CA2065814A1 - Dispenser device - Google Patents
Dispenser deviceInfo
- Publication number
- CA2065814A1 CA2065814A1 CA 2065814 CA2065814A CA2065814A1 CA 2065814 A1 CA2065814 A1 CA 2065814A1 CA 2065814 CA2065814 CA 2065814 CA 2065814 A CA2065814 A CA 2065814A CA 2065814 A1 CA2065814 A1 CA 2065814A1
- Authority
- CA
- Canada
- Prior art keywords
- bottle
- bottle according
- medicament
- receiving
- frustoconical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003814 drug Substances 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 239000007787 solid Substances 0.000 claims abstract description 11
- 230000000295 complement effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 229920003023 plastic Polymers 0.000 abstract description 2
- 239000004033 plastic Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 4
- 239000000470 constituent Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3216—Rigid containers disposed one within the other
- B65D81/3222—Rigid containers disposed one within the other with additional means facilitating admixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2031—Separating means having openings brought into alignment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2037—Separating means having valve means
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
TITLE OF THE INVENTION
DISPENSER DEVICE
ABSTRACT OF THE DISCLOSURE
A single chambered plastic bottle is provided with a dislodgeable holder device having a recess to hold a solid medicament free of contact with a liquid filling the bottle, whereby components of a mixture may be maintained separately until comingling is desired. The holder device is dislodged by means of a plunger activated by depression of the flexible bottom of the bottle.
DISPENSER DEVICE
ABSTRACT OF THE DISCLOSURE
A single chambered plastic bottle is provided with a dislodgeable holder device having a recess to hold a solid medicament free of contact with a liquid filling the bottle, whereby components of a mixture may be maintained separately until comingling is desired. The holder device is dislodged by means of a plunger activated by depression of the flexible bottom of the bottle.
Description
TITLE OF T~E ~NVENTION
DISPENSER DEVICE
BACKGROUND OF TX~ INVENTIO~
Dispenser devices having multiple compartments for separately enclosed materials to be mixed prior to use are disclosed in U.S. patents 3,340,873, 3,354,883, 3,397,694, 3,~11,503~
4,331,14~, 4,412,836, 4,330,531 and 4,950,237. These systemæ are complex, contain many parts, and are expensive to manufacture.
QBJECTS OF TE~ INVEMTI~N
It is an object of the invention to provide a single-compartment dispenser device having means to hold a solid and a liquid separately until the time of administration. Another object is to provide a less expensive dispenser deYice for maintaining a solid and a liquid ~eparately until the time of administration. Still another object is to provide a more easily manufactured dispenser device ~or maintaining a solid and a liquid separately until the time of administration. A further object is to provide a simpli~ied and inexp~ensive ophthalmic dispenser. There and other objects of th present invention will be apparent from the following description.
SUMMARY OF THE INVENTION
This invention relates to fluid dispensing devices in which constituents of the fluid migture can be maintained in isolation from one another and in which the separated constituents can be mixed in vitro, when desired, by placing the conætituents in communication with one another. A dislodgeable holder serves to maintain separation of the mixture components but can be dislodged by a plunger which is activated by the depression of the flexible bottom of the device. Thereby a mi~ture having a limited effective life once mixed may be preserved indefinitely by maintaining separate components until use is desired. While one of the constituents must be liquid the other component i6 a solid, for example a pharmaceutical tablet. The valve is operated manually by the patient and the dispenser either inverted or shaken to cause the until now separated substances to mix.
The body of the dispenser, which may be provided with a removable cap, can thereafter be squeezed thereby causing droplet, flow or jet of mixed fluid to be emitted from an outlet nozzle of the dispenser. Alternatively, the dispenser includes a septum to permit withdrawal of the mi~ed æubstances using a hypodermic needle or the like.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is a cross-sectional side elevation of the dispenser device of this invention before mixing the components.
Figure 2 is a cross-sectional side elevation of the dispenser device of this invention a~ter mixing the components.
It should be understood that the drawings are not necessarily to scale and that the embodiments are sometimes illustrated by graphic symbols, phantom lo lines, dia~rammatic representations and fragmentary views. In certain instances, details which are not necessary for an understanding of the present invention or which render other details difficult to perceive may have been omitted. It should be understood, of course, that the invention is not necessarily limited to the particular embodiments . i~lustrated herein.
DETAILED ~SCRIPTION
The dispenser device of the pre~ent invention preferably is made of a plastic material, for example, lo~ density polyethylene, by a conventional blow molding technique to produce the bottom and mid body section, inserting the tablet containing meanæ, and subsequently molding the body section to produce the upper section of the dispenser device. If, however, the neck is sufficiently wide to permit insertion of the holder device, the entire bottle can be made In one step. It is to be understood that the present invention is not limited to the specific material from which the di~penser device of the present invention is made, or the particular process by which it is made as it will be understood by those skilled in the art that many different materials and various manufacturing techniques may be employed.
The dispensing device of the present invention has a bellows bottom to permit in situ mixing of the contents at time of use, and a dropper dispenser tip calibrated to deliver predetermined amount of solution. Both bellows bottom vials and dropper dispenser tips are known in the art.
The dispensing device of the present invention comprises a bottle means 10 having bellows bottom 11 and dispenser means 12, for example, a dropper tip. Bottle 10 is filled with a liquid 13, such as, for example, a physiologically acceptable ophthalmic liquid. Tablet holding means 14 i~ an enlongated member having a cut-out section 15 for holding a solid medicament 16. The holding means 14 may have a constant, or tapered cross section and the circumference or outer wall of holding means 14 may be circular or non-circular, e.g., cylindrical or oval. The holding 14 means 14 preferably has a tapered cross section, such as, for example, a frustoconical member, to facilitate both seating and .
unseating against seating means 19. A push member 17 extends from the bottom of member 15 to or near to the bottom of bottle 10.
Seating means 19 has inner wall 20 that is complementary in shape to the outer wall of member 14 and is thereby adapted to form a seal preventing liquid 13 from contacting medicament 16. Seating means 19 is held by one or more eupport means 21 extending from shoulder 22 of bottle 10 to the member 0716~/6052A - 5 - 18343 lS. The bottom of support 21 is provided with flange means 23 to prevent seating means 19 from movement.
In this position cut-out section 15 is surrounded by inner walls 20 of seating means 21 and is not in contact ~ith liquid 13.
To dissolve the medicament 16, as æhown in figure 2, the bellows bottom 11 of bottle 10 ie pushed up thereby moving push Imember 17 in the same direction and li~ting member 14 away from its seated position. The cut-out section of member 14 and lo medicament 16 are now in contact with liquid 13.
When medicament 16 i3 fully dissolved, the medicament solution is ready to be dispersed from dispenser means 12.
As indicated previously, the drawings are not necessarily to scale and the solid medicament supporting and receiving means within the bottle have been enlarged to facilitate an understanding of the invention. These means, however, are preferably small enough to pass through the neck of the bottle whereby the bottle iæ conveniently manufactured in one step.
DISPENSER DEVICE
BACKGROUND OF TX~ INVENTIO~
Dispenser devices having multiple compartments for separately enclosed materials to be mixed prior to use are disclosed in U.S. patents 3,340,873, 3,354,883, 3,397,694, 3,~11,503~
4,331,14~, 4,412,836, 4,330,531 and 4,950,237. These systemæ are complex, contain many parts, and are expensive to manufacture.
QBJECTS OF TE~ INVEMTI~N
It is an object of the invention to provide a single-compartment dispenser device having means to hold a solid and a liquid separately until the time of administration. Another object is to provide a less expensive dispenser deYice for maintaining a solid and a liquid ~eparately until the time of administration. Still another object is to provide a more easily manufactured dispenser device ~or maintaining a solid and a liquid separately until the time of administration. A further object is to provide a simpli~ied and inexp~ensive ophthalmic dispenser. There and other objects of th present invention will be apparent from the following description.
SUMMARY OF THE INVENTION
This invention relates to fluid dispensing devices in which constituents of the fluid migture can be maintained in isolation from one another and in which the separated constituents can be mixed in vitro, when desired, by placing the conætituents in communication with one another. A dislodgeable holder serves to maintain separation of the mixture components but can be dislodged by a plunger which is activated by the depression of the flexible bottom of the device. Thereby a mi~ture having a limited effective life once mixed may be preserved indefinitely by maintaining separate components until use is desired. While one of the constituents must be liquid the other component i6 a solid, for example a pharmaceutical tablet. The valve is operated manually by the patient and the dispenser either inverted or shaken to cause the until now separated substances to mix.
