JPH05209318A - Calcium alginate fiber having excellent liquid absorbing property and covering material for medical use - Google Patents

Abstract

PURPOSE:To obtain calcium alginate fiber having excellent liquid absorbing properties of electrolyte solutions such as bodily fluid, physiological saline solution, etc., and having good mechanical performances such as strength or brittleness. CONSTITUTION:The objective calcium alginate fiber has 20-50g/g absorptivity of physiological saline solution when immersed at 37 deg.C for 4hr and the objective medical covering material consisting of the fiber. Since the fiber and the material are excellent in the absorptivity of bodily fluid and adhesion to lesion, they prevent microbial infection and the proliferation, thus have healing promotion effect.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a calcium alginate fiber excellent in absorption of an aqueous electrolyte solution such as body fluid, and a medical covering material comprising the same. More specifically, the present invention relates to a calcium alginate fiber suitable for treating wounds (including not only those caused by mechanical external force but also burns, chemical injuries, etc.) and pressure ulcers because of its excellent absorption of body fluids, and a medical covering material comprising the same. ..

[0002]

2. Description of the Related Art Extruding an aqueous solution of an alkali metal alginate into an aqueous solution containing calcium ions to form calcium alginate fibers is described in, for example, British Patent Nos. 567641, 568771 and 57165.
No. 7, JP-A-61-174499 and the like are known. The calcium alginate fiber thus obtained has been generally used as a surgical suture, gauze, absorbent cotton, etc. after converting a part of calcium alginate into a form of sodium.

[0003]

However, such alginate fibers have the drawbacks of being brittle, weak, and sensitive to moisture, and since the surface of the fibers is sodium alginate, it may cause damage to wounds and When used as a covering material for pressure ulcers, there was a problem that fibers were sticky to the wound. On the other hand, calcium alginate fibers that have not been converted to the sodium salt form have the drawback of being brittle and weak, and are difficult to put to practical use as they are.
In addition, these alginate fibers (eg sorbusan,
(Commercially available under the trade name of Kaltostat), the absorbability of body fluid was still insufficient.

The present invention has been made in view of the background of the prior art, and its object is to improve the sensitivity to water and to be easily handled, while having a high liquid absorbing property to an electrolyte solution such as body fluid or physiological saline. It is intended to provide a calcium alginate fiber which has excellent mechanical properties (strength and brittleness) and can be suitably used for wounds and pressure ulcers, and a medical covering material comprising the same.

[0005]

Means for Solving the Problems As a result of various studies to achieve the above object, the present inventors have found that an aqueous solution containing a soluble alginate (referred to as a dope) is added to a spinning bath containing a calcium salt. Upon spinning, the fiber obtained by adjusting the calcium salt concentration in the coagulation bath to a specific range corresponding to the dope concentration has improved strength, brittleness, and moisture sensitivity while having good electrolyte absorption. It has been found that the present invention has the present invention.

That is, according to the present invention: The physiological saline absorbency X represented by the following formula is 20 to 5
Calcium alginate fiber characterized by being 0 g / g, physiological saline absorbability X = (AB) / B (where A is immersed in physiological saline at 37 ° C. for 4 hours and then at 350 G for 10 minutes) 1. The weight of the fiber after centrifugal dehydration treatment, B represents the weight of the fiber when absolutely dried) and 1. There is provided a medical covering material comprising calcium alginate fibers having a physiological saline absorbability X of 25 to 50 g / g.

The calcium alginate fiber according to the present invention is obtained by extruding an aqueous solution (spinning dope) of a water-soluble alginate, such as sodium alginate, potassium alginate and sodium alginate, into a coagulating solution containing calcium salt. It is obtained by
The physiological saline absorption X measured by the following method is 20 to 5
It is important to be within the range of 0 g / g.

Calcium alginate fiber Bg (absolute dry weight) was immersed in physiological saline at 37 ° C. for 4 hours, and then 3
After dehydration under a centrifugal force of 50 G for 10 minutes, the weight Ag of the absorbed calcium alginate fiber is measured. At this time, the physiological saline absorbency X is represented by the following formula: X = (AB) / B: (g / g).

