JPH06145B2 - Sterile dissolution solution introducing device and dissolution solution introducing method using the same - Google Patents
Sterile dissolution solution introducing device and dissolution solution introducing method using the sameInfo
- Publication number
- JPH06145B2 JPH06145B2 JP61031491A JP3149186A JPH06145B2 JP H06145 B2 JPH06145 B2 JP H06145B2 JP 61031491 A JP61031491 A JP 61031491A JP 3149186 A JP3149186 A JP 3149186A JP H06145 B2 JPH06145 B2 JP H06145B2
- Authority
- JP
- Japan
- Prior art keywords
- bottle
- solution
- piercing
- protector
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims description 7
- 238000004090 dissolution Methods 0.000 title description 33
- 239000007788 liquid Substances 0.000 claims description 55
- 239000003814 drug Substances 0.000 claims description 38
- 230000001012 protector Effects 0.000 claims description 28
- 229940079593 drug Drugs 0.000 claims description 27
- 230000001954 sterilising effect Effects 0.000 claims description 20
- 229920001971 elastomer Polymers 0.000 claims description 19
- 238000004659 sterilization and disinfection Methods 0.000 claims description 19
- 239000006166 lysate Substances 0.000 claims description 6
- 239000000243 solution Substances 0.000 description 42
- 238000011109 contamination Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
Description
【発明の詳細な説明】 ＜産業上の利用分野＞ 本発明は、無菌状態で一方の薬瓶より他方の薬瓶への生
理食塩液や蒸留水、ブドウ糖液などの液体（以下、溶解
液という。）を導入するための無菌型溶解液導入器に関
する。DETAILED DESCRIPTION OF THE INVENTION <Field of Industrial Application> The present invention relates to a liquid such as a physiological saline solution, distilled water, or glucose solution from one vial to the other in a sterile state (hereinafter referred to as a dissolution liquid). The present invention relates to an aseptic solution introducer for introducing a.
また本発明は、上記無菌型溶解液導入器を用いて行う新
しい溶解液導入方法に関する。The present invention also relates to a new method for introducing a solution using the above-described aseptic solution introducing device.
尚、本考案に言う溶解液導入器とは、針部の軸方向に沿
って液体流通孔と気体流通孔とが並列に形成され、かつ
その両端に薬瓶のゴム栓に刺通するための刺通部を設け
た針、またはこの針を針部として有する、無菌状態で一
方の薬瓶より他方の薬瓶へ溶解液を導入するための器具
を言う。In addition, the solution introducing device referred to in the present invention has a liquid flow hole and a gas flow hole formed in parallel along the axial direction of the needle portion, and has both ends for piercing the rubber stopper of the drug vial. It is a needle provided with a piercing part, or an instrument having this needle as a needle part for aseptically introducing the solution from one drug bottle to the other drug bottle.
＜従来の技術＞ 抗生剤や血液製剤のように溶液の状態で保存が困難な薬
剤は、保存中の品質維持のために凍結乾燥され粉末にさ
れたものが市販されている。このような粉末状の医薬品
を患者に投与する場合には、一般にこれを溶解液に溶解
させて注射液や点滴液に調剤して用いており、従って溶
解液の入った瓶（以下、溶解液瓶という。）から薬剤の
入った瓶（以下、薬剤瓶という。）に溶解液を無菌的に
導入するための操作が必要である。<Prior Art> Drugs such as antibiotics and blood products that are difficult to store in a solution state are commercially available in freeze-dried and powdered form in order to maintain quality during storage. When administering such a powdered drug to a patient, it is generally used by dissolving it in a solution to prepare an injection solution or an infusion solution, and therefore a bottle containing the solution (hereinafter referred to as a solution solution). It is necessary to aseptically introduce the solution from the bottle) into the bottle containing the drug (hereinafter referred to as the drug bottle).