The body of the dispenser, which may be provided with a removable cap, can thereafter be squeezed thereby causing droplet, flow or jet of mixed fluid to be emitted from an outlet nozzle of the dispenser. Alternatively, the dispenser includes a septum to permit withdrawal of the mi~ed æubstances using a hypodermic needle or the like.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is a cross-sectional side elevation of the dispenser device of this invention before mixing the components.
Figure 2 is a cross-sectional side elevation of the dispenser device of this invention a~ter mixing the components.
It should be understood that the drawings are not necessarily to scale and that the embodiments are sometimes illustrated by graphic symbols, phantom lo lines, dia~rammatic representations and fragmentary views. In certain instances, details which are not necessary for an understanding of the present invention or which render other details difficult to perceive may have been omitted. It should be understood, of course, that the invention is not necessarily limited to the particular embodiments . i~lustrated herein.
DETAILED ~SCRIPTION
The dispenser device of the pre~ent invention preferably is made of a plastic material, for example, lo~ density polyethylene, by a conventional blow molding technique to produce the bottom and mid body section, inserting the tablet containing meanæ, and subsequently molding the body section to produce the upper section of the dispenser device. If, however, the neck is sufficiently wide to permit insertion of the holder device, the entire bottle can be made In one step. It is to be understood that the present invention is not limited to the specific material from which the di~penser device of the present invention is made, or the particular process by which it is made as it will be understood by those skilled in the art that many different materials and various manufacturing techniques may be employed.
The dispensing device of the present invention has a bellows bottom to permit in situ mixing of the contents at time of use, and a dropper dispenser tip calibrated to deliver predetermined amount of solution. Both bellows bottom vials and dropper dispenser tips are known in the art.
The dispensing device of the present invention comprises a bottle means 10 having bellows bottom 11 and dispenser means 12, for example, a dropper tip. Bottle 10 is filled with a liquid 13, such as, for example, a physiologically acceptable ophthalmic liquid. Tablet holding means 14 i~ an enlongated member having a cut-out section 15 for holding a solid medicament 16. The holding means 14 may have a constant, or tapered cross section and the circumference or outer wall of holding means 14 may be circular or non-circular, e.g., cylindrical or oval. The holding 14 means 14 preferably has a tapered cross section, such as, for example, a frustoconical member, to facilitate both seating and .
unseating against seating means 19. A push member 17 extends from the bottom of member 15 to or near to the bottom of bottle 10.
Seating means 19 has inner wall 20 that is complementary in shape to the outer wall of member 14 and is thereby adapted to form a seal preventing liquid 13 from contacting medicament 16. Seating means 19 is held by one or more eupport means 21 extending from shoulder 22 of bottle 10 to the member 0716~/6052A - 5 - 18343 lS. The bottom of support 21 is provided with flange means 23 to prevent seating means 19 from movement.
In this position cut-out section 15 is surrounded by inner walls 20 of seating means 21 and is not in contact ~ith liquid 13.
To dissolve the medicament 16, as æhown in figure 2, the bellows bottom 11 of bottle 10 ie pushed up thereby moving push Imember 17 in the same direction and li~ting member 14 away from its seated position. The cut-out section of member 14 and lo medicament 16 are now in contact with liquid 13.
When medicament 16 i3 fully dissolved, the medicament solution is ready to be dispersed from dispenser means 12.
As indicated previously, the drawings are not necessarily to scale and the solid medicament supporting and receiving means within the bottle have been enlarged to facilitate an understanding of the invention. These means, however, are preferably small enough to pass through the neck of the bottle whereby the bottle iæ conveniently manufactured in one step.
Claims (16)
1. A single chamber bottle having top liquid dispensing means, a neck, a shoulder and a bellows bottom, support means extending downwardly from the upper region of the bottle and joined to a seating member, receiving means to receive a solid medicament seated within the seating member, and means disposed between the receiving means and the bellows bottom for unseating the receiving means.
