JPH0470288B2 - - Google Patents
Info
- Publication number
- JPH0470288B2 JPH0470288B2 JP61065005A JP6500586A JPH0470288B2 JP H0470288 B2 JPH0470288 B2 JP H0470288B2 JP 61065005 A JP61065005 A JP 61065005A JP 6500586 A JP6500586 A JP 6500586A JP H0470288 B2 JPH0470288 B2 JP H0470288B2
- Authority
- JP
- Japan
- Prior art keywords
- mumps
- virus
- cells
- human
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 claims description 36
- 208000005647 Mumps Diseases 0.000 claims description 27
- 208000010805 mumps infectious disease Diseases 0.000 claims description 27
- 229960005486 vaccine Drugs 0.000 claims description 21
- 230000002238 attenuated effect Effects 0.000 claims description 16
- 230000001154 acute effect Effects 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 6
- 206010061218 Inflammation Diseases 0.000 claims description 5
- 230000004054 inflammatory process Effects 0.000 claims description 5
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims description 3
- 241000711386 Mumps virus Species 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 20
- 210000004027 cell Anatomy 0.000 description 16
- 241000287828 Gallus gallus Species 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 13
- 229940095293 mumps vaccine Drugs 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 210000001840 diploid cell Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 238000011081 inoculation Methods 0.000 description 9
- 235000013601 eggs Nutrition 0.000 description 8
- 230000007918 pathogenicity Effects 0.000 description 8
- 238000003306 harvesting Methods 0.000 description 7
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 210000005260 human cell Anatomy 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 238000002255 vaccination Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 108091006905 Human Serum Albumin Proteins 0.000 description 3
- 102000008100 Human Serum Albumin Human genes 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 201000005505 Measles Diseases 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 3
- 210000000991 chicken egg Anatomy 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 210000001161 mammalian embryo Anatomy 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241000700198 Cavia Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 201000009906 Meningitis Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 210000001643 allantois Anatomy 0.000 description 2
- 210000001691 amnion Anatomy 0.000 description 2
- 235000021120 animal protein Nutrition 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000000926 neurological effect Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 210000003681 parotid gland Anatomy 0.000 description 2
- 201000005404 rubella Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 210000003501 vero cell Anatomy 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 206010027250 Meningitis mumps Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 206010034038 Parotitis Diseases 0.000 description 1
- 208000020584 Polyploidy Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 229940030156 cell vaccine Drugs 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000007431 microscopic evaluation Methods 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 208000005963 oophoritis Diseases 0.000 description 1
- 201000005737 orchitis Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 210000001850 polyploid cell Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229960003131 rubella vaccine Drugs 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH05062/85-0 | 1985-11-26 | ||
| CH506285 | 1985-11-26 | ||
| CH00133/86-0 | 1986-01-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62126137A JPS62126137A (ja) | 1987-06-08 |
| JPH0470288B2 true JPH0470288B2 (fr) | 1992-11-10 |
Family
ID=4287306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6500586A Granted JPS62126137A (ja) | 1985-11-26 | 1986-03-25 | 流行性耳下腺炎に対する生ワクチン |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS62126137A (fr) |
| ZA (1) | ZA866843B (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9421748B2 (en) | 2011-12-29 | 2016-08-23 | Compagnie Generale Des Etablissements Michelin | Tire operating surface for tire testing road wheel |
| US9581525B2 (en) | 2012-09-30 | 2017-02-28 | Compagnie Generale Des Etablissements Michelin | Method of applying particulate material along a tire footprint during tire testing on a tire testing surface |
| US9702789B2 (en) | 2012-10-31 | 2017-07-11 | Compagnie Generale Des Etablissements Michelin | Method and apparatus for distributing particulate material along a tire footprint during tire test |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55147227A (en) * | 1979-05-04 | 1980-11-17 | Handai Biseibutsubiyou Kenkyukai | Preparrtion of attenuated live mumps vaccine |
-
1986
- 1986-03-25 JP JP6500586A patent/JPS62126137A/ja active Granted
- 1986-09-09 ZA ZA866843A patent/ZA866843B/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55147227A (en) * | 1979-05-04 | 1980-11-17 | Handai Biseibutsubiyou Kenkyukai | Preparrtion of attenuated live mumps vaccine |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9421748B2 (en) | 2011-12-29 | 2016-08-23 | Compagnie Generale Des Etablissements Michelin | Tire operating surface for tire testing road wheel |
| US9581525B2 (en) | 2012-09-30 | 2017-02-28 | Compagnie Generale Des Etablissements Michelin | Method of applying particulate material along a tire footprint during tire testing on a tire testing surface |
| US9702789B2 (en) | 2012-10-31 | 2017-07-11 | Compagnie Generale Des Etablissements Michelin | Method and apparatus for distributing particulate material along a tire footprint during tire test |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA866843B (en) | 1987-04-29 |
| JPS62126137A (ja) | 1987-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |