JPH0611285B2 - Dosing device - Google Patents

Dosing device

Info

Publication number
JPH0611285B2
JPH0611285B2 JP9834892A JP9834892A JPH0611285B2 JP H0611285 B2 JPH0611285 B2 JP H0611285B2 JP 9834892 A JP9834892 A JP 9834892A JP 9834892 A JP9834892 A JP 9834892A JP H0611285 B2 JPH0611285 B2 JP H0611285B2
Authority
JP
Japan
Prior art keywords
bottle
receiving
drug
seating
shoulder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP9834892A
Other languages
Japanese (ja)
Other versions
JPH05111523A (en
Inventor
ブニン レオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPH05111523A publication Critical patent/JPH05111523A/en
Publication of JPH0611285B2 publication Critical patent/JPH0611285B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3216—Rigid containers disposed one within the other
    • B65D81/3222—Rigid containers disposed one within the other with additional means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2031—Separating means having openings brought into alignment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2037—Separating means having valve means

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Description

【発明の詳細な説明】Detailed Description of the Invention

【０００１】本発明の目的は、投与のときまで固体と液
体を別々に保持する手段を有する一区画投薬装置を提供
するにある。さらに本発明の目的は、投与のときまで固
体と液体を別々に保持する一層安価な投薬装置を提供す
るにある。なおさらに本発明の目的は、投与のときまで
固体と液体を別々に保持する一層容易に製造される投薬
装置を提供するにある。さらに本発明の目的は、簡単に
した安価な眼科用投薬装置を提供するにある。本発明の
他の目的は以下の記載から明かとなろう。It is an object of the present invention to provide a one-compartment dosing device having means for holding the solid and liquid separately until the time of administration. A further object of the present invention is to provide a less expensive dosing device that holds the solid and liquid separately until the time of administration. A still further object of the present invention is to provide a more easily manufactured dosing device that holds the solid and liquid separately until the time of administration. A further object of the invention is to provide a simplified and inexpensive ophthalmic medication device. Other objects of the present invention will be apparent from the following description.

【０００２】本発明は、液体混合物の成分を互いに隔離
して保持でき、また望むときは分離した成分を互いに連
通させることによって分離した成分を容器内で混合でき
る液体投薬装置に関する。移動可能なホルダーは混合物
成分を分離して保持する役目をするが、装置の柔軟性の
ある底を押下げることにより動作するプランジャーによ
り移動できる。こうして、一旦混合すると限られた有効
寿命を有する混合物を、使用が望まれるまで成分を別々
に保持することによって無期限に保存できる。成分の一
つは液体でなければならないが、他の成分は固体、例え
ば製薬錠剤である。弁は患者により手で操作され、投薬
容器は分けられていた物質が混合されるまで逆さにする
か振とうされる。The present invention relates to a liquid dosing device in which the components of a liquid mixture can be kept separate from one another and, if desired, the separated components can be mixed in a container by communicating the separated components with one another. The moveable holder serves to hold the mixture components separately, but can be moved by a plunger that is actuated by pushing down on the flexible bottom of the device. Thus, once mixed, the mixture, which has a limited useful life, can be stored indefinitely by holding the components separately until use is desired. One of the ingredients must be a liquid, while the other is a solid, eg a pharmaceutical tablet. The valve is manually operated by the patient and the dosing container is inverted or shaken until the separated substances are mixed.

【０００３】取りはずし可能なキャップを備えることの
できる投薬容器本体をその後絞ることができ、それによ
って混合流体の液滴、流、またはジェットを投薬容器の
出口ノズルから出させる。一方、投薬容器は皮下注射針
などを使い混合物質をとりだすための隔壁を含む。The dosing container body, which may be provided with a removable cap, may then be squeezed, thereby causing a droplet, stream, or jet of mixed fluid to exit the dosing container outlet nozzle. On the other hand, the medication container includes a partition for taking out the mixed substance using a hypodermic needle or the like.

【０００４】添付図面は必ずしも共通の尺度をもつもの
ではなく、また実施態様はときどきグラフ記号、幻影
線、模式図、断片図で示されることを理解すべきであ
る。ある場合には、本発明の理解に必要でない説明、ま
たは他の説明を理解することを困難にする詳細は省かれ
ている。勿論、本発明はここに示す特定の実施態様に必
ずしも限定されないことを理解すべきである。It should be understood that the accompanying drawings are not necessarily to a common scale, and that embodiments are sometimes referred to in graphical symbols, phantom lines, schematic drawings, and fragmentary views. In some cases, details that are not necessary for an understanding of the invention, or that make other descriptions difficult, are omitted. Of course, it should be understood that the invention is not necessarily limited to the particular embodiments shown.

【０００５】本発明の投薬装置は、好ましくはプラスチ
ック材料、たとえば低密度ポリエチレンからつくられ
る。通常の吹出し成形法によって底部および中央部分を
つくり、錠剤含有手段を挿入し、ついで本体部を成形し
て投薬装置の上部をつくる。しかし、首の部分がホルダ
ー装置を挿入できるのに十分広いときは全ボトルを１工
程でつくることができる。多くの異なる材料および種々
の製造技術を使用できることは当業者に理解できるの
で、本発明は、本発明の投薬装置を製造する特定の材料
または特定の製造方法に限定されない。The dosing device of the present invention is preferably made of a plastic material such as low density polyethylene. The bottom and middle parts are made by conventional blow molding methods, the tablet containing means are inserted, and then the body is molded to make the upper part of the dosing device. However, if the neck part is wide enough for the holder device to be inserted, the whole bottle can be made in one step. The present invention is not limited to a particular material or particular method of manufacture of the dosing device of the present invention, as those skilled in the art will appreciate that many different materials and various manufacturing techniques can be used.

【０００６】本発明の投薬装置は、使用時内容物を系内
で混合するじゃばら状の底部と、所定量の溶液を送り出
すのを検定する滴下投薬チップを有している。じゃばら
状の底部の水薬瓶および滴下投薬チップは当該技術分野
で既知である。The dosing device of the present invention has a bellows-shaped bottom for mixing the contents in the system during use, and a dropping dosing tip for testing the delivery of a predetermined amount of solution. Bellow-shaped bottom vials and drop dosing tips are known in the art.

【０００７】本発明の投薬装置は、じゃばら状の底部１
１を有するボトル手段１０および投薬手段１２、たとえ
ば滴下チップを含む。ボトル１０には、たとえば生理学
的に許容される眼科用の液体のような液体１３を充てん
する。錠剤保持手段１４は、固形薬剤１６を保持するた
め切断部分１５を有する伸長された部材である。保持手
段１４は一定のまたはテーパーのついた断面を有するこ
とができ、保持手段１４の周囲または外壁は円形または
非円形、たとえば円筒状または長円形であることができ
る。保持手段１４は、着座手段１９に対し着座および座
部から離れるという両者を容易にするために、たとえば
円錐台形部材のような、テーパーのついた断面を有する
のが好ましい。押し部材１７は、部材１５の底からボト
ル１０の底またはその近くまで伸びている。着座手段１
９は、部材１４の外壁の形状を相補する内壁２０を有
し、それによって液体１３が薬剤１６と接触するのを防
ぐシールを形成するのに適合している。着座手段１９
は、ボトル１０の肩部２２から部材１５まで伸びている
一つ以上の支持手段２１によって保持される。支持手段
２１の底部は、着座手段１９が動くのを防止するためフ
ランジ手段２３を備えている。この位置で、切断部分１
５は着座手段１９の内壁２０によって囲まれ、液体１３
とは接触しない。The dosing device of the present invention has a bellows-shaped bottom portion 1.
1 includes a bottle means 10 and a dosing means 12, eg a drip tip. The bottle 10 is filled with a liquid 13, for example a physiologically acceptable ophthalmic liquid. The tablet holding means 14 is an elongated member having a cutting portion 15 for holding the solid medicine 16. The retaining means 14 can have a constant or tapered cross section and the perimeter or outer wall of the retaining means 14 can be circular or non-circular, eg cylindrical or oval. The retaining means 14 preferably has a tapered cross section, eg a frustoconical member, to facilitate both seating and disengaging from the seating means 19. The pushing member 17 extends from the bottom of the member 15 to or near the bottom of the bottle 10. Seating means 1
9 is adapted to have an inner wall 20 that complements the shape of the outer wall of member 14, thereby forming a seal that prevents liquid 13 from contacting drug 16. Seating means 19
Are held by one or more support means 21 extending from the shoulder 22 of the bottle 10 to the member 15. The bottom of the support means 21 is provided with flange means 23 to prevent the seating means 19 from moving. At this position, the cutting part 1
5 is surrounded by the inner wall 20 of the seating means 19 and the liquid 13
Does not come into contact with.

