JPH05184643A - Liquid transport bag and its manufacture - Google Patents
Liquid transport bag and its manufactureInfo
- Publication number
- JPH05184643A JPH05184643A JP4006654A JP665492A JPH05184643A JP H05184643 A JPH05184643 A JP H05184643A JP 4006654 A JP4006654 A JP 4006654A JP 665492 A JP665492 A JP 665492A JP H05184643 A JPH05184643 A JP H05184643A
- Authority
- JP
- Japan
- Prior art keywords
- film
- layer
- gas barrier
- liquid transport
- transport bag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Laminated Bodies (AREA)
- Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、ガスバリヤ性を必要と
するアミノ酸輸液などに使用される輸液バッグ及びその
製造方法に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an infusion bag used for an amino acid infusion requiring gas barrier properties and a method for producing the same.
【0002】[0002]
【従来の技術】輸液容器は、従来からのガラス容器に替
わり、軽量で丈夫であり取扱い易さから、近年、プラス
チック容器が広く使われるようになって来た。このプラ
スチック輸液容器には、バッグ形態のものとボトル形態
のものとがある。バッグ形態の輸液バッグは、ポリエチ
レンなどのポリオレフィン系樹脂やポリ塩化ビニルなど
から作られており、充填される輸液は、アミノ酸輸液
剤、電解質輸液剤、糖質輸液剤などである。2. Description of the Related Art Infusion containers have been widely used in recent years in place of conventional glass containers because of their light weight, toughness, and ease of handling. This plastic infusion container is classified into a bag type and a bottle type. The bag-shaped infusion bag is made of a polyolefin resin such as polyethylene or polyvinyl chloride, and the infusion to be filled is an amino acid infusion agent, an electrolyte infusion agent, a sugar infusion agent, or the like.
【0003】[0003]
【発明が解決しようとする課題】しかしながら、アミノ
酸輸液は、酸素によって変質するため、アミノ酸輸液用
輸液バッグには、長期保存や輸送のために、ガスバリヤ
性が必要となる。比較的にガスバリヤ性の良好なポリ塩
化ビニルは、樹脂中に含まれる可塑剤の輸剤への溶出な
どの危惧があり、ポリオレフィン系樹脂は、ガスバリヤ
性が劣る問題があるため、図2に示したように、輸液バ
ッグ(200)の外側に、ポリ塩化ビニリデンやエチレ
ン・ビニルアルコール共重合樹脂を構成材料とした、例
えば、ポリエステル(303)/ポリ塩化ビニリデン
(302)/無延伸ポリプロピレン(301)構成の多
層フィルムの外装材(300)で二重包装していた。本
発明は、ポリオレフィン系樹脂製の輸液バッグに本体成
形と同時にガスバリヤ性を付与し、多層フィルムの外装
材での二重包装を不要とした輸液バッグ及びその製造方
法を提供するものである。However, since the amino acid infusion solution is deteriorated by oxygen, the amino acid infusion solution bag needs a gas barrier property for long-term storage and transportation. Polyvinyl chloride, which has a relatively good gas barrier property, has a risk of elution of the plasticizer contained in the resin into the infusate, and the polyolefin resin has a problem of poor gas barrier property. As described above, for example, polyester (303) / polyvinylidene chloride (302) / unstretched polypropylene (301) having polyvinylidene chloride or ethylene / vinyl alcohol copolymer resin as a constituent material on the outside of the infusion bag (200). It was double-wrapped with the exterior material (300) of the multilayer film having the structure. The present invention provides an infusion bag made of a polyolefin resin, which is provided with gas barrier properties at the same time as the main body is formed, and which does not require double wrapping with an outer packaging material of a multilayer film, and a method for producing the same.
【0004】[0004]
【課題を解決するための手段】第1の本発明は、プラス
チック製のバッグ形態の輸液容器において、その胴部の
周壁表面に、少なくとも片面に無機化合物の薄膜を形成
した熱可塑性樹脂フィルムを構成層とするガスバリヤ性
の単層又は多層フィルムが、接着層を介して貼着されて
いる輸液バッグである。第2の本発明は、ブロー成形金
型内に少なくとも片面に無機化合物の薄膜を形成した熱
可塑性樹脂フィルムを構成層とするガスバリヤ性の単層
又は多層フィルムを挿着し、輸液バッグの胴部を熱可塑
性樹脂でブロー成形すると同時に、前記の単層又は多層
フィルムを胴部の周壁に接着層を介して貼着した輸液バ
ッグの製造方法である。According to a first aspect of the present invention, in a plastic bag type infusion container, a thermoplastic resin film having a thin film of an inorganic compound formed on at least one surface thereof is formed on the peripheral wall surface of the body of the infusion container. A single-layer or multi-layer film having gas barrier properties as a layer is an infusion bag adhered via an adhesive layer. A second aspect of the present invention is to insert a gas barrier single layer or multilayer film having a thermoplastic resin film having a thin film of an inorganic compound formed on at least one surface as a constituent layer into a blow molding die, Is blow-molded with a thermoplastic resin, and at the same time, the single-layer or multi-layer film is attached to the peripheral wall of the body via an adhesive layer.
【0005】上述の少なくとも片面に無機化合物の薄膜
を形成したとは、熱可塑性樹脂フィルムの輸液バッグの
周壁に貼着した時のバッグ側面若しくは外側面の何方か
一方又は両面に無機化合物の薄膜を形成したものであ
る。無機化合物としては、酸化珪素(Six Oy , x=
1又は2 ,y =0〜3)又は酸化マグネシウム(Mg
O)などを用いられる。そして、その薄膜は、真空蒸着
法、スパッタリング法、イオンプレーティング法などに
よって蒸着して得られ、蒸着膜の厚みは、少なくとも5
00Å以上であり、好ましくは800Å〜1200Åで
ある。The above-mentioned formation of a thin film of an inorganic compound on at least one side means that a thin film of an inorganic compound is formed on one or both sides of the bag side surface or outer side surface when the thermoplastic resin film is attached to the peripheral wall of the infusion bag. It was formed. As the inorganic compound, silicon oxide (Si x O y , x =
1 or 2, y = 0 to 3) or magnesium oxide (Mg
O) etc. are used. Then, the thin film is obtained by vapor deposition by a vacuum vapor deposition method, a sputtering method, an ion plating method, or the like, and the vapor deposition film has a thickness of at least 5
It is not less than 00Å, preferably 800Å to 1200Å.
【0006】また、接着層は、アクリル系樹脂、ビニル
系樹脂及びワックス類などの接着剤を塗布した層であ
り、バッグ本体のブロー成形時のパリソン又は樹脂膜の
溶融樹脂温度に依って溶融してバック周壁の表面に接着
するものである。The adhesive layer is a layer coated with an adhesive such as an acrylic resin, a vinyl resin and waxes, and melts depending on the temperature of the molten resin in the parison or the resin film during blow molding of the bag body. It adheres to the surface of the back peripheral wall.
【0007】また、ブロー成形金型内に単層又は多層フ
ィルムを挿着する方法は、真空吸引法、静電気付着法及
び接着剤による接着法などを用いる。Further, as a method for inserting the single-layer or multi-layer film into the blow molding die, a vacuum suction method, an electrostatic adhesion method, a bonding method using an adhesive, or the like is used.
【0008】また、輸液バッグの胴部の熱可塑性樹脂と
しては、主にポリエチレンやポリプロピレンなどのポリ
オレフィン系樹脂を用いる。A polyolefin resin such as polyethylene or polypropylene is mainly used as the thermoplastic resin for the body of the infusion bag.
【0009】[0009]
【作用】本発明の輸液バッグの胴部の表面に成形と同時
に貼着された単層又は多層のフィルムは、少なくとも片
面に無機化合物の薄膜を形成した熱可塑性樹脂フィルム
を構成層としているので、ガスバリヤ性を有している。
このため、従来のポリオレフィン系樹脂製の輸液バッグ
のように、ガスバリヤ性を有する多層フィルムの外装材
で輸液バッグを二重包装する必要がない。The single-layer or multi-layer film, which is adhered to the surface of the body of the infusion bag of the present invention at the same time as molding, has a thermoplastic resin film having a thin film of an inorganic compound formed on at least one surface as a constituent layer. Has gas barrier properties.
Therefore, unlike the conventional infusion bag made of polyolefin resin, there is no need to doubly package the infusion bag with the exterior material of the multilayer film having gas barrier properties.
【0010】[0010]
【実施例】図1は、本発明の一実施例の輸液バッグの斜
視図(a)とその横断面図(b)である。まず、輸液バ
ッグ(100)の胴部(110)に貼着する、無機化合
物の薄膜を形成した熱可塑性フィルムを構成層としたガ
スバリヤ性の多層フィルム(103)を作製するため
に、12μm のポリエステルフィルムに、酸化珪素を片
面に1000Åの厚みで真空蒸着法で蒸着した12μm
のポリエステルフィルムを、ウレタン系接着剤を用いて
ドライラミネーシヨン法で非蒸着面を接着するように積
層し、さらに、蒸着面には、30μm のポリエチレンフ
ィルムをウレタン系接着剤を用いて接着し、その多層フ
ィルム(103)のポリエチレン面にグラビア印刷法で
アクリル系樹脂の接着層(102)を形成した。DESCRIPTION OF THE PREFERRED EMBODIMENTS FIG. 1 is a perspective view (a) and a cross-sectional view (b) of an infusion bag according to an embodiment of the present invention. First, in order to prepare a gas barrier multi-layer film (103) having a thermoplastic film formed with a thin film of an inorganic compound as a constituent layer, which is stuck to the body part (110) of the infusion bag (100), a 12 μm polyester film is used. 12 μm of silicon oxide deposited on one side of the film by the vacuum deposition method to a thickness of 1000 Å on one side.
Of the polyester film is laminated by a dry lamination method using a urethane adhesive so that the non-deposited surface is adhered. Further, a 30 μm polyethylene film is adhered to the evaporated surface with a urethane adhesive, An adhesive layer (102) of acrylic resin was formed on the polyethylene surface of the multilayer film (103) by a gravure printing method.
【0011】次に、シートブロー成形機を用い、輸液バ
ッグの胴部を形成するために取り付けられたブロー金型
のキャビティー面に、作製したガスバリヤ性の多層フィ
ルム(103)を所定の位置に接着層(102)を金型
の内側に向け挿着し真空吸引法で固定し、ダイヘッドか
ら二枚の平行したポリエチレン(101)の溶融樹脂膜
を押し出し、その二枚の溶融樹脂膜を前述のブロー金型
で挟んで二枚の溶融樹脂膜間に空気を吹き込むと、輸液
バッグ(100)を成形すると同時に輸液バッグ(10
0)の胴部(110)の表面にガスバリヤ性の多層フィ
ルム(103)が貼着した。なお、ブロー金型は、図1
(a)に示したように、輸液バッグ(100)の胴部
(110)の上端の注出口取付け部の左右と左端と右端
及び下端に所定幅の二枚の溶融樹脂膜の熱融着部(11
1)を形成するように設計されている。Next, using a sheet blow molding machine, the produced gas barrier multilayer film (103) is placed at a predetermined position on the cavity surface of a blow mold attached to form the body of the infusion bag. The adhesive layer (102) was inserted toward the inside of the mold and fixed by a vacuum suction method, and two parallel molten resin films of polyethylene (101) were extruded from the die head. When air is blown between two molten resin films sandwiched by blow molds, the infusion bag (100) is molded and at the same time the infusion bag (10) is formed.
The gas barrier multilayer film (103) was attached to the surface of the body (110) of (0). The blow mold is shown in Fig. 1.
As shown in (a), the heat-sealing portion of two molten resin films having a predetermined width at the left and right, the left end, the right end and the lower end of the spout attachment part at the upper end of the body part (110) of the infusion bag (100). (11
It is designed to form 1).
【0012】次に、作製したガスバリヤ性の多層フィル
ム(103)を表面に貼着した輸液バッグ(100)の
上端の注出口取付け部と上端と左端と右端及び下端の熱
融着部の外側の不要部分を切断除去し、図1に示したよ
うに、輸液バッグの上端の注出口取付け部に、前以てイ
ンジェクション成形法で作製した口部にゴム栓(12
1)を有する注出口(120)を超音波シール法で熱融
着して、容量が500mlでガスバリヤ性多層フィルム
(103)/接着層(102)/ポリエチレン(10
1)構成の本発明の輸液バッグ(100)を作製した。Next, the infusion bag (100) on the surface of which the produced gas barrier multi-layer film (103) is adhered is attached to the spout attachment part at the upper end and the outer side of the heat-sealed part at the upper end, the left end, the right end and the lower end. Unnecessary parts are cut and removed, and as shown in FIG. 1, a rubber stopper (12) is attached to the spout attachment part at the upper end of the infusion bag at the mouth part previously prepared by the injection molding method.
The spout (120) having 1) is heat-sealed by an ultrasonic sealing method to obtain a gas barrier multi-layer film (103) / adhesive layer (102) / polyethylene (10) with a capacity of 500 ml.
An infusion bag (100) of the present invention having the constitution 1) was produced.
【0013】次に、作製した本発明の輸液バッグを評価
したところ、滅菌後(105°C・40分)のガスバリ
ヤ性は、40°C・65%RHの三ヶ月の経時試験では
0.7cc/m2 ・24hrs・atmであり、アミノ
酸輸液に充分に使用出来ることが確認され、しかも、滅
菌後の450mμ水中透過率は、80%以上であった。
さらに、落下強度を確認するため、所定量充填した輸液
バッグを120cmの高さからコンクリート床上に5回
の繰返し落下試験を行ったが、破損したものはなかっ
た。Next, the produced infusion solution bag of the present invention was evaluated. As a result, the gas barrier property after sterilization (105 ° C. for 40 minutes) was 0.7 cc in a three-month aging test at 40 ° C. and 65% RH. / M 2 · 24 hrs · atm, which was confirmed to be sufficiently usable for amino acid infusion, and the transmittance in 450 mμ water in sterilized water was 80% or more.
Further, in order to confirm the drop strength, an infusion bag filled with a predetermined amount was subjected to a repeated drop test 5 times on a concrete floor from a height of 120 cm, but no damage was found.
【0014】[0014]
【発明の効果】本発明の輸液バッグは、輸液バッグの胴
部の表面に少なくとも片面に無機化合物の薄膜を形成し
た熱可塑性樹脂フィルムを構成層とするガスバリヤ性の
単層又は多層フィルムを貼着しているので、従来のポリ
オレフィン系樹脂製の輸液バッグように、ガスバリヤ性
の外装材で二重包装する必要がない。EFFECT OF THE INVENTION The infusion bag of the present invention has a gas barrier single-layer or multi-layer film having a thermoplastic resin film having a thin film of an inorganic compound formed on at least one surface on the surface of the body of the infusion bag. Therefore, unlike the conventional infusion bag made of a polyolefin resin, it is not necessary to double-wrap with a gas barrier exterior material.
【0015】また、第2の発明によれば、このガスバリ
ヤ性のフィルムの輸液バッグの胴部の表面への貼着は、
輸液バッグの胴部のブロー成形と同時にブロー金型内で
行われるため、フィルム貼着の工程を別途に設ける必要
がない。According to the second invention, the gas barrier film is attached to the surface of the body of the infusion bag.
Since it is performed in the blow mold at the same time as the blow molding of the body part of the infusion bag, it is not necessary to separately provide a film attaching step.
【図1】本発明の輸液バッグの斜視図(a)とその横断
面図(b)である。FIG. 1 is a perspective view (a) and a cross-sectional view (b) of an infusion bag of the present invention.
【図2】従来の外装材で二重包装された輸液バッグの斜
視図(a)とその横断面図(b)である。FIG. 2 is a perspective view (a) and a transverse cross-sectional view (b) of a conventional infusion bag double-wrapped with an exterior material.
100,200……輸液バッグ 101……ポリオレフィン系樹脂(ポリエチレン) 102……接着層 103……無機化合物の薄膜を形成した熱可塑性樹脂フ
ィルムを構成層とするフィルム 110……バッグ胴部 111……熱融着部 120……注出口 121……ゴム栓 300……外装材 301……ポリプロピレン(無延伸) 302……ポリ塩化ビニリデン 303……ポリエステル100, 200 ... Infusion bag 101 ... Polyolefin resin (polyethylene) 102 ... Adhesive layer 103 ... Film having a thermoplastic resin film formed with a thin film of an inorganic compound as a constituent layer 110 ... Bag body 111 ... Heat-sealed part 120 …… Spout 121 …… Rubber stopper 300 …… Exterior material 301 …… Polypropylene (unstretched) 302 …… Polyvinylidene chloride 303 …… Polyester
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.5 識別記号 庁内整理番号 FI 技術表示箇所 B65D 85/84 7445−3E // B29L 9:00 4F 22:00 4F ─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 5 Identification code Office reference number FI technical display location B65D 85/84 7445-3E // B29L 9:00 4F 22:00 4F
Claims (2)
おいて、その胴部の周壁表面に、少なくとも片面に無機
化合物の薄膜を形成した熱可塑性樹脂フィルムを構成層
とする単層又は多層フィルムが、接着層を介して貼着さ
れていることを特徴とする輸液バッグ。1. A single-layer or multi-layer film comprising a thermoplastic resin film having a thin film of an inorganic compound formed on at least one surface thereof is adhered to a peripheral wall surface of a body portion of a plastic bag-shaped infusion container. An infusion bag characterized by being attached via layers.
機化合物の薄膜を形成した熱可塑性樹脂フィルムを構成
層とする単層又は多層フィルムを挿着し、輸液バッグの
胴部を熱可塑性樹脂でブロー成形すると同時に、前記の
単層又は多層フィルムを、胴部の周壁に接着層を介して
貼着したことを特徴とする輸液バッグの製造方法。2. A single-layer or multi-layer film having a thermoplastic resin film having a thin film of an inorganic compound formed on at least one surface as a constituent layer is inserted into a blow molding die, and a body portion of an infusion bag is made of the thermoplastic resin. A method for manufacturing an infusion bag, characterized in that the single-layer or multi-layer film is adhered to the peripheral wall of the body via an adhesive layer at the same time as the blow molding with.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP00665492A JP3216192B2 (en) | 1992-01-17 | 1992-01-17 | Infusion bag and manufacturing method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP00665492A JP3216192B2 (en) | 1992-01-17 | 1992-01-17 | Infusion bag and manufacturing method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05184643A true JPH05184643A (en) | 1993-07-27 |
JP3216192B2 JP3216192B2 (en) | 2001-10-09 |
Family
ID=11644367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP00665492A Expired - Fee Related JP3216192B2 (en) | 1992-01-17 | 1992-01-17 | Infusion bag and manufacturing method thereof |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP3216192B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101799348A (en) * | 2010-02-26 | 2010-08-11 | 四川沱牌药业有限责任公司 | Application of double-layer vacuum time-delay leak detection technique in large capacity injection |
CN101804000A (en) * | 2010-02-26 | 2010-08-18 | 四川沱牌药业有限责任公司 | Double-side vacuum large volume injection and process for detecting liquid leakage rapidly |
-
1992
- 1992-01-17 JP JP00665492A patent/JP3216192B2/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101799348A (en) * | 2010-02-26 | 2010-08-11 | 四川沱牌药业有限责任公司 | Application of double-layer vacuum time-delay leak detection technique in large capacity injection |
CN101804000A (en) * | 2010-02-26 | 2010-08-18 | 四川沱牌药业有限责任公司 | Double-side vacuum large volume injection and process for detecting liquid leakage rapidly |
Also Published As
Publication number | Publication date |
---|---|
JP3216192B2 (en) | 2001-10-09 |
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Date | Code | Title | Description |
---|---|---|---|
LAPS | Cancellation because of no payment of annual fees |