HK74990A - N-phenylmethyl-alkynamide derivatives and compositions for use as analgesics - Google Patents

N-phenylmethyl-alkynamide derivatives and compositions for use as analgesics

Info

Publication number
HK74990A
HK74990A HK749/90A HK74990A HK74990A HK 74990 A HK74990 A HK 74990A HK 749/90 A HK749/90 A HK 749/90A HK 74990 A HK74990 A HK 74990A HK 74990 A HK74990 A HK 74990A
Authority
HK
Hong Kong
Prior art keywords
alkynamide
phenylmethyl
analgesics
derivatives
compositions
Prior art date
Application number
HK749/90A
Other languages
English (en)
Inventor
John Michael Janusz
Thomas Robert Lahann
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of HK74990A publication Critical patent/HK74990A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK749/90A 1983-07-14 1990-09-20 N-phenylmethyl-alkynamide derivatives and compositions for use as analgesics HK74990A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/514,204 US4532139A (en) 1983-07-14 1983-07-14 Compounds and compositions useful for producing analgesia

Publications (1)

Publication Number Publication Date
HK74990A true HK74990A (en) 1990-09-28

Family

ID=24046218

Family Applications (1)

Application Number Title Priority Date Filing Date
HK749/90A HK74990A (en) 1983-07-14 1990-09-20 N-phenylmethyl-alkynamide derivatives and compositions for use as analgesics

Country Status (15)

Country Link
US (1) US4532139A (xx)
EP (1) EP0132114B1 (xx)
JP (1) JPS6084251A (xx)
AU (1) AU566192B2 (xx)
CA (1) CA1244049A (xx)
DE (1) DE3460820D1 (xx)
DK (1) DK345884A (xx)
GB (1) GB2144415B (xx)
HK (1) HK74990A (xx)
IE (1) IE57567B1 (xx)
MY (1) MY101021A (xx)
NZ (1) NZ208899A (xx)
PH (1) PH20512A (xx)
SG (1) SG45190G (xx)
ZA (1) ZA845348B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493848A (en) * 1983-07-14 1985-01-15 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US4681897A (en) * 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
DE3520761A1 (de) * 1984-06-11 1985-12-12 Ajinomoto Co., Inc., Tokio/Tokyo Verwendung von vanillylamin oder vanillylamiden zur foerderung des fettstoffwechsels
GB2178031B (en) 1985-06-10 1989-07-26 Procter & Gamble Phenylacetic acid amides having anti-inflammatory and analgesic activity
US5013759A (en) * 1985-06-10 1991-05-07 The Procter & Gamble Company Compounds and compositions having anti-inflammatory and analgesic activity
US4689182A (en) * 1985-12-20 1987-08-25 Warner-Lambert Company Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
US4990533A (en) * 1985-12-20 1991-02-05 Warner-Lambert Co. Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
US4980366A (en) * 1986-08-19 1990-12-25 Warner-Lambert Co. Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity
US5045565A (en) * 1987-03-09 1991-09-03 The Procter & Gamble Company Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5099030A (en) * 1987-03-09 1992-03-24 The Procter & Gamble Company Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5461075A (en) * 1988-06-17 1995-10-24 The Procter & Gamble Company Use of vanilloids for the prevention of lesions due to herpes simplex infections
US5322862A (en) * 1990-05-22 1994-06-21 Nippon Kayaku Kabushiki Kaisha Resin molding composition for preventing gnawing damage by animals
US5762963A (en) * 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids
US6248788B1 (en) 1996-11-06 2001-06-19 The Regents Of The University Of California Therapeutic method with capsaicin and capasicin analogs
US6239180B1 (en) 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US6689399B1 (en) 2000-03-16 2004-02-10 James R. Dickson Transdermal delivery of an anti-inflammatory composition
US7192612B2 (en) * 2001-02-22 2007-03-20 Purdue Research Foundation Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer
US6759064B2 (en) 2001-02-22 2004-07-06 Purdue Research Foundation Compositions based on vanilloid-catechin synergies for prevention and treatment of cancer
CA2457622A1 (en) * 2001-08-10 2003-02-20 Kava Pharmaceuticals, Inc. Kavalactone compositions and methods of use
EP1450824A4 (en) * 2001-11-02 2005-09-28 Elan Corp Plc PHARMACEUTICAL COMPOSITION
EP1551402A4 (en) * 2002-09-23 2009-05-27 Verion Inc PHARMACEUTICAL COMPOSITIONS NOT INDUCING ABUSE
CA2510181C (en) * 2002-12-18 2011-03-08 Algorx Pharmaceuticals, Inc. Administration of capsaicinoids
EP2907503A1 (en) 2003-04-10 2015-08-19 Neurogesx, Inc. Methods and compositions for administration of TRPV1 agonists
US20080268092A1 (en) * 2004-12-01 2008-10-30 Dacanay Rhodel G Capsaicin Nutritional Supplement
KR20070121666A (ko) * 2005-02-14 2007-12-27 노이로제스엑스, 인코포레이티드 Ｔｒｐｖ１ 작용제의 전달용 장치
US20060222690A1 (en) * 2005-03-30 2006-10-05 Bley Keith R Low-concentration capsaicin patch and methods for treating neuropathic pain
US8158682B2 (en) * 2008-09-12 2012-04-17 Vallinex, Inc. Instillation administration of capsaicinoids for the treatment of pain
ES2647087T3 (es) 2010-07-27 2017-12-19 Flex Pharma, Inc. Métodos y composiciones para prevenir y aliviar los calambres musculares y para la recuperación de la irritabilidad neuromuscular y de la fatiga después del ejercicio
CN101973903A (zh) * 2010-10-12 2011-02-16 浙江大学 辣椒碱同系物的合成方法
US20120310140A1 (en) 2010-12-01 2012-12-06 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
PL3358965T3 (pl) 2015-10-09 2020-02-28 Axichem Ab Pasza dla ptaków, zwłaszcza drobiu, zawierająca syntetyczne pochodne kapsaicynoidów do użytku profilaktycznego i leczenia infekcji Salmonellą
WO2018136943A1 (en) 2017-01-23 2018-07-26 Flex Pharma, Inc. Compositions and methods affecting exercise performance
AU2018351640B2 (en) * 2017-10-20 2024-02-29 Axichem Ab Synthetic capsaicin analogues as bioenhancers