【０００８】薬剤１６を溶かすには、図２に示したよう
に、ボトル１０のじゃばら状の底部１１を押し上げ、そ
れによって押し部材１７を同一方向に動かしリフト部材
１４をその着座位置から離す。部材１４の切断部分と薬
剤１６は液体１３と接触する。薬剤１６が完全に溶けた
ら、薬剤溶液を投薬手段１２から分散する準備ができ
る。To dissolve the drug 16, as shown in FIG. 2, the bellows-like bottom 11 of the bottle 10 is pushed up, thereby moving the pushing member 17 in the same direction and moving the lifting member 14 away from its seated position. The cut portion of the member 14 and the medicine 16 come into contact with the liquid 13. Once the drug 16 is completely dissolved, the drug solution is ready to be dispensed from the dosing means 12.

【０００９】前述のように、図面は必ずしも共通の尺度
をもつものではなく、ボトル内の固体薬剤支持手段と受
取り手段を理解を容易にするため拡大してある。しか
し、これらの手段は、好ましくはボトルの首の部分を通
りぬけられるほど十分小さく、それによってボトルを１
工程で都合よく製造することができる。As mentioned above, the drawings are not necessarily to a common scale and have been expanded to facilitate understanding of the solid drug support means and receiving means within the bottle. However, these means are preferably small enough to allow them to pass through the neck of the bottle, thereby
It can be conveniently manufactured in process.

【図面の簡単な説明】[Brief description of drawings]

【図１】図１は成分を混合前の本発明の投薬装置の断面
側立面図である。1 is a cross-sectional side elevational view of the dosing device of the present invention prior to mixing the components.

【図２】図２は成分を混合後の本発明の投薬装置の断面
側立面図である。FIG. 2 is a cross-sectional side elevational view of the dosing device of the present invention after mixing the components.

【符号の説明】[Explanation of symbols]

１０ ボトル １１ じゃばら状の底部 １２ 投薬手段 １３ 液体 １４ 保持手段 １６ 薬剤 １７ 押し部材 １９ 着座手段 ２１ 支持手段 ２２ 肩部 ２３ フランジ手段 10 Bottle 11 Bellows Bottom 12 Medication Means 13 Liquid 14 Holding Means 16 Drugs 17 Pushing Member 19 Seating Means 21 Supporting Means 22 Shoulders 23 Flange Means

Claims (16)