2. A bottle according to claim 1 wherein the seating member and the receiving member are complementary in shape.
3. A bottle according to claim 2 wherein the receiving member comprises an elongated member having constant or tapered cylindrical, or non-cylindrical cross-section.
4. A bottle according to claim 3 wherein the receiving member is a frustoconical or cylindrical member.
5. A bottle according to claim 4 wherein the receiving member is frustoconical.
6. A bottle according to claim 1 wherein the support means extend downwardly from about the shoulder of the bottle.
7. A bottle according to claim 1 wherein the unseating means comprises an elongated member disposed between the receiving member and the bellows bottom.
8. A bottle according to claim 1 wherein the chamber is filed with an ophthalmic liquid.
9. A bottle according to claim 1 wherein the receiving means contains a solid medicament.
10. A bottle according to claim 9 wherein the medicament is an opthalmic medicament.
11. A bottle according to claim 9 wherein the medicament is in the form of a tablet.
12. A single chamber bottle having top dropper dispensing means, a neck, a shoulder and a bellows bottom, support means extending downwardly from the shoulder of the bottle supporting a frustoconical seating member, a frustoconical receiving member having means to receive a solid medicament seated within the seating member, and an elongated member for unseating the seating member disposed between the frustoconical receiving member and the bellows bottom.
13. A bottle according to claim 12 wherein the chamber is filled with an ophthalmic liquid.
14. A bottle according to claim 12 wherein the receiving means contains a solid medicament.
15. A bottle according to claim 9 wherein the medicament is an ophthalmic medicament.
16. A bottle according to claim 9 wherein the medicament is in the form of a tablet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68735191A | 1991-04-18 | 1991-04-18 | |
| US687,351 | 1991-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2065814A1 true CA2065814A1 (en) | 1992-10-19 |
Family
ID=24760114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2065814 Abandoned CA2065814A1 (en) | 1991-04-18 | 1992-04-14 | Dispenser device |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0509754A3 (en) |
| JP (1) | JPH0611285B2 (en) |
| CA (1) | CA2065814A1 (en) |
| IE (1) | IE921238A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0702967B1 (en) * | 1994-04-11 | 2001-11-07 | Tsukada Medical Research Co., Ltd. | Portable pain-killing apparatus |
| CA2145868A1 (en) * | 1994-04-12 | 1995-10-13 | Osamu Tsukada | Accordion container for chemical |
| JP4608301B2 (en) * | 2004-12-14 | 2011-01-12 | 大成化工株式会社 | Dissolving eye dropper kit |
| EP2385920A4 (en) * | 2009-01-12 | 2012-10-24 | Aktivpak Inc | Packaged products, inserts and compartments for aseptic mixing of substances, along with methods for use therewith |
| KR20160071287A (en) | 2014-12-11 | 2016-06-21 | 이상희 | Drug keeping device for patients |
| MX2022011091A (en) * | 2020-03-18 | 2022-12-15 | Brev Angela Srl | Pre-filled container, method of use and related production method. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354883A (en) * | 1965-03-08 | 1967-11-28 | Southerland Elizabeth Lee | Disposable syringe having frangible means for mixing plural medicaments |
| DE3152033A1 (en) * | 1981-12-31 | 1983-07-07 | Alfred Von 4178 Kevelaer Schuckmann | Container for the sterile transfer of drugs |
| GB2235897A (en) * | 1989-09-15 | 1991-03-20 | Plaspharm | Plastics dispenser body having injection and blow moulded parts. |
-
1992
- 1992-04-14 EP EP19920303332 patent/EP0509754A3/en not_active Withdrawn
- 1992-04-14 CA CA 2065814 patent/CA2065814A1/en not_active Abandoned
- 1992-04-16 IE IE123892A patent/IE921238A1/en not_active Application Discontinuation
- 1992-04-18 JP JP9834892A patent/JPH0611285B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0611285B2 (en) | 1994-02-16 |
| JPH05111523A (en) | 1993-05-07 |
| EP0509754A2 (en) | 1992-10-21 |
| IE921238A1 (en) | 1992-10-21 |
| EP0509754A3 (en) | 1993-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |