JPH05186357A - Absorption-inhibitory means for digested product of food/ beverage - Google Patents

Abstract

PURPOSE:To provide the subject means readily takeable during one's meal, containing, as active ingredient, sodium polyacrylate in an acidic aqueous liquid. CONSTITUTION:The objective means can be obtained by adding, as active ingredient, sodium polyacrylate to an acidic aqueous liquid (e.g. an aqueous solution of ascorbic acid or citric acid; fruit juice such as of lemon or orange). Specifically, 2-3g of sodium polyacrylate is dissolved in 100ml of an acidic liquid and the pH value of the resulting solution is adjusted to <=5. The amount to be taken is 0.05 to 0.1g/adult/day. This product gives activity even at a low level because it can be penetrated and dispersed throughout the foods taken in the stomach by taking the sodium polyacrylate in the form of solution. This means is also useful for obesity prevention, hepatic dysfunction improvement, hyperlipemia improvement, diabetics improvement, or constipation prevention.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to means for suppressing absorption of digested and decomposed products of foods, means for preventing obesity, means for improving hyperlipidemia, means for improving diabetes, means for preventing constipation, and means for improving liver dysfunction. In the present specification, "digestion and degradation products of food and drink" include nutrients which are direct products of digestion and degradation, and metabolites which are indirect products of digestion and degradation.

[0002]

2. Description of the Related Art Except in times of complete food shortage or in countries that are still suffering from hunger, the harmful effects of excessive nutrition have always been difficult for people to overcome. It is needless to explain again that it causes many problems such as health and beauty. This is because even if you understand it in your head, the simplest and most reliable dietary control is not easily implemented. Various symptoms caused by over-nutrition include obesity, hyperlipidemia, arteriosclerosis, heart disease, so-called various adult diseases such as diabetes, and liver dysfunction.
Therefore, various methods (mostly for the purpose of preventing obesity of women) have been proposed and implemented as folk remedies. Many are also offered as commercial services. However, as far as the applicant knows, it seems that a method that can be easily executed, is highly safe, and has a positive effect has not yet appeared. On the other hand, medically, for example, amphetamine, fenflamin, phaseolamine, mazindol and the like which are commercially available in Europe and America are available as pharmaceuticals. However, all of these act directly or indirectly on the feeding and satiety centers of the hypothalamus of the brain. For this reason, side effects such as habit, spiritual uplifting, insomnia, and dry mouth may be accompanied, and the efficacy may be reduced by continuous administration. In order to solve such a problem, the inventor of the present application has previously proposed a means for suppressing absorption of food and drink digestive degradation products, which is obtained by coating a flocculant, for example, sodium polyacrylate with an aqueous enteric film. 3-120227 publication). These are characterized in that they form flocs of digestive degradation products due to aggregation and cross-linking effects in the intestine, thereby suppressing absorption in the intestinal tract, and have remarkable utility effects and extremely high safety. ..

[0003]

By the way, as with anything, it is most desirable that daily routines can be carried out naturally in daily life. This is because it is not long-lasting to say that you do something by holding it up, as the words of the Sankabozu. The same applies to the intake of the above-mentioned means for suppressing the absorption of digested and decomposed products of food and drink, and it is preferable that the intake is carried out naturally in the daily diet. The general form for that is a healthy drink form,
That is, it is a "drink form". Granules and tablets have a strong image of medicines, and it is difficult to take them in the public or while eating. In addition, the appearance of rabbits, horns, granules and tablets cannot be put into the mouth together with food and chewed. It means that we should try again after eating. Especially when eating with people, it is easy to forget about it later. If it is a drink, it will not happen. This is because it can be easily ingested during meals like drinking water, soup, tea, beer or juices.

However, conventional coagulants, especially polyacrylic acid soda, which is a suitable coagulant, are added to foods in a very small amount, as is clear from the fact that it is recognized as a thickener. It shows a strong viscosity even if it is used alone. When it is directly contained in the oral cavity, it sticks all over the mouth, which is uncomfortable, and the discomfort lasts for a long time (usually around 1 hour) but may not disappear yet. For this reason, conventionally, it has not been possible to realize a means for removing digested and decomposed products of food and drink in a drinkable form. The present invention has been made in order to further study this problem and to enhance its effect, and an object of the present invention is to provide a means for suppressing absorption of digested and decomposed products of food and drink which can be drunk during meals as a drink. In addition, there is also provided an obesity preventing means, hyperlipidemia improving means, diabetes improving means, constipation preventing means, and liver dysfunction improving means utilizing such absorption suppressing effect.

[0005]

Means for Solving the Problems In order to achieve the above object, the means for inhibiting absorption of digested and decomposed products of food and drink according to the present invention is characterized by containing sodium polyacrylate as an active ingredient in an acidic aqueous liquid. Similarly, the present invention means for preventing obesity, means for improving hyperlipidemia, means for improving diabetes, means for preventing constipation and means for improving liver dysfunction also contain sodium polyacrylate as an active ingredient in an acidic aqueous liquid. To do. The means for suppressing the absorption of digested and decomposed products of food and drink, the means for preventing obesity, the means for improving hyperlipidemia, the means for improving diabetes, the means for preventing constipation, and the means for improving liver dysfunction will be collectively referred to as the "drinking means of the present invention".

[0006] The acidic aqueous liquid may be any acidic liquid that can be drunk by humans and animals. It may be a chemically or industrially produced specific component dissolved in water, or it may be one used as a food or beverage and exhibiting acidity. For example, generally, there are aqueous solutions of ascorbic acid, citric acid, acetic acid, etc., and those obtained by diluting various types of vinegar, and juices and juices of citrus fruits such as lemon and orange. The acidity is pH 5 or less, preferably pH 2.5 to 3.5. At this acidity, 2-3 g of sodium polyacrylate is dissolved in 100 ml of the acid solution, and the fluidity is sufficient for drinking (measured by a viscometer is about 0.3-0.6 poise). ).

[0007] As will be shown in the Examples below, the intake amount is considered to be effective for adults, usually about 0.05 to 0.1 gram per day. Therefore, assuming that the concentration is 2-3 grams per 100 milliliters, the daily concentration is only 1.7-
Drinking 5.0 milliliters is enough.
(It goes without saying that it is possible to further dilute this as a stock solution and to use it for drinking.) Although an extreme example was given, the point is that the present invention is suitable as a drink. It means that various drinking means can be realized. There are two modes of implementation, one is ingesting a small amount of such a high concentration and the other is ingesting a low concentration of a certain amount of a drink as a drink. If the drinking is further advanced, it is also preferable that the beverage is seasoned like honey lemon and the beverage itself is used. In the examples described later, ascorbic acid 10 per 100 ml of water
00 milligrams of aqueous solution was used. At this time, the pH was about 2.8, the taste was such that the taste was sour, and when a little sweetness was added, a so-called sports drink-like taste with a refreshing feeling was obtained, which was very suitable.

[0008]

[Action] Needless to say, gastric juice is strongly acidic. Therefore, inside the stomach, especially in the first and second phases of the stomach (cardiac or gastric body)
, The same acidic condition as before drinking is maintained. Therefore, sodium polyacrylate is dispersed and mixed in food in a solution state. When applying for a means for suppressing the absorption of digested and decomposed products of food and drink, etc., the inventor decided to cover these aggregating agents such as sodium polyacrylate with an aqueous enteric film, or take those encapsulated in an enteric capsule. However, in the stomach, it was intended to be dispersed and mixed in food in the form of granules or tablets, capsules (hard capsules, soft capsules) and the like. In the case of the drinking means of the present invention, this sodium polyacrylate is already present as a solution in an aqueous liquid before drinking, and it is mixed and dispersed in food and drink while maintaining this state even in the stomach, giving a strong stomach kneading. As a result of further infiltrating into the details in the food by the action, the cohesive effect is further enhanced, and the effect is large at the same intake amount, and when the same effect is expected, the intake amount of the present invention can be drastically reduced. I can. It is thought that it is not only the effect on the stomach,
Compared with the conventional means for suppressing the absorption of digested and decomposed products of food and drink,
With the drinking means of the present invention, almost the same effect was observed at an intake of about 1/10 to 1/40.

From the third phase of the stomach (pylorus) to the upper small intestine (duodenum to jejunum), the digestive decomposition of food further progresses, and it is simultaneously absorbed while being digested into molecular form. In the portion and thereafter, aggregation of food and drink digestion decomposition products with sodium polyacrylate is performed. Since the sodium polyacrylate is already dispersed as a solution in the food and drink digestion decomposition product, the aggregate of the food and drink digestion decomposition product is more effectively formed. The means for removing food digestion degradation products of the prior application also dissolves the water-based enteric-coated film covering the outer periphery from the gastric phase 3 to the upper part of the small intestine, and after that portion, the food digestion decomposition products are aggregated. In the inside, the sodium polyacrylate itself became a large agglomerated state and was not dispersed and mixed with the food necessary for the purpose. As a result, sufficient floc formation could not be achieved, leading to a decrease in the effect of the effect. This is because after the water-based enteric film is dissolved, before the tablets, fine particles, and granules are sufficiently dispersed, especially water and the like infiltrate from the outside first, and agglomerates centering on sodium polyacrylate are formed to cause the intestinal tract to remain undispersed. It is thought to pass. In any case, in the present invention, as a result of being liquefied, and as a result that the same acidic state is maintained in the stomach with a high stirring effect, it is far more detailed than before in foods and drinks and digestive degradation products. Since they are dispersed and mixed, the efficiency of cohesion and the effect of utility are further enhanced.

The agglomerates form flocs (lumps) in which the digestion and decomposition products of foods and drinks and sodium polyacrylate are mainly cross-links, and the surface is paste-like or thick (dissolving kataguri), and the small intestine. Above all, when passing through the jejunum, which is the main absorption site, absorption of this aggregate from the intestinal wall is suppressed. Therefore, the digested and decomposed products of food and drink are suppressed from being absorbed in a predetermined amount according to the dose of the drinking means of the present invention, and are excreted outside the body as feces. Aggregates include lipids, carbohydrates,
Etc., and various products (nutrients, etc.) produced by digestion and decomposition of food and drink are included. Therefore, the drinking means of the present invention that suppresses these absorptions also acts as an obesity preventing means. In addition, the surface of the aggregate is paste-like or thick (dissolved in kataguri), and this is mixed with food residue or feces, so that it smoothly passes through the intestine. Without causing damage to the intestinal membrane,
On the contrary, the defecation promoting effect is clearly seen, and it also works effectively as a constipation preventing means. Further, from the results of the examples, blood lipids and leucine aminopeptidase, cholinesterase, and the like are also shown to have an improving effect on index items of liver dysfunction, which is also expected as a means for improving hepatic dysfunction. It is a thing.

[0011]

EXAMPLES Examples will be described below. These are for explaining the present invention in more detail, but the present invention is not limited thereto. [Preparation of Drinking Means] An acidic aqueous liquid was prepared by dissolving 1000 mg of ascorbic acid per 100 ml in a so-called sports drink-like aqueous liquid prepared by adding an electrolyte to water. The acidity of this liquid was pH 2.8, and the taste was such that the taste was not sour. 100 to this liquid
0.05 g of sodium polyacrylate was dissolved per milliliter and used as a drinking means. No significant difference in viscosity or fluidity was observed before and after the addition of sodium polyacrylate (viscosity: about 0.02 poise, below 20 degrees Celsius).

[Test Example] The test conditions are as follows. Subject Gender Age Height Initial weight Health condition Feces A Type of job A Woman 56 150 75.0Kg No abnormalities Constipation Nurse B Women 55 156 82.7Kg No abnormalities Constipation Housewife C Woman 57 160 88.5Kg No abnormalities Constipation Housewife D Woman 56 55.152 2Kg No abnormalities Constipation Housewife E Male 55 170 170 78.8Kg No abnormalities Constipation Office worker F Woman 43 162 162 77.5Kg No abnormalities Constipation Nurse Exam period 4 months from July to October 1991 Ingestion mode Lunch and dinner Ingest 100 ml once in a meal (equivalent to about 0.1 g of sodium polyacrylate per day). In addition, no particular condition was attached to the content of the meal, and each subject maintained the eating habits of the person until then. Data collection method For all subjects, before the start of the test and every month after the start,
Blood general test and biochemical test About 40 items were measured and changes were observed continuously.

