JPH05170623A - Hair-growing accelerator - Google Patents

Abstract

PURPOSE:To provide a hair-growing accelerator which has not only action to inhibit hairs from falling but also to accelerate hair growth. CONSTITUTION:The accelerator comprises (A) oxendolone (16beta-ethyl-17beta- hydroxy-4-estren-3-one) and/or allylestrenol (17 alpha-allyl-17beta-hydroxy-estr-4-ene) and (B) an alcohol essence of Thuja orientalis where the amount of (A) is 0.001 to 2wt.% and (B) is 10 to 50v/v%.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth accelerating agent, and more particularly to improvement of a hair growth accelerating agent using a lateral oak leaf extract.

[0002]

BACKGROUND OF THE INVENTION There are many possible causes of alopecia and dullness. In particular, physiological signs such as male pattern baldness and seborrhea are due to increased androgenic stimulation due to excessive accumulation of androgen. It is said that. However, recently, the main body of this androgen activity in organs such as hair root and sebaceous gland is 5α-produced by reduction of testosterone by testosterone-5α-reductase in these target organs.
Dihydrotestosterone (hereinafter abbreviated as 5α-DHT)
Was revealed.

[0003] That is, testosterone (male hormone) produced in the testes and adrenal glands is carried to the sebaceous glands by flowing in the bloodstream, and by testosterone-5α-reductase in sebaceous gland cells, a more potent male hormone, 5α.
-Converted to DHT. While this 5α-DHT binds to an intracellular receptor and acts on the nucleus to promote the growth of sebaceous gland cells, it itself goes out of the sebaceous gland cells and acts on the hair bulb through the bloodstream, It is said that it inhibits division of hair matrix cells in some parts and prevents hair growth.

Therefore, it is considered that the symptoms such as male pattern baldness and hair loss can be reduced or prevented by inhibiting the reductase activity and the binding between 5α-DHT and the receptor protein. However, some substances having these inhibitory effects have been found.

[0005]

However, these substances have unfavorable side effects even if the inhibition rate of reductase activity is high, and the inhibition rate of the binding between 5α-DHT and the receptor protein is very low. However, there is a problem that the hair-repairing effect is substantially inferior. Furthermore, testosterone-5
Although hair loss can be suppressed only by α-reductase inhibition, new hair growth was not significantly effective, and hair loss was prevented only. The present invention has been made in view of the above problems of the prior art, and it is an object of the present invention to provide a hair growth promoter having few side effects and an excellent hair growth promoting action.

[0006]

[Means for Solving the Problems] In order to achieve the above-mentioned object, as a result of diligent studies by the present inventors, as a result of the synergistic action of oxendron and / or allylestrenol and the lateral Kashiwa leaf extract, an excellent hair growth promoting action was obtained. Find out what to do,
It completed the present invention. That is, the hair growth-promoting agent according to claim 1 of the present application is characterized in that it contains oxendron and / or allylestrenol and a lateral kashiwa leaf extract.

The structure of the present invention will be described below. The oxendron used in the present invention has a chemical name of 1
6β-Ethyl-17β-hydroxy-4-estrene-
It is called 3-one, which is a white to pale yellow powder and is odorless. Allylestrenol has a chemical name of 17α-allyl-17β-hydroxy-estre-4-ene, which is a white crystal or crystalline powder and is odorless. Also,
Very soluble in ethanol, acetone, chloroform or dioxane, easily soluble in methanol or ether, almost insoluble in water.

In the present invention, the blending amount of oxendron or allylestrenol is 0.00 in the hair growth promoter.
About 1-2% by weight is suitable. A larger amount of the compound tends to have a stronger effect on promoting hair growth, but if too much is used, side effects may occur. In addition, the lateral Kashiwa leaf extract used in the present invention can be obtained by extracting the lateral Kashiwa leaf used as a herbal medicine with alcohol. The amount of this side kashiwa leaf extract is preferably about 10 to 50 v / v% in the hair growth promoter.

In addition to the above-mentioned essential components, the hair growth-promoting agent used in the present invention includes various components used in ordinary hair nourishing agents such as hinokitiol, a bactericidal agent such as a cationic surfactant, a refreshing agent such as menthol, and the like. Oils such as olive oil, squalane, higher alcohols, glycerin, 1,3-butylene glycol, maltitol, moisturizers such as PCA-sodium, crude drugs such as glycyrrhizin, amino acids and amino sugars, other surfactants, fragrances, antioxidants , An ultraviolet absorber, a dye, ethanol, water and the like can be added within a range that does not impair the effects of the present invention. Further, the hair growth-promoting agent according to the present invention can be used in various forms such as lotion, emulsion and cream.

[0010]

The preferred embodiments of the present invention will be described below. The present invention is not limited to the embodiments. Also,
Unless otherwise specified, the blending amount is shown by weight%.

Hair Loss Inhibitory Action First, the hair loss inhibiting action of the hair growth-promoting agent according to the present invention was examined together with comparative examples. The hair loss suppressing effect was evaluated by the change in the number of hair loss during washing before and after the use of the hair growth stimulant. Number of subjects: 10 each Measurement period: 4 months (the first 2 months is the period without hair growth promoter application, the next 2 months is the period with hair growth promoter application) Test method: Wash hair every 2 days, Hairs were collected once a week and the number of them was counted. Evaluation method: The number of hairs removed for each period is the data for the number of hairs removed 8 times in total for 2 months without the application of a hair growth stimulant, and the data for the number of hairs removed 8 times in total for 2 months after the application of the hair growth stimulant. Was collected for each period and expressed as the number of hairs removed per one time in the form of average value ± α. The unit is a book. The judgment of the effect was displayed as follows from the difference of the average value of each period. ++: The number of plucked hairs decreased by 70 or more, and a remarkable effect was recognized. +: The number of plucked hairs decreased by 40 or more, and a considerable effect was recognized. ±: The number of plucked hairs decreased by 10 or more, and it was recognized that there was some effect. -: The number of plucked hairs was reduced by less than 10, and it cannot be said that there is an effect.

Test agent 1: 0.2% oxendron / 70
% Ethanol Solution Test Agent 2: 70% ethanol solution (100 ml) was added with 20 to 30 g of lateral Kashiwa leaves and allowed to stand for 1 week, and the supernatant was collected to obtain an extract of lateral Kashiwa leaves Test Agent 3: Example of the present invention That is, add 20 to 30 g of Kashiwa leaf to 100 ml of 70% ethanol solution and
The mixture was allowed to stand for a week and the supernatant was collected to obtain a lateral Kashiwa leaf extract. On the other hand, 200 mg of oxendron was added to 100% of 70% ethanol.
It was dissolved in ml to prepare a 0.2% oxendron solution. Then, to 300 ml of the above-mentioned oxendron solution, 200 ml of the lateral Kashiwa leaf extract was added to obtain a hair growth promoter having a greenish or brownish aroma (500 ml).

The results are shown in Tables 1 to 3 below.

[Table 1] Test Agent 1 ───────────────────────────────── Panel No. Non-application period Application period Judgment ───────────────────────────────── 1 170 ± 41 123 ± 34 + 2 223 ± 52 140 ± 48 ++ 3 345 ± 62 292 ± 44 + 4 127 ± 31 113 ± 23 − 5 421 ± 57 302 ± 48 ++ 6 312 ± 37 301 ± 22 ± 7 255 ± 44 198 ± 27 + 8 358 ± 32 318 ± 68 + 9 219 ± 61 186 ± 48 ± 10 379 ± 44 311 ± 23 + ───────────────────────────────── ──

[Table 2] Test Agent 2 ───────────────────────────────── Panel No. Non-application period Application period Judgment ───────────────────────────────── 1 423 ± 23 378 ± 55 + 2 273 ± 42 259 ± 23 ± 3 276 ± 41 192 ± 46 ++ 4 354 ± 28 329 ± 23 -5 228 ± 37 188 ± 31 + 6 384 ± 37 342 ± 44 + 7 412 ± 51 322 ± 31 + + 8 267 ± 45 238 ± 37 ± 9 399 ± 48 328 ± 31 + 10 177 ± 59 148 ± 33 ± ──────────────────────────────── ──

[Table 3] Test Agent 3 ───────────────────────────────── Panel No. Non-application period Application period Judgment ───────────────────────────────── 1 275 ± 38 189 ± 48 ++ 2268 ± 47 239 ± 28 ± 3 394 ± 43 287 ± 54 ++ 4 421 ± 54 361 ± 38 + 5 273 ± 33 243 ± 41 ± 6 197 ± 42 138 ± 37 + 7 347 ± 31 258 ± 45 + + 8 238 ± 38 219 ± 29 ± 9 363 ± 49 309 ± 22 + 10 232 ± 51 177 ± 43 + ───────────────────────────────── As a result, although the hair growth accelerating agent according to the present example is also useful for preventing hair loss, oxendron or side extract of Kashiwa leaf alone has a hair loss preventing effect, and has a synergistic effect on hair loss prevention. It is understood that is not very strong.