When the physiological saline absorbency is less than 20 g / g, when the alginic acid fiber is used for surgical and medical applications such as a wound dressing, the body fluid absorbency becomes insufficient and a healing promoting effect cannot be obtained. Moreover, the strength and brittleness of the fibers are insufficient, so that the object of the present invention cannot be achieved. While 50
When it exceeds g / g, not only is it unsuitable as a medical covering material because the shape retention during absorption of body fluid is reduced, but it is also necessary to lower the calcium salt concentration in the coagulation bath during the production of the fiber. Therefore, the coagulability is lowered and spinning becomes difficult.

The method for producing the calcium alginate fiber of the present invention is not particularly limited, but the above-mentioned alginate aqueous solution (dope) is filtered to remove insoluble matters and dusts, and then defoamed. In the method of extruding into a calcium salt solution (for example, calcium chloride aqueous solution) from a spinneret having 0.5 mm spinning holes, the calcium ion concentration of the coagulation bath is appropriately changed according to the coagulation bath temperature, dope concentration, dope viscosity, etc. Can be easily obtained. That is, it is achieved by adjusting the concentration of calcium ions in the coagulation bath according to the dope concentration and the spinning conditions. If the calcium ion concentration becomes too high, the physiological saline absorption X becomes too small, and conversely calcium ion When the concentration becomes too low, X becomes too large and the alginic acid fiber of the present invention cannot be obtained.

The dope to be used may be in a viscosity range in which spinning is possible, and it may be appropriately adjusted by the concentration of soluble alginate, the concentration of dope, addition of an auxiliary agent and the like. The preferred viscosity is in the range of 50 to 2000 poise, more preferably 100 to 1500 poise. The coagulation bath is preferably an aqueous solution containing an aqueous solution of calcium ions (eg calcium chloride) that can be exchanged with the cations of the water-soluble alginate to insolubilize them, but other than calcium ions within the range not impairing the object of the present invention. Other metal ions may be included.

Further, the coagulated gel-like alginic acid fiber may be washed with water and stretched if necessary. When the washing and stretching are carried out at a high temperature, the washing effect can be improved and the stretching ratio can be increased, which is preferable from the viewpoint of improving the strength.

The washed and drawn fibers are preferably dehydrated once before being subjected to the drying step. If the fibers are dried without undergoing the dehydration step, the single yarns will stick to each other after the drying. The handling property in the processing step may be deteriorated.

The calcium alginate fiber of the present invention thus obtained can be used, for example, as a woven or knitted fabric, a non-woven fabric, a sheet such as a sheet, a mat or the like, a fiber aggregate such as tow or cotton, or a powder. Since it has body fluid absorbability and fiber physical properties, and has good adhesion to the wound surface, it is desirable to use it as a sheet material such as a cloth and use it as a medical covering material.

At this time, other fibers or agents may be added within a range that does not impair the absorbability of body fluids and within a range that does not hinder the treatment of wounds and pressure ulcers.

Examples of such agents include collagen, eggshell membranes, chitin and chitosan, which may be suspended or dispersed in the dope. The particle size of the agent is
From the viewpoint of spinnability, 0.5 times or less of the spinning hole diameter is desirable,
The blending ratio is 99.99: 0.01-5 by weight.
The range of 0:50 (alginate: additive) is preferable,
If the content is less than 0.01% by weight, the effect of promoting the healing of wounds and pressure ulcers is not observed. On the other hand, when it exceeds 50% by weight, the spinnability is lowered and, at the same time, the mechanical properties of the obtained fiber are insufficient.

