CN210277848U

CN210277848U - Clinical continuous blood component centrifugal separation and treatment system

Info

Publication number: CN210277848U
Application number: CN201822176070.9U
Authority: CN
Inventors: 包奕强; 曾庆松
Original assignee: Chengdu Chuanghefeng Biotechnology Co ltd
Current assignee: Chengdu Chuanghefeng Biotechnology Co ltd
Priority date: 2018-12-24
Filing date: 2018-12-24
Publication date: 2020-04-10
Anticipated expiration: 2028-12-24

Abstract

The utility model relates to the field of medical equipment, in particular to a clinical continuous blood component centrifugal separation and treatment system, which comprises an extracorporeal circulation pipeline, a purification device and pipeline auxiliary equipment, wherein the extracorporeal circulation pipeline comprises a first-stage blood separation pipeline, a second-stage blood separation pipeline, a blood separation guarantee circuit, a plasma purification pipeline and a blood mixing pipeline; the pipeline auxiliary equipment and the purification device are hermetically connected in the extracorporeal circulation pipeline. The utility model utilizes the separation cup to separate blood into blood cells and plasma by adopting a centrifugal technology, replaces the membrane separation of blood, leads the plasma separation to be more thorough and have higher purity, reduces the dosage of anticoagulant, can greatly save the time of blood purification or treatment by continuous separation, and greatly reduces the production cost; and a blood separation guarantee loop and a blood mixing loop are designed in the extracorporeal circulation pipeline.

Description

Clinical continuous blood component centrifugal separation and treatment system

Technical Field

The utility model relates to the field of medical equipment, concretely relates to be used for clinical continuous type blood composition centrifugation and treatment system.

Background

The blood purification therapy is a clinical treatment technology developed by technologies such as hemodialysis and exsanguination, is rapidly developed in the late twentieth century, and becomes an indispensable treatment method in clinical practice.

A blood purification system generally comprises an extracorporeal circuit, which comprises a blood outflow circuit and a blood return circuit, and a blood purification device connected to the extracorporeal circuit. In the process of blood purification treatment, blood is led out of a human body through the blood outflow pipeline, purified by the blood purification device and then returned to the human body through the blood backflow pipeline, so that harmful substances such as pathogenic factors in the blood are removed.

The core technology in blood purification therapy is the separation of blood components, and currently, the mainstream separation technologies include a centrifugal separation technology, a membrane separation technology, and an adsorption separation technology.

The membrane separation technology is to use a filter made of hollow fiber membranes with certain pore sizes to fill and separate substances with different molecular weights, and the commonly used filters include a hemodialyzer, a plasma separator and a plasma component separator. The membrane separation technology has the advantages of high separation efficiency, easy adjustment of electrolyte balance and the like. However, the membrane separation technology has the defects of relative specificity and incapability of simultaneously considering target substances with different molecular weights and different hydrophilic and hydrophobic properties; moreover, repeated treatment is needed, so that the treatment cost is increased, the tolerance of a patient is also sharply reduced, and the production cost of the membrane is high and is not easy to popularize.

The adsorption separation technology is that the adsorbent is filled in an adsorber to make a disposable sterile medical apparatus, then the blood is led out from the human body and passes through an adsorption column in a blood perfusion or plasma perfusion mode to specifically or relatively specifically adsorb one or more pathogenic factors, and the commonly used adsorber comprises a disposable hemoperfusion device, a disposable endotoxin adsorber, a disposable plasma bilirubin adsorber, a DNA immunoadsorption column, a blood fat adsorption column, a leukocyte adsorption column and the like. The adsorption separation technique has an advantage of being able to form relatively specific adsorption separation and removal of a target substance, but the adsorption separation has a disadvantage that the electrolyte balance is difficult to adjust.

For some diseases, the pathogenic substances are usually composed of several substances with different properties, even hundreds of them, which brings the challenge to separate blood components and the pathogenic substances in plasma by using a certain separation technology alone. Therefore, it has been an important research direction in the field to combine the advantages of centrifugal separation, membrane separation and adsorption separation techniques and to comprehensively utilize the advantages of the three.

