sci., 69, 3, 327-331, (1980)).
In the present invention, the compounding amount of dantrolene is usually about O.OOO1 to 1O% by weight, preferably about O.OO1 based on the total amount of the hair restorer.
~ 5% by weight. If the blending amount is less than O.OOO1% by weight, the hair loss preventing effect and the hair growth promoting effect are not sufficient, and even if the blending amount exceeds 1O% by weight, the effect corresponding to the blending amount cannot be obtained. Moreover, the stability of the hair nourishing agent becomes problematic.

In the hair nourishing agent of the present invention, in addition to dantrolene, which is an active ingredient, minoxidil, diazoxide, and
Various antiandrogens, such as oxendron, 4-
Androstene-3,17-dione-17-cyclic ethylene ketal derivatives such as nicotinic acid and its derivatives, carbronium chloride, vitamin E acetate, vitamin E nicotinate, pantothenic acid and its derivatives,
Biotin, glycyrrhizinic acid, glycyrrhetinic acid, Cordyceps sinensis extract, Korean ginseng extract, assembly extract, capsicum extract, cepharanthin, placenta extract,
For the purpose of increasing the effect of the present invention, ethinyl estradiol, carpronium chloride, photosensitizer, other vitamins, amino acids and the like can be appropriately selected and mixed at the same time.

Further, in the hair nourishing agent of the present invention, additives usually used in hair nourishing cosmetics, such as hinokitiol,
Hexachlorophene, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and bithionol, cooling agents such as menthol, salicylic acid, zinc and its derivatives, drugs such as lactic acid and its alkyl esters, Oil oil such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols, other surfactants, fragrances, antioxidants, UV absorbers, pigments, ethanol, water, moisturizers, thickeners, etc. It can be appropriately selected and blended within a range that does not impair the effects of the invention.

The hair nourishing agent of the present invention can be produced by a known method. That is, since dantrolene is usually in the form of powder, it is dissolved in ethanol or the like, adjusted to have a predetermined concentration, and optionally blended with the above-mentioned other active ingredients, additives, etc., and then according to a conventional method. By treatment, it can be prepared in any shape applicable to the scalp, such as liquid, milky, ointment, etc., for example, hair tonic, lotion, hair cream and the like. The obtained hair nourishing agent achieves the hair loss preventing effect and the hair growth promoting effect by appropriately using an appropriate amount according to a conventional method.

[0014]

EXAMPLES The present invention will be described in more detail with reference to Examples and Test Examples, but the present invention is not limited to these Examples. Test Example 1 Test for Proliferation of Cultured Hair Mother Cells Hair tissues of a mouse were collected and incubated in serum-free medium at 37 ° C., 5% C
Hair mother cells were cultured for 6 days under O ₂ condition (Tanigaki
N. et al. Arch Dermatol Res 282: 4O2-4O7 (199O)).
Dantrolene obtained from Sigma was adjusted to a concentration of 10 ^-9 to 10 ^-4 M when dissolved in the medium, and the culture was started 1.
Dantrolene was added to each medium on the day. The control group was cultured only in serum-free medium without adding dantrolene. After culturing for 6 days, the cells were detached from the dish and the number of cells was determined. The effect of dantrolene was expressed as a relative ratio when the number of cells in the control group was 100%. The results are shown in Table 1.

[0015]

[Table 1]

As is clear from Table 1, dantrolene exhibits a growth promoting effect on cultured hair mother cells, and particularly when the concentration of dantrolene in the medium is 1 O ^-6 M and 1 O ^-7 M, a remarkable growth promoting effect. showed that.

Test Example 2 Hair Growth Acceleration Test Using C3H Mice Dantrolene obtained from Sigma was dissolved in ethanol to prepare a concentration of 1% by weight. The back of a C3H male mouse (8 weeks old) was shaved to a size of about 2 × 4 cm, and the solution was applied to the shaved portion once a day for 15 days from the next day.
O. 1 ml of each was applied, and the effect on hair regrowth at that site was examined. In addition, ethanol containing no dantrolene was applied to the control group. The effect of dantrolene was expressed as a relative ratio when the hair weight of the control group (ethanol application group) was 100%. The results are shown in Table 2.

[0018]

[Table 2]

As is clear from Table 2, dantrolene showed a remarkable hair growth promoting effect as compared with the control group.

Example 1 Hair tonics were produced by a conventional method by mixing the components according to the following formulation. [Components] [Blended amount (W / V%)] Dantrolene 0.03 95% Ethanol 70 Polyoxyethylene hydrogenated castor oil [6OE.O.] 1 Propylene glycol 5 Perfume Trace water balance (Adjust to 100)

Example 2 A lotion was produced by a conventional method by mixing the components according to the following formulation. [Components] [Blending amount (W / V%)] Hydroxyethyl cellulose 0.4 Ethanol 5 Butane-1,3-diol 5 Paraoxybenzoic acid ester 0.2 Dantrolene 0.05 Perfume 1 Water balance (adjusted to 100)

Example 3 A hair cream was produced by a conventional method by mixing the components according to the following formulation. [Components] [Amount (W / V%)] Beeswax 5 Lanolin 4 Vaseline 5 Liquid paraffin 33 Polyoxyethylene 2OE.O. 4 Sorbitan monostearate paraoxybenzoate 0.2 Perfume Trace amount dantrolene 0.1 Borax 1 water balance (adjusted to 100)

Example 4 Hair tonics were produced by a conventional method by mixing the components according to the following formulation. [Components] [Blended amount (W / V%)] Polyoxyethylene hydrogenated castor oil [6OE.O.] 1 Propylene glycol 5 Perfume Trace amount dantrolene 3 95% Ethanol 60 Water balance (adjusted to 100)

[0024]

EFFECTS OF THE INVENTION The hair nourishing agent of the present invention has a strong hair nourishing action and can significantly exhibit effects such as hair loss prevention and hair growth promotion.

Claims (1)

[Claims] 1. Formula (I): A hair nourishing agent containing dantrolene represented by the formula (1) as an active ingredient.