Further, in the present invention, a drug may be incorporated in the alginic acid fiber for the purpose of preventing infection of the affected area and its peripheral area, chemotherapeutic treatment of the infected area, and promoting healing. The method of addition is arbitrary, and in the case of a water-insoluble drug, the method of addition to the spinning dope is suitable.
In this case, from the viewpoint of spinnability, it is preferable that the diameter of the drug is fine particles having a diameter of 0.5 times the spinning hole diameter or less. On the other hand, in the case of a water-soluble drug, it may be eluted into the coagulation bath or water during spinning or post-processing, so the method of impregnating the obtained calcium alginate fiber with a solution containing the drug and then drying is preferred. .. Regardless of the method of addition, the drug is added to the inside or surface of the fiber, so it should exert a sufficient effect on the prevention of infection of the pressure ulcer affected area and its surrounding area, the chemical treatment of the infected area, and the promotion of healing. You can

Examples of the drug preferably used include, for example,
(1) Pobindon iodine, chlorhexidine gluconate, mercury chrome, iodine, as a drug used for the purpose of preventing infection of the affected area and its peripheral area and treating the infected area,
Iodotinki, thimerosal, bactericidal disinfectants such as bromezole, sulfadiazine, external sulfa agents such as silver sulfadiazine, fradiomycin sulfate, gentamicin sulfate, erythromycin, and antibiotics such as tetracycline, and these may be used alone, Moreover, you may use it in combination of 2 or more type. (2) Hyaluronate, chondroitin sulfate, gelatin, superficial inflammatory disease therapeutic agent (eg, 1,4-dimethyl-7-isopropylazulene), fiber Dissolving enzyme agents (eg, fibrinolidine, deoxyribonuclease), tissue absorption enhancers (eg, calf blood extract), anti-ulcer agents (eg, bendazac, guaiazulene), ulcer treatment agents (eg,
Al chlorohydroxy allantoinate), an epidermal formation promoter (for example, epidermal growth factor), a granulation formation promoter (for example, prostaglandin E ₁ ), further, fibronectin, a fibroblast growth factor, an amino acid (particularly, Methionine, histidine, arginine, cystine), various vitamins, androgen, histamine, growth hormone and the like can be mentioned, and these may be used alone or in combination of two or more kinds.

[0019]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

[0020]

Example 1 A 3% by weight aqueous solution of sodium alginate (Nakarai Desk Co., Ltd., 1000 cps) was prepared and filtered through a filter paper (No 63F, Toyo Roshi Kaisha, Ltd.) using a pressure filter. .. This aqueous solution was spun into a calcium chloride aqueous solution having various concentrations shown in Table 1 at a discharge rate of 1.4 ml / min using a wet spinning machine. On this occasion,
A 30-hole die having a diameter of 0.2 mm was used. The obtained gel-like fiber is stretched (stretching ratio 1.36 times),
After thoroughly washing, it was dried and wound at a winding speed of 4.9 m / min. The absorbency of physiological saline in the obtained fiber was measured according to the method described above. Further, the tensile strength was measured according to a conventional method. The results are shown in Table 1.

Further, when the obtained fibers (No. 1 to 6) were formed into a plain weave and applied to a wound part and the healing effect was examined, good results were obtained in all cases.

[0022]

Example 2 Example 1 was repeated except that the concentrations of the sodium alginate aqueous solution and the calcium chloride aqueous solution were changed as shown in Table 2. The results are shown in Table 2.

[0023]

[Example 3] Sodium alginate (manufactured by Nakarai Desk Co., Ltd., 1000 cps) was added to sodium alginate (manufactured by Nakarai Desk Co., Ltd., microorganism-derived) at a sodium alginate / sodium hyaluronate weight ratio of 9
Mix to 6/4. A 3 wt% aqueous solution of this mixture was prepared, and a filter paper (No63F,
It was passed through Toyo Roshi Kaisha, Ltd. and filtered. This aqueous solution was mixed with a wet spinning machine at a discharge rate of 1.4 ml / min.
It was spun into an aqueous solution of calcium chloride of 05 mol / liter. At this time, a 30-hole die having a diameter of 0.2 mm was used. The gel fiber thus obtained was stretched (stretching ratio 1.
36 times), thoroughly washed and then dried, and winding speed 4.
It was wound up at 9 m / min. The obtained fiber is cut into 5 mm,
Add water to obtain a normal papermaking concentration and disperse it
Paper was made using a PPI standard sheet machine so that the basis weight was 100 g / m ² . No elution of hyaluronic acid to the coagulation bath was observed during spinning and papermaking.