The existing blood purification system has the following problems: the extracorporeal circulation pipeline of the blood purification system is not provided with a blood pressure detector joint, a sample reserving bag and a waste liquid bag; secondly, most of the separation of blood components in the blood purification system adopts membrane separation technology to separate blood into plasma and blood cells, however, the membrane separation has the following problems: 1. the production technology of the required film does not need to be imported domestically, so the cost is higher; 2. blood with small membrane separation blood flow volume is easy to coagulate and block membrane filtering holes, and the dosage of blood anticoagulant is required to be increased for preventing blood coagulation, and the blood anticoagulant is harmful to human bodies; 3. the existing blood component centrifugal separation can only realize intermittent separation and can not realize continuous separation and collection, so the treatment time is long, and the treatment of patients is not facilitated.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide an adopt centrifugal technology to uninterruptedly continuous separation blood composition, utilize the clean system of the pathogenic factor in membrane separation or adsorption separation removal plasma to alleviate patient's economic burden and reduce single treatment time, with the problem of proposing in solving above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme:

a clinical continuous blood component centrifugal separation and treatment system comprises an extracorporeal circulation pipeline and a purification device, and is characterized by comprising pipeline auxiliary equipment, wherein the extracorporeal circulation pipeline comprises a first-stage blood separation pipeline, a second-stage blood separation pipeline, a blood separation guarantee circuit, a plasma purification pipeline and a blood mixing pipeline; the pipeline auxiliary equipment and the purification device are hermetically connected in the extracorporeal circulation pipeline.

The utility model discloses in, pipeline auxiliary assembly includes that machine hemostix, anticoagulant puncture ware subassembly, anticoagulant pump line, a plurality of filter, a plurality of pressure detector connect, first blood pump line, second blood pump line, first separation cup, second separation cup, blood feedback bag, plasma collect bag, normal saline puncture ware subassembly, plasma pump line and waste liquid bag.

In the utility model, the purification device comprises first to nth-stage treatment devices.

In the utility model, the external circulation pipeline is composed of a first connecting pipe, a second connecting pipe, a third connecting pipe, a fourth connecting pipe, a fifth connecting pipe and a fifth connecting pipe.

In the utility model discloses, the filter includes first filter, second filter, third filter, is connected with first pressure detector joint 16 on the first filter 15, is connected with second pressure detector joint 51 on the second filter 50.

Furthermore, the first-stage blood separation tube is composed of a twelfth connection tube 27, a thirteenth connection tube 29, a fourteenth connection tube 31, a fifteenth connection tube 33, and a second blood pump tube 30 and a second separation cup 32 connected in the tube; the second-stage blood separation tube is composed of a seventh connecting tube 19, an eighth connecting tube 21, a ninth connecting tube 23, a tenth connecting tube 25, a first separation cup 24 and a first blood pump tube 22 connected to the tubes.

The blood separation ensuring circuit includes a seventeenth connection tube 39, a thirty ninth connection tube 86, and an eleventh connection tube 26.

The utility model discloses in, pipeline auxiliary assembly still includes anticoagulant drip chamber, stays a kind bag, normal saline drip chamber, blood transfusion ware subassembly.