このような溶解液導入操作においては、従来たとえば、
円板状の板とこの板の中央部を貫通してその両面に突設
した形の針部とからなる溶解液導入器や、この溶解液導
入器にさらに円筒状のケーシングを設け、このケーシン
グが前記円板状の板によって上下２つの部屋に分割され
るように形成された溶解液導入器（実開昭５７−１１７
３５１号公報）などが用いられている。またこれらの溶
解液導入器を用いて溶解液の導入操作を行う場合には、
菌による汚染を防止するために針部に被冠してあるプロ
テクタを取り外し、まず一方の刺通部を溶解液瓶のゴム
栓に刺通し、次いで他方の刺通部を薬剤瓶のゴム栓に刺
通（第６図参照）、それから溶解液瓶と薬剤瓶の位置を
逆転して溶解液が自身の重力によって液体流通孔を通っ
て薬剤瓶の中へ導入されるようにしていた。In such a solution introducing operation, conventionally, for example,
Dissolving liquid introducer consisting of a disc-shaped plate and needles penetrating the central part of this plate and protruding on both sides thereof, and this dissolving liquid introducing device is further provided with a cylindrical casing. Is formed by the disc-shaped plate so as to be divided into two chambers, an upper chamber and a lower chamber.
No. 351) is used. When performing the operation of introducing the solution using these solution introducing devices,
Remove the protector capped on the needle to prevent contamination by bacteria, first pierce one of the piercing parts into the rubber stopper of the solution bottle, and then pierce the other piercing part into the rubber stopper of the drug bottle. Then, the positions of the dissolution liquid bottle and the medicine bottle were reversed, and the dissolution liquid was introduced into the medicine bottle through the liquid circulation hole by its own gravity.
＜従来技術の問題点＞ しかしながら、従来の溶解液導入器は、刺通部を溶解液
瓶に刺通した時に、一般に溶解液瓶は僅かではあるが減
圧になっており、また液体流通孔も気体流通孔も両方の
刺通部に開口しているので、もう一方の刺通部から外気
が侵入し溶解液瓶内を汚染する虞れがあり問題であっ
た。<Problems of the prior art> However, in the conventional solution introducing device, when the piercing part is pierced into the solution bottle, the solution bottle is generally slightly depressurized, and the liquid circulation hole is also formed. Since the gas flow holes are also opened in both piercing parts, there is a possibility that outside air may enter from the other piercing part and contaminate the inside of the dissolution liquid bottle.
また従来の溶解液導入器は、液体流通孔と気体流通孔の
開口部の高さが異っているため、一方の刺通部を溶解液
瓶のゴム栓に刺通した後もう一方の刺通部を薬剤瓶に刺
通する場合、第６図に示すような液体流通孔の開口部が
薬剤瓶の内にあり気体流通孔の開口部が薬剤瓶の外にあ
るような状態が生じ、一般に薬剤瓶は減圧になっている
ので、気体流通孔から外気が進入し溶解液瓶内および薬
剤瓶内を汚染する虞れがあり問題であった。Further, in the conventional solution introducing device, since the heights of the openings of the liquid flow hole and the gas flow hole are different, one of the piercing parts is pierced into the rubber stopper of the solubilizing solution bottle and the other is pierced. When the passage portion is pierced into the medicine bottle, a state occurs in which the opening of the liquid circulation hole is inside the medicine bottle and the opening of the gas circulation hole is outside the medicine bottle as shown in FIG. Since the chemical bottle is generally depressurized, there is a risk that outside air may enter through the gas flow hole and contaminate the inside of the dissolution liquid bottle and the inside of the chemical bottle.
＜問題点を解決するための手段＞ 本願発明者は上記第１番目の問題点に鑑み鋭意検討を行
った結果、溶解液導入器の刺通部に除菌フィルタ付きの
プロテクタを被冠することに想到した。ところがこの刺
通部に除菌フィルタ付きのプロテクタを被冠した溶解液
導入器について実験を行ったところ、上記第２番目の問
題が生じることが分った。そこでさらに検討を行った結
果、液体流通孔と気体流通孔の開口部の高さをほぼ同じ
高さにすれば、より完全に溶解液導入操作中の外気の侵
入による汚染を無くすることができることに想到し、本
発明を完成した。<Means for Solving Problems> As a result of earnest studies in view of the above-mentioned first problem, the inventor of the present application wears a protector with a sterilization filter on the piercing part of the solution introducing device. Was conceived. However, when an experiment was conducted on a lysate introducer in which a protector with a sterilization filter was attached to the piercing part, it was found that the second problem described above occurred. Therefore, as a result of further study, if the heights of the openings of the liquid flow hole and the gas flow hole are almost the same, it is possible to more completely eliminate the contamination caused by the invasion of the outside air during the operation of introducing the solution. And completed the present invention.
また本発明の溶解液導入器を用いて従来の溶解液導入方
法と同様に、先に溶解液瓶のゴム栓に刺通し次いで薬剤
瓶のゴム栓に刺通する方式で溶解液導入操作を行った場
合、しばしば溶解液が流れなくなるという問題が生じた
ので、この点について鋭意検討を行ったところ、先に薬
剤瓶のゴム栓に刺通して薬剤瓶の内部の気圧を外気と同
じくした後溶解液瓶のゴム栓に刺通することにより、前
記問題点が解決されることを見出し、本願の第２番目の
発明を完成した。Further, similarly to the conventional dissolution liquid introduction method using the dissolution liquid introduction device of the present invention, the dissolution liquid introduction operation was performed by a method of first piercing the rubber stopper of the dissolution liquid bottle and then piercing the rubber stopper of the drug bottle. In this case, there was often the problem that the dissolution liquid would not flow, so when we made a thorough study on this point, we first pierced the rubber stopper of the drug bottle to make the internal pressure of the drug bottle equal to the outside air, and then the dissolution liquid bottle. It was found that the above problems can be solved by piercing the rubber plug of No. 3, and completed the second invention of the present application.
すなわち本発明は、溶解液導入器の針部の２つの刺通部
に被冠したプロテクタのうち、少なくとも一方のプロテ
クタが除菌フィルタ付きプロテクタであることを特徴と
する無菌型溶解液導入器であり、液体流通孔と気体流通
孔の開口部は、針部の軸方向に沿ってほぼ同じ高さに形
成されたものが好ましい。That is, the present invention relates to an aseptic solution introducing device, wherein at least one of the protectors covered with the two piercing portions of the needle of the solution introducing device is a protector with a sterilization filter. It is preferable that the openings of the liquid flow hole and the gas flow hole are formed at substantially the same height along the axial direction of the needle portion.
また本発明は、無菌型溶解液導入器の一方の刺通部に除
菌フィルタ付きプロテクタを被冠したまま、他方の刺通
部を薬剤瓶のゴム栓に刺通し、該薬剤瓶内の気圧を外気
と同じくした後、前記除菌フィルタ付きプロテクタを取
り外し、該プロテクタを取り外した刺通部を溶解液瓶の
ゴム栓に刺通し、前記溶解液瓶が無菌型溶解液導入器を
挾んで前記薬剤瓶の上に乗るように配置することを特徴
とする溶解液導入方法である。Also, the present invention, while the protector with a sterilization filter is capped on one of the piercing parts of the aseptic solution introducing device, the other piercing part is pierced into the rubber stopper of the drug bottle, and the atmospheric pressure in the drug bottle is adjusted After making it the same as the outside air, remove the protector with the sterilization filter, pierce the rubber stopper of the dissolution liquid bottle with the piercing part with the protector removed, and the dissolution liquid bottle sandwiches the sterile type dissolution liquid introduction device and the drug bottle. It is a method for introducing a dissolution liquid, which is characterized in that the dissolution liquid is introduced so as to be placed on top of.
＜作用＞ 本発明の溶解液導入器は、少なくとも一方の刺通部に除
菌フィルタ付きプロテクタを被冠してあるので、その一
方の刺通部に除菌フィルタ付きプロテクタを被冠したま
まもう一方の刺通部を薬剤瓶に刺通した場合、外気は除
菌フィルタで浄化された後気体流通孔を通って薬剤瓶内
に導入されるので、薬剤瓶内が汚染されることはない。<Operation> Since the lysate introducer of the present invention has at least one of the piercing portions capped with the sterilization filter, the other piercing portion still has the sterilization filter-protected protector. When one of the piercing parts is pierced into the medicine bottle, the outside air is purified by the sterilization filter and then introduced into the medicine bottle through the gas circulation hole, so that the inside of the medicine bottle is not contaminated.
また、本発明の溶解液導入器は、針部の軸方向に沿って
形成された液体流通孔と気体流通孔の開口部の高さがほ
ぼ等しいので、もう一方の刺通部を溶解液瓶に刺通した
場合、液体流通孔と気体流通孔の開口部はほぼ同時に溶
解液瓶内の雰囲気に露出されることになり、従って汚染
した外気が気体流通孔を通って薬剤瓶内に入り、次いで
液体流通孔を通って溶解液瓶内に流入するというような
第６図に示すのと同様の現象を生ずることはなく、瓶内
が汚染されることもない。Further, in the solution introducing device of the present invention, since the height of the opening of the liquid flow hole and the opening of the gas flow hole formed along the axial direction of the needle portion is substantially equal, the other piercing part is used as the solution bottle. When pierced into, the opening of the liquid flow hole and the gas flow hole will be exposed to the atmosphere in the dissolution liquid bottle almost at the same time, and therefore contaminated outside air enters the drug bottle through the gas flow hole, Next, the phenomenon similar to that shown in FIG. 6 such as flowing into the dissolution liquid bottle through the liquid circulation hole does not occur, and the inside of the bottle is not contaminated.
また本発明の溶解液導入方法は、まず薬剤瓶内の気圧を
外部の気圧と等しくした後に薬剤瓶内部と溶解液瓶内部
とを連通しているので、溶解液導入器を介して連通され
た薬剤瓶内の気圧は僅かではあるが溶解液瓶内の気圧よ
り大きくなり、従って溶解液導入器を介して薬剤瓶が下
に溶解液瓶が上になるように配置した場合、気体は高圧
側から低圧側に移動するので、薬剤瓶内の空気が気体流
通孔を通ってスムーズに溶解液瓶内に流入することがで
き、従って溶解液ももう一方の液体流通孔を通ってスム
ーズに薬剤瓶内に導入される。Further, in the dissolution liquid introducing method of the present invention, first, the atmospheric pressure inside the drug bottle is made equal to the atmospheric pressure outside, and then the inside of the drug bottle and the inside of the dissolution liquid bottle are communicated with each other. The air pressure inside the drug bottle is slightly higher than the air pressure inside the solution bottle. Therefore, when the drug bottle is placed downward and the solution bottle up through the solution introducer, the gas is on the high pressure side. Since it moves from the low pressure side to the low pressure side, the air in the drug bottle can smoothly flow into the dissolution liquid bottle through the gas circulation hole, and therefore the dissolution liquid also smoothly flows through the other liquid circulation hole. Will be introduced in.
＜実施例＞ 次に図面を用いて本発明の実施例について説明する。<Example> Next, the Example of this invention is described using drawing.
第１図および第２図はそれぞれ本発明の溶解液導入器の
一実施例を示す正面図および平面図（プロテクタは省略
してある）、第３図は第２図のＸ−Ｘ線断面図、第４図
は本発明の溶解液導入器を薬液瓶に連通し外気を導入す
る操作の説明図、第５図は本発明の溶解液導入器を用い
た溶解液導入操作の説明図であり、第６図は従来の溶解
液導入器を用いた溶解液導入操作の問題点説明図であ
る。1 and 2 are a front view and a plan view (a protector is omitted) showing an embodiment of the solution introducing device of the present invention, and FIG. 3 is a sectional view taken along line XX of FIG. FIG. 4 is an explanatory view of an operation of communicating the dissolution liquid introducing device of the present invention with a chemical liquid bottle to introduce outside air, and FIG. 5 is an explanatory view of a dissolution liquid introducing operation using the dissolution liquid introducing device of the present invention. FIG. 6 is an explanatory view of problems in a solution introducing operation using a conventional solution introducing device.
第１〜３図に示されるように本発明の溶解液導入器は、
両端が開いた円筒状ケーシング(1)の内部に、このケー
シング(1)と共に一体に成形された分離板(2)と、この分
離板(2)を貫通する針部(5)および、この針部(5)の刺通
部（５ａ）および（５ｂ）に被冠したプロテクタ（省略
してある）とからなり、針部(5)には液体流通孔(3)と気
体流通孔(4)とが針部(5)の軸方向に沿って平行に形成さ
れており、プロテクタの少なくとも一方は除菌フィルタ
付きプロテクタである。そして前記液体流通孔(3)と気
体流通孔(4)の開口部（３ａと４ａ、３ｂと４ｂ）は、
第６図のように気体流通孔の開口部（４ａ）が薬剤瓶(1
1)の外側にあり液体流通孔の開口部（３ａ）が薬剤瓶の
内側にあるようなことの起らないように、近接した高さ
に形成されており、好ましくは、ほぼ同じ高さに形成さ
れている。As shown in FIGS. 1 to 3, the solution introducing device of the present invention is
Inside the cylindrical casing (1) whose both ends are open, a separating plate (2) integrally formed with this casing (1), a needle portion (5) penetrating the separating plate (2), and this needle. A protector (not shown) capped on the piercing parts (5a) and (5b) of the part (5), and the needle part (5) has a liquid flow hole (3) and a gas flow hole (4). And are formed parallel to each other along the axial direction of the needle portion (5), and at least one of the protectors is a protector with a sterilization filter. The openings (3a and 4a, 3b and 4b) of the liquid flow hole (3) and the gas flow hole (4) are
As shown in FIG. 6, the opening (4a) of the gas flow hole is the medicine bottle (1
The openings (3a) on the outside of 1) are not close to each other so that the opening (3a) of the liquid circulation hole is not on the inside of the medicine bottle. Has been formed.
除菌フィルタ付きプロテクタは、通常使用されている形
状のプロテクタの閉鎖端を取り外してそこに除菌フィル
タを詰めたもので良く、円筒状の筒体の一方の開放端が
針部との嵌合部を形成し、他方の開放端がポリアミドや
ポリ塩化ビニルなど製の膜状のフィルタまたは発泡ポリ
ウレタンや脱脂綿やセルロース繊維など製の層状のフィ
ルタで閉鎖されたものである（第４図参照）。A protector with a sterilization filter may be one in which the closed end of a protector of a commonly used shape is removed and the sterilization filter is packed therein, and one open end of the cylindrical tubular body fits with the needle part. And the other open end is closed by a membrane filter made of polyamide or polyvinyl chloride or a layered filter made of foamed polyurethane, absorbent cotton or cellulose fiber (see FIG. 4).
図中(6)は転がり防止用載置面であり、環状の小突起(8
1)および(82)は口部の小さな薬瓶を使用した場合に、刺
通部（５ａ）および／または（５ｂ）を薬瓶のゴム栓に
真直ぐに刺通できるようにするもので、薬瓶の口部が丁
度嵌め込まれる大きさに形成されている。In the figure, (6) is the rolling-prevention mounting surface, which has a small annular protrusion (8
(1) and (82) are for enabling the piercing part (5a) and / or (5b) to be pierced straight into the rubber stopper of the vial when a vial with a small mouth is used. The mouth of the bottle is formed to fit exactly.
本発明の溶解液導入器を使用した溶解液導入操作につい
ては、第４図に示すように、まず溶解液導入器のプロテ
クタ（省略してある）を取り外し、除菌フィルタ付きプ
ロテクタ(9)を被冠したまま、刺通部（５ｂ）を薬剤瓶
(11)のゴム栓(12)に刺通し、液体流通孔(3)および気体
流通孔(4)から薬剤瓶(11)内に除菌フィルタ付きプロテ
クタ(9)で過された清浄な外気を導入して、瓶(11)内
の気圧を瓶(11)外の気圧と等しくする。次にもう一方の
刺通部（５ａ）を第５図に示すように溶解液瓶(13)のゴ
ム栓(14)に刺通すれば、溶解液(15)は自身の重力によっ
て液体流通孔(3)を通って薬剤瓶(11)に導入される。Regarding the operation of introducing the lysate using the lysate introducer of the present invention, as shown in FIG. 4, first, the protector (not shown) of the lysate introducer is removed, and the protector (9) with the sterilization filter is attached. With the cap still attached, the piercing part (5b)
Penetrate the rubber stopper (12) of (11) and introduce clean outside air passed by the protector (9) with the sterilization filter into the drug bottle (11) from the liquid circulation hole (3) and the gas circulation hole (4). Then, the atmospheric pressure inside the bottle (11) is made equal to the atmospheric pressure outside the bottle (11). Next, the other piercing part (5a) is pierced through the rubber stopper (14) of the dissolution liquid bottle (13) as shown in FIG. It is introduced into the medicine bottle (11) through (3).
尚刺通部（５ａ）の溶解液瓶(13)のゴム栓(14)への刺通
は、瓶(13)を持ってそのゴム栓(14)を刺通部（５ａ）に
押し当てて行っても良いし、第６図のように溶解液瓶(1
3)を下に置いて上から刺通部（５ａ）を瓶(13)のゴム栓
(14)に押し当てて行っても良い。To pierce the rubber stopper (14) of the dissolution liquid bottle (13) of the piercing portion (5a), hold the bottle (13) and press the rubber stopper (14) against the piercing portion (5a). You can go, or you can go to the dissolution bottle (1
Place 3) underneath and insert the piercing part (5a) from above into the rubber stopper of the bottle (13).
You may press against (14).
＜効果＞ 以上述べてきたことから明らかなように、本発明の溶解
液導入器は次のような利点を有する。<Effect> As is clear from what has been described above, the solution introducing device of the present invention has the following advantages.
(1) 溶解液導入器の針部の２つの刺通部のうち少なく
とも一方の刺通部に除菌フィルタ付きプロテクタを被冠
してあるので、この刺通部に除菌フィルタ付きプロテク
タを被冠したまま他方の刺通部を薬瓶のゴム栓に刺通し
た場合、液体流通孔や気体流通孔から外部の汚染された
空気がそのまま瓶内に導入されることがなく、除菌フィ
ルタで過された清浄な空気が導入されるので、瓶内が
外部からの空気によって汚染されることがない。(1) Since at least one of the two piercing parts of the needle of the dissolving solution introducing device is covered with a protector with a sterilization filter, this piercing part is covered with a protector with a sterilizing filter. When the other piercing part is pierced into the rubber stopper of the drug vial while still capped, external contaminated air is not introduced into the vial as it is from the liquid circulation hole or gas circulation hole. Since the passed clean air is introduced, the inside of the bottle is not contaminated by the air from the outside.