The water absorption of the obtained fiber is 30 g.
/ G.

[0025]

Example 4 A yarn was produced in the same manner as in Example 3 except that the dope concentration was 4% and the obtained drawn yarn was dehydrated with ethanol. The obtained fiber was put into a crimping machine and then 3
It was cut into cm length, passed through a card to make a web, and then needle punched to obtain a nonwoven fabric having a basis weight of 200 g / m ² .

[0026]

Example 5 Sodium alginate (manufactured by Nakarai Desk Co., Ltd., 1000 cps) was mixed with a fine powder of egg shell membrane (average particle size 10 μm) so that the weight ratio of sodium alginate / egg shell membrane was 15/1. A 3.2 wt% aqueous solution of this mixture was prepared, and a Naslon filter (manufactured by Nippon Seisen Co., Ltd., Finebore N) was used using a pressure filter.
F, NF-14, 80 μm) and filtered. Discharge rate of this aqueous solution was 2.1 ml / mi using a wet spinning machine.
It was spun into an aqueous solution of calcium chloride of 0.05 mol / l. At this time, a 30-hole die having a diameter of 0.2 mm was used. The obtained gel-like fiber was stretched (stretching ratio 1.29 times), thoroughly washed, then ethanol was added thereto to dehydrate it, and it was dried and wound up at a winding speed of 4.9 m / min. The obtained fiber was cut into 5 mm, water was added and dispersed to obtain a usual papermaking concentration, and papermaking was performed using a TAPPI standard sheet machine so that the basis weight was 100 g / m ² .

[0027]

Example 6 With respect to the alginic acid fiber papers obtained in Examples 3 and 5, the absorbency of physiological saline was measured according to the method described above. Also, the absorbability of bovine serum was measured by the same method as in the case of physiological saline. As a comparative example, a commercially available alginate wound dressing (ARGIDERM: Viaderm Pharma
The same evaluation was performed for “Cuticals”. The results are shown in Table 3.

[0028]

Example 7 In Example 1, fibers obtained by adjusting the concentration of calcium in the coagulating bath to 0.05 mol / liter were cut into a length of 5 mm, and then paper-made to obtain 100 g / m ² of basis weight and Example 3, 1m ^{2 of} tincture of iodine on the paper obtained in 5
After impregnation at a rate of 500 ml per unit, it was dried. When these papers were fasted for 10 days and attached to the pressure ulcer part of the rabbit generated by pressurizing the dead weight of the rabbit on the depilated third trochanter of a rabbit weighing 3 kg, normal granulation was observed. A smooth healing process such as healing from the wound periphery was observed, and no bacterial infection was found on the face of the foot. Further, the adhesion to the face of the foot, the releasability from the face of the foot, and the absorbability of body fluid were also sufficiently satisfactory. Among them, when the samples obtained in Examples 3 and 5 were used, healing was fast.

[0029]

[Table 1]

[0030]

[Table 2]

[0031]

[Table 3]

[0032]

The calcium alginate fiber of the present invention is
Since it excels in absorbing body fluids and adhering to wounds,
When used as a covering material for pressure ulcer, it can prevent bacterial infection and reproduction of the affected part and has a healing promoting effect. Furthermore, the fiber of the present invention has strength, brittleness, and
Since the sensitivity to water is improved and the handleability thereof is improved, it has an advantage that good treatment is possible when used for a wound or pressure ulcer.

Claims (3)

[Claims] 1. A physiological saline absorption X represented by the following formula:
Is 20 to 50 g / g, calcium alginate fiber. Saline absorbability X = (A−B) / B (where A is the weight of the fiber after being immersed in physiological saline at 37 ° C. for 4 hours and then subjected to centrifugal dehydration at 350 G for 10 minutes, and B is absolutely dried) Indicates the weight of the fiber at the time.) 2. The calcium alginate fiber according to claim 1, which contains 0.01 to 50% by weight based on the weight of the fiber of at least one selected from the group consisting of collagen, eggshell membranes, chitin and chitosan. 3. A physiological saline absorbency X is 25 to 50 g / g.
A medical dressing made of calcium alginate fiber.