The connection relationship between the pipeline auxiliary equipment and the purification device which are hermetically connected in the extracorporeal circulation pipeline is as follows: one end of the first connecting pipe 3 is connected to a first port of the five-way joint; one end of the fourth connecting tube 11 is connected to one end of the anticoagulant pump tube, and the other end of the fourth connecting tube 11 is connected to the anticoagulant drip chamber; the other end of the anticoagulant pump tube is connected to the second port of the five-way joint through a third connecting tube 9; one end of a second connecting pipe 5 is connected to the third port of the five-way joint, the other end of the second connecting pipe 5 is connected with the first port of the Y-shaped pipe, the second port of the Y-shaped pipe is connected with the sample retention bag, one end of a fifth connecting pipe 14 is connected with the fourth port of the five-way joint, and the other end of the fifth connecting pipe 14 is connected with one end of the first filter; the other end of the first filter is connected to a first-stage blood separation pipeline and a second-stage blood separation pipeline through a sixth connecting pipe 17 and a first three-way joint 18, the first-stage blood separation pipeline and the second-stage blood separation pipeline are connected with the upper port of a plasma collection bag through a fourth three-way joint 34 and a sixteenth connecting pipe 35, and the lower port of the plasma collection bag is connected to the first port of a three-way pipe 37; the second port of the three-way pipe 37 is connected with the thirty-ninth connecting pipe 86 and the eleventh connecting pipe 26 through the seventeenth connecting pipe 39 and the four-way joint 40 to form a blood separation guarantee loop; the third port of the three-way pipe 37 is connected with the first port of the fifth three-way joint 42 through the eighteenth connecting pipe 41, the second port of the fifth three-way joint 42 is connected with one end of the plasma pump pipe 43 through the twenty-first connecting pipe 47, the third port of the fifth three-way joint 42 is connected with one end of the normal saline drip chamber through the twentieth connecting pipe 45, the other end of the normal saline drip chamber is connected with the normal saline piercing component, the other end of the plasma pump pipe 43 is connected with one end of the second filter 50 through the twenty-second connecting pipe 49, the other end of the second filter 50 is connected with the first port of the sixth three-way joint 53 through the twenty-third connecting pipe 52, the second port of the sixth three-way joint 53 is connected with one end of the first-stage therapeutic device 55 through the twenty-fourth connecting pipe 54, the first port of the eighth three-way joint 59 is connected with the third port of the sixth three-way joint 53 through the twenty-seventh connecting pipe 60, the second port of the eighth three-way joint 59 is connected with A bypass is formed, the third port of the seventh three-way joint 57 is connected with the first port of the ninth three-way joint 64 through a twenty-eighth connecting pipe 62, the second port of the ninth three-way joint 64 is connected with one end of the second-stage therapeutic device through a second ninth connecting pipe 65, the other end of the second-stage therapeutic device is connected with the third port of the eighth three-way joint 59 through a thirty-third connecting pipe 67, the third port of the ninth three-way joint 64 is connected with the second port of the thirteenth three-way joint 69 through a thirty-eleventh connecting pipe 68, the first port of the thirteenth three-way joint 69 is connected with the first port of the eleventh three-way joint 74 through a thirty-third connecting pipe 73, the third port of the thirteenth three-way joint 69 is connected with the waste liquid bag 72 through a thirty-second connecting pipe 70, the second port of the eleventh three-way joint 74 is connected with the four-way joint 40 through a thirty-fourth connecting pipe 75, the third port of the eleventh three-way joint 74 is connected with one end of the third, the other end of the third filter 77 is connected to the upper end of the blood return bag 80 through a thirty-sixth connecting tube 78, the lower end of the blood return bag is connected to one end of a blood dropping funnel 83 through a thirty-seventh connecting tube 81, and the other end of the blood dropping funnel is connected to the blood transfusion set 85 through a thirty-eighth connecting tube 84.

Furthermore, the first connecting pipe 3 is provided with a first hemostatic clamp 2, the second connecting pipe 5 is provided with a second hemostatic clamp 6, the twentieth connecting pipe 45 is provided with a third hemostatic clamp 44, the twenty-seventh connecting pipe 60 is provided with a fifth hemostatic clamp 61, the twenty-eighth connecting pipe 62 is provided with a sixth hemostatic clamp 63, the thirty-second connecting pipe 70 is provided with a seventh hemostatic clamp 71, and the thirty-sixth connecting pipe 78 is provided with an eighth hemostatic clamp 79.

The utility model discloses a theory of operation does:

blood is collected from a human body through a blood collector and flows into an extracorporeal circulation pipeline, anticoagulant enters the extracorporeal circulation pipeline through an anticoagulant puncture outfit, and the anticoagulant flows into the extracorporeal circulation pipeline through an anticoagulant pump pipe and supplies power to the anticoagulant pump through an anticoagulant pump to be mixed with the blood; blood mixed with anticoagulant is pumped into a separation cup by a blood pump pipe and provided with power by a blood pump, the separation cup rotates at a high speed under the action of a centrifugal machine, the blood in the separation cup generates centrifugal force under the high-speed rotation of the separation cup, the blood is separated into plasma and blood cells under the action of the centrifugal force, the blood components in the separation cup are sequentially layered from outside to inside into blood cells and plasma, the plasma comes out firstly, the plasma enters a plasma collection bag along a pipeline, the centrifugal cup stops rotating after reaching the plasma collection amount, the blood pump is reversed at the moment, the blood cells are provided with power by the blood pump, and the blood cells flow back along the blood pump pipe and enter a blood feedback bag; at this time, the plasma is powered by a plasma pump to sequentially pass through an X filter, a first-stage therapeutic device, a second-stage therapeutic device, a third-stage therapeutic device or an N-stage therapeutic device to remove pathogenic substances, and the purified blood flows back to the human body through a pipeline.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model utilizes the separation cup to separate blood into blood cells and plasma by adopting the centrifugal technology, replaces the membrane separation of blood, continuously adopts the continuous blood centrifugal separation technology to save the blood processing time, reduces the single treatment time of patients, and saves the product cost compared with the prior membrane separation technology;

2. the utility model utilizes the principle of the peristaltic pump to supply power to help the anticoagulant, the normal saline, the blood, the plasma and the blood cells to flow in the extracorporeal circulation pipeline;

3. the utility model discloses a design has blood separation guarantee return circuit, and is incomplete when the separation appears, perhaps other troubles appear in the centrifugal cup, and at this moment the valve on the pipeline can be manually opened, and the liquid in the plasma bag carries out the secondary separation through blood guarantee return circuit reentrant centrifugal cup, ensures the quality of separation back plasma. Therefore, the situation that the extracorporeal blood is insufficiently separated or cannot be separated into blood cells and blood plasma when the separating cup breaks down can be effectively prevented;

4. the blood pressure detector is arranged on the filter in the extracorporeal circulation pipeline, the blood pressure detector can detect the pressure value of the blood vessel pipeline in the extracorporeal circulation pipeline in real time, and the pressure value of the pipeline is utilized to judge whether the purification system is abnormal or not and judge whether the abnormal condition of the patient per se occurs or not;

5. the utility model provides an external circulation pipeline's front end is connected one through the five-way pipe and is stayed a kind bag, connects to stay to install the hemostatic clamp in the pipeline of a kind bag, stays a kind bag and can gather the blood that the part is not purified as comparing the sample.

Drawings

Fig. 1 is a schematic structural view of the present invention;

the reference signs are: 1 is a machine blood collector, 2 is a first hemostatic clamp, 3 is a first connecting tube, 4 is a five-way tube, 5 is a second connecting tube, 6 is a second hemostatic clamp, 7 is a Y-shaped tube, 8 is a sample retention bag, 9 is a third connecting tube, 10 is an anticoagulant pump tube, 11 is a fourth connecting tube, 12 is an anticoagulant drip chamber, 13 is an anticoagulant puncture outfit component, 14 is a fifth connecting tube, 15 is a first filter, 16 is a first pressure detector joint, 17 is a sixth connecting tube, 18 is a first three-way joint, 19 is a seventh connecting tube, 20 is a second three-way joint, 21 is an eighth connecting tube, 22 is a first blood pump tube, 23 is a ninth connecting tube, 24 is a first centrifuge cup, 25 is a tenth connecting tube, 26 is an eleventh connecting tube, 27 is a twelfth connecting tube, 28 is a third three-way joint, 29 is a thirteenth connecting tube, 30 is a second blood pump tube, 31 is a fourteenth connecting tube, a sample collection tube, a, 32 is a second centrifuge cup, 33 is a fifteenth connecting tube, 34 is a fourth three-way joint, 35 is a sixteenth connecting tube, 36 is a plasma bag, 37 is a three-way tube, 38 is a second hemostatic clamp, 39 is a seventeenth connecting tube, 40 is a first four-way joint, 41 is an eighteenth connecting tube, 42 is a fifth three-way joint, 43 is a nineteenth connecting tube, 44 is a third hemostatic clamp, 45 is a twentieth connecting tube, 46 is a physiological saline puncture outfit component, 47 is a twenty-first connecting tube, 48 is a plasma pump tube, 49 is a twenty-second connecting tube, 50 is a second filter, 51 is a second pressure detector joint, 52 is a twenty-third connecting tube, 53 is a sixth three-way joint, 54 is a twenty-fourth connecting tube, 55 is a first-stage therapeutic instrument, 56 is a twenty-fifth connecting tube, 57 is a seventh three-way joint, 58 is a twenty-sixth connecting tube, 59 is an eighth three-way joint, 60 is a twenty-seventh connecting tube, 60 is a blood, 61 is a fifth hemostatic clamp, 62 is a twenty-eighth connecting tube, 63 is a sixth hemostatic clamp, 64 is a ninth three-way joint, 65 is a twenty-ninth connecting tube, 66 is a second-stage therapeutic device, 68 is a thirtieth connecting tube, 69 is a thirteenth connecting tube, 70 is a thirty-eleventh connecting tube, 71 is a seventh hemostatic clamp, 72 is a waste fluid bag, 73 is a thirty-second connecting tube, 74 is an eleventh three-way joint, 75 is a thirty-third connecting tube, 76 is a thirty-fourth connecting tube, 77 is a third filter, 78 is a thirty-fifth connecting tube, 79 is an eighth hemostatic clamp, 80 is a blood return bag, 81 is a thirty-sixth connecting tube, 82 is a blood return valve, 83 is a blood dropping funnel, 84 is a thirty-seventh connecting tube, 85 is a blood transfusion set, and 86 is a thirty-eighth connecting tube.

