JPH0468952B2 - - Google Patents
Info
- Publication number
- JPH0468952B2 JPH0468952B2 JP61235943A JP23594386A JPH0468952B2 JP H0468952 B2 JPH0468952 B2 JP H0468952B2 JP 61235943 A JP61235943 A JP 61235943A JP 23594386 A JP23594386 A JP 23594386A JP H0468952 B2 JPH0468952 B2 JP H0468952B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- separator
- chamber
- outlet
- valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 claims description 106
- 239000008280 blood Substances 0.000 claims description 106
- 238000004140 cleaning Methods 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 16
- 230000037452 priming Effects 0.000 claims description 14
- 239000000306 component Substances 0.000 claims description 12
- 239000002504 physiological saline solution Substances 0.000 claims description 12
- 238000001179 sorption measurement Methods 0.000 claims description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 9
- 239000012503 blood component Substances 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 239000003463 adsorbent Substances 0.000 claims description 6
- 210000000601 blood cell Anatomy 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 4
- 238000010241 blood sampling Methods 0.000 claims description 3
- 210000004180 plasmocyte Anatomy 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 1
- 230000008929 regeneration Effects 0.000 description 13
- 238000011069 regeneration method Methods 0.000 description 13
- 238000000926 separation method Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 3
- 230000001172 regenerating effect Effects 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Description
【発明の詳細な説明】
＜産業上の利用分野＞
本発明は、血液に含まれているコレステロール
等の有害成分を選択的に除去する血中成分除去装
置の洗浄・プライミング方法に関する。DETAILED DESCRIPTION OF THE INVENTION <Industrial Application Field> The present invention relates to a method for cleaning and priming a blood component removal device that selectively removes harmful components such as cholesterol contained in blood.
＜従来の技術＞
従来、特開昭59−197255号公報に開示されてい
るような血中成分除去装置が公知である。この除
去装置は、供血者から採取した血液を送液する第
１ポンプと、血液を血漿と血球成分に分離する血
漿分離部と、血漿に含まれている特定成分（例え
ばリポ蛋白等）を選択的に除去する選択的除去部
と、この選択的除去部に前記血漿分離部で分離さ
れた血漿を送液する第２ポンプと、前記血漿分離
部で分離された血球成分に前記特定成分が除去さ
れた血漿を混合させる混合部とを設け、上記第１
及び第２のポンプを手動操作でスピードコントロ
ールして、血液に含まれている前記特定成分を除
去するようにしている。<Prior Art> Conventionally, a blood component removal device as disclosed in Japanese Unexamined Patent Publication No. 59-197255 is known. This removal device consists of a first pump that sends blood collected from a donor, a plasma separation section that separates blood into plasma and blood cell components, and a plasma separation section that selects specific components (such as lipoproteins) contained in plasma. a second pump that sends the plasma separated in the plasma separation section to the selective removal section, and a second pump that removes the specific component from the blood cell components separated in the plasma separation section; a mixing section for mixing the collected plasma;
The speed of the second pump is manually controlled to remove the specific component contained in the blood.
このような装置では、治療に先立ち血液回路を
洗浄液で洗浄する動作、血液回路を生理食塩水で
満たすプライミング動作が行なわれる。一方、前
記血漿分離部並びに前記選択的除去部に予め滅菌
液が充填されたウエツト型のセパレータ並びに吸
着器が用いられる。これらセパレータ等は空気が
混入しないようにして前記血液回路に接続される
必要があるが前記血液回路内に残つた空気が前記
洗浄・プライミング動作の過程で前記セパレータ
並びに吸着器に混入するとこれら部分に溜り機能
を劣化させてしまう。そこで、従来は前記セパレ
ータ等接続される血液回路の接続口まで液を満た
した後、前記セパレータ等を接続しており、手動
操作部分が多く、洗浄・プライミング作業が煩雑
であつた。 In such a device, prior to treatment, an operation of cleaning the blood circuit with a cleaning liquid and a priming operation of filling the blood circuit with physiological saline are performed. On the other hand, a wet type separator and adsorber are used in which the plasma separation section and the selective removal section are filled with a sterilizing solution in advance. These separators, etc. need to be connected to the blood circuit in a manner that prevents air from entering, but if air remaining in the blood circuit gets mixed into the separator and adsorber during the cleaning and priming process, these parts This will deteriorate the storage function. Therefore, conventionally, the separator and the like were connected after being filled with liquid up to the connection port of the blood circuit to which the separator and the like were connected, which required many manual operations and complicated cleaning and priming operations.
＜発明が解決しようとする問題点＞
本発明の解決しようとする技術的課題は、前記
血中成分除去装置の洗浄・プライミング動作の過
程で前記血液回路内の空気が前記セパレータ等に
混入することがなく、自動化に適した洗浄・プラ
イミング動作を実現することにある。<Problems to be Solved by the Invention> A technical problem to be solved by the present invention is that air in the blood circuit gets mixed into the separator etc. during the cleaning/priming operation of the blood component removal device. The goal is to realize cleaning and priming operations that are suitable for automation.
＜問題点を解決するための手段＞
本発明の方法は、
血液を採取する採血部と、
血液を戻す返血部と、
内室と外室とが膜によつて仕切られ、内室には
流入口と流出口とが設けられ、外室には流出口が
設けられ、内部が滅菌液で満たされたウエツト型
のセパレータと、
吸着剤が充填され、流入口と流出口とが設けら
れ、内部が滅菌液で満たされたウエツト型の吸器
と、
前記採血部と前記セパレータの内室の流入口と
の間、前記セパレータの内室の流出口と前記返血
部との間、前記セパレータの外室の流出口と前記
吸着器の流入口との間、並びに前記吸着器の流出
口と前記セパレータの内室の流出口側との間に
夫々設けられた血液回路と、
前記採血部と前記セパレータの内室の流入口と
の間の血液回路に設けられ、大気開放用のバルブ
とレベル計とを備えた第１のチヤンバーと、
前記セパレータの内室の流出口と前記返血部と
の間の血液回路に設けられ、大気開放用のバルブ
とレベル計とを備えた第２のチヤンバーと、
前記セパレータの外室の流出口と前記吸着器の
流入口との間の血液回路に設けられ、大気開放用
のバルブとレベル計とを備えた第３のチヤンバー
と、
前記吸着器の流出口と前記セパレータの内室の
流出口側との間の血液回路に設けられ、大気開放
用のバルブとレベル計とを備えた第４のチヤンバ
ーと、
前記採血部と前記セパレータの内室の流入口と
の間の血液回路に設けられた血液ポンプと、
前記セパレータの外室の流出口と前記吸着器の
流入口との間の血液回路に設けらた血漿ポンプ
と、
生理食塩水が入れられた生食バツグと、
前記吸着器の流出口側にバルブを介し接続され
た排出口と、
前記第１、第２、第３及び第４のチヤンバーの
レベル計から検出信号から与えられ、制御出力に
よつてこれらチヤンバーのバルブ、並びに前記排
出口に設けられたバルブを開閉し、前記血液ポン
プ及び前記血漿ポンプを駆動する制御装置
とを備え、前記血液ポンプによつて、前記採血部
から採血した血液を前記セパレータに送つて血漿
と血球とに分離し、分離された血漿を血漿ポンプ
で前記吸着器に送り、血漿に含まれる有害成分を
選択的に除去し、前記セパレータで分離された血
球成分と、前記吸着器で有害成分が除去された血
漿とを混合して前記返血部より返血する血中成分
除去装置における洗浄・プライミング方法であつ
て、
洗浄・プライミングを行うに当り、前記セパレ
ータを装置から外し、このセパレータの内室の流
入口が接続された血液回路と、このセパレータの
内室の流出口が接続された血液回路及び外室の流
出口が接続された血液回路との間にダミーチユー
ブを接続し、前記吸着器を装置から外し、前記吸
着器の流入口が接続された血液回路とこの吸着器
の流出口が接続された血液回路との間にダミーチ
ユーブを接続し、前記生食バツグと前記採血部と
を接続し、前記制御装置の制御出力に基づき、前
記第１のチヤンバーのバルブを開とし、他のチヤ
ンバーのバルブは閉とした状態で、前記血液ポン
プを駆動し、前記生食バツグから生理食塩水を前
記第１のチヤンバーが設けられた血液回路に満た
して空気抜きを行い、前記第１のチヤンバーのレ
ベルが所定レベルに達したとき、前記第２のチヤ
ンバーのバルブを開とし同様に前記第２のチヤン
バーが設けられた血液回路の空気抜き行い、順
次、同様に前記第３、第４のチヤンバーが設けら
れた血液回路の空気抜きを行い、これら血液回路
の空気抜き及び洗浄に使用した生理食塩水を前記
排出口より排出し、この状態で前記セパレータ並
びに前記吸着器を前記ダミーチユーブに代えて装
置に接続し、洗浄・プライミング動作を終了する
ようにしたことにある。<Means for Solving the Problems> The method of the present invention includes a blood collection section for collecting blood, a blood return section for returning blood, an inner chamber and an outer chamber, which are separated by a membrane, and the inner chamber is separated by a membrane. An inlet and an outlet are provided, an outlet is provided in the outer chamber, a wet-type separator is filled with a sterilizing liquid, and an adsorbent is filled, an inlet and an outlet are provided, a wet-type suction device whose inside is filled with sterile liquid; between the blood collection section and the inlet of the inner chamber of the separator; between the outlet of the inner chamber of the separator and the blood return section; blood circuits provided between the outflow port of the outer chamber and the inflow port of the adsorption device, and between the outflow port of the adsorption device and the outflow port side of the inner chamber of the separator; a first chamber provided in the blood circuit between the inlet of the inner chamber of the separator and equipped with a valve for opening to the atmosphere and a level meter; and a first chamber provided between the outlet of the inner chamber of the separator and the blood return section. a second chamber provided in a blood circuit