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3024281A (en) * 1962-03-06 Amidomethylation of aromatic
US2710299A (en) * 1950-10-21 1955-06-07 Thomae Gmbh Dr K Process for the production of crystalline vanillyl amides
DE938014C (de) * 1952-11-05 1956-01-19 Beiersdorf & Co A G P Verfahren zur Herstellung kristallisierter Vanillylamide
US2845449A (en) * 1956-07-11 1958-07-29 California Research Corp Thioamide production
NL269079A (xx) * 1960-09-09 1964-06-25
US3108038A (en) * 1962-01-08 1963-10-22 Du Pont Anilide nematocides
US3192213A (en) * 1962-10-12 1965-06-29 Olin Mathieson Aminoalkyl anilides
US3167556A (en) * 1963-11-19 1965-01-26 Olin Mathieson Basic derivatives of anilides
SE353319B (xx) * 1964-08-15 1973-01-29 Sumitomo Chemical Co
US3201401A (en) * 1964-09-17 1965-08-17 Olin Mathieson Aminoalkoxy and aminoalkylthioanilide compounds
GB1150051A (en) * 1966-03-11 1969-04-30 Science Union & Cie New Phenylisopropylamide Derivatives and Process for Preparing Them
US3780103A (en) * 1967-03-30 1973-12-18 Ciba Geigy Corp Alkylhydroxybenzylamides
US4031186A (en) * 1975-07-10 1977-06-21 Rohm And Haas Company Arylaminoalkylthioamides
DE2752366A1 (de) * 1977-11-24 1979-05-31 Bayer Ag 3,3-dimethyl-4-penten-thiosaeureamide und verfahren zu ihrer herstellung
US4244730A (en) * 1979-07-02 1981-01-13 Chevron Research Company Herbicidal N-haloacetyl-2-alkyl-6-acylanilines
US4372972A (en) * 1979-09-14 1983-02-08 Rohm And Haas Company N-Substituted alkynyl anilines

Also Published As

Publication number Publication date
IE841814L (en) 1985-01-14
DE3460820D1 (en) 1986-10-30
DK345884A (da) 1985-01-15
GB8417625D0 (en) 1984-08-15
ZA845348B (en) 1985-03-27
GB2144415B (en) 1987-11-25
IE57567B1 (en) 1992-12-16
US4532139A (en) 1985-07-30
CA1244049A (en) 1988-11-01
JPS6084251A (ja) 1985-05-13
SG45190G (en) 1990-08-17
MY101021A (en) 1991-06-29
PH20512A (en) 1987-01-26
AU3058684A (en) 1985-01-17
EP0132114B1 (en) 1986-09-24
DK345884D0 (da) 1984-07-13
GB2144415A (en) 1985-03-06
NZ208899A (en) 1988-03-30
EP0132114A1 (en) 1985-01-23
JPH0472820B2 (xx) 1992-11-19
AU566192B2 (en) 1987-10-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)