a is a first valve, b is a second valve, c is a third valve, d is a fourth valve, e is a fifth valve, f is a sixth valve, g is a seventh valve, h is an eighth valve, i is a ninth valve, j is a tenth valve, k is an eleventh valve, and l is a tenth valve.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Example, as shown in fig. 1:

a clinical continuous blood component centrifugal separation and treatment system comprises an extracorporeal circulation pipeline, a purification device and pipeline auxiliary equipment, wherein the extracorporeal circulation pipeline comprises a first-stage blood separation pipeline, a second-stage blood separation pipeline, a blood separation guarantee circuit, a plasma purification pipeline and a blood mixing pipeline; the pipeline auxiliary equipment and the purification device are hermetically connected in the extracorporeal circulation pipeline;

pipeline auxiliary assembly includes machine hemostix, anticoagulant puncture ware subassembly, anticoagulant pump line, first to third filter, first to third pressure detector connects, first blood pump line, second blood pump line, first separation cup, second separation cup, blood feedback bag, plasma collection bag, normal saline puncture ware subassembly, plasma pump line and waste liquid bag.

The first stage blood separating tube consists of a twelfth connecting tube 27, a thirteenth connecting tube 29, a fourteenth connecting tube 31, a fifteenth connecting tube 33, a second blood pump tube 30 and a second separating cup 32 which are connected in the tube; the second-stage blood separation tube is composed of a seventh connecting tube 19, an eighth connecting tube 21, a ninth connecting tube 23, a tenth connecting tube 25, a first separation cup 24 and a first blood pump tube 22 connected to the tubes. The blood separation ensuring circuit includes a seventeenth connection tube 39, a thirty ninth connection tube 86, and an eleventh connection tube 26.

Install first hemostatic clamp 2 on the first connecting pipe 3, install second hemostatic clamp 6 on the second connecting pipe 5, install third hemostatic clamp 44 on the twentieth connecting pipe 45, install fifth hemostatic clamp 61 on the twenty-seventh connecting pipe 60, install sixth hemostatic clamp 63 on the twenty-eighth connecting pipe 62, install seventh hemostatic clamp 71 on the thirty-second connecting pipe 70, install eighth hemostatic clamp 79 on the thirty-sixth connecting pipe 78.

Description of the drawings: in this patent, a is a first valve, b is a second valve, c is a third valve, d is a fourth valve, e is a fifth valve, f is a sixth valve, g is a seventh valve, h is an eighth valve, i is a ninth valve, j is a tenth valve, k is an eleventh valve, and l is a tenth valve. The first to twelfth valves are installed on the treatment machine for clamping the connection pipes in the system.