between the chamber and provided with a valve for opening to the atmosphere and a level meter; and a second chamber provided in a blood circuit between the outflow port of the outer chamber of the separator and the inflow port of the adsorber. , a third chamber provided with a valve for opening to the atmosphere and a level meter; a valve for opening to the atmosphere provided in the blood circuit between the outlet of the adsorber and the outlet side of the inner chamber of the separator; and a level meter; a blood pump provided in a blood circuit between the blood collection section and the inlet of the inner chamber of the separator; and an outlet of the outer chamber of the separator and the adsorption chamber. a plasma pump installed in a blood circuit between the inflow port of the adsorption device; a saline bag containing physiological saline; an outlet connected to the outflow port side of the adsorption device via a valve; , the control output is given from the detection signals from the level meters of the second, third, and fourth chambers, and the valves of these chambers and the valve provided at the discharge port are opened and closed, and the blood pump and the plasma a control device for driving a pump, the blood pump sends the blood collected from the blood collection section to the separator to separate it into plasma and blood cells, and the plasma pump sends the separated plasma to the adsorber. Blood is sent, selectively removes harmful components contained in the plasma, and mixes the blood cell components separated by the separator with the plasma from which harmful components have been removed by the absorber, and returns the blood from the blood return unit. A cleaning and priming method for a blood component removal device, in which the separator is removed from the device and the blood circuit connected to the inlet of the inner chamber of this separator and the blood circuit connected to the inlet of the inner chamber of this separator are A dummy tube is connected between the blood circuit to which the outflow port is connected and the blood circuit to which the outflow port of the outer chamber is connected, the adsorber is removed from the device, and the blood circuit to which the inflow port of the adsorbent is connected is connected. A dummy tube is connected between the blood circuit connected to the outlet of the adsorbent, the saline bag and the blood collection section are connected, and the temperature of the first chamber is adjusted based on the control output of the control device. Driving the blood pump with the valve open and the valves of the other chambers closed, filling the blood circuit in which the first chamber is provided with physiological saline from the saline bag and removing air; When the level of the first chamber reaches a predetermined level, the valve of the second chamber is opened and the blood circuit in which the second chamber is provided is similarly vented, and in turn, the third, The blood circuit provided with the fourth chamber is vented, and the physiological saline used for venting and washing the blood circuit is discharged from the outlet, and in this state, the separator and adsorption device are placed in the dummy tube. Instead, it is connected to the device and the cleaning/priming operation is completed.
＜実施例＞
以下、図面に従い本発明を詳細に説明する。図
は本発明実施例の構成説明図である。１aは供血
者の腕等（図示せず）から血液を採取する採血
部、１bは供血者の腕等に血液を戻す返血部、２a
〜２fは血液、血漿、再生液用のチヤンバー、３a
〜３gは圧力計、４aは血液を送液する第１のポン
プ（血液ポンプ）、４bは血漿を送液する第２のポ
ンプ（血漿ポンプ）、４cは再生液を送液する第３
のポンプ（再生液ポンプ）、５は例えばチユーブ
状の膜によつて内部が内室と外室とに仕切られ、
前記内室には流入口５aと流出口５bが設けられ、
前記外室には流出口５cが設けられ、内部が滅菌
液で満たされたウエツト型のセパレータ、６a，
６bは吸着剤が充填され、夫々に流入口６a1，６b1
と流出口６a2，６b2とが設けられ、内部が滅菌液
で満たされたウエツト型の吸着器、７は混合部、
８a〜８hは吸着器６a，６bの動作を血中成分除去
動作と再生動作とに切換えるバルブ、８i，８jは
洗浄液の排出経路を切換えるバルブ、９は吸着器
６a，６bの再生状態をチエツクする為の導電率
計、１０は生理食塩水が入れられた生食バツグ、
１１は吸着器６a，６bを再生する再生液が入れら
れた再生液バツグ、１２は返血部１bに至る部分
に設けれた気泡検出器、１３はヒータである。<Example> The present invention will be described in detail below with reference to the drawings. The figure is a configuration explanatory diagram of an embodiment of the present invention. 1 a is a blood collection unit that collects blood from the donor's arm (not shown), 1 b is a blood return unit that returns blood to the donor's arm, etc., and 2 a
~2 f is a chamber for blood, plasma, and regeneration fluid; 3 a
~ 3g is a pressure gauge, 4a is the first pump that pumps blood (blood pump), 4b is the second pump (plasma pump) that pumps plasma, and 4c is a pump that pumps regeneration fluid. Third
The pump (regeneration liquid pump) 5 is partitioned internally into an inner chamber and an outer chamber by, for example, a tube-shaped membrane,
The inner chamber is provided with an inlet 5 a and an outlet 5 b ,
The outer chamber is provided with an outlet 5 c and a wet separator 6 a filled with a sterilizing liquid.
6 b is filled with adsorbent, and has inflow ports 6 a1 and 6 b1, respectively.
7 is a mixing part ;
8 a to 8 h are valves that switch the operation of the adsorbers 6 a and 6 b between blood component removal operation and regeneration operation, 8 i and 8 j are valves that switch the discharge path of the cleaning liquid, and 9 are adsorbers 6 a , 6 a conductivity meter to check the regeneration status of b ; 10 a saline bag containing physiological saline;
Reference numeral 11 designates a regeneration liquid bag containing regeneration liquid for regenerating the adsorbers 6 a and 6 b , 12 a bubble detector provided in a portion leading to the blood return section 1 b , and 13 a heater.
このような構成の本発明実施例の動作は、採血
部１aに接続される針を生食バツグ１０に穿刺し、
返血部１bに接続される針を供血者より外した状
態とし、セパレータ５並びに吸着器６a，６bは接
続せず、点線で示すダミーチユーブ１４〜１６を
接続した状態で洗浄を行う。ダミーチユーブ１４
はセパレータ５の流入口５aが接続される血液回
路に一端が接続され、他端は二股に分れセパレー
タ５の流出口５b，５cが接続される血液回路に接
続され、ダミーチユーブ１５は吸着器６aの流入
口６a1及び流出口６a2が接続される回路に接続さ
れ、ダミーチユーブ１６は吸着器６bの流入口６b
１及び流出口６b2が接続される回路に接続される。 The operation of the embodiment of the present invention having such a configuration is to puncture the saline bag 10 with the needle connected to the blood sampling section 1a ,
Washing is performed with the needle connected to the blood return unit 1 b removed from the donor, the separator 5 and adsorbers 6 a and 6 b not connected, and dummy tubes 14 to 16 shown by dotted lines connected. . dummy tube 14
One end is connected to the blood circuit to which the inflow port 5 a of the separator 5 is connected, and the other end is connected to a blood circuit that is bifurcated and connected to the outflow ports 5 b and 5 c of the separator 5 . is connected to the circuit to which the inlet 6 a1 and outlet 6 a2 of the adsorber 6 a are connected, and the dummy tube 16 is connected to the inlet 6 b of the adsorber 6 b.
1 and the outflow port 6 b2 are connected to the circuit.
この状態で先ずチヤンバー２bのバルブ２b′を
開とし、チヤンバー２c〜２fのバルブ２c′〜２f′
を開とし、血液ポンプ４aだけを駆動する。これ
により、採血部１aからチヤンバー２bに至る血液
回路内の空気抜きが行われる。即ち、この部分の
空気は回路内に導かれた生理食塩水によつてチヤ
ンバー２bのバルブ２b′部分より大気に逃がされ
る。各チヤンバー２b〜２fにはレベル計が設けら
れており、チヤンバー２bに満たされた生理食塩
水が所定のレベルに達すると、バルブ２b′を閉
じ、この部分の空気抜きを完了する。 In this state, first open valve 2 b ′ of chamber 2 b , then open valves 2 c ′ to 2 f ′ of chamber 2 c to 2 f .
is opened and only blood pump 4a is driven. As a result, the air in the blood circuit from the blood sampling section 1 a to the chamber 2 b is vented. That is, the air in this portion is released to the atmosphere through the valve 2 b ′ portion of the chamber 2 b by the physiological saline introduced into the circuit. Each of the chambers 2b to 2f is provided with a level meter, and when the physiological saline filled in the chamber 2b reaches a predetermined level, the valve 2b ' is closed to complete air removal from this portion.
次いで、チヤンバー２fのバルブ２f′を開とし、
チヤンバー２bからダミーチユーブ１４を通つて
チヤンバー２fに至る血液回路内の空気抜きが同
様に行われる。尚、血漿ポンプ４b以降の回路に
は、血漿ポンプ４bが駆動されていない為、生理
食塩水は流れない。 Next, open valve 2 f ' of chamber 2 f ,
The air in the blood circuit from chamber 2b through dummy tube 14 to chamber 2f is similarly vented. Note that physiological saline does not flow into the circuit after the plasma pump 4b because the plasma pump 4b is not driven.
これに引き続き、血漿ポンプ４bを駆動し、チ
ヤンバー２cのバルブ２c′を開とし、ダミーチユ
ーブ１４から血漿ポンプ４bを通つてチヤンバー
２cに至る回路の空気抜きが行われる。更に再生
ポンプ４cを駆動し、再生液バツグ１１から再生
液ポンプ４cを通つてチヤンバー２dに至る血液回
路の空気抜きが行われる。 Subsequently, the plasma pump 4b is driven, the valve 2c ' of the chamber 2c is opened, and the circuit from the dummy tube 14 through the plasma pump 4b to the chamber 2c is vented. Furthermore, the regeneration pump 4c is driven, and the blood circuit from the regeneration liquid bag 11 through the regeneration liquid pump 4c to the chamber 2d is vented.
最後に、チヤンバー２eのバルブ２e′を開とし、
チヤンバー２c並びにチヤンバー２dからダミーチ
ユーブ１５，１６を通つてチヤンバー２eに至る
血液回路の空気抜きが行われる。 Finally, open valve 2 e ′ of chamber 2 e ,
The blood circuit from chamber 2 c and chamber 2 d to chamber 2 e via dummy tubes 15 and 16 is vented.
