JPH06145035A - Ultraviolet ray preventing cosmetic - Google Patents
Ultraviolet ray preventing cosmeticInfo
- Publication number
- JPH06145035A JPH06145035A JP30075592A JP30075592A JPH06145035A JP H06145035 A JPH06145035 A JP H06145035A JP 30075592 A JP30075592 A JP 30075592A JP 30075592 A JP30075592 A JP 30075592A JP H06145035 A JPH06145035 A JP H06145035A
- Authority
- JP
- Japan
- Prior art keywords
- esculin
- lysine
- cosmetic
- ultraviolet
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
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- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は化粧料に関し、詳しく
は、紫外線防止効果に優れた化粧料を提供するものであ
る。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics, and more specifically, to a cosmetic excellent in the effect of preventing ultraviolet rays.
【０００２】[0002]
【従来の技術】日焼けを防止するために、紫外線吸収
剤、紫外線散乱剤等を配合した化粧料が使用されてい
る。このような従来の化粧料は、皮膚に塗布され、皮膚
の表面で紫外線を吸収、散乱させて紫外線を防止するも
のである。2. Description of the Related Art In order to prevent sunburn, cosmetics containing an ultraviolet absorber, an ultraviolet scatterer and the like are used. Such conventional cosmetics are applied to the skin and absorb and scatter ultraviolet rays on the surface of the skin to prevent ultraviolet rays.
【０００３】したがって、これらの紫外線防止化粧料
は、衣類等による摩擦や洗滌で脱離しやすく、そのため
に日焼け防止効果の持続性が良くないという問題点があ
った。また、遮断できる紫外線の波長領域がＵＶ−Ｂ、
ＵＶ−Ｃ領域に限られ、より長波長のＵＶ−Ａ領域で効
果のある紫外線吸収剤が少なく、わずかに粉末状の4-te
rt-フ゛チル-4'-メトキシ-シ゛ヘ゛ンソ゛イルメタン（例えばジボダン社製パ
ルソール1789）を油剤等に溶解させたものが利用されて
いるにすぎなかった。Therefore, these UV-preventive cosmetics have a problem that they are easily removed by rubbing or washing due to clothes or the like, and thus the sunburn-preventing effect is not long-lasting. In addition, the wavelength range of ultraviolet rays that can be blocked is UV-B,
Limited to the UV-C region, there are few UV absorbers that are effective in the longer wavelength UV-A region, and slightly powdered 4-te
Only a solution obtained by dissolving rt-butyl-4'-methoxy-dibenzoylmethane (for example, Parsol 1789 manufactured by Givaudan) in an oil agent or the like was used.
【０００４】一方、ジヒドロキシアセトン（ＤＨＡ）
と、染料の一種であるラウソン（Lawson）を併用する
と、皮膚角層中で紫外線や短波長領域の可視光線を吸収
させる効果を有することが報告されており（フレグラン
ス ジャーナル No. 43 (1980)）、特に日光過敏症患者
に対する紫外線防止法として有効性を示す報告が多数知
られている（例えば、International Journal of Derma
tology 11, No.2, 67 (1972)。しかし、この方法は、あ
る程度のサンスクリーン効果を持続して発揮することが
できるが、皮膚を美容上好ましくない色調に変化させた
り、光線吸収効果が小さいなどの問題が残されている。On the other hand, dihydroxyacetone (DHA)
It has been reported that when used together with Lawson, which is a type of dye, it has the effect of absorbing ultraviolet rays and visible light in the short wavelength region in the stratum corneum of the skin (Fragrance Journal No. 43 (1980)). , And there are many reports that show its effectiveness as a UV protection method, especially for patients with photosensitivity (for example, International Journal of Derma
tology 11, No.2, 67 (1972). However, although this method can continuously exhibit a certain degree of sunscreen effect, it still has problems such as changing the skin to a cosmetically unfavorable color tone and having a small light absorption effect.
【０００５】ところで、ある種の植物に含まれているエ
スクリンが紫外線吸収作用、血管抵抗性の増強作用、リ
ポキシゲナーゼ阻害活性等を有すること、エスクリンを
構成するエスクレチンが紫外線吸収作用を有することが
知られているが、ＵＶ−Ａ領域での吸収作用は十分なも
のではない。By the way, it is known that esculin contained in some plants has an ultraviolet absorbing action, a vascular resistance enhancing action, a lipoxygenase inhibitory activity, etc., and that esculetin, which constitutes esculin, has an ultraviolet absorbing action. However, the absorption effect in the UV-A region is not sufficient.
【０００６】[0006]
【発明が解決しようとする課題】本発明は、このような
観点からなされたものであり、上記問題点を克服するた
めに、耐摩擦性、耐洗滌性に優れ、持続性の良いＵＶ−
Ａ領域を中心とした紫外線防止効果を有する化粧料を提
供することを課題とする。SUMMARY OF THE INVENTION The present invention has been made from such a point of view, and in order to overcome the above-mentioned problems, it is excellent in abrasion resistance and washing resistance, and has good UV-sustainability.
An object of the present invention is to provide a cosmetic having an ultraviolet ray prevention effect mainly in the A region.
【０００７】[0007]
【課題を解決するための手段】本発明者は、上記課題を
解決するために鋭意研究を行った結果、エスクリンが皮
膚角層中の特定のアミノ酸と反応して紫外線、特にＵＶ
−Ａを吸収する層を形成することを見出し、本発明に至
った。Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventor has found that esculin reacts with a specific amino acid in the stratum corneum of the skin to emit ultraviolet rays, particularly UV rays.
The inventors have found that a layer that absorbs -A is formed and have reached the present invention.
【０００８】すなわち本発明は、エスクリンを、化粧料
全量に対し０．０１〜１０重量％含有する紫外線防止化
粧料である。また本発明は、エスクリンとともに、さら
にリジン又は／及びアルギニンを化粧料全量に対し０．
０１〜１０重量％含有する紫外線防止化粧料を提供す
る。That is, the present invention is an ultraviolet-preventing cosmetic containing esculin in an amount of 0.01 to 10% by weight based on the total amount of the cosmetic. Further, in the present invention, together with esculin, lysine and / or arginine is added to the cosmetic in an amount of 0.
Provided is an anti-UV cosmetic containing 0.1 to 10% by weight.
【０００９】以下、本発明を詳細に説明する。 ＜１＞エスクリン エスクリン（エスクレチン−６−β−グルコシド）は、
グルコースにエスクレチンが結合したクマリン配糖体の
一種である（化１）。The present invention will be described in detail below. <1> Esculin Esculin (esculetin-6-β-glucoside) is
It is a type of coumarin glycoside in which esculetin is bound to glucose (chemical formula 1).
【００１０】[0010]
【化１】 [Chemical 1]
【００１１】エスクリン自体、ある程度の紫外線吸収作
用を有するが、リジン又は／及びアルギニン（以下、
「リジン等」という。）と反応することにより、紫外線
吸収作用が向上し、吸収波長がＵＶ−Ａ側にシフトす
る。通常、皮膚にはリジン等のアミノ酸が含まれている
ため、皮膚角層に吸収された後、これらのアミノ酸と反
応することにより紫外線防止作用を有する層を形成す
る。[0011] Esculin itself has a certain degree of ultraviolet absorption, but lysine and / or arginine (hereinafter,
It is called "lysine". ), The ultraviolet absorbing action is improved and the absorption wavelength is shifted to the UV-A side. Usually, the skin contains amino acids such as lysine, so after being absorbed into the stratum corneum of the skin, it reacts with these amino acids to form a layer having an ultraviolet ray preventing action.
【００１２】エスクリンは、天然界においてセイヨウト
チノキ（マロニエ）やトネリコ等の樹皮に含有している
が、含有率はせいぜい０．２重量％程度にすぎない。し
たがって、前記植物の樹皮から各種の単離法により単離
したものを使用するのが好ましい。例えば、第９回和漢
薬シンポジウム１９７５、４６ページに記載されている
方法で、白色、無臭の結晶としてエスクリンが得られ
る。また、市販されているものを使用してもよい。[0012] Esculin is contained in the bark of horse chestnuts, horse chestnuts and the like in the natural world, but its content is only about 0.2% by weight at most. Therefore, it is preferable to use those isolated from the bark of the plant by various isolation methods. For example, esculin can be obtained as white and odorless crystals by the method described on page 46 of the 9th Japanese and Chinese Medicine Symposium 1975. Moreover, you may use what is marketed.
【００１３】エスクリンは、皮膚に塗布すると皮膚中に
存在する酵素により、この結合が切断されることが知ら
れている。It is known that when applied to skin, esculin is cleaved by an enzyme present in the skin.
【００１４】＜２＞リジン等 前述したように、通常皮膚中にリジン等が含まれている
ので、エスクリンのみでも紫外線防止効果を発揮し得る
が、さらにリジン又はアルギニンを併用すると前記効果
を確実にすることができる。尚、これらのアミノ酸は単
独でも任意の混合物でも使用できる。<2> Lysine and the like As described above, since lysine and the like are usually contained in the skin, esculin alone can exert the ultraviolet ray-preventing effect, but if lysine or arginine is used in combination, the above-mentioned effect can be ensured. can do. These amino acids can be used alone or in any mixture.
【００１５】また、エスクリン単独では溶解度が１％程
度であるが、リジン等を併用すると１０％以上溶解させ
ることができるので、この点でも好ましい。リジン等の
含有量は、化粧料全量に対し０．０１〜１０重量％、好
ましくは１．０〜２．５が好ましい。Although the solubility of esculin alone is about 1%, the combined use of lysine or the like can dissolve 10% or more, and this is also preferable. The content of lysine and the like is 0.01 to 10% by weight, preferably 1.0 to 2.5, based on the total amount of the cosmetic.
【００１６】リジン等を併用する場合、特に、エスクリ
ンが高濃度の場合には、エスクリンの溶解度を高めるた
めに、予めリジン等と共に化粧料に配合しておくとよ
い。一方、エスクリンが低濃度である場合は、エスクリ
ンを含む化粧料とリジン等を含む化粧料を、使用時に手
の平等で混合して用いてもよい。また、これらの化粧料
のうち一方を塗布し、続いて他方の化粧料を塗布しても
よい。When lysine or the like is used in combination, especially when esculin is at a high concentration, it is advisable to preliminarily mix it with lysine or the like in the cosmetic material in order to increase the solubility of esculin. On the other hand, when the concentration of esculin is low, the cosmetics containing esculin and the cosmetics containing lysine may be mixed in the palm of the hand before use. Further, one of these cosmetics may be applied, and subsequently the other cosmetic may be applied.
【００１７】＜３＞その他の成分 本発明の化粧料には、上記成分の他、通常の化粧料に用
いられる各種の化粧品用基剤及び添加物、例えば無機顔
料、有機顔料、無機粉体、有機粉体、炭化水素類、シリ
コーン類、エステル類、トリグリセリド類、ラノリン
類、ワックス類、ロウ類、動植物油、界面活性剤、多価
アルコール類などの基剤や、糖類、ビタミンＡ、ビタミ
ンＢ群、ビタミンＥなどのビタミン類、アミノ酸類、グ
リチルリチン若しくはグリチルレチン酸あるいはこれら
の誘導体などの抗炎症剤、酸化防止剤、防腐剤、香料、
増粘剤、収斂剤、細胞賦活剤、美白剤、肌荒れ改善剤、
さらに従来使用されている紫外線吸収剤、紫外線散乱剤
等の添加物を配合することができる。ただし、リジン等
を併用する場合は、脂肪酸は添加しない方がよい。<3> Other Components In the cosmetic of the present invention, in addition to the above components, various cosmetic bases and additives used in ordinary cosmetics, such as inorganic pigments, organic pigments, inorganic powders, Organic powder, hydrocarbons, silicones, esters, triglycerides, lanolins, waxes, waxes, bases such as animal and vegetable oils, surfactants, polyhydric alcohols, sugars, vitamin A, vitamin B Group, vitamins such as vitamin E, amino acids, anti-inflammatory agents such as glycyrrhizin or glycyrrhetinic acid or derivatives thereof, antioxidants, preservatives, fragrances,
Thickener, astringent, cell activating agent, whitening agent, skin roughening agent,
Further, additives such as UV absorbers and UV scatterers which have been conventionally used can be added. However, when lysine or the like is used in combination, it is better not to add fatty acid.
【００１８】また、本発明の化粧料の剤型は特に制限さ
れず、通常の化粧料の製法に従って製造することができ
る。The dosage form of the cosmetic of the present invention is not particularly limited, and the cosmetic can be manufactured according to a usual cosmetic manufacturing method.
【００１９】[0019]
【作用】以下に、本発明に用いるエスクリン及びリジン
等の作用を示す。 ＜１＞エスクリンの作用 下記試料（５０％エタノール−水）について、分光光度
計を用いて吸収スペクトルを測定した。The action of esculin and lysine used in the present invention will be shown below. <1> Action of Esculin The absorption spectrum of the following sample (50% ethanol-water) was measured using a spectrophotometer.