The working process of the embodiment is as follows:

before the use, the normal saline puncture device assembly is connected to the normal saline, the ninth valve i and the tenth valve j are in a closed state, the eleventh valve k is in an open state, and the eleventh valve k is manually opened. A third hemostatic clamp 44 and a seventh hemostatic clamp 71, wherein the peristaltic pump matched with the plasma pump tube 48 starts to rotate clockwise, and the physiological saline flows along a twenty-first connecting tube 45, a nineteenth connecting tube 43, a fifth three-way joint 42, a twenty-first connecting tube 47, the plasma pump tube 48, a twenty-second connecting tube 49, a second filter 50, a twenty-third connecting tube 52, a sixth three-way joint 53, a twenty-fourth connecting tube 54, a first-stage therapeutic device 55, a twenty-fifth connecting tube 56, a seventh three-way joint 57, a twenty-sixth connecting tube 58, an eighth three-way joint 59, a thirty-third connecting tube 67, a second-stage therapeutic device 66, a twenty-ninth connecting tube 65, a ninth three-way joint 64, a thirty-eleventh connecting tube 68, a thirteenth connecting tube 69, a thirty-second connecting tube 70 and a waste liquid bag 72, and the physiological saline can flush the first-stage therapeutic device 55 and the second-stage therapeutic device 66 through the tubes, the waste liquid after washing flows into the waste liquid bag 72 and is collected. Or the first-stage filter or the second-stage filter can be washed separately through the opening and closing matching relationship of the fifth hemostatic clamp 61 and the sixth hemostatic clamp 63. After the flushing process is completed, the seventh hemostatic clamp 71 is closed, and the next working process is performed.

When the blood collector 1 for machine is used for puncturing a blood vessel of a human body, the first hemostatic clamp 2 is opened, the peristaltic pump matched with the anticoagulant pump tube 10 and the peristaltic pump matched with the first blood pump tube 30 are started, the second valve b, the third valve c, the fifth valve e, the fourth valve d, the seventh valve g, the ninth valve i, the eleventh valve k and the twelfth valve l are in a closed state, the first valve a, the sixth valve f, the tenth valve j and the eighth valve h are in an open state, the second centrifugal cup 32 rotates, the second hemostatic clamp 6 is opened, whole blood enters the sample reserving bag 8, the second hemostatic clamp 6 is closed after sample reserving is finished, anticoagulant and whole blood are mixed and then enter the second centrifugal cup 32 through the twelve connecting tubes 27 along the fifth connecting tube 14, plasma and blood cells are centrifugally separated, the separated plasma enters the plasma bag 36, when a collection set value is reached, the second centrifugal cup 32 stops rotating, the first centrifugal cup 24 is started, at this time, the first valve a and the seventh valve g are closed, and the second valve b, the fifth valve e, the fourth valve d, the eighth valve h, the ninth valve i, the tenth valve j, and the tenth valve l are opened. Immediately after the second centrifuge cup 32 stops rotating, the plasma pump matched with the plasma pump pipe 48 starts to work, the plasma flows through the second filter 50, and since the fifth hemostatic clamp 61 and the sixth hemostatic clamp 63 are both in a closed state, the plasma sequentially passes through the first-stage therapeutic device 55, the second-stage therapeutic device 66, the thirtieth connecting pipe 68, the thirty-second connecting pipe 73, the eleventh three-way joint 74, the blood transfusion bag 80, the blood transfusion valve 82, the blood dropping funnel 83, the blood transfusion device component 85 and finally returns to the human body. Immediately after the first centrifugal cup 24 is started, the peristaltic pump cooperating with the first blood pump tube 22 starts to operate, the valve f is in a closed state, whole blood is pumped into the first centrifugal cup 24 to start centrifugal separation, and separated plasma enters the plasma bag 36 along the tenth connecting tube 25 and the sixteenth connecting tube 35. Immediately after the second centrifuge cup 32 stops rotating, the peristaltic pump engaged with the second blood pump tube 30 rotates counterclockwise to return the blood cells in the second centrifuge cup 32 to the blood transfusion bag 80, through the blood transfusion valve 82, the blood drip chamber 83, the blood transfusion set 85, and finally back to the human body.