尚、この間、ダミーチユーブ１５，１６部分で
は、バルブ８a〜８hが開閉制御され、ダミーチユ
ーブ１５，１６へ別々に生理食塩水が流される。
また、バルブ８i，８jが開閉制御され、洗浄液は
排出口D1，D2、並びに返血部１bの三箇所より排
出される。 During this time, the valves 8 a to 8 h are controlled to open and close in the dummy tubes 15 and 16, and physiological saline is flowed into the dummy tubes 15 and 16 separately.
Further, the valves 8 i and 8 j are controlled to open and close, and the cleaning liquid is discharged from three locations: the discharge ports D 1 and D 2 and the blood return section 1 b .
このようにして血液回路が洗浄され、血液回路
内の空気抜きが終了した後、ダミーチユーブ１４
〜１６を外し、空気が入らない状態にしてセパレ
ータ５、吸着器６a，６bを血液回路に接続する。
この後、洗浄液を流し、血液回路の洗浄・プライ
ミングを行う。 After the blood circuit has been cleaned in this way and air has been removed from the blood circuit, the dummy tube 14
16 and connect the separator 5 and adsorbers 6 a and 6 b to the blood circuit in a state where no air enters.
After this, a cleaning solution is poured to clean and prime the blood circuit.
次いで、採血部１aに接続された針を生食バツ
グ１０より外し、返血部１bに接続された針と共
に供血者に穿刺し治療を開始する。血中成分除去
動作は従来方法として変らないので説明は省略す
るが、吸着器６a，６bの再生は再生液バツグ１１
より再生液を流し行われる。これら吸着器の再生
の程度は導電率計９でチエツクされる。 Next, the needle connected to the blood collection section 1a is removed from the saline bag 10, and the blood donor is punctured together with the needle connected to the blood return section 1b to begin treatment. The blood component removal operation is the same as the conventional method, so the explanation will be omitted, but the regeneration of the adsorbers 6a and 6b is performed using the regeneration liquid bag 11.
This is done by pouring more regenerating liquid. The degree of regeneration of these adsorbers is checked with a conductivity meter 9.
本発明では、ダミーチユーブ１４〜１６の接続
を除いて、ポンプ４a〜４cの制御、チヤンバー２
ｂ〜２fのバルブ２b′〜２f′の制御、バルブ８a〜８j
の制御は制御装置（図示せず）からの制御信号に
基づいて自動的に行われる。 In the present invention, except for the connection of the dummy tubes 14 to 16, the control of the pumps 4 a to 4 c and the control of the chamber 2
Control of valves 2 b ′ to 2 f ′, valves 8 a to 8 j
The control is automatically performed based on a control signal from a control device (not shown).
＜発明の効果＞
以上詳しく説明したように本発明によれば、前
記血中成分除去装置装置の洗浄・プライミングの
過程で血液回路内の空気が前記セパレータ及び前
記吸着器に混入することがない。また前記洗浄・
プライミング動作は、前記ダミーチユーブ等の接
続を除いて自動化出来る為、操作性を向上させる
ことが出来る。<Effects of the Invention> As described in detail above, according to the present invention, air in the blood circuit does not get mixed into the separator and the adsorber during the cleaning and priming process of the blood component removal device. In addition, the cleaning
Since the priming operation can be automated except for the connection of the dummy tube, etc., operability can be improved.
図は本発明実施例の構成説明図である。
１a……採血部、１b……返血部、２a〜２f……
チヤンバー、３a〜３h……圧力計、４a……血液
ポンプ、４b……血漿ポンプ、４c……再生液ポン
プ、５……ウエツト型セパレータ、６a，６b……
ウエツト型吸着器、７……混合部、８a〜８j……
バルブ、１０……生食バツグ、１４〜１６……ダ
ミーチユーブ。
The figure is a configuration explanatory diagram of an embodiment of the present invention. 1 a ...Blood collection department, 1 b ...Blood return department, 2 a to 2 f ...
Chamber, 3a to 3h ...Pressure gauge, 4a ...Blood pump, 4b ...Plasma pump, 4c ...Regenerating fluid pump, 5...Wet type separator, 6a , 6b ...
Wet type adsorber, 7... Mixing section, 8 a to 8 j ...
Bulb, 10... raw food bag, 14-16... dummy tube.
Claims (1)
流入口と流出口とが設けられ、外室には流出口が
設けられ、内部が滅菌液で満たされたウエツト型
のセパレータと、 吸着剤が充填され、流入口と流出口とが設けら
れ、内部が滅菌液で満たされたウエツト型の吸器
と、 前記採血部と前記セパレータの内室の流入口と
の間、前記セパレータの内室の流出口と前記返血
部との間、前記セパレータの外室の流出口と前記
吸着器の流入口との間、並びに前記吸着器の流出
口と前記セパレータの内室の流出口側との間に
夫々設けられた血液回路と、 前記採血部と前記セパレータの内室の流入口と
の間の血液回路に設けられ、大気開放用のバルブ
とレベル計とを備えた第１のチヤンバーと、 前記セパレータの内室の流出口と前記返血部と
の間の血液回路に設けられ、大気開放用のバルブ
とレベル計とを備えた第２のチヤンバーと、 前記セパレータの外室の流出口と前記吸着器の
流入口との間の血液回路に設けられ、大気開放用
のバルブとレベル計とを備えた第３のチヤンバー
と、 前記吸着器の流出口と前記セパレータの内室の
流出口側との間の血液回路に設けられ、大気開放
用のバルブとレベル計とを備えた第４のチヤンバ
ーと、 前記採血部と前記セパレータの内室の流入口と
の間の血液回路に設けられた血液ポンプと、 前記セパレータの外室の流出口と前記吸着器の
流入口との間の血液回路に設けられた血漿ポンプ
と、 生理食塩水が入れられた生食バツグと、 前記吸着器の流出口側にバルブを介し接続され
た排出口と、 前記第１、第２、第３及び第４のチヤンバーの
レベル計から検出信号が与えられ、制御出力によ
つてこれらチヤンバーのバルブ、並びに前記排出
口に設けられたバルブを開閉し、前記血液ポンプ
及び前記血漿ポンプを駆動する制御装置 とを備え、前記血液ポンプによつて、前記採血部
から採取した血液を前記セパレータに送つて血漿
と血球とに分離し、分離された血漿を血漿ポンプ
で前記吸着器に送り、血漿に含まれる有害成分を
選択的に除去し、前記セパレータで分離された血
漿成分と、前記吸着器で有害成分が除去された血
漿とを混合して前記返血部より返血する血中成分
除去装置における洗浄・プライミング方法であつ
て、 洗浄・プライミングを行うに当り、前記セパレ
ータを装置から外し、このセパレータの内室の流
入口が接続された血液回路と、このセパレータの
内室の流出口が接続された血液回路及び外室の流
出口が接続された血液回路との間にダミーチユー
ブを接続し、前記吸着器を装置から外し、前記吸
着器の流入口が接続された血液回路とこの吸着器
の流出口が接続された血液回路との間にダミーチ
ユーブを接続し、前記生食バツグと前記採血部と
を接続し、前記制御装置の制御出力に基づき、前
記第１のチヤンバーのバルブを開とし、他のチヤ
ンバーのバルブは閉とした状態で、前記血液ポン
プを駆動し、前記生食バツグから生理食塩水を前
記第１のチヤンバーが設けられた血液回路に満た
して空気抜きを行い、前記第１のチヤンバーのレ
ベルが所定レベルに達したとき、前記第２のチヤ
ンバーのバルブを開とし同様に前記第２のチヤン
バーが設けられた血液回路の空気抜き行い、順
次、同様に前記第３、第４のチヤンバーが設けら
れた血液回路の空気抜きを行い、これら血液回路
の空気抜き及び洗浄に使用した生理食塩水を前記
排出口より排出し、この状態で前記セパレータ並
びに前記吸着器を前記ダミーチユーブに代えて装
置に接続し、洗浄・プライミング動作を終了する
ようにしたことを特徴とする血中成分除去装置の
洗浄・プライミング方法。[Scope of Claims] 1. A blood collection section for collecting blood, a blood return section for returning blood, an inner chamber and an outer chamber are separated by a membrane, and the inner chamber is provided with an inlet and an outlet. A wet separator is provided with an outlet in the outer chamber and the inside is filled with a sterilizing liquid, and a wet separator is filled with an adsorbent and has an inlet and an outlet and the inside is filled with a sterilizing liquid. between the blood collection section and the inlet of the inner chamber of the separator, between the outlet of the inner chamber of the separator and the blood return section, and between the outlet of the outer chamber of the separator and the adsorption device. a blood circuit provided between the inflow port of the adsorbent and the outflow port of the inner chamber of the separator, and between the blood sampling section and the inflow port of the inner chamber of the separator; a first chamber provided in a blood circuit between the separator and equipped with a valve for opening to the atmosphere and a level meter; a second chamber provided with a valve for opening to the atmosphere and a level meter; a second chamber provided in the blood circuit between the outlet of the outer chamber of the separator and the inlet of the adsorber, and equipped with a valve for opening to atmosphere and a level meter; and a fourth chamber provided in the blood circuit between the outlet of the adsorber and the outlet side of the inner chamber of the separator, and provided with a valve for opening to the atmosphere and a level meter. a blood pump provided in a blood circuit between the blood collection section and the inlet of the inner chamber of the separator; and a blood pump provided in the blood circuit between the blood collection section and the inlet of the inner chamber of the separator, and the blood pump between the outlet of the outer chamber of the separator and the inlet of the adsorber. a plasma pump provided in the circuit; a saline bag containing physiological saline; an outlet connected to the outlet side of the adsorber via a valve; and the first, second, third, and fourth cells. A control device receives a detection signal from a level meter of the chamber, opens and closes the valves of these chambers and the valve provided at the outlet according to the control output, and drives the blood pump and the plasma pump. The blood collected from the blood collection section is sent to the separator by the blood pump to separate it into plasma and blood cells, and the separated plasma is sent to the adsorber by the plasma pump to remove harmful components contained in the plasma. A cleaning/priming method for a blood component removal device in which plasma components selectively removed and separated by the separator are mixed with plasma from which harmful components have been removed by the adsorber, and blood is returned from the blood return section. When performing cleaning and priming, the separator is removed from the device, and the blood circuit connected to the inlet of the inner chamber of this separator, the blood circuit connected to the outlet of the inner chamber of this separator, and Connect a dummy tube between the blood circuit to which the outflow port of the outer chamber is connected, remove the adsorption device from the device, and connect the blood circuit to which the inflow port of the adsorption device is connected and the outflow port of this adsorption device. A dummy tube is connected between the saline bag and the blood collection section, and the valve of the first chamber is opened based on the control output of the control device, and the valve of the other chamber is opened. With the valve closed, the blood pump is driven to fill the blood circuit in which the first chamber is provided with physiological saline from the saline bag to evacuate air, and the level of the first chamber is set to a predetermined level. When the level is reached, the valve of the second chamber is opened and the blood circuit in which the second chamber is provided is similarly evacuated, and the blood circuit in which the third and fourth chambers are provided in the same manner is sequentially removed. Air is removed from the circuit, and the physiological saline used for air removal and cleaning of these blood circuits is discharged from the outlet. In this state, the separator and adsorber are connected to the device in place of the dummy tube, and the cleaning and cleaning are performed. A method for cleaning and priming a blood component removal device, characterized in that a priming operation is terminated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61235943A JPS6392356A (en) | 1986-10-03 | 1986-10-03 | Method for washing and priming blood component removing apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61235943A JPS6392356A (en) | 1986-10-03 | 1986-10-03 | Method for washing and priming blood component removing apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6392356A JPS6392356A (en) | 1988-04-22 |
| JPH0468952B2 true JPH0468952B2 (en) | 1992-11-04 |
Family
ID=16993523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61235943A Granted JPS6392356A (en) | 1986-10-03 | 1986-10-03 | Method for washing and priming blood component removing apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6392356A (en) |
-
1986
- 1986-10-03 JP JP61235943A patent/JPS6392356A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6392356A (en) | 1988-04-22 |
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