JPH0480003B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a hair growth agent. The present invention aims to use a human placenta extract as a hair growth agent for hair growth, hair graying prevention, and the like. It is well known that human placenta extract has been used as a skin treatment agent as a wound repair accelerator because it has an activating effect on the skin, and has been used in the treatment of burns. Recently, it has been used as a treatment for pigmentation such as age spots and dark skin, or as a cosmetic agent. However, the conventional method of using human placenta extract is to include it in a cream or emulsion and apply it to the skin surface, aiming for natural absorption from the skin surface, which has poor absorption efficiency and reduces its effectiveness. I couldn't perform to my full potential. Furthermore, there have been no products that use human placenta extracts as hair growth or other hair growth agents. Therefore, in the present invention, human placenta extract is not simply applied to the skin and left to natural absorption, but is used in conjunction with a substance that is highly absorbable to the skin, which has a great effect on hair growth. The aim is to reach the mother cells rapidly and immediately exert a strong activating effect. To explain the present invention in detail below, the placenta is washed with water and minced according to a conventional method, and after blood is removed, it is immersed in a mixture of acetone water and hydrochloric acid and extracted at room temperature, and 4 to 5 times the volume of acetone is added to the extracted solution. The precipitate that has separated out is filtered, washed with acetone, and dried over calcium chloride in a desiccator. It contains protein and no steroids. Another method for producing placenta substrates is to wash the placenta with physiological saline, remove blood, and perform low-temperature metabolism, then mince it and heat it on a water bath to coagulate the proteins, soak it in hydrochloric acid solution, and add pepsin to decompose it. Chlorine ions in hydrochloric acid are removed from the supernatant by centrifugation, and the precipitate is hydrolyzed again with hydrochloric acid, heated on a water bath to remove the hydrochloric acid, and treated in the same manner as the supernatant to obtain a solution. Plant extracts are obtained from plants containing plant proteins such as gum tragacanth, saponin-containing substances such as horse chestnut, cyclamen or soybean lucerne. When the powder of this plant extract is thoroughly mixed with a carbonate such as soda and sufficient whey is added, the whey component is combined with the plant extract powder to form an ointment. These forming substances have extremely high permeability to cells. The above-mentioned placenta extract is added to these fat-free base materials to form an ointment type, lotion type, etc. depending on the usage mode. The above fat-free base material with placenta extract added has recently been used as a treatment for Parkinson's disease.
One of the side effects is hirsutism, which is a problem3.
4-Dioxyphenyl-L-alanine, so-called L
It is also good to add dopa. Dopa is an amino acid that is formed when the enzyme tyrosinase hydroxylates it to tyrosine in the liver and melanocytes. Dopa is decarboxylated by aromatic amino acid decarboxylase to produce dopamine, an intermediate in melanin formation. Form. Examples will be explained below. Example 1-1 Placenta extract obtained by conventional method 10 parts (parts by weight) Whey 85 parts Pyridoxine 1 part Ascorbic acid 2 parts Vitamin E acetate 2 parts A water-soluble solution can be obtained by mixing the above materials well. . Use this solution by thoroughly rubbing it into the skin of your head. Due to the permeability of placenta extract and whey into the skin, the placenta extract itself activates the dermal papilla, hair matrix cells, etc. At the same time, amino acids are decarboxylated by the action of the phosphate ester activated in vivo of other pyridoxines. As a coenzyme for enzymes and aminotransferases, it plays an important role in protein metabolism in the body and prevents hair loss. In addition, ascorbic acid, which is effective against capillary disorders, anemia, scurvy, etc., gives shine to the hair, improves and promotes permeation and absorption into the skin, metabolism and peripheral circulation, and protects the skin. Vitamin E acetate dilated peripheral blood vessels to promote blood circulation, and the combination of ascorbic acid and vitamin E prevented oxidation of the solution. The following data were obtained for a specific example implemented using this example.

[Table] Example 1-2 Placenta extract obtained by conventional method 10 parts whey 84 parts riboflavin 1 part pyridoxine 1 part ascorbic acid 2 parts vitamin E acetate 2 parts Riboflavin was added to the above solution to increase hair metabolism. . Example 1-3 Placenta extract obtained by conventional method 10 parts whey 82.96 parts pyridoxine 1 part riboflavin 1 part tryptophan 1 part ascorbic acid 2 parts vitamin E acetate 2 parts ethinyl estradiol 0.04 part The above ethinyl estradiol is synthetic estrone. By adding this, it is especially effective for typical baldness. Example 1-4 Placenta extract obtained by conventional method 10 parts whey 87.45 parts pyridoxine 1 part riboflavin 1 part cobalamin 0.5 part prednisolone 0.05 part The above prednisolone is a synthetic adrenocortical hormone and is already well-known as a drug for alopecia areata. be. Example 1-5 Placenta extract obtained by conventional method 10 parts Zerol (trade name, manufactured by Merz, Germany)
84.45 parts pyridoxine 1 part riboflavin 1 part cobalamin 0.5 parts vitamin E acetate 2 parts tryptophan 1 part prednisolone 0.05 parts The above Zerol is from Germany. It is the trade name of whey manufactured by Merz. Cobalamin (vitamin B ₁₂ ) is effective in reducing the function of nervous tissue. Example 2-1 300 g of tragacanth powder and 3 g of soda powder are thoroughly stirred, 10 g of whey is added thereto, and 250 g of boric acid is added to obtain an ointment. The above ointment (fat-free base material purified from plant extract protein) 85 parts Placenta extract obtained by conventional method 10 parts Pyridoxine 1 part Ascorbic acid 2 parts Vitamin E acetate 2 parts Stir the above well to make the ointment. obtain. The above ointment acts on skin cells and has a strong effect of dilating pores and stimulating blood circulation. Others are Example (1-1)
It is similar to The following data were obtained for a specific example implemented using this example.

[Table] Example 2-2 Fat-free base purified from plant extract protein 84 parts Placenta extract obtained by conventional method 10 parts Riboflavin 1 part Pyridoxine 1 part Ascorbic acid 2 parts Vitamin E acetate 2 parts Example 3-1 Ointment of Example 2-1 81 parts Placenta extract obtained by conventional method 10 parts L-Dopa 5 parts Calcium paretoterate 2 parts Nicotinic acid 1 part Phenyl salicylate 1 part By adding L-Dopa, the Penetration into the scalp is facilitated by the penetrating power of the non-fat base material formed by other placenta treatment agents, plant extracts and whey, making it a powerful agent. The following data were obtained for a specific example implemented using this example.

【table】

Claims (1)

[Scope of Claims] 1. A hair growth agent prepared by adding whey to a placenta extract purified by a conventional method and blending the same into a general hair growth material base material. 2. A hair growth agent made by adding whey to a placenta extract purified by a conventional method, adding thereto a fat-free base material purified from a plant extract protein, and blending the mixture with a general hair growth material base material. 3. A hair growth agent prepared by adding a placenta preparation to a fat-free base material purified from whey and plant extracted proteins, and adding 3,4-dioxyphenyl-L-alanine thereto.