As a result of the measurement, the improving effect was observed especially in serum leucine aminopeptidase, cholinesterase, triglyceride, total cholesterol, beta lipoprotein and the like. The data are shown in FIGS. 1 to 5 (correspondence between each broken line and the subject is shown in each figure). For all subjects,
The reduction and improvement of each component of the above items in serum was observed, and the effect of drinking appeared. The total cholesterol level is originally 3
Although it gradually decreases over a period of one month to half a year or one year, it was clearly reduced in 4 out of 6 subjects (ABDF) in this study, and a utility effect was also proved in this respect. .. The changes in body weight were as follows. Subject Initial weight after 4 months Reduction A 75.0Kg 71.3Kg 3.7Kg B 82.7Kg 78.4Kg 4.3Kg C 88.5Kg 86.6Kg 1.9Kg D 55.2Kg 52.8Kg 2.4Kg E 78 8kg 75.3kg 3.5kg F 77.5kg 74.2kg 3.3kg

Also, daily changes in defecation attitude (number of times, amount of stool, stool quality, defecation state, etc.) and various consciousness changes after the use of the means of the embodiment are taken every day.
Recorded for a month. Before the test started, all were constipation habits. 3 days to 1 week after the start of intake
I started seeing 3 defecations. The hardness and quality of the stool were good. It was also observed that the stool color changed to a beautiful bile color. This means that the drinking means of the present invention aggregates bile, bile acid and the like and discharges them out of the body.
Bile acids are mainly produced mainly in blood lipids and are reabsorbed in the jejunum.
The metabolism of fat in the body is promoted. In this respect, the drinking means of the present invention has an effect of improving hyperlipidemia and further improving liver dysfunction.

In the drinking means of the present invention, dietary fiber or chitin,
You may mix chitosan etc. The utility effect is further enhanced.

[0016]

As described above, the drinking means of the present invention contains sodium polyacrylate as an active ingredient in an acidic aqueous liquid, and exhibits the same properties as ordinary beverages.
Therefore, unlike the conventional ones, it is easy to take during meals. In addition, as a result of liquefaction, permeation and dispersion of fine details in food in the stomach are performed, and as a result, the same effect is exhibited in a much smaller amount than the conventional one. Further, in the prior art, it was necessary to coat the powder or granules of sodium polyacrylate with an aqueous enteric film. This task is quite complicated. The material for the water-based enteric film, for example, hydroxypropylmethylcellulose acetate succinate, is insoluble in a flammable and highly toxic solvent such as acetone, and is sprayed onto sodium polyacrylate granules for drying. , This requires considerable equipment and man-hours. Therefore, it cannot be denied that the cost will increase. The drinking means of the present invention only requires the addition and stirring of sodium polyacrylate into an aqueous liquid exhibiting acidity, and can be manufactured extremely easily and inexpensively.

[Brief description of drawings]

FIG. 1 is a diagram showing the altered state of serum leucine aminopeptidase upon taking the drinking means of the present invention.

FIG. 2 is a diagram showing the state of changes in serum cholinesterase associated with the administration of the drinking means of the present invention.

FIG. 3 is a diagram showing a change state of serum triglyceride upon taking the drinking means of the present invention.

FIG. 4 is a diagram showing a change state of serum total cholesterol associated with taking the drinking means of the present invention.

FIG. 5 is a diagram showing changes in serum beta lipoprotein associated with taking the drinking means of the present invention.

Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display area A61K 31/78 ADP

Claims (6)

[Claims] 1. A means for suppressing absorption of digested and decomposed products of food and drink, comprising sodium polyacrylate as an active ingredient in an acidic aqueous liquid. 2. A means for preventing obesity, which comprises sodium polyacrylate as an active ingredient in an acidic aqueous liquid. 3. A means for improving hyperlipidemia, which comprises sodium polyacrylate as an active ingredient in an acidic aqueous liquid. 4. A means for improving diabetes, which comprises sodium polyacrylate as an active ingredient in an acidic aqueous liquid. 5. A constipation-preventing means comprising sodium polyacrylate as an active ingredient in an acidic aqueous liquid. 6. A means for improving liver dysfunction, which comprises sodium polyacrylate as an active ingredient in an acidic aqueous liquid.