【特許請求の範囲】[Claims] 【請求項１】 頂部液体投与手段、首部、肩部、じゃば
ら状の底部、ボトルの上部領域から下方に伸び着座部材
に結合している支持手段、着座部材内に着座している固
形薬剤を受取る受取り手段、および受取り手段を座部か
ら離すために受取り手段とじゃばら状の底部との間に配
置された手段を含む単一室ボトル。1. A top liquid dosing means, a neck, a shoulder, a bellows bottom, a support means extending downwardly from the upper region of the bottle and coupled to a seating member, and receiving a solid drug seated in the seating member. A single-chamber bottle comprising a receiving means, and means arranged between the receiving means and the bellows bottom for separating the receiving means from the seat. 【請求項２】 前記着座部材と受取り部材が形状におい
て相補的である請求項１記載のボトル。2. The bottle according to claim 1, wherein the seating member and the receiving member are complementary in shape. 【請求項３】 前記受取り部材が、一定のまたはテーパ
ーのついた円筒形または非円筒形断面を有する伸びた部
材を含む請求項２記載のボトル。3. The bottle of claim 2 wherein said receiving member comprises an elongated member having a constant or tapered cylindrical or non-cylindrical cross section. 【請求項４】 前記受取り部材が円錐台形または円筒形
部材である請求項３記載のボトル。4. The bottle according to claim 3, wherein the receiving member is a truncated cone or a cylindrical member. 【請求項５】 前記受取り部材が円錐台形である請求項
４記載のボトル。5. The bottle of claim 4, wherein the receiving member is frustoconical. 【請求項６】 前記支持手段がボトルのほぼ肩部から下
方に伸びている請求項１記載のボトル。6. A bottle according to claim 1, wherein said support means extends downwards from substantially the shoulder of the bottle. 【請求項７】 前記座部から離す手段が、受取り部材と
じゃばら状の底部の間とに配置された伸びた部材を含む
請求項１記載のボトル。7. The bottle of claim 1 wherein the means for moving away from the seat includes an elongated member disposed between the receiving member and the bellows bottom. 【請求項８】 前記室に眼科用液体を充てんする請求項
１記載のボトル。8. The bottle according to claim 1, wherein the chamber is filled with an ophthalmic liquid. 【請求項９】 前記受取り手段が固形薬剤を含有する請
求項１記載のボトル。9. The bottle according to claim 1, wherein the receiving means contains a solid drug. 【請求項１０】 前記薬剤が眼科用薬剤である請求項９
記載のボトル。10. The drug according to claim 9, which is an ophthalmic drug.
The listed bottle. 【請求項１１】 前記薬剤が錠剤の形態である請求項９
記載のボトル。11. The drug according to claim 9, which is in the form of a tablet.
The listed bottle. 【請求項１２】 頂部滴下投薬手段、首部、肩部、じゃ
ばら状の底部、ボトルの肩部から下方に伸びて円錐台形
着座部材を支持する支持手段、着座部材内に着座してい
る固形薬剤を受取るための手段を有する円錐台形受取り
部材、および円錐台形受取り部材とじゃばら状の底部と
の間に配置された着座部材から座部から離れるための伸
びた部材を含む単一室ボトル。12. Top drip dosing means, neck, shoulder, bellows bottom, support means extending downwardly from the shoulder of the bottle to support the frustoconical seating member, and solid drug seated in the seating member. A single-chamber bottle comprising a frustoconical receiving member having means for receiving, and an elongated member for leaving the seat from a seating member disposed between the frustoconical receiving member and the bellows bottom. 【請求項１３】 前記室に眼科用液体を充てんする請求
項１２記載のボトル。13. The bottle according to claim 12, wherein the chamber is filled with an ophthalmic liquid. 【請求項１４】 前記受取り手段が固形薬剤を含む請求
項１２記載のボトル。14. The bottle of claim 12 wherein said receiving means comprises a solid drug. 【請求項１５】 前記薬剤が眼科用薬剤である請求項９
記載のボトル。15. The drug according to claim 9, which is an ophthalmic drug.
The listed bottle. 【請求項１６】 前記薬剤が錠剤の形態である請求項９
記載のボトル。16. The drug according to claim 9, which is in the form of a tablet.
The listed bottle.
JP9834892A 1991-04-18 1992-04-18 Dosing device Expired - Lifetime JPH0611285B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68735191A 1991-04-18 1991-04-18
US687351 1991-04-18

Publications (2)

Publication Number Publication Date
JPH05111523A JPH05111523A (en) 1993-05-07
JPH0611285B2 true JPH0611285B2 (en) 1994-02-16

Family

ID=24760114

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9834892A Expired - Lifetime JPH0611285B2 (en) 1991-04-18 1992-04-18 Dosing device

Country Status (4)

Country Link
EP (1) EP0509754A3 (en)
JP (1) JPH0611285B2 (en)
CA (1) CA2065814A1 (en)
IE (1) IE921238A1 (en)

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CA2145868A1 (en) * 1994-04-12 1995-10-13 Osamu Tsukada Accordion container for chemical
JP4608301B2 (en) * 2004-12-14 2011-01-12 大成化工株式会社 Dissolving eye dropper kit
JP2012515121A (en) * 2009-01-12 2012-07-05 アクティヴパック， インコーポレイテッド Packaged products, inserts and compartments for aseptic mixing of substances and methods for use therewith
KR20160071287A (en) 2014-12-11 2016-06-21 이상희 Drug keeping device for patients
WO2021186485A1 (en) * 2020-03-18 2021-09-23 Brevetti Angela S.R.L. Pre-filled container, method of use and related production method

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US3354883A (en) * 1965-03-08 1967-11-28 Southerland Elizabeth Lee Disposable syringe having frangible means for mixing plural medicaments
DE3152033A1 (en) * 1981-12-31 1983-07-07 Alfred Von 4178 Kevelaer Schuckmann Container for the sterile transfer of drugs
GB2235897A (en) * 1989-09-15 1991-03-20 Plaspharm Plastics dispenser body having injection and blow moulded parts.

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CA2065814A1 (en) 1992-10-19
IE921238A1 (en) 1992-10-21
JPH05111523A (en) 1993-05-07
EP0509754A3 (en) 1993-04-07
EP0509754A2 (en) 1992-10-21

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