JPH054066B2 - - Google Patents
Info
- Publication number
- JPH054066B2 JPH054066B2 JP60145705A JP14570585A JPH054066B2 JP H054066 B2 JPH054066 B2 JP H054066B2 JP 60145705 A JP60145705 A JP 60145705A JP 14570585 A JP14570585 A JP 14570585A JP H054066 B2 JPH054066 B2 JP H054066B2
- Authority
- JP
- Japan
- Prior art keywords
- strain
- pasteurella multocida
- mutant strain
- pasteurella
- fermentable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000606856 Pasteurella multocida Species 0.000 claims description 53
- 229940051027 pasteurella multocida Drugs 0.000 claims description 53
- 229930006000 Sucrose Natural products 0.000 claims description 14
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 12
- 241000282898 Sus scrofa Species 0.000 claims description 10
- 208000015181 infectious disease Diseases 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 229960001212 bacterial vaccine Drugs 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 4
- 101710194807 Protective antigen Proteins 0.000 claims description 3
- 230000034659 glycolysis Effects 0.000 claims description 3
- 230000002458 infectious effect Effects 0.000 claims description 3
- 239000003471 mutagenic agent Substances 0.000 claims description 3
- 206010034107 Pasteurella infections Diseases 0.000 claims description 2
- 201000005115 pasteurellosis Diseases 0.000 claims description 2
- 150000003445 sucroses Chemical class 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 description 12
- 230000002008 hemorrhagic effect Effects 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 8
- 229960005486 vaccine Drugs 0.000 description 8
- 229920001817 Agar Polymers 0.000 description 7
- 239000008272 agar Substances 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 241000282887 Suidae Species 0.000 description 6
- 239000002504 physiological saline solution Substances 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- 239000003053 toxin Substances 0.000 description 6
- 231100000765 toxin Toxicity 0.000 description 6
- 241000588779 Bordetella bronchiseptica Species 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000002956 necrotizing effect Effects 0.000 description 4
- 210000001944 turbinate Anatomy 0.000 description 4
- 206010003694 Atrophy Diseases 0.000 description 3
- 241000700198 Cavia Species 0.000 description 3
- 230000037444 atrophy Effects 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 231100000518 lethal Toxicity 0.000 description 3
- 230000001665 lethal effect Effects 0.000 description 3
- 230000001338 necrotic effect Effects 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- WTLKTXIHIHFSGU-UHFFFAOYSA-N 2-nitrosoguanidine Chemical compound NC(N)=NN=O WTLKTXIHIHFSGU-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000009630 liquid culture Methods 0.000 description 2
- 231100000219 mutagenic Toxicity 0.000 description 2
- 230000003505 mutagenic effect Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 108091008717 AR-A Proteins 0.000 description 1
- 201000008283 Atrophic Rhinitis Diseases 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 206010012559 Developmental delay Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000606860 Pasteurella Species 0.000 description 1
- 108010059749 Pasteurella multocida toxin Proteins 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010039088 Rhinitis atrophic Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60145705A JPS626673A (ja) | 1985-07-04 | 1985-07-04 | パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60145705A JPS626673A (ja) | 1985-07-04 | 1985-07-04 | パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS626673A JPS626673A (ja) | 1987-01-13 |
| JPH054066B2 true JPH054066B2 (sv) | 1993-01-19 |
Family
ID=15391208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60145705A Granted JPS626673A (ja) | 1985-07-04 | 1985-07-04 | パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS626673A (sv) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790954B2 (en) * | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
-
1985
- 1985-07-04 JP JP60145705A patent/JPS626673A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS626673A (ja) | 1987-01-13 |
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