【００２０】 （１） ラウソン ０．００５％、リジン０．００５％ （２） エスクリン ０．００５％ （３） エスクリン ０．００５％、リジン０．００５％ 結果を図１に示す。この結果から、エスクリンは単独よ
りもリジンを共存させた方が紫外線吸収作用が向上し、
さらに吸収波長がＵＶ−Ａ側にシフトすることがわか
る。(1) Rawson 0.005%, Lysine 0.005% (2) Esculin 0.005% (3) Esculin 0.005%, Lysine 0.005% The results are shown in FIG. From this result, esculin improves the ultraviolet absorption effect in the presence of lysine than alone,
Further, it can be seen that the absorption wavelength shifts to the UV-A side.
【００２１】＜２＞リジン等の作用 リジン以外のアミノ酸をエスクリンと共存させ、上記と
同様に吸収スペクトルを測定した。<2> Action of lysine, etc. An amino acid other than lysine was made to coexist with esculin, and the absorption spectrum was measured in the same manner as above.
【００２２】（１） エスクリン ０．００５％ （２） エスクリン ０．００５％、リジン ０．００
５％ （３） エスクリン ０．００５％、アルギニン０．００
５％ （４） エスクリン ０．００５％、ヒスチジン０．００
５％ 結果を図２に示す。この結果から、エスクリンは、リジ
ンあるいはアルギニンと共存させると紫外線吸収作用が
向上し、さらに吸収波長がＵＶ−Ａ側にシフトするが、
ヒスチジンではこのような効果が得られないことがわか
る。(1) Esculin 0.005% (2) Esculin 0.005%, lysine 0.00
5% (3) Esculin 0.005%, Arginine 0.00
5% (4) Esculin 0.005%, Histidine 0.00
The 5% result is shown in FIG. From this result, when esculin coexists with lysine or arginine, the ultraviolet absorbing action is improved, and the absorption wavelength shifts to the UV-A side.
It is understood that such effect cannot be obtained with histidine.
【００２３】以上説明したように、エスクリンは皮膚中
に存在するリジン等と反応することによって、ＵＶ−Ａ
を中心とした紫外線防止作用を示す。この作用は、化粧
料中にエスクリンとともにリジン等を含有させることに
より確実となる。As explained above, esculin reacts with lysine and the like present in the skin to give UV-A.
It shows an ultraviolet ray-preventing action centered on. This action is ensured by including lysine and the like together with esculin in the cosmetic.
【００２４】[0024]
【実施例】以下に、本発明の実施例を説明する。尚、以
下の配合量は重量部である。EXAMPLES Examples of the present invention will be described below. The following compounding amounts are parts by weight.
【００２５】[0025]
【実施例１〜７】 （製法）表１Ａ及びＢの成分を７０℃で各々撹拌しなが
ら溶解した後、Ｂの成分にＡの成分を加えて予備乳化を
行い、ホモミキサーで均一に乳化した。その後、撹拌し
ながら５０℃まで冷却し、これに５０℃に加熱したＣの
成分を撹拌しながら加え、３０℃になるまで撹拌しなが
ら冷却し、実施例１〜７の乳液を得た。同様にして、エ
スクリンを含まない比較例１、２の乳液を得た。Examples 1 to 7 (Production method) Ingredients shown in Table 1A and B were dissolved at 70 ° C. with stirring, respectively, and then ingredient A was added to ingredient B to carry out preliminary emulsification and homogenize with a homomixer. . Then, it cooled to 50 degreeC, stirring, and the component of C heated at 50 degreeC was added to this with stirring, and cooled to 30 degreeC, stirring, and the emulsion of Examples 1-7 was obtained. Similarly, emulsions of Comparative Examples 1 and 2 containing no esculin were obtained.
【００２６】[0026]
【表１】 [Table 1]
【００２７】（評価）上記で得られた各実施例及び比較
例の乳液について、紫外線防止効果を調べるために、Ｓ
ＰＦ（Sun protection factor：日焼け止め指数）値を
測定した。(Evaluation) In order to examine the effect of preventing ultraviolet rays from the emulsions of the respective Examples and Comparative Examples obtained above, S was added.
The PF (Sun protection factor) value was measured.
【００２８】＜方法＞ＳＰＦ測定法は、以下に示すモル
モット皮膚表皮を用いた代替法により行った。尚、本方
法はＦＤＡ法（ヒトの皮膚に日焼け止め剤を塗布して紫
外線を照射し、日焼け止め剤を使用しない場合に対して
皮膚に同等の炎症を起こさせる照射エネルギー量（時
間）の比で表す方法）と非常に高い相関を示す方法であ
る。<Method> The SPF measurement method was carried out by the following alternative method using guinea pig skin epidermis. This method is based on the FDA method (the ratio of the amount of irradiation energy (time) that causes the skin to be inflamed to the same level as when the sunscreen was not used by applying a sunscreen to human skin and irradiating it with ultraviolet rays. This is a method showing a very high correlation with the method shown in.
【００２９】ヘアレスモルモットの皮膚組織を剥離し、
真皮下の脂肪、筋肉をピンセットで除去し、ディスパー
ゼ（合同酒精（株）製タンパク分解酵素：バチルス・ポ
リミキサ由来）を１０００ＰＵ／ｍｌを含むリン酸緩衝
生理食塩水に浸漬し、３７℃で２〜３時間処理した。Peel the skin tissue of hairless guinea pigs,
Fat and muscle under the dermis are removed with tweezers, and dispase (Proteolytic enzyme manufactured by Godo Shusei Co., Ltd .: Bacillus polymixa) is immersed in phosphate buffered saline containing 1000 PU / ml, and the temperature is 2 to 37 ° C. Treated for 3 hours.
【００３０】人工光線源は Solar Light Co.社製のモデ
ル１４Ｓ型ソーラーシミュレーターを、紫外線強度計に
はトプコン社製のUVR-305/365D(III) ＵＶラジオメータ
ーを用いて測定を行った。尚、照射した紫外線の波長は
２９０〜４００ｎｍ（ＵＶＢ＋ＵＶＡ領域）、紫外線強
度は７ｍＷ／ｃｍ2、照射時間は５分間とした。The artificial light source was a Model 14S solar simulator manufactured by Solar Light Co., and the UV intensity meter was a UVR-305 / 365D (III) UV radiometer manufactured by Topcon. The wavelength of the irradiated ultraviolet rays was 290 to 400 nm (UVB + UVA region), the ultraviolet intensity was 7 mW / cm 2 , and the irradiation time was 5 minutes.
【００３１】上記ヘアレスモルモット表皮の表面側に、
各試料を２ｍｇ／ｃｍ2となるように塗布し、この膜を
２ｃｍ×２ｃｍの正方形の窓孔を有する７．６ｃｍ ×
３．６ｃｍの長方形のホルダーの窓孔に接着し、スタン
ドでこのホルダーを垂直に保持した。On the surface side of the hairless guinea pig epidermis,
Each sample was coated so as to have a dose of 2 mg / cm 2, and this film was 7.6 cm × having a 2 cm × 2 cm square window.
It was adhered to the window of a 3.6 cm rectangular holder and held vertically by a stand.
【００３２】この表皮の試料面にソーラーシミュレータ
ーの照射部を、他方の面に紫外線強度計の受光部をあ
て、試料及び表皮を透過する紫外線強度Ｅ（ｍＷ／ｃｍ
2）を測定した。一方試料を塗布しない膜を用いて同様
に紫外線強度Ｅ0を測定し、Ｅ／Ｅ0をＳＰＦ値とした。
結果を表２に示す。The irradiation part of the solar simulator is placed on the sample surface of this epidermis, and the light receiving part of the ultraviolet intensity meter is placed on the other surface, and the ultraviolet intensity E (mW / cm) that passes through the sample and the epidermis is set.
2 ) was measured. On the other hand, the ultraviolet intensity E 0 was similarly measured using a film on which the sample was not applied, and E / E 0 was taken as the SPF value.
The results are shown in Table 2.
【００３３】[0033]
【表２】 [Table 2]
【００３４】この結果から明らかなように、エスクリン
を含有する本発明の紫外線防止化粧料は、ＳＰＦ値が高
く、紫外線防止効果に優れている。また、リジンを併用
することにより、さらに高い効果が得られることがわか
る。As is clear from these results, the ultraviolet protective cosmetic of the present invention containing esculin has a high SPF value and an excellent ultraviolet protective effect. Moreover, it is found that a higher effect can be obtained by using lysine together.
【００３５】[0035]
【実施例８】次に、本発明の紫外線防止化粧料として、
クリームにおける実施例を説明する。[Embodiment 8] Next, as an ultraviolet protective cosmetics of the present invention,
An example of cream will be described.
【００３６】表３Ａ、Ｂの成分を、各々８０℃に加熱し
て溶解させて均一に混合した後、Ａの成分にＢの成分を
加え、撹拌して乳化させ、撹拌しながら３０℃まで冷却
する。The ingredients shown in Table 3A and B are heated to 80 ° C. to be melted and uniformly mixed. Then, the ingredient B is added to the ingredient A, stirred to emulsify, and cooled to 30 ° C. with stirring. To do.
【００３７】[0037]
【表３】 [Table 3]
【００３８】[0038]
【実施例９】化粧水における実施例を説明する。表４Ａ
の成分を混合し、室温下で溶解する。これに、室温下で
溶解させたＢの成分を加えて可溶化する。[Embodiment 9] An example of a lotion will be described. Table 4A
The ingredients of 1 are mixed and dissolved at room temperature. The component B dissolved at room temperature is added to this to solubilize it.
【００３９】[0039]
【表４】 [Table 4]
【００４０】[0040]
【発明の効果】本発明の化粧料は、有効成分であるエス
クリンが皮膚中に存在するリジン等あるいは併用したリ
ジン等と反応して紫外線吸収層を形成するため、紫外線
防止効果に優れているだけでなく、前記紫外線吸収層の
耐摩耗性、耐洗滌性がよく、持続性に優れている。EFFECT OF THE INVENTION The cosmetics of the present invention are excellent in the effect of preventing ultraviolet rays because the active ingredient esculin reacts with lysine present in the skin or lysine used in combination to form an ultraviolet absorbing layer. In addition, the ultraviolet absorption layer has good wear resistance and washing resistance, and is excellent in durability.
【図１】 エスクリンをリジンと反応させた場合の吸収
スペクトルの変化を示す図。FIG. 1 is a diagram showing a change in absorption spectrum when esculin is reacted with lysine.
【図２】 エスクリンと反応させるアミノ酸の種類を変
えた場合の吸収スペクトルの変化を示す図。FIG. 2 is a view showing a change in absorption spectrum when the kind of amino acid reacted with esculin is changed.
Claims (2)
１〜１０重量％含有する紫外線防止化粧料。1. The amount of esculin is 0.0 based on the total amount of cosmetics.
A UV-proof cosmetic containing 1 to 10% by weight.
量に対し０．０１〜１０重量％含有する請求項１記載の
紫外線防止化粧料。2. The ultraviolet protective cosmetics according to claim 1, which contains 0.01 to 10% by weight of lysine and / or arginine with respect to the total amount of the cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4300755A JP3072578B2 (en) | 1992-11-11 | 1992-11-11 | UV protection cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4300755A JP3072578B2 (en) | 1992-11-11 | 1992-11-11 | UV protection cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH06145035A true JPH06145035A (en) | 1994-05-24 |
| JP3072578B2 JP3072578B2 (en) | 2000-07-31 |
Family
ID=17888710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4300755A Expired - Fee Related JP3072578B2 (en) | 1992-11-11 | 1992-11-11 | UV protection cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3072578B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004080432A1 (en) * | 2003-03-10 | 2004-09-23 | Songwoo Kim | Composition for lip cosmetics |
| FR2912313A1 (en) * | 2007-02-13 | 2008-08-15 | Biolog Vegetale Yves Rocher Sa | Combination, useful for the preparation of cosmetic or dermatological composition to prevent and/or treat skin aging, comprises wheat germ extract and esculin |
| CN100418535C (en) * | 2005-07-15 | 2008-09-17 | 武汉爱民制药有限公司 | Aescin medicine composition and its prepn process and use |
| CN104367486A (en) * | 2014-11-28 | 2015-02-25 | 长春理工大学 | Application of fraxinol glucosides in uvioresistant cosmetics |
-
1992
- 1992-11-11 JP JP4300755A patent/JP3072578B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004080432A1 (en) * | 2003-03-10 | 2004-09-23 | Songwoo Kim | Composition for lip cosmetics |
| CN100418535C (en) * | 2005-07-15 | 2008-09-17 | 武汉爱民制药有限公司 | Aescin medicine composition and its prepn process and use |
| FR2912313A1 (en) * | 2007-02-13 | 2008-08-15 | Biolog Vegetale Yves Rocher Sa | Combination, useful for the preparation of cosmetic or dermatological composition to prevent and/or treat skin aging, comprises wheat germ extract and esculin |
| CN104367486A (en) * | 2014-11-28 | 2015-02-25 | 长春理工大学 | Application of fraxinol glucosides in uvioresistant cosmetics |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3072578B2 (en) | 2000-07-31 |
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