JPH10306028A - Drug for controlling intestinal function by lipid digestive absorbent inhibition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject medicine capable of improving bad feces caused by chitosan by formulating a mixture between Bifidobacterium bifidum or intestinal useful fungi and chitosan having lipid digestive absorbent inhibitory activity as an active ingredient. SOLUTION: This medicine contains a mixture between chitosan and Bifidobacterium bifidum or intestinal useful fungi as an active ingredient. As the Bifidobacterium bifidum, live Bifidobacterium bifidum is utilized. Further, in order to more enhance the effect, vegetable Plantago asiatica L. and apple fibers plus oligosaccarides are preferably added By this process, the objective drug for controlling intestinal function capable of being expected effects, for example, absorptive control for diet lipids, getting rid of constipation by means of multiplication of intestinal useful fungi, e.g. Bifidobacterium bifidum and the like, suppression for generation of large bowel cancer, prevention for obesity and lowering of cholesterol in blood is obtained.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to suppression of dietary lipid absorption, elimination of constipation due to growth of useful intestinal bacteria such as bifidobacteria,
The present invention relates to a lipid digestion-absorption-inhibiting intestinal preparation that can be expected to have effects such as suppression of the occurrence of colorectal cancer, prevention of obesity, and reduction of blood cholesterol.

[0002]

2. Description of the Related Art The Ministry of Health and Welfare has changed the name of adult disease to "lifestyle-related disease" and has put more emphasis on prevention than on health promotion and treatment since childhood. Cancer, which accounts for about 60% of the causes of death,
Heart disease, cerebrovascular disorder, and the like are deeply related to lifestyle such as diet, and the most urgent issue is diabetes in which complications such as blindness and renal failure, which are rapidly increasing, are serious problems. Obesity is one of the risk factors. Changes in dietary habits and excessive intake of fat due to satiation have been pointed out as causes, and appetite suppressants by drugs and chitosan, which is attracting attention due to absorption of ingested lipids → inhibition of absorption in the digestive tract → excretion from the body .

[0003] Drugs such as appetite suppressants and fat accumulation inhibitors are
It is not something that can be handled by ordinary people, and side effects such as vomiting and hormonal imbalance are pointed out and strict monitoring by a doctor is required.

[0004] Chitosan, which is biomass, has excellent biocompatibility and is extremely safe from research reports by public institutions, universities, and advanced companies with the support of the Ministry of Education, and inhibits digestion and absorption of lipids, lowers blood cholesterol, The effect of inhibiting metastasis of the tumor has been confirmed. However, while ingestion of chitosan in large amounts for the purpose of preventing obesity is very effective, it also has disadvantages such as "constipation", which causes inconvenience, and users can reduce lipid digestion absorption and slimming effects without knowing the cause. The reality is that some people are worried about the gorge of poor expectations and convenience.

[0005]

In order to solve one problem, microscopic prescriptions that induce new problems are not integrated into "all ones" but are necessary for maintaining the health and beauty of human beings. Not good, kind.

[0006] The present invention is intended to prevent diabetes and obesity, which are the most serious of the lifestyle-related diseases referred to as adult diseases. It is an object of the present invention to provide a lipid digestion / absorption-inhibiting intestinal for the purpose of improving poor stool.

[0007]

As means for achieving the above object, it is extremely dangerous to prescribe a laxative or the like in a short-circuit manner while keeping the cause. This is because it is a factor that creates new adverse effects.

The inventor is a pioneer in commercializing biomass chitin and chitosan materials as health foods in the Japanese market. For many years, gathering information from the patrons' side has found that sometimes people have constipation or vice versa. The results always have a cause. While paying attention, it was discovered that it occurs due to various conditions such as the way of ingestion, age, physical condition, stress, living environment and the like.

The causative agent is clearly chitosan. However, it is impossible to clarify why it is a dietary fiber similar to cellulose. Every day, I was shocked to notice that I was passing on serious facts as I was caught by a prejudice when observing the stool. It is nothing but color, shape, smell and other imbalances of intestinal flora. Chitosan that strengthens immunity. Chitosan that prevents bacterial growth. However, there was a pit in a place where they believed and believed that "they inhibit the growth of general bacteria but have little effect on useful bacteria such as lactic acid bacteria." It is a chitosan that inhibits the growth of pathogenic and non-pathogenic bacteria such as Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus. Under conditions below the borderline, even useful bacteria in the brain, such as bifidobacteria, are prevented from growing and decrease, and it is only natural that the intestinal environment deteriorates.

[0010] The present invention relates to a mixture of bifidobacteria or useful enteric fungi, in order to improve the disadvantageous inconvenience and the synergistic effect of health of chitosan having an effect of inhibiting lipid digestion and absorption under certain conditions. Is contained as an active ingredient.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION In the practice of the present invention, chitosan used was Yaizu Suisan Kagaku Kogyo Co., Ltd., and bifidobacterium used was Meiji Dairy Co., Ltd. To enhance the effect, vegetable psyllium and apple fiber were added, and oligosaccharides: Raffinose from Meiji Sugar Co., Ltd. were added, and all were composed of natural ingredients that were kind to the body.

[0012]

Since the present invention is configured as described above, it has the following effects.

The live Bifidobacterium directly supplies the Bifidobacterium. Vegetable psyllium and apple fiber suppress the decrease of bifidobacteria due to stomach acid, enclose living bacteria and deliver them to the intestine alive, suppress appetite with satiety, adsorb fat and sugar, increase stool volume, Helps to maintain intestinal environment.
Oligosaccharides serve as a direct feed for bifidobacteria and the like in the intestine, and are very effective in growing useful bacteria.

The improvement in convenience was remarkable. Relief of constipation. Improvement of solid stool. Comfortable bowels. Floating in the water with a good yellow stool,
The smell has been reduced. The result is only one week.

In addition, improvement such as dullness of the face, puffiness, complexion, headache, decrease in body odor, sleep, good awakening, and improvement in physical condition were observed. The intestine is the source of the body that absorbs the nutrients it eats and builds its body. The useful bacteria in the corner, especially the bifidobacteria, decrease with aging, and also decrease due to additives, drugs, carnivores, oils and fats, tobacco, alcohol, etc., and are liable to cause immunodeficiency, physical weakness and the like as shown in O-157 and the like. Just as the stomach and stomach hurts when things are bad, the bifidobacteria are then drastically reduced, making it impossible to digest or absorb nutrients. Stress is extremely bad for the body. If physical strength declines due to reduced digestive absorption, even life itself is threatened. Intestinal health, that is, the balance of intestinal bacteria, is all about life.

Elderly people, people with low physical strength, and stressed people commonly have young useful bacteria such as bifidobacteria,
Proven to be definitely less than healthy people. If such a person consumes a large amount of chitosan, the physical condition will be disturbed due to a decrease in useful intestinal bacteria, rather than the suppression of lipid digestion and absorption. Welsh bacteria and Escherichia coli, which are representatives of bad bacteria and are called spoilage bacteria, produce harmful bacteria such as ammonia, amines, and hydrogen sulfide. It produces not only carcinogens but also aging agents. Inhibition of lipid digestion and absorption by ingestion of chitosan can only be used if gut health is maintained. Supplementation of the bifidobacterium and creation of an environment for its growth are essential for maintaining the chitosan effect and youth.

[0017]

EXAMPLE From the viewpoint of preservation of viable Bifidobacteria, a juice type was prepared which was encapsulated in an aluminum stick with granule finish and dissolved in water or the like. The required amount can be taken twice a day, and the width can be freely adjusted depending on the person, constitution and time. Chitosan was used in an amount of 1000 mg per bag in consideration of the balance between “suppression of lipid digestion and absorption” and “taste” and “inhibition of growth of useful bacteria” in taste. According to the guidance of the professor of the University of Tokyo, Tomotsu Mitsuoka, a bifidobacterium-resistant bifidobacterium developer, the number of oral births was set at 5 billion per bag, based on a 10-billion oral dose that could reach alive. In addition to oligosaccharides and dietary fiber, it was made with a refreshing citrus flavor to make it easier to drink. Dissolve 6 g per bag with about 180 ml of water and drink.

The sticks described in Table 1 were given to 32 persons 2 times a day.
Bags were monitored for one week. The subjects are women in their 20s and 50s. A: 20s, B: 30s, C: 40s,
D: 50s. Take 1 bag after breakfast and dinner. All subjects are women who suffer from constipation.

As shown in Table 2, the effect of improving constipation symptoms is extremely excellent. Prepares intestinal environment while suppressing lipid digestion and absorption, and shows no side effects. 24
Those who tend to have little effect after that are addicts of a very strong constipation drug, and it takes time from accustomed to stimulation with laxatives to normalization of the intestinal environment. For 30 people who do not like drinking in terms of taste, this can be solved by changing the taste. The lipid absorption inhibiting intestinal preparation according to the present invention is composed of a natural material, and by continuing it, it is possible to improve symptoms of almost 100% of humans and prevent inconvenience caused by ingestion of chitosan.

In order to prevent silent arteriosclerosis and lifestyle-related diseases and achieve youthful health and longevity,
It is important to make clean and smooth blood. It is urgent for people on a slim diet, the elderly and hospitalized patients, modern people who are exposed to stressful environments, smoking, binge eating, drugs and additives, etc. to suppress lipid and sugar absorption and improve bowel movements. In addition to chitosan, it suppresses the growth of harmful bacteria in the intestine, synthesizes vitamins, assists in digestion and absorption, and at the same time replenishes ace grade bifidobacteria or useful fungi that play an important role in health, Triple support of plant dietary fiber and dietary oligosaccharides is the most primitive, old and new, natural and gentle health method for human beings to create an environment that can reach the intestine as it is.

[Table 1]

[Table 2]

[Table 3]

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[Procedure amendment]

[Submission date] February 12, 1998

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claims

[Correction method] Change

[Correction contents]

[Claims]

Claims (1)

[Claims] 1. An intestinal preparation for inhibiting lipid digestion and absorption, comprising a mixture of chitosan and bifidobacteria or useful enteric fungi as an active ingredient.