(2) 液体流通孔と気体流通孔の開口部の高さが針部の
軸方向に沿ってほぼ等しく形成されているので、第６図
に示すような気体流通孔を通って外部の汚染された空気
が侵入するというようなことが起らず、従って瓶内が外
気で汚染されることがない。(2) Since the heights of the openings of the liquid flow hole and the gas flow hole are formed to be almost equal along the axial direction of the needle part, there is no external contamination through the gas flow hole as shown in FIG. The air does not enter, so that the inside of the bottle is not contaminated with outside air.
第１図および第２図はそれぞれ本発明の溶解液導入器の
一実施例を示す正面図および平面図であり（プロテクタ
は省略してある）、第３図は第２図のＸ−Ｘ線断面図で
ある。また第４図は本発明の溶解液導入器を薬剤瓶に連
通し外気を導入する操作の説明図、第５図は本発明の溶
解液導入器を用いた溶解液導入操作の説明図である。 また第６図は従来の溶解液導入器を用いた溶解液導入操
作の問題点説明図である。 ＜主な符号の説明＞ ３：液体流通孔 ４：気体流通孔 3a、3b、4a、4b：開口部 ５：針部 5a、5b：刺通部 ９：除菌フィルタ付きプロテクタ 10：除菌フィルタ 11：薬剤瓶 13：溶解液瓶1 and 2 are a front view and a plan view, respectively, showing an embodiment of the solution introducing device of the present invention (a protector is omitted), and FIG. 3 is a line XX of FIG. FIG. Further, FIG. 4 is an explanatory view of an operation of communicating the dissolution liquid introducing device of the present invention with a drug bottle to introduce outside air, and FIG. 5 is an explanatory view of a dissolution liquid introducing operation using the dissolution liquid introducing device of the present invention. . Further, FIG. 6 is a diagram for explaining problems in the solution introducing operation using the conventional solution introducing device. <Description of main symbols> 3: Liquid circulation hole 4: Gas circulation hole 3a, 3b, 4a, 4b: Opening portion 5: Needle portion 5a, 5b: Penetration portion 9: Protector with sterilization filter 10: Sterilization filter 11: Drug bottle 13: Solution bottle
Claims (3)
し、液体流通孔と気体流通孔が該両端の刺通部に開口す
る溶解液導入器において、２つの刺通部に被冠されたプ
ロテクタの少なくとも一方が除菌フィルタ付きプロテク
タであることを特徴とする無菌型溶解液導入器。1. In a solution introducing device having piercing portions protected by protectors at both ends, and a liquid circulation hole and a gas circulation hole opening at the piercing portions at both ends, two piercing portions are capped. At least one of the protected protectors is a protector with a sterilization filter.
流通孔と気体流通孔の開口部の高さがほぼ同じ高さであ
る特許請求の範囲第１項記載の無菌型溶解液導入器。2. The aseptic solution according to claim 1, wherein the heights of the openings of the liquid flow hole and the gas flow hole formed along the axial direction of the needle portion are substantially the same. Introducer.
通孔が該両端の刺通部に開口する溶解液導入器におい
て、一方の刺通部に除菌フィルタ付きプロテクタを被冠
した状態で他方の刺通部を薬剤瓶のゴム栓に刺通し、該
薬剤瓶内の気圧を外気と同じくした後、前記除菌フィル
タ付きプロテクタを取り外し、該プロテクタを取り外し
た刺通部を溶解液瓶のゴム栓に刺通し、前記溶解液瓶が
無菌型溶解液導入器を挟んで前記薬剤瓶の上に乗るよう
に配置することを特徴とする溶解液導入方法。3. A lysate introducer having piercing portions at both ends, and a liquid circulation hole and a gas circulation hole opening at the piercing portions at both ends, wherein one piercing portion is covered with a protector with a sterilization filter. Insert the other piercing part into the rubber stopper of the drug bottle in a capped state, equalize the atmospheric pressure in the drug bottle to the outside air, remove the protector with the sterilization filter, and dissolve the piercing part with the protector removed. A method for introducing a dissolving solution, which is characterized in that the dissolving solution bottle is pierced through a rubber stopper of the solution bottle so that the dissolving solution bottle is placed on the drug bottle with an aseptic solution introducing device interposed therebetween.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61031491A JPH06145B2 (en) | 1986-02-15 | 1986-02-15 | Sterile dissolution solution introducing device and dissolution solution introducing method using the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61031491A JPH06145B2 (en) | 1986-02-15 | 1986-02-15 | Sterile dissolution solution introducing device and dissolution solution introducing method using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62189072A JPS62189072A (en) | 1987-08-18 |
| JPH06145B2 true JPH06145B2 (en) | 1994-01-05 |
Family
ID=12332726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61031491A Expired - Fee Related JPH06145B2 (en) | 1986-02-15 | 1986-02-15 | Sterile dissolution solution introducing device and dissolution solution introducing method using the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH06145B2 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0259196U (en) * | 1988-10-24 | 1990-04-27 | ||
| JPH0852196A (en) * | 1994-08-09 | 1996-02-27 | Material Eng Tech Lab Inc | Transfusion container having connecting port for medicine |
| JP2001340429A (en) * | 2000-06-01 | 2001-12-11 | Welfide Corp | Mixing injector for separating microorganism and stopper body using the same, and drug solution container with the stopper body |
| ES2586679T3 (en) * | 2007-06-13 | 2016-10-18 | Carmel Pharma Ab | Medical device and disposal |
| EP2351549B1 (en) | 2008-11-25 | 2016-03-30 | JMS Co., Ltd. | Connector |
| EP2351550A1 (en) * | 2008-11-25 | 2011-08-03 | JMS Co., Ltd. | Connector |
| CA3068441C (en) | 2009-07-29 | 2024-01-09 | Icu Medical, Inc. | Fluid transfer devices and methods of use |
| JP5502579B2 (en) * | 2010-04-21 | 2014-05-28 | テルモ株式会社 | Medical device connector and drug administration device |
| EP2793978B1 (en) | 2011-12-22 | 2023-03-08 | ICU Medical, Inc. | Fluid transfer devices and methods of use |
| CA2931195C (en) | 2013-11-25 | 2019-09-24 | Icu Medical, Inc. | Methods and systems for filling iv bags with therapeutic fluid |
| JP5875617B2 (en) * | 2014-03-13 | 2016-03-02 | テルモ株式会社 | Medical device connector and drug administration device |
| CA3006951C (en) | 2015-12-04 | 2024-05-14 | Icu Medical, Inc. | Systems, methods, and components for transferring medical fluids |
| USD851745S1 (en) | 2016-07-19 | 2019-06-18 | Icu Medical, Inc. | Medical fluid transfer system |
| JP7046051B2 (en) | 2016-07-25 | 2022-04-01 | アイシーユー・メディカル・インコーポレーテッド | Systems and components for trapping air bubbles in medical fluid transfer modules and systems |
| US11590057B2 (en) | 2020-04-03 | 2023-02-28 | Icu Medical, Inc. | Systems, methods, and components for transferring medical fluids |
| CN111658521A (en) * | 2020-06-28 | 2020-09-15 | 常州海斯卡智能护理技术有限公司 | Medicine dispensing needle head for penicillin bottle |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5757848B2 (en) * | 1977-03-16 | 1982-12-07 | Hitachi Ltd |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0137637Y2 (en) * | 1980-09-19 | 1989-11-13 | ||
| JPS59500600A (en) * | 1982-04-06 | 1984-04-12 | バクスタ−、インターナショナル、インコ−ポレイテッド | Medical liquid drug component mixing device with sterile coupling |
-
1986
- 1986-02-15 JP JP61031491A patent/JPH06145B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5757848B2 (en) * | 1977-03-16 | 1982-12-07 | Hitachi Ltd |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62189072A (en) | 1987-08-18 |
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