Blood support circuit function description:

when the first centrifugal cup 24 is out of order, the plasma in the plasma bag 36 which is not completely separated by the centrifugal cup may be mixed with blood cells except for the plasma, at this time, the seventh valve g, the third valve c, the fifth valve e and the second hemostatic clamp 38 are opened, the ninth valve i, the eighth valve h, the second valve b, the fourth valve d and the sixth valve f are closed, and after the failure is processed, the peristaltic pump matched with the first blood pump tube 22 rotates clockwise to re-pump the plasma which is not separated at the bottom in the plasma bag 36 into the first centrifugal cup 24 for re-separation.

When the second centrifugal cup 32 is out of order, the plasma in the plasma bag 36 which is not completely separated by the centrifugal cup may be mixed with blood cells except for the plasma, at this time, the seventh valve g, the fourth valve d, the sixth valve f and the second hemostatic clamp 38 are opened, the ninth valve i, the eighth valve h, the second valve b, the third valve c and the fifth valve e are in a closed state, and after the failure is processed, the peristaltic pump matched with the second blood pump tube 30 rotates clockwise to re-pump the plasma which is not completely separated in the plasma bag 36 into the second centrifugal cup 32 for re-separation.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A clinical continuous blood component centrifugal separation and treatment system comprises an extracorporeal circulation pipeline, a purification device and pipeline auxiliary equipment, wherein the extracorporeal circulation pipeline comprises a first-stage blood separation pipeline, a second-stage blood separation pipeline, a blood separation guarantee circuit, a plasma purification pipeline and a blood mixing pipeline; the pipeline auxiliary equipment and the purification device are hermetically connected in the extracorporeal circulation pipeline.

2. The system of claim 1, wherein the line set of auxiliary equipment comprises a machine blood collector, an anticoagulant spike assembly, an anticoagulant pump line, a plurality of filters, a plurality of pressure detector connectors, a first blood pump line, a second blood pump line, a first separation cup, a second separation cup, a blood return bag, a plasma collection bag, a saline spike assembly, a plasma pump line, and a waste bag; the purification device comprises first to Nth stages of therapeutic devices; the extracorporeal circulation pipeline consists of a first connecting pipe, a second connecting pipe, a third connecting pipe, a fourth connecting pipe, a fifth connecting pipe and a fifth connecting pipe.

3. The system of claim 2, wherein the filter comprises a first filter, a second filter, and a third filter, the first filter (15) having a first pressure detector connector (16) connected thereto, and the second filter (50) having a second pressure detector connector (51) connected thereto.

4. The system for clinical continuous blood component centrifugation and treatment according to claim 1, wherein the first-stage blood separation tube is composed of a twelfth connection tube (27), a thirteenth connection tube (29), a fourteenth connection tube (31), a fifteenth connection tube (33), and a second blood pump tube (30) and a second separation cup (32) connected in-line; the second-stage blood separation tube consists of a seventh connecting tube (19), an eighth connecting tube (21), a ninth connecting tube (23), a tenth connecting tube (25), a first separation cup (24) and a first blood pump tube (22) which are connected with the tubes.

5. The system for clinical continuous blood component centrifugation and treatment according to claim 1, wherein the blood separation assurance circuit comprises a seventeenth connection tube (39), a thirty-ninth connection tube (86), and an eleventh connection tube (26).

6. The system of claim 2, wherein the line set further comprises an anticoagulant drip chamber, a sample retention bag, a saline drip chamber, and a blood transfusionist assembly.

7. The system of claim 2, wherein the connection between the line set-up and the purification device is sealed in the extracorporeal circulation line by: one end of the first connecting pipe (3) is connected to a first port of the five-way joint; one end of a fourth connecting pipe (11) is connected to one end of the anticoagulant pump pipe, and the other end of the fourth connecting pipe (11) is connected with the anticoagulant drip chamber; the other end of the anticoagulant pump tube is connected to the second port of the five-way joint through a third connecting tube (9); one end of a second connecting pipe (5) is connected to a third port of the five-way joint, the other end of the second connecting pipe (5) is connected with a first port of a Y-shaped pipe, a second port of the Y-shaped pipe is connected with a sample reserving bag, one end of a fifth connecting pipe (14) is connected with a fourth port of the five-way joint, and the other end of the fifth connecting pipe (14) is connected with one end of a first filter; the other end of the first filter is connected to a first-stage blood separation pipeline and a second-stage blood separation pipeline through a sixth connecting pipe (17) and a first three-way joint (18), the first-stage blood separation pipeline and the second-stage blood separation pipeline are connected with the upper port of a plasma collection bag through a fourth three-way joint (34) and a sixteenth connecting pipe (35), and the lower port of the plasma collection bag is connected to the first port of a three-way pipe (37); a second port of the three-way pipe (37) is connected with a thirty-ninth connecting pipe (86) and an eleventh connecting pipe (26) through a seventeenth connecting pipe (39) and a four-way joint (40) to form a blood separation guarantee loop; a third port of the three-way pipe (37) is connected with a first port of a fifth three-way joint (42) through an eighteenth connecting pipe (41), a second port of the fifth three-way joint (42) is connected with one end of a plasma pump pipe (43) through a twenty-first connecting pipe (47), a third port of the fifth three-way joint (42) is connected with one end of a normal saline dropping funnel through a twentieth connecting pipe (45), the other end of the normal saline dropping funnel is connected with a normal saline piercing component, the other end of the plasma pump pipe (43) is connected with one end of a second filter (50) through a twenty-second connecting pipe (49), the other end of the second filter (50) is connected with a first port of a sixth three-way joint (53) through a twenty-third connecting pipe (52), a second port of the sixth three-way joint (53) is connected with one end of a first-stage therapeutic device (55) through a twenty-fourth connecting pipe (54), a first port of an eighth three-way joint (59) is connected with a third port of a sixth three-way joint (53) through a twenty The second port of the eighth three-way joint (59) is connected with the second port of the seventh three-way joint (57) through a twenty-sixth connecting pipe (58) to form a bypass, the third port of the seventh three-way joint (57) is connected with the first port of the ninth three-way joint (64) through a twenty-eighth connecting pipe (62), the second port of the ninth three-way joint (64) is connected with one end of the second-stage therapeutic apparatus through a second ninth connecting pipe (65), the other end of the second-stage therapeutic apparatus is connected with the third port of the eighth three-way joint (59) through a thirty-third connecting pipe (67), the third port of the ninth three-way joint (64) is connected with the second port of the thirteenth three-way joint (69) through a thirty-eleventh connecting pipe (68), the first port of the thirteenth three-way joint (69) is connected with the first port of the eleventh connecting pipe (74) through a thirty-third connecting pipe (73), and the third port of the thirteenth three-way joint (69) is connected with a waste liquid bag (72) through a thirty-second connecting pipe (70) The second port of the eleventh three-way joint (74) is connected with the four-way joint (40) through a thirty-fourth connecting pipe (75), the third port of the eleventh three-way joint (74) is connected with one end of a third filter (77) through a thirty-fifth connecting pipe (76), the other end of the third filter (77) is connected with the upper end of a blood transfusion bag (80) through a thirty-sixth connecting pipe (78), the lower end of the blood transfusion bag is connected with one end of a blood dropping funnel (83) through a thirty-seventh connecting pipe (81), and the other end of the blood dropping funnel is connected with a blood transfusion device component (85) through a thirty-eighth connecting pipe (84).

8. The system for clinical continuous blood component centrifugation and treatment according to claim 7, wherein the first connecting tube (3) is provided with a first hemostatic clamp (2), the second connecting tube (5) is provided with a second hemostatic clamp (6), the twentieth connecting tube (45) is provided with a third hemostatic clamp (44), the twenty-seventh connecting tube (60) is provided with a fifth hemostatic clamp (61), the twenty-eighth connecting tube (62) is provided with a sixth hemostatic clamp (63), the thirty-second connecting tube (70) is provided with a seventh hemostatic clamp (71), and the thirty-sixth connecting tube (78) is provided with an eighth hemostatic clamp (79).