JPH0477430A - Pharmaceutical composition containing yeast extract - Google Patents
Pharmaceutical composition containing yeast extractInfo
- Publication number
- JPH0477430A JPH0477430A JP2189409A JP18940990A JPH0477430A JP H0477430 A JPH0477430 A JP H0477430A JP 2189409 A JP2189409 A JP 2189409A JP 18940990 A JP18940990 A JP 18940990A JP H0477430 A JPH0477430 A JP H0477430A
- Authority
- JP
- Japan
- Prior art keywords
- yeast extract
- chinese
- reishi
- drug
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940041514 candida albicans extract Drugs 0.000 title claims abstract description 34
- 239000012138 yeast extract Substances 0.000 title claims abstract description 34
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 18
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 36
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 36
- 241000411851 herbal medicine Species 0.000 claims description 16
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims description 14
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 7
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 6
- 239000003814 drug Substances 0.000 abstract description 16
- 229940079593 drug Drugs 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 7
- 239000000203 mixture Substances 0.000 abstract description 7
- 230000009471 action Effects 0.000 abstract description 4
- 230000006386 memory function Effects 0.000 abstract description 4
- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 230000000050 nutritive effect Effects 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000000284 extract Substances 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- 238000011160 research Methods 0.000 description 5
- 230000032683 aging Effects 0.000 description 4
- 230000003712 anti-aging effect Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 102000000588 Interleukin-2 Human genes 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 229940005524 anti-dementia drug Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000003308 immunostimulating effect Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 239000002664 nootropic agent Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000009758 senescence Effects 0.000 description 2
- 206010057248 Cell death Diseases 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- -1 and if desired Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 235000019784 crude fat Nutrition 0.000 description 1
- 238000012364 cultivation method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000000968 medical method and process Methods 0.000 description 1
- 230000008897 memory decline Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、漢方薬の薬理作用を増強する酵母エキス含有
医薬組成物に関する。DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to a yeast extract-containing pharmaceutical composition that enhances the pharmacological action of Chinese herbal medicine.
（従来の技術） 漢方薬である霊芝（学名：マンネンタケ： Ｇａｎ。(Conventional technology) Reishi (scientific name: Gan) is a Chinese herbal medicine.
ｄｅｒｖａａ Ｌｕｃｉｄｕ＋＊ Ｃｕｒｔｅｒ Ｆｒ
、 ＫＡＲ３Ｔ）は、中国において古来より不老長寿の
霊験あらたかな“神薬゛として用いられてきた。近年で
は、霊芝に抗老化作用が存在することを証明するため、
その科学的解明が盛んに行われている。その結果、老化
に関する研究の一側面である免疫学的研究によって、霊
芝はインターロイキン−２（Ｉｎｔｅｒｌｅｕｋｉｎ
−２）産生能上昇作用、ナチュラルキラー細胞（Ｎａｔ
ｕｒａｌｋｉｌｌｅｒ ｃｅｌｌ）の活性化作用（坪倉
道明ら：和漢薬学会誌、５．５２２−５２３．１９８８
） 、さらに、顕著な抗腫瘍活性化作用（荻田善−ら：
Ｔｈｅｒａｐｅｕｔｉｃ Ｒｅ５ｅａｒｃｈ、 ８．
８４５−８５２．１９８８）を有することが判明した。dervaa Lucidu+* Carter Fr
, KAR3T) has been used in China since ancient times as a miraculous "sacred medicine" for eternal youth and longevity.In recent years, in order to prove that reishi has anti-aging effects,
Scientific elucidation of this phenomenon is actively being carried out. As a result, immunological research, which is one aspect of research on aging, has shown that Reishi has been linked to interleukin-2 (Interleukin-2).
-2) Production capacity increasing effect, natural killer cells (Nat
ural killer cell) (Michiaki Tsubokura et al.: Journal of the Japanese and Chinese Pharmaceutical Society, 5.522-523.1988
), and furthermore, a remarkable antitumor activation effect (Yoshi Ogita et al.:
Therapeutic Research, 8.
845-852.1988).
