JPH0481963B2 - - Google Patents
Info
- Publication number
- JPH0481963B2 JPH0481963B2 JP60050851A JP5085185A JPH0481963B2 JP H0481963 B2 JPH0481963 B2 JP H0481963B2 JP 60050851 A JP60050851 A JP 60050851A JP 5085185 A JP5085185 A JP 5085185A JP H0481963 B2 JPH0481963 B2 JP H0481963B2
- Authority
- JP
- Japan
- Prior art keywords
- water
- skin
- arbutin
- soluble polymers
- soluble polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 26
- 229920003169 water-soluble polymer Polymers 0.000 claims description 23
- 238000002360 preparation method Methods 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 229960000271 arbutin Drugs 0.000 description 12
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 229940058015 1,3-butylene glycol Drugs 0.000 description 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N 1,4-Benzenediol Natural products OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- 125000003158 alcohol group Chemical group 0.000 description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- -1 hydroquinone glycoside Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 3
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 235000017788 Cydonia oblonga Nutrition 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 125000002353 D-glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- SKJVHCUTOXBZCP-OCOFDJSDSA-N O[C@H]1[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO.C1(O)=CC=C(O)C=C1 Chemical compound O[C@H]1[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO.C1(O)=CC=C(O)C=C1 SKJVHCUTOXBZCP-OCOFDJSDSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- OIKBVOIOVNEVJR-UHFFFAOYSA-N hexadecyl 6-methylheptanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCC(C)C OIKBVOIOVNEVJR-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 125000000687 hydroquinonyl group Chemical group C1(O)=C(C=C(O)C=C1)* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Description
［産業上の利用分野］
本発明は使用性良好で、安定性良く、かつ保湿
効果にも優れた皮膚外用剤に関する。
［従来の技術］
化粧料や医薬部外品、医薬品などの皮膚外用剤
においては、系の粘度を上げて安定性を保つた
り、コクのある使用感を出したり、手に取りやす
くまた流れにくくしたり、あるいは皮膚に対する
保湿作用を期待したり、さまざまな目的で水溶性
高分子が配合されている。
しかしながら、水溶性高分子は優れた作用を有
する反面、使用感触がべたついたものになりやす
いことや、皮膚に塗布したときに上滑りする感じ
があるなどの理由から、ともすれば消費者から嫌
われることが多く、皮膚外用剤、とくに化粧料に
配合するには難点となつていた。
［発明が解決しようとする問題点］
本発明者らはこのような事情にかんがみて水溶
性高分子が有する使用感触上のべたつきや上滑り
感を改善することを目的に鋭意検討した結果、水
溶性高分子とともに特定のハイドロキノンの配糖
体を配合すると、上記問題が解決することを見い
だし、本発明を完成するに至つた。
［問題点を解決するための手段］
すなわち、本発明は、水溶性高分子と該水溶性
高分子と同重量以上のハイドロキノン−β−Ｄ−
グルコシドを含有することを特徴とする皮膚外用
剤である。
本発明で用いる水溶性高分子は、化粧料、医薬
部外品、医薬品などの皮膚外用剤で一般的に用い
られる水溶性高分子であり、具体例としては、た
とえばアラビアゴム、トラガントガム、カラギー
ナン、ペクチン、クインスシード（マルメロ）抽
出物などの植物系水溶性高分子、キサンタンガ
ム、プルランなどの微生物系水溶性高分子、コラ
ーゲン、カゼイン、アルブミン、ゼラチンなどの
動物系水溶性高分子、カルボキシメチルデンプ
ン、メチルヒドロキシデンプンなどのデンプン系
水溶性高分子、メチルセルロース、エチルセルロ
ース、ヒドロキシエチルセルロース、カルボキシ
メチルセルロースなどのセルロース系水溶性高分
子、ポリビニルアルコール、ポリビニルピロリド
ン、カルボキシビニルポリマーなどのビニル系水
溶性高分子、ポリアクリル酸およびその塩、ポリ
アクリルイミドなどのアクリル系水溶性高分子あ
るいはアルギン酸などが挙げられる。
配合量は皮膚外用剤全量中の0.01〜５重量％が
一般的であり、好ましくは0.1〜１重量％である。
本発明において、水溶性高分子とともに皮膚外
用剤中に配合され、水溶性高分子にべたつきある
いは上滑りをおさえるハイドロキノンの配糖体は
下記一般式（）で表される。
すなわち式（）中ＲはＤ−グルコース残気で
あり、ハイドロキノンにβ結合したハイドロキノ
ン−β−Ｄ−グルコシド（一般名：アルブチン）
である。
アルブチンの配合量は、皮膚外用剤全量中の
0.1〜30重量％、好ましくは６〜20重量％であり、
水溶性高分子と同重量以上配合したとき、べたつ
き抑制効果の点でよい。
水溶性高分子および上記アルブチンを配合でき
る皮膚外用剤は、通常の皮膚外用剤、たとえば、
水溶液系、可溶化系、乳化系、粉末分散系、水−
油２層系、水−油−粉末３層系など、どのような
基剤でもよく、用途も化粧水、乳液、クリーム、
パツクなどの基礎化粧料、口紅、フアンデーシヨ
ンなどのメーキヤツプ化粧料、シヤンプー、リン
ス、ヘアトニツクなどの頭髪化粧料などの化粧
料、医薬部外品など多岐にわたる。
本発明の皮膚外用剤には必要に応じて、本発明
の効果を損なわない範囲で、保湿剤、増粘剤、防
腐剤、乳化剤、酸化防止剤、金属イオン封鎖剤、
紫外線吸収剤、粉末、顔料、薬剤、色素、香料な
どを配合できる。
［発明の効果］
本発明の皮膚外用剤は、水溶性高分子を配合し
て安定性、使用感あるいは皮膚に対する保湿作用
などに優れているにもかかわらず、水溶性高分子
