JPH0575388B2 - - Google Patents
Info
- Publication number
- JPH0575388B2 JPH0575388B2 JP13318185A JP13318185A JPH0575388B2 JP H0575388 B2 JPH0575388 B2 JP H0575388B2 JP 13318185 A JP13318185 A JP 13318185A JP 13318185 A JP13318185 A JP 13318185A JP H0575388 B2 JPH0575388 B2 JP H0575388B2
- Authority
- JP
- Japan
- Prior art keywords
- tank
- reaction solution
- enzyme reaction
- enzyme
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006911 enzymatic reaction Methods 0.000 claims description 118
- 239000007788 liquid Substances 0.000 claims description 110
- 239000012528 membrane Substances 0.000 claims description 85
- 239000000126 substance Substances 0.000 claims description 73
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- 108090000790 Enzymes Proteins 0.000 claims description 57
- 238000000108 ultra-filtration Methods 0.000 claims description 48
- 239000002994 raw material Substances 0.000 claims description 14
- 239000004094 surface-active agent Substances 0.000 claims description 14
- 239000012736 aqueous medium Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 170
- 229940088598 enzyme Drugs 0.000 description 55
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 24
- -1 L-tyrosine and 3 Chemical class 0.000 description 23
- 238000006243 chemical reaction Methods 0.000 description 23
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- 210000004027 cell Anatomy 0.000 description 20
- 238000000034 method Methods 0.000 description 19
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 16
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- 230000001580 bacterial effect Effects 0.000 description 13
- 239000005720 sucrose Substances 0.000 description 13
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 12
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 10
- 229940041514 candida albicans extract Drugs 0.000 description 10
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- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 6
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
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- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 5
- 229940045946 sodium taurodeoxycholate Drugs 0.000 description 5
- YXHRQQJFKOHLAP-FVCKGWAHSA-M sodium;2-[[(4r)-4-[(3r,5r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 YXHRQQJFKOHLAP-FVCKGWAHSA-M 0.000 description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 4
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| JP13318185A JPS61289890A (ja) | 1985-06-19 | 1985-06-19 | 酵素を用いた有用物質の製造法 |
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| JPS61289890A JPS61289890A (ja) | 1986-12-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13318185A Granted JPS61289890A (ja) | 1985-06-19 | 1985-06-19 | 酵素を用いた有用物質の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61289890A (enrdf_load_stackoverflow) |
-
1985
- 1985-06-19 JP JP13318185A patent/JPS61289890A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61289890A (ja) | 1986-12-19 |
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