[0014] The hair growth promoting effect Next, the hair growth promoting effect, was investigated actually applied to the panel, which has been plagued by such each alopecia.

Test Example 1 A test subject is a 41-year-old man who has been suffering from hair loss for 10 years. As a result of external application of each of the above-mentioned test agents 1 and 2 twice a day for about 3 months, hair loss was reduced, and a slight amount of downy hair was observed, but no remarkable hair increase was observed.

Next, when the hair growth-promoting agent of Test Agent 3 (Example product) was applied externally to the test subject twice a day for about 3 months, vellus hair on the forehead part became bristle, which caused hair growth. Is about 1 cm
I went down. In addition, around 5 months after the start of external application, obvious vellus or terminal hair was observed around the external application site,
More interestingly, the development of many comedones on the hair root was observed. The appearance of comedones is considered to be due to the accumulation of lipids due to the obstruction of the pores by the bristles of the downy hairs.

Test Example 2 The subject has been suffering from hair loss, thinning hair, and gray hair for 15 years 4
An 8 year old man. As a result of external application of each of the above-mentioned test agents 1 and 2 twice a day for about 3 months, a decrease in hair loss was observed, but no significant hair increase was observed. Next, when the hair growth-promoting agent related to Test Agent 3 was externally applied in the same manner, white hair decreased and hair growth was further observed within about 3 months.

Test Example 3 A subject suffers from alopecia areata having a diameter of about 4 cm at the crown 5
A 2 year old woman. When the above-mentioned hair growth-promoting agent was externally applied to the test subject, vellus hairs were found around the bald patch in about one and a half months, and when the external application was continued for another one month, many bristles became visible. After about one month, bristles developed on almost the entire surface, and the hair loss spots became inconspicuous. This recovery is considered to be about a month earlier than would normally be expected to heal.

As described above, it is recognized that the hair growth-promoting agent according to the present invention has an excellent hair growth-promoting effect as well as a hair loss-suppressing effect, and this hair growth-promoting effect is different from that of oxendron, which is an essential component. It was clarified that it was the first to be exhibited by the synergistic action with the lateral Kashiwa leaf extract.
Similar effects were obtained with allylestrenol. Next, more specific formulation examples of the present invention will be described.

Example 1 Hair growth promoter (lotion tie)
Flop) 95% Ethanol 20% oxendolone 0.2 side Kashiwaba extract (70% ethanol solution) 30.0 carpronium chloride 1.0 Effect castor oil (EO40 mol) adduct 2.0 Pantothenyl ethyl ether 0.1 Ion exchange Water 46.7 (Manufacturing method) Oxendron, lateral Kashiwa leaf extract, carpronium chloride, hydrogenated castor oil (EO40 mol) adduct, and pantothenyl ethyl ether were dissolved in 95% ethanol, and then ion-exchanged water was added and mixed. A transparent liquid hair growth promoter was obtained.

Example 2 Hair Growth Promoter (Cream Type) (A) Liquid Paraffin 30.0% Stearic Acid 2.0 White Vaseline 10.3 Allyl Estrenol 0.1 Side Kashiwa Leaf Extract (70% Ethanol Solution) 20 0.0 Vitamin E nicotinate 0.1 Polyoxyethylene sorbitan monostearate 3.8 Sorbitan monostearate 4.2 Ethylparaben Trace amount (B) Triethanolamine 1.0 Polyethylene glycol 1500 2.0 Ion-exchanged water 26.5 (Production method) The oil phase (A) and the water phase (B) are each added to 80
The mixture was heated to 0 ° C., and both components were mixed and emulsified at the same temperature while stirring and cooled to room temperature to obtain a hair growth promoter.

Example 3 Hair Growth Promoter (Emulsion Type) (A) Purified Jojoba Oil 10.0% Oxendron 0.2 Side Kashiwa Leaf Extract (70% Ethanol Solution) 30.0 Benzyl Nicotinate 2.0 Pantothenylethyl Ether 0.01 Lanolin 2.0 Isopropyl myristate 2.5 Polyoxyethylene cetyl alcohol 1.8 Sorbitan monostearate 0.8 (B) Triethanolamine 1.0 Glycerin 4.0 Ion-exchanged water 45.69 (Production method ) According to Example 2.

[0023]

As described above, according to the hair growth-promoting agent of the present invention, by containing oxendron and / or allylestrenol and the lateral Kashiwa leaf extract, not only the hair loss-suppressing action but also the excellent effect is suppressed. A hair growth promoting action can be obtained.

Claims (1)

[Claims] 1. A hair growth-promoting agent comprising oxendrone and / or allylestrenol and a lateral Kashiwa leaf extract.