特有のべたつきや上滑り感がなく、かつ安全性も
良好で優れた皮膚外用剤である。
［実施例］
つぎに実施例により本発明をさらに詳細に説明
する。本発明は、これによつて何ら限定されるも
のではない。
実施例 １
化粧水
エタノール 20.0
１，３−ブチレングリコール 5.0
カルボキシビニルポリマー 0.3
POE（ポリオキシエチレン、以下同じ、15モル）
オレイルエーテル 0.8
エチルパラベン 0.1
アルブチン 6.0
精製水 残余
（製法）
エタノールの一部にPOEオレイルエーテルお
よびエチルパラベンを溶解する。べつに精製水と
エタノールの残部に１，３−ブチレングリコー
ル、カルボキシビニルポリマーおよびアルブチン
を溶解する。エタノール相を水相中に添加し、可
溶化して化粧水を得た。
実施例 ２
実施例１のアルブチンを0.5重量％に減量した
他は実施例１に準じて、実施例２を得た。
比較例 １
実施例１のアルブチンを除いた他は実施例１に
準じて、比較例１を得た。
実施例１〜２、比較例１の使用性（べたつき）
を女性美容専門パネルの実使用試験によつて判
定、評価した。
（判定）
Ａ；べたつかない。
Ｂ；わずかにべたつくが、使用性上問題のない範
囲である。
Ｃ；べたつく。
Ｄ；著しくべたつく。
結果を表−１に示す。
アルブチンが、水溶性高分子のべたつきを防止
していることが明らかである。
[Industrial Field of Application] The present invention relates to an external skin preparation that is easy to use, has good stability, and has excellent moisturizing effects. [Conventional technology] In external skin preparations such as cosmetics, quasi-drugs, and pharmaceuticals, it is necessary to increase the viscosity of the system to maintain stability, create a rich feeling of use, and make it easy to pick up and difficult to run off. Water-soluble polymers are added for a variety of purposes, including moisturizing and moisturizing effects on the skin. However, while water-soluble polymers have excellent effects, they tend to be disliked by consumers because they tend to feel sticky and have a slippery feel when applied to the skin. Therefore, it has been difficult to incorporate it into external skin preparations, especially cosmetics. [Problems to be Solved by the Invention] In view of the above circumstances, the inventors of the present invention have conducted intensive studies with the aim of improving the stickiness and slippery feeling that water-soluble polymers have when using them. The inventors have discovered that the above problem can be solved by blending a specific hydroquinone glycoside with a polymer, and have completed the present invention. [Means for Solving the Problems] That is, the present invention provides a water-soluble polymer and a hydroquinone-β-D-
This is an external skin preparation characterized by containing glucoside. The water-soluble polymer used in the present invention is a water-soluble polymer commonly used in external skin preparations such as cosmetics, quasi-drugs, and pharmaceuticals. Specific examples include gum arabic, gum tragacanth, carrageenan, Plant-based water-soluble polymers such as pectin and quince seed (quince) extract, microbial-based water-soluble polymers such as xanthan gum and pullulan, animal-based water-soluble polymers such as collagen, casein, albumin, and gelatin, carboxymethyl starch, Starch-based water-soluble polymers such as methyl hydroxy starch, cellulose-based water-soluble polymers such as methylcellulose, ethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, vinyl-based water-soluble polymers such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, polyacrylic Examples include acids and their salts, acrylic water-soluble polymers such as polyacrylimide, and alginic acid. The blending amount is generally 0.01 to 5% by weight, preferably 0.1 to 1% by weight, based on the total amount of the skin external preparation. In the present invention, the glycoside of hydroquinone that is blended into a skin external preparation together with a water-soluble polymer to suppress stickiness or slippage of the water-soluble polymer is represented by the following general formula (). That is, in formula (), R is D-glucose residue, and hydroquinone-β-D-glucoside (generic name: arbutin) is β-bonded to hydroquinone.
It is. The amount of arbutin in the total amount of the skin external preparation is
0.1 to 30% by weight, preferably 6 to 20% by weight,
When blended with the same weight or more as the water-soluble polymer, it is good in terms of stickiness suppressing effect. External skin preparations that can contain a water-soluble polymer and the above-mentioned arbutin include common external skin preparations, such as:
Aqueous solution system, solubilization system, emulsion system, powder dispersion system, water-
Any base can be used, such as a two-layer oil system or a three-layer water-oil-powder system, and can be used for lotions, emulsions, creams, etc.
There is a wide range of products, including basic cosmetics such as face masks, makeup cosmetics such as lipstick and foundation, cosmetics such as hair cosmetics such as shampoo, conditioner, and hair tonic, and quasi-drugs. The skin external preparation of the present invention may contain, as necessary, a humectant, a thickener, a preservative, an emulsifier, an antioxidant, a sequestering agent, within a range that does not impair the effects of the present invention.
UV absorbers, powders, pigments, drugs, pigments, fragrances, etc. can be added. [Effects of the Invention] Although the skin external preparation of the present invention contains a water-soluble polymer and is excellent in stability, feeling of use, and moisturizing effect on the skin, it does not suffer from the stickiness and slippery characteristic of water-soluble polymers. It is an excellent external preparation for the skin, with no sensation and good safety. [Example] Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited to this in any way. Example 1 Lotion ethanol 20.0 1,3-butylene glycol 5.0 Carboxyvinyl polymer 0.3 POE (polyoxyethylene, same hereinafter, 15 mol)
Oleyl ether 0.8 Ethylparaben 0.1 Arbutin 6.0 Purified water Remaining (manufacturing method) Dissolve POE oleyl ether and ethylparaben in a portion of ethanol. Separately, dissolve 1,3-butylene glycol, carboxyvinyl polymer, and arbutin in purified water and the remainder of ethanol. The ethanol phase was added into the aqueous phase and solubilized to obtain a lotion. Example 2 Example 2 was obtained in accordance with Example 1 except that the amount of arbutin in Example 1 was reduced to 0.5% by weight. Comparative Example 1 Comparative Example 1 was obtained according to Example 1 except that arbutin was used. Usability of Examples 1-2 and Comparative Example 1 (stickiness)
was determined and evaluated through actual use tests by a panel specializing in women's beauty. (Judgment) A: Not sticky. B: Slightly sticky, but within a range that poses no problem in terms of usability. C: Sticky. D: Significantly sticky. The results are shown in Table-1. It is clear that arbutin prevents the water-soluble polymer from becoming sticky.
【表】
実施例 ３
栄養乳液
(A) ビースワツクス 10
ワセリン 2.0
脱臭ラノリン 1.5
ホホバ油 6.0
セチルイソオクタノエート 4.0
POE−２−オクチルドデカノール 2.0
エチルパラベン 0.2
ブチルパラベン 0.1
香 料 0.3
(B) ヒドロキシプロピルセルロース 0.2
キサンタンガム 0.5
アルブチン 1.0
ジプロピレングリコール 2.0
Ｌ−アルギニン 0.2
精製水 残余
（製法） 実施例３に準じる。
比較例 ２
実施例３からハイドロキノン−β−Ｄ−グルコ
サミンを除いたほかは実施例３と同様にして、比
較例２を得た。
実施例３、比較例２の使用製（上滑り感）を女
性美容専門パネルの実使用試験によつて判定、評
価した。
（判定）
Ａ；上滑りせず、肌になじむ。
Ｂ；わずかに上滑りするが、とくに気になる程で
はない。
Ｃ；上滑りする。
Ｄ；著しく上滑りし、肌になじまない。
結果を表−２に示す。
アルブチンが、水溶性高分子の上滑り感を防止
していることが明らかである。[Table] Example 3 Nutrient emulsion (A) Beeswax 10 Vaseline 2.0 Deodorized lanolin 1.5 Jojoba oil 6.0 Cetyl isooctanoate 4.0 POE-2-octyldodecanol 2.0 Ethylparaben 0.2 Butylparaben 0.1 Fragrance 0.3 (B) Hydroxypropyl cellulose 0.2 Xanthan gum 0.5 Arbutin 1.0 Dipropylene glycol 2.0 L-arginine 0.2 Purified water Remainder (manufacturing method) According to Example 3. Comparative Example 2 Comparative Example 2 was obtained in the same manner as Example 3 except that hydroquinone-β-D-glucosamine was removed. The usability (slip feeling) of Example 3 and Comparative Example 2 was determined and evaluated by a practical use test conducted by a panel specializing in women's beauty. (Judgment) A: Does not slip on the skin and blends into the skin. B: There is a slight upward slip, but it is not particularly noticeable. C: Slips upward. D: Significant slippage and does not blend into the skin. The results are shown in Table-2. It is clear that arbutin prevents the slippery feeling of water-soluble polymers.
【表】
実施例 ４
化粧水
(A) 精製水 全体が100になる量
グリセリン 20
カルボキシビニルポリマー 0.2
アルブチン 15.0
１，３−ブチレングリコール 2.0
(B) エタノール 15.0
精製レシチン 0.02
POE（60）硬化ヒマシ油 1.0
香 料 0.05
メチルパラベン 0.1
（製法）
(A)の水相部および(B)のアルコール部をそれぞれ
均一溶解した後、水相部にアルコール部を加えて
可溶化し、化粧水を得た。
実施例 ５
水性エツセンス
(A) 精製水 全体が100になる量
１，３−ブチレングリコール 10.0
マルチトール 2.0
アルギニン 0.1
コラーゲン 0.1
カルボキシメチルポリマー 0.1
アルブチン 1.0
ジプロピレングリコール 5.0
(B) エタノール 5.0
POE（60）硬化ヒマシ油 1.0
ビタミンＥアセテート 0.1
香 料 0.05
オレイルアルコール 0.2
メチルパラベン 0.2
(C) 水酸化カリウム 0.1
（製法）
(A)の水相部および(B)のアルコール部をそれぞれ
均一溶解した後、水相部にアルコール部を加えて
混合可溶化し、ついで(C)の水酸化カリウムを加え
てエツセンスを得た。[Table] Example 4 Lotion (A) Purified water Amount to make the total 100 Glycerin 20 Carboxyvinyl polymer 0.2 Arbutin 15.0 1,3-butylene glycol 2.0 (B) Ethanol 15.0 Purified lecithin 0.02 POE (60) hydrogenated castor oil 1.0 Fragrance: 0.05 Methylparaben: 0.1 (Production method) After uniformly dissolving the water phase (A) and the alcohol part (B), the alcohol part was added to the water phase for solubilization to obtain a lotion. Example 5 Aqueous essence (A) Purified water 1,3-butylene glycol 10.0 Maltitol 2.0 Arginine 0.1 Collagen 0.1 Carboxymethyl polymer 0.1 Arbutin 1.0 Dipropylene glycol 5.0 (B) Ethanol 5.0 POE (60) hardening Castor oil 1.0 Vitamin E acetate 0.1 Fragrance 0.05 Oleyl alcohol 0.2 Methylparaben 0.2 (C) Potassium hydroxide 0.1 (Production method) After uniformly dissolving the water phase of (A) and the alcohol part of (B), add them to the water phase. An alcohol part was added to mix and solubilize, and then potassium hydroxide (C) was added to obtain essence.
Claims (1)
のハイドロキノン−β−Ｄ−グルコシドを含有す
ることを特徴とする皮膚外用剤。1. A skin external preparation characterized by containing a water-soluble polymer and hydroquinone-β-D-glucoside in an amount equal to or more than the same weight as the water-soluble polymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5085185A JPS61210008A (en) | 1985-03-14 | 1985-03-14 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5085185A JPS61210008A (en) | 1985-03-14 | 1985-03-14 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61210008A JPS61210008A (en) | 1986-09-18 |
| JPH0481963B2 true JPH0481963B2 (en) | 1992-12-25 |
Family
ID=12870219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5085185A Granted JPS61210008A (en) | 1985-03-14 | 1985-03-14 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61210008A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0733635A (en) * | 1993-07-21 | 1995-02-03 | Kao Corp | Skin external preparation |
| JPH1179932A (en) * | 1997-09-12 | 1999-03-23 | Kanebo Ltd | Emulsified skin lotion |
| US6344183B2 (en) | 1998-04-09 | 2002-02-05 | National Starch And Chemical Investment Holding Corporation | Aerosol hair cosmetic compositions containing non-ionically derivatized starches |
| US6562325B2 (en) | 1998-04-09 | 2003-05-13 | National Starch And Chemical Investment Holding Corporation | Use of stabilized starches in low VOC, polyacrylic acid-containing hair cosmetic compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57145803A (en) * | 1981-03-05 | 1982-09-09 | Sunstar Inc | External decoloring agent for skin |
| JPS58154507A (en) * | 1982-03-09 | 1983-09-14 | Sunstar Inc | Skin bleaching agent for external use |
| JPS6016906A (en) * | 1983-07-07 | 1985-01-28 | Pola Chem Ind Inc | External drug for skin |
-
1985
- 1985-03-14 JP JP5085185A patent/JPS61210008A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61210008A (en) | 1986-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |