JPH0472820B2 - - Google Patents

Info

Publication number
JPH0472820B2
JPH0472820B2 JP59145860A JP14586084A JPH0472820B2 JP H0472820 B2 JPH0472820 B2 JP H0472820B2 JP 59145860 A JP59145860 A JP 59145860A JP 14586084 A JP14586084 A JP 14586084A JP H0472820 B2 JPH0472820 B2 JP H0472820B2
Authority
JP
Japan
Prior art keywords
alkynamide
pharmaceutically acceptable
composition
vanillyl
octadecinamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59145860A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6084251A (ja
Inventor
Maikuru Yaanusu Jon
Robaato Rahan Tomasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of JPS6084251A publication Critical patent/JPS6084251A/ja
Priority to US06/779,793 priority Critical patent/US4638366A/en
Publication of JPH0472820B2 publication Critical patent/JPH0472820B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP59145860A 1983-07-14 1984-07-13 鎮痛用新規化合物および組成物 Granted JPS6084251A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US06/779,793 US4638366A (en) 1984-07-13 1985-09-24 Automatic iris adjustment system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US514204 1983-07-14
US06/514,204 US4532139A (en) 1983-07-14 1983-07-14 Compounds and compositions useful for producing analgesia

Publications (2)

Publication Number Publication Date
JPS6084251A JPS6084251A (ja) 1985-05-13
JPH0472820B2 true JPH0472820B2 (enExample) 1992-11-19

Family

ID=24046218

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59145860A Granted JPS6084251A (ja) 1983-07-14 1984-07-13 鎮痛用新規化合物および組成物

Country Status (15)