すなわち、霊芝は抗老化作用の一つとして免疫賦活作用
を有することが明らかになったのである。また、老化の
もう一つの側面である痴呆の研究により、霊芝には、加
齢による学習・記憶機能の低下を遅延させる作用のある
ことが判明している（荻田善−ら：老化促進モデルマウ
ス（ＳＡＭ）研究協議会抄録集、５．２７−２８．１９
８８）。これらのことから霊芝の抗老化作用が科学的に
立証されている。In other words, it has been revealed that Reishi mushroom has an immunostimulatory effect as one of its anti-aging effects. In addition, research on dementia, which is another aspect of aging, has revealed that reishi has the effect of delaying the decline in learning and memory functions due to aging (Yoshio Ogita et al.: Aging Acceleration Model). Mouse (SAM) Research Council Abstracts, 5.27-28.19
88). From these facts, the anti-aging effects of Reishi mushrooms have been scientifically proven.
自然界において霊芝は、古木十万本に２〜３本しか採取
できないという貴重品でめったに人目に触れるものでは
なかったが、約２０年前より栽培法が確立され、良質の
霊芝が利用できるようになり、医薬組成物としての有用
性が近年高まってきた。In nature, Reishi mushrooms were rare, as only two or three out of every 100,000 old trees could be harvested, and they were rarely seen by the public. However, a cultivation method was established about 20 years ago, and high-quality Reishi mushrooms are now available. As a result, its usefulness as a pharmaceutical composition has increased in recent years.
一方、酵母エキスは蛋白質、脂質、有機酸、アミノ酸、
ビタミン、ミネラル、糖質、核酸関連物質などの有用な
成分を含んでおり、微生物培養の培地や動物の飼料の素
材などとして用いられている。また、熱、水分、他の添
加物などから大きな影響を受けないことから、加工に適
し、さらに抗酸化作用も有している。On the other hand, yeast extract contains proteins, lipids, organic acids, amino acids,
It contains useful ingredients such as vitamins, minerals, carbohydrates, and nucleic acid-related substances, and is used as a culture medium for microorganisms and as an ingredient in animal feed. In addition, it is suitable for processing because it is not significantly affected by heat, moisture, and other additives, and it also has an antioxidant effect.
（発明が解決しようとする課題）
このような酵母エキスの利点を生かし、漢方薬と組み合
わせた医薬組成物は今までなかった。(Problems to be Solved by the Invention) Until now, there has been no pharmaceutical composition that takes advantage of such advantages of yeast extract and combines it with Chinese herbal medicine.
そこで、本発明は、酵母エキスに漢方薬、特に霊芝を含
有させることにより、栄養価に冨む酵母エキスの有用成
分が霊芝等の漢方薬の薬効を増強させ、しかも、組成物
の物理化学的な安定性を高めるように、酵母エキスを含
有した医薬組成物を得ることを目的とした。Therefore, the present invention provides that by containing Chinese herbal medicine, especially Reishi mushroom, in yeast extract, the useful components of the yeast extract rich in nutritional value can enhance the medicinal efficacy of Chinese medicine such as Reishi mushroom, and furthermore, the physicochemical properties of the composition can be improved. The purpose of the present invention was to obtain a pharmaceutical composition containing yeast extract so as to increase its stability.
（課題を解決するための手段）
本発明は、漢方薬、好ましくは霊芝と酵母エキスを含有
することを特徴とする酵母エキス含有医薬組成物である
。(Means for Solving the Problems) The present invention is a yeast extract-containing pharmaceutical composition characterized by containing a Chinese herbal medicine, preferably Reishi mushroom, and yeast extract.
本発明でいう漢方薬は、古代中国から発生した医療法で
ある漢方医療の体系下で用いられている生薬・処方であ
ればどのようなものでも利用できる。その中でも、現在
もっとも注目され、かつ切望されている抗老化作用およ
び免疫賦活化作用を有しているという理由から、霊芝を
用いるのが効果的である。霊芝はそのまま粉末状にした
もの、熱水抽出したもの、エーテル抽出したもの等が用
いられるが、特に霊芝を熱水抽出し熱時ろ過処理したも
のを用いると良い。The herbal medicine referred to in the present invention can be any crude drug or prescription used under the system of herbal medicine, which is a medical method that originated in ancient China. Among them, it is effective to use Ganoderma lucidum because it has anti-aging effects and immunostimulatory effects that are currently attracting the most attention and are highly desired. Reishi mushrooms can be used in powder form, hot water extracted, ether extracted, etc., but it is especially good to use reishi mushrooms that have been extracted with hot water and filtered while hot.
酵母エキスは酵母サツカロミセス・セレビシェ（Ｓａｃ
ｃｈａｒｏｍ ｃｅｓ ｃｅｒｅｖｉｓｉａｅ）から抽
出したものであればどのようなものでも利用できる。そ
の中でも、乾燥酵母１ｇ中に蛋白質４００■以上および
チアミン（塩酸チアミンとして０００１１ｇ以上を含ん
でいることから、ビール酵母から抽出したエキスが特に
好ましい。Yeast extract is derived from the yeast Saccharomyces cerevisiae (Sac
Any extract extracted from Charom ces cerevisiae can be used. Among these, extracts extracted from brewer's yeast are particularly preferred because 1 g of dry yeast contains 400 μ or more of protein and thiamine (00011 g or more as thiamine hydrochloride).
酵母エキスは粉末状、ペースト状または液体状のものが
利用できるが、医薬組成物の製造の観点から粉末状の酵
母エキスを利用するのが好ましい。The yeast extract can be used in powder, paste, or liquid form, but from the viewpoint of manufacturing a pharmaceutical composition, it is preferable to use a powdered yeast extract.
本発明の医薬組成物の製造法は以下のとおりである。す
なわち、霊芝を霊芝の約２０倍量（重量比）の水で熱水
抽出を行い、水量が半分になるまで煮沸する。それを凍
結乾燥した物を霊芝エキスとして用いる。また、酵母エ
キスは、ビール醗酵工程から副生じた生酵母を水酸化ナ
トリウムや水で脱苦味洗浄し、その精製生酵母を自己消
化させ、その自己消化液を菌体分離ろ過、濃縮、ろ過、
乾燥したものを用いる。そして、霊芝エキスおよび酵母
エキス、さらに所望により乳糖、でんぷんなどの賦形剤
などを混合する。The method for producing the pharmaceutical composition of the present invention is as follows. That is, Reishi mushroom is extracted with hot water using about 20 times the amount (weight ratio) of Reishi mushroom, and then boiled until the amount of water is reduced to half. The freeze-dried product is used as Reishi extract. In addition, yeast extract is produced by removing bitterness from the raw yeast produced by the beer fermentation process with sodium hydroxide and water, allowing the purified raw yeast to autolyse, and then using the autolysed liquid to separate the cells, concentrate, filter, and remove the bitterness.
Use dried ones. Then, reishi extract, yeast extract, and if desired, excipients such as lactose and starch are mixed.
酵母エキスと漢方薬の割合は、漢方薬の種類、薬効等に
よって任意に定めることができる。漢方薬として霊芝を
用いる場合は霊芝１重量部に対し酵母エキスを０．１〜
１０重量部使用することが好ましい。０．１重量部より
小さい場合は、酵母エキスによる薬効増強作用が認めら
れず、また、１０重量部を超えると、酵母エキスによる
さらなる増強作用が認められないので好ましくない。The ratio of yeast extract to Chinese herbal medicine can be arbitrarily determined depending on the type of Chinese medicine, medicinal efficacy, etc. When using Reishi as a Chinese medicine, add 0.1 to 1 part of yeast extract to 1 part by weight of Reishi.
Preferably, 10 parts by weight are used. If it is less than 0.1 part by weight, the yeast extract will not exhibit any medicinal efficacy enhancing effect, and if it exceeds 10 parts by weight, no further enhancing effect by the yeast extract will be observed, which is not preferable.
本発明の医薬組成物は経口剤としては錠剤、カプセル剤
、顆粒、細粒、シロップ剤等、注射剤としては無菌溶液
剤または懸濁液剤で処方される。The pharmaceutical composition of the present invention is formulated as a tablet, capsule, granule, granule, syrup, etc. for oral administration, and as a sterile solution or suspension for injection.
用量は、漢方薬の薬効等により決定されるが、漢方薬と
して霊芝を用いる場合は霊芝原生薬換算量１ｇ〜５ｇを
全日量とし、１日数回にわけて用いるのが好ましい。The dose is determined depending on the medicinal efficacy of the Chinese herbal medicine, but when using Reishi as a Chinese herbal medicine, it is preferable to use a total daily dose of 1 to 5 g in terms of Ganoderma crude drug, divided into several doses a day.
（実施例）
本発明医薬組成物を例えば抗痴呆薬として使用する場合
、−例として次のような処方によって用いることができ
る。(Example) When the pharmaceutical composition of the present invention is used as an anti-dementia drug, for example, it can be used in the following formulation.
＋１１ 霊芝熱水抽出エキス ４５ｇ（原生薬換算
霊芝 ５００ｇ）
（２）酵母エキス ９０ｇ
（３） 乳１！ １１５ｇ全量
２５０ｇ
成分子ｌ）、（２）および（３）を混和し、混合物を圧
縮錠剤機で圧縮して錠剤１錠あたり成分（１）を４５■
含有する錠剤を１０００個製造した。得られた錠剤は、
２錠×３回／日で経口使用する。+11 Reishi hot water extract 45g (reishi mushroom equivalent 500g) (2) Yeast extract 90g (3) Milk 1! 115g total amount
250g Ingredients (1), (2) and (3) are mixed together and the mixture is compressed using a compression tablet machine to give 45g of Ingredient (1) per tablet.
1000 tablets containing the following were manufactured. The obtained tablets are
Use 2 tablets x 3 times/day orally.
（試験例）
老化促進モデルマウス（Ｓｅｎｅｓｃｅｎｃｅ Ａｃｃ
ｅｌｅｒａｔｅｄ Ｍｏｕｓｅ ： ＳＡＭ）であるＳ
ＡＭ−Ｐ／８系マウスをＡ、 Ｂ、 Ｃ（各７匹）、Ｄ
（６匹）の４群に分け、表１の混合飼料を一定期間自由
摂取させた後、学習・記憶試験を行った。(Test example) Senescence accelerated model mouse (Senescence Acc
S that is an elevated Mouse (SAM)
AM-P/8 mice A, B, C (7 each), D
The animals were divided into 4 groups (6 animals) and allowed to freely consume the mixed feed shown in Table 1 for a certain period of time, and then a learning/memory test was conducted.
ここで、市販の粉末飼料ＣＥ−２の組成は、水分８．７
％、粗蛋白質２４．８％、粗脂肪４．４％、粗繊維３．
５％、粗灰分７．０％、可溶性窒素物５１．６％で、カ
ロリーは１００ｇ当り３４５．２Ｃａｌである。Here, the composition of commercially available powdered feed CE-2 is water content: 8.7
%, crude protein 24.8%, crude fat 4.4%, crude fiber 3.
5%, crude ash 7.0%, soluble nitrogen 51.6%, and calorie is 345.2 Cal per 100g.
また、ここで、霊芝熱水抽出エキスは、霊芝粉末１００
重量部を熱水抽出後凍結乾燥して、８重量部の霊芝熱水
抽出エキスとしたものである。In addition, here, the reishi hot water extract is reishi powder 100%
Part by weight was extracted with hot water and freeze-dried to obtain 8 parts by weight of a hot water extract of Ganoderma lucidum.
投与条件は、４ヶ月齢のマウスに１ケ月間の短期投与と
した。The administration conditions were short-term administration for 1 month to 4-month-old mice.
学習・記憶試験は受動的回避反応実験により行った。す
なわち、第１日月、マウスをシャトルケージの明室に入
れ、３分間放置してケージに馴らした。第２日月、マウ
スをシャトルケージの明室に置き、暗室内に完全に入る
までの時間（反応潜時）を測定し、獲得試行の結果を得
た。マウスが暗室に入ると同時に戸を閉め、３秒間１．
０ｍＡの電撃ショックを与えた。第３日月、マウスをシ
ャトルケージの明室に置き、暗室内に完全に入るまでの
反応潜時を測定し、再生試行の結果を得た。受動的回避
実験前に予め自発的運動量を測定した。Learning and memory tests were conducted using passive avoidance reaction experiments. That is, on the first day and month, the mice were placed in the light room of the shuttle cage and left for 3 minutes to acclimatize to the cage. On the second day and month, the mouse was placed in the light room of the shuttle cage, and the time it took to completely enter the dark room (response latency) was measured to obtain the results of the acquisition trial. As soon as the mouse enters the dark room, close the door and 1.
An electric shock of 0 mA was given. On the third day, the mouse was placed in the light room of the shuttle cage, and the reaction latency until it completely entered the dark room was measured to obtain the results of the reproduction trial. Voluntary locomotion was measured in advance before the passive avoidance experiment.
結果を表２に示す。The results are shown in Table 2.
表２ 短期投与による学習・記憶機能への影響平均上標
準誤差
表２から明らかなように、ＣＥ−２投与群（Ａ群）と比
較して、霊芝熱水抽出エキス含有ＣＢ−２投与群（Ｂ群
）では、再生試行の反応潜時の有意な延長はみられなか
った。また乾燥ビール酵母エキス１０％含有ＣＥ−２投
与群（０群）においても再生試行の反応潜時の有意な延
長はみられなかったのに対し、霊芝熱水抽出エキス＋乾
燥ビール酵母エキス１０％含有ＣＢ−２投与群（Ｄ群）
は再生試行の反応潜時の有意な延長を示した。すなわち
、酵母エキスによる霊芝の学習・記憶低下遅延作用の増
強がみられた。Table 2 Effects on learning and memory functions due to short-term administration In (Group B), no significant prolongation of response latency in playback trials was observed. In addition, no significant prolongation of the reaction latency in the regeneration trial was observed in the CE-2 administration group (group 0) containing 10% dried beer yeast extract; % containing CB-2 administration group (Group D)
showed a significant prolongation of response latency in playback trials. In other words, yeast extract enhanced the effects of reishi on retarding learning and memory decline.
（発明の効果）
本発明の医薬組成物は、従来の漢方薬に酵母エキスを添
加することによって漢方薬単独で使用した時よりもさら
に優れた薬理作用をもつものであって、漢方薬製剤とし
て効果が期待できる。(Effects of the Invention) The pharmaceutical composition of the present invention has a pharmacological effect that is even better than that when the Chinese herbal medicine is used alone by adding yeast extract to a conventional Chinese herbal medicine, and is expected to be effective as a Chinese herbal medicine preparation. can.
また、特に漢方薬として霊芝を使用した本発明の医薬組
成物は、学習・記憶機能への効果にすぐれ、抗痴呆薬と
して有効である。In addition, the pharmaceutical composition of the present invention using Reishi mushroom as a Chinese herbal medicine has excellent effects on learning and memory functions, and is effective as an anti-dementia drug.
特許出願人アサヒビール株式会社Patent applicant Asahi Breweries, Ltd.
Claims (4)
酵母エキス含有医薬組成物。(1) A yeast extract-containing pharmaceutical composition characterized by containing a Chinese herbal medicine and yeast extract.
載の医薬組成物。(3) The pharmaceutical composition according to claim 1, wherein the yeast extract is a brewer's yeast extract.
量部含有することを特徴とする請求項１記載の医薬組成
物。(4) The pharmaceutical composition according to claim 1, which contains 0.1 to 10 parts by weight of yeast extract per 1 part by weight of Ganoderma lucidum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2189409A JP2998102B2 (en) | 1990-07-19 | 1990-07-19 | Anti-dementia agent containing yeast extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2189409A JP2998102B2 (en) | 1990-07-19 | 1990-07-19 | Anti-dementia agent containing yeast extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0477430A true JPH0477430A (en) | 1992-03-11 |
| JP2998102B2 JP2998102B2 (en) | 2000-01-11 |
Family
ID=16240791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2189409A Expired - Fee Related JP2998102B2 (en) | 1990-07-19 | 1990-07-19 | Anti-dementia agent containing yeast extract |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2998102B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005213205A (en) * | 2004-01-30 | 2005-08-11 | Okinawa Pref Gov | Brain function improving agent and food using yeast extract fraction |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240365A (en) * | 2010-05-14 | 2011-11-16 | 湖南瑞丹科技有限公司 | Pharmaceutical composition for enhancing organism immunity and preparation method thereof |
-
1990
- 1990-07-19 JP JP2189409A patent/JP2998102B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005213205A (en) * | 2004-01-30 | 2005-08-11 | Okinawa Pref Gov | Brain function improving agent and food using yeast extract fraction |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2998102B2 (en) | 2000-01-11 |
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