Country Link
US (1) US4532139A (enExample)
EP (1) EP0132114B1 (enExample)
JP (1) JPS6084251A (enExample)
AU (1) AU566192B2 (enExample)
CA (1) CA1244049A (enExample)
DE (1) DE3460820D1 (enExample)
DK (1) DK345884A (enExample)
GB (1) GB2144415B (enExample)
HK (1) HK74990A (enExample)
IE (1) IE57567B1 (enExample)
MY (1) MY101021A (enExample)
NZ (1) NZ208899A (enExample)
PH (1) PH20512A (enExample)
SG (1) SG45190G (enExample)
ZA (1) ZA845348B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493848A (en) * 1983-07-14 1985-01-15 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US4681897A (en) * 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
DE3520761A1 (de) * 1984-06-11 1985-12-12 Ajinomoto Co., Inc., Tokio/Tokyo Verwendung von vanillylamin oder vanillylamiden zur foerderung des fettstoffwechsels
US5013759A (en) * 1985-06-10 1991-05-07 The Procter & Gamble Company Compounds and compositions having anti-inflammatory and analgesic activity
GB2178031B (en) 1985-06-10 1989-07-26 Procter & Gamble Phenylacetic acid amides having anti-inflammatory and analgesic activity
US4990533A (en) * 1985-12-20 1991-02-05 Warner-Lambert Co. Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
US4689182A (en) * 1985-12-20 1987-08-25 Warner-Lambert Company Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
US4980366A (en) * 1986-08-19 1990-12-25 Warner-Lambert Co. Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity
US5045565A (en) * 1987-03-09 1991-09-03 The Procter & Gamble Company Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5099030A (en) * 1987-03-09 1992-03-24 The Procter & Gamble Company Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5461075A (en) * 1988-06-17 1995-10-24 The Procter & Gamble Company Use of vanilloids for the prevention of lesions due to herpes simplex infections
US5322862A (en) * 1990-05-22 1994-06-21 Nippon Kayaku Kabushiki Kaisha Resin molding composition for preventing gnawing damage by animals
US5762963A (en) * 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids
US6239180B1 (en) 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US6248788B1 (en) 1996-11-06 2001-06-19 The Regents Of The University Of California Therapeutic method with capsaicin and capasicin analogs
US6689399B1 (en) 2000-03-16 2004-02-10 James R. Dickson Transdermal delivery of an anti-inflammatory composition
US6759064B2 (en) 2001-02-22 2004-07-06 Purdue Research Foundation Compositions based on vanilloid-catechin synergies for prevention and treatment of cancer
US7192612B2 (en) * 2001-02-22 2007-03-20 Purdue Research Foundation Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer
JP2005507865A (ja) * 2001-08-10 2005-03-24 シンタ ファーマシューティカルズ コーポレーション カヴァラクトン組成物および使用法
WO2003039561A1 (en) * 2001-11-02 2003-05-15 Elan Corporation, Plc Pharmaceutical composition
CA2499994C (en) * 2002-09-23 2012-07-10 Verion, Inc. Abuse-resistant pharmaceutical compositions
AU2003299691B2 (en) * 2002-12-18 2008-06-05 Algorx Pharmaceuticals, Inc. Administration of capsaicinoids
US7943166B2 (en) 2003-04-10 2011-05-17 Neurogesx, Inc. Methods and compositions for administration of TRPV1 agonists
US20080268092A1 (en) * 2004-12-01 2008-10-30 Dacanay Rhodel G Capsaicin Nutritional Supplement
ZA200707492B (en) * 2005-02-14 2009-02-25 Neurogesx Inc Device for delivery of TRPV1 agonists
CA2602832A1 (en) * 2005-03-30 2006-10-05 Keith R. Bley Low-concentration capsaicin patch and methods for treating neuropathic pain
US8158682B2 (en) * 2008-09-12 2012-04-17 Vallinex, Inc. Instillation administration of capsaicinoids for the treatment of pain
EP3295794A1 (en) 2010-07-27 2018-03-21 Flex Pharma, Inc. Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise
CN101973903A (zh) * 2010-10-12 2011-02-16 浙江大学 辣椒碱同系物的合成方法
US20120310140A1 (en) 2010-12-01 2012-12-06 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
KR20180095505A (ko) 2015-10-09 2018-08-27 악시켐 아베 합성 캡사이신류 유도체를 포함하는 조류 사료 및 특히 가금류 사료, 및 살모넬라 감염의 예방적 용도나 처치를 위한 조류 사료
WO2018136943A1 (en) 2017-01-23 2018-07-26 Flex Pharma, Inc. Compositions and methods affecting exercise performance
CN111479565A (zh) * 2017-10-20 2020-07-31 艾克西化学公司 作为生物增强剂的合成辣椒碱类似物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3024281A (en) * 1962-03-06 Amidomethylation of aromatic
US2710299A (en) * 1950-10-21 1955-06-07 Thomae Gmbh Dr K Process for the production of crystalline vanillyl amides
DE938014C (de) * 1952-11-05 1956-01-19 Beiersdorf & Co A G P Verfahren zur Herstellung kristallisierter Vanillylamide
US2845449A (en) * 1956-07-11 1958-07-29 California Research Corp Thioamide production
NL269079A (enExample) * 1960-09-09 1964-06-25
US3108038A (en) * 1962-01-08 1963-10-22 Du Pont Anilide nematocides
US3192213A (en) * 1962-10-12 1965-06-29 Olin Mathieson Aminoalkyl anilides
US3167556A (en) * 1963-11-19 1965-01-26 Olin Mathieson Basic derivatives of anilides
SE353319B (enExample) * 1964-08-15 1973-01-29 Sumitomo Chemical Co
US3201401A (en) * 1964-09-17 1965-08-17 Olin Mathieson Aminoalkoxy and aminoalkylthioanilide compounds
GB1150051A (en) * 1966-03-11 1969-04-30 Science Union & Cie New Phenylisopropylamide Derivatives and Process for Preparing Them
US3780103A (en) * 1967-03-30 1973-12-18 Ciba Geigy Corp Alkylhydroxybenzylamides
US4031186A (en) * 1975-07-10 1977-06-21 Rohm And Haas Company Arylaminoalkylthioamides
DE2752366A1 (de) * 1977-11-24 1979-05-31 Bayer Ag 3,3-dimethyl-4-penten-thiosaeureamide und verfahren zu ihrer herstellung
US4244730A (en) * 1979-07-02 1981-01-13 Chevron Research Company Herbicidal N-haloacetyl-2-alkyl-6-acylanilines
US4372972A (en) * 1979-09-14 1983-02-08 Rohm And Haas Company N-Substituted alkynyl anilines

Also Published As

Publication number Publication date
EP0132114B1 (en) 1986-09-24
GB8417625D0 (en) 1984-08-15
GB2144415B (en) 1987-11-25
CA1244049A (en) 1988-11-01
EP0132114A1 (en) 1985-01-23
MY101021A (en) 1991-06-29
PH20512A (en) 1987-01-26
JPS6084251A (ja) 1985-05-13
DK345884A (da) 1985-01-15
ZA845348B (en) 1985-03-27
IE841814L (en) 1985-01-14
HK74990A (en) 1990-09-28
DE3460820D1 (en) 1986-10-30
US4532139A (en) 1985-07-30
AU566192B2 (en) 1987-10-08
IE57567B1 (en) 1992-12-16
SG45190G (en) 1990-08-17
NZ208899A (en) 1988-03-30
GB2144415A (en) 1985-03-06
AU3058684A (en) 1985-01-17
DK345884D0 (da) 1984-07-13

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