CN115007331A

CN115007331A - Blood component separator and method of use

Info

Publication number: CN115007331A
Application number: CN202210422567.2A
Authority: CN
Inventors: 鄂青; 华强; 沈文强
Original assignee: Felderson Jiangsu Biotechnology Co ltd
Current assignee: Felderson Jiangsu Biotechnology Co ltd
Priority date: 2022-04-21
Filing date: 2022-04-21
Publication date: 2022-09-06
Anticipated expiration: 2042-04-21
Also published as: CN115007331B

Abstract

The invention relates to a blood component separator and a use method thereof, and the blood component separator comprises a separator body, a consumable component matched with the separator body, and a temperature control device for controlling the temperature of the separator, wherein the consumable component comprises a centrifugal cup, a collection system and a pipeline system which are connected with the centrifugal cup; the invention can realize that the blood can be separated in a totally closed pipeline; the first guide pipe, the pump pipe and other pipelines can be conveniently combed and fixed through the mounting plate, the first guide pipe, the pump pipe and other pipelines can be conveniently mounted on the separation equipment, the mounting time is saved, and the mounting error is avoided; the liquid channel designed in the centrifugal cup can also enable liquid to be more concentrated in the middle of the bottom of the cup when the liquid is returned, so that the residue is reduced.

Description

Blood component separator and method of use

Technical Field

The invention relates to the technical field of blood separation, in particular to a blood component separator and a using method thereof.

Background

The blood component separator adopts the centrifugal separation method to collect plasma, blood enters the centrifugal cup rotating at a high speed for centrifugal separation, the blood after centrifugation can form blood cell stratification and plasma stratification, the plasma in the plasma stratification is sequentially conveyed to the plasma collecting bag through the plasma outlet of the centrifugal cup, along with the reduction of the plasma in the centrifugal cup and the increase of blood cells, the blood cell components gradually reach the plasma outlet, in order to prevent the blood cell components from entering the plasma collecting bag, the domestic common practice is as follows: a blood cell detector is arranged between the plasma outlet of the centrifugal cup and the plasma collecting bag to detect blood cells, when the blood cell detector finds the blood cells, the collection of the blood plasma is stopped, the blood cell detector enters a returning process, and the blood cells in the centrifugal cup are returned to the human body of a blood donor. In the Chinese invention patent, the application number: 201610748006.6, the following drawbacks are addressed: due to the limited level of sensitivity of the blood cell detector to the detection of the minute components in the blood cells, when it detects the blood cell component, some of the minute components in the blood cell component have passed over the blood cell detector into the plasma collection bag, such as: platelets, leukocyte components, etc. Therefore, monitoring of blood cell components using this method has limited control over plasma quality, and the collected plasma contains a large amount of blood cell components such as platelets and leukocytes.

Among them, the centrifugal cup is often used as an instrument for separating serum, plasma, precipitated protein or examining urinary sediment. The centrifugal cup can be used for quickly precipitating suspended particles in the mixed solution so as to separate components of various substances with different specific gravities, but the conventional centrifugal cup has the following problems:

1. blood residue can occur, which not only is waste, but also causes the situation of difficult cleaning;

2. in a collecting system of the centrifugal cup type blood component separator, pipelines and conduits have no good carding and fixing structures, so that the whole system is disordered, is inconvenient to install on collecting equipment and is easy to influence use; the traditional method of the sub-packaging tube of the traditional collection system is that a blood transfusion socket is arranged, but once the sub-packaging tube is opened, the sub-packaging tube cannot be closed again, so that bacteria enter the sub-packaging tube, and the integral use is influenced;

3. the blood plasma collection requires a constant temperature of 22 ℃, and the existing separator cannot achieve the effect of intelligent constant temperature;

4. the process of collecting platelets is complicated.

Disclosure of Invention

(1) Technical problem to be solved

The present invention is directed to overcome the deficiencies of the prior art and to provide a blood component separator and a method for using the same to solve the above mentioned problems.

(2) Technical scheme

In order to realize the purpose of the invention, the technical scheme adopted by the invention is as follows:

a blood component separator comprises a separator body, a consumable component matched with the separator body, and a temperature control device for controlling the temperature of the separator, wherein the consumable component comprises a centrifugal cup, a collection system and a pipeline system which are connected with the centrifugal cup; the centrifugal cup comprises a cup body and a cup bottom, and a plurality of liquid channels are arranged at the cup bottom of the centrifugal cup.

Furthermore, an outer core is arranged in the cup body, the lower end of the outer core is arranged on the upper end face of the cup bottom, and the inner cavity of the cup body is divided into a first cavity located outside the outer core and a second cavity located in the outer core through the outer core.

Furthermore, the inner wall of the outer core is connected with an inner core, the lower end of the inner core is fixedly connected to the upper end face of the cup bottom, a third chamber is separated from the inner core through the inner core, the first chamber and the third chamber are communicated through the liquid channel, the upper end of the cup body is fixedly connected with a protection head through a support frame, the lower end of the protection head is fixedly connected with a central conduit, the lower end of the protection head is fixedly connected with an inner umbrella, the upper end of the inner umbrella is fixedly connected with the outer umbrella, a support sheet is padded at the lower end of the support frame, and an elastic ring is installed in the lower end of the protection head.

Further, the pipeline system comprises two first conduits, the first conduits are fixedly connected with one side of the upper end of the centrifugal cup, a T-shaped tee joint is fixedly connected with the first conduit at the lower end, the lower end of the T-shaped tee joint is fixedly connected with a pressure monitor, one side of the first conduit at the lower end, which is far away from the centrifugal cup, is fixedly connected with an outer cone through way, one side of the outer cone through way is fixedly connected with a through way protective sleeve, the outer cone through way passes through the through way protective sleeve to be connected with a collecting system, the first conduit at the upper end is fixedly connected with a pump pipe, one side of the pump pipe, which is far away from the first conduit, is fixedly connected with a blood filter component, one side of the blood filter component, which is far away from the pump pipe, is fixedly connected with an inner cone through way, the upper end of the inner cone through way is fixedly connected with a first three-way pipe, the upper end of the first three-way is fixedly connected with a Y-shaped tee joint, and the upper end of the Y-shaped tee joint is fixedly connected with a first sampling bag and a needle holder, the needle protection device is characterized in that the pump pipe and the first guide pipe are fixedly mounted on the mounting plate, one side of the pump pipe is fixedly connected with the liquid medicine filter, one side of the pump pipe is fixedly connected with the transfer bag, the top end of the first three-way pipe is fixedly mounted with the needle protector, and the upper end of the needle protector is fixedly connected with the puncture needle protection sleeve.

Furthermore, the collecting system comprises a collecting bag, a blood transfusion socket is formed in one side of the upper end of the collecting bag, the middle of the upper end of the collecting bag is fixedly connected with a second three-way pipe through a hose, the second three-way pipe is directly connected with an outer cone, the second three-way pipe is far away from one side of the outer cone, which is directly connected with a five-way pipe, the ports of the five-way pipe are fixedly connected with sub-packaging pipes through hoses, the upper ends of the sub-packaging pipes are fixedly connected with silicon rubber sealing connectors, and the upper end of the collecting bag is far away from one side of the blood transfusion socket and is fixedly connected with a second sampling bag.

Furthermore, the separator body is further provided with a peristaltic pump, a bowl photoelectric sensor, valves and a platelet scale, wherein the peristaltic pump is arranged on the upper portion of the separator body, the bowl photoelectric sensor is arranged on the side wall of the centrifugal cup, the valves are respectively arranged on the outer front face of the separator body, and the platelet scale is arranged on the outer side face of the separator body.

Furthermore, a centrifugal bin body is arranged in the middle of the separator body, a centrifugal bowl for fixing a centrifugal cup is arranged in the centrifugal bin body, a centrifugal bin cover for plugging the centrifugal bowl is arranged at an outer end of the centrifugal bin body, one end of the centrifugal bin cover is movably connected to the upper end face of the centrifugal bin body through a hinge, a coil spring capable of automatically opening the centrifugal bin cover is arranged in the hinge, one end of the hinge is connected to the inner side of the centrifugal bin body through a rotating shaft, the coil spring is wound on the rotating shaft, the other end of the hinge is fixedly connected to the centrifugal bin cover through a hinge rotating seat, a centrifugal bin cover lock is arranged at the other end of the centrifugal bin cover, the centrifugal bin cover is locked to the upper end face of the centrifugal bin body through the centrifugal bin cover lock, the centrifugal bin cover lock comprises a shifting plate arranged on the upper end face of the centrifugal bin body, a base plate fixedly connected to the upper end of the centrifugal bin body is arranged on the front side of the shifting plate, a clamping block is connected to the upper end of the backing plate in a swinging mode, a clamping protrusion is arranged at the front end of the clamping block, a limiting block is arranged at the rear end of the clamping block and located above the backing plate, a supporting frame fixedly connected to the upper end of the centrifugal bin body is arranged on the front side of the clamping block, a locking block is arranged at the upper end of the supporting frame in a swinging mode, a first clamping groove matched with the clamping protrusion is formed in one side of the locking block, a second clamping groove is formed in the upper end of the locking block, and a reset spring is arranged between the lower end of the locking block and the supporting frame in a cushioning mode; the outer end of the bin cover of the centrifugal machine is provided with a cup cover hook, and the cup cover hook is matched with the second clamping groove.

Furthermore, the temperature control device comprises a temperature sensor, a refrigerator, a radiator and a control device, the temperature sensor is arranged inside the centrifugal bin body, the refrigerator and the radiator are both arranged outside the centrifugal bin body, the temperature sensor is connected with the control device, the temperature in the centrifugal bin is conducted into the control device, and the control device controls the on and off of the series circuit, so that the refrigerator and the radiator are controlled.

Further, the control device comprises a support box and a heat conducting plate, the heat conducting plate is fixedly inserted in the support box, one end of the heat conducting plate, which is positioned outside the support box, is connected with the temperature sensor, a movable piston is movably arranged in the support box and divides the support box into a first accommodating cavity and a second accommodating cavity, the heat conducting plate is arranged in the second accommodating cavity, mercury is stored in the second accommodating cavity, one end of the movable piston, which is far away from the second accommodating cavity, is fixedly connected with a movable support rod, the movable support rod is movably inserted on a sealing plate, the sealing plate is fixedly connected in the support box, the movable support rod is wound and connected with a return spring, two ends of the return spring are respectively and fixedly connected on the side wall of the movable support rod and the side wall of the sealing plate, and a supporting plate is fixedly connected with the free end of the movable support rod, and the lateral wall fixedly connected with No. two electrode contact of bearing plate, fixedly connected with and No. two electrode contact assorted electrode contact on the inside wall of supporting box, the bearing plate keeps away from the one end fixedly connected with No. three electrode contact of No. two electrode contact, fixedly connected with and No. three electrode contact assorted electrode contact on the closing plate, and No. four electrode contact movable sleeve establish outside the movable support pole.

Further, a method for using the blood component separator comprises the steps of rough collection and fine adjustment, wherein the rough collection comprises the following steps:

the method comprises the following steps: collecting anticoagulated whole blood into a centrifuge cup rotating at a high speed through a peristaltic pump;

step two: the blood components are layered in a centrifuge cup rotating at high speed;

step three: separating the plasma, and collecting the plasma in a transfer plasma bag;

step four: after the bowl photoelectric sensor detects the interface of the plasma and the red blood cells, the collection of anticoagulated whole blood is stopped at proper time;

step five: continuously returning the separated plasma to the separation cup, and elutriating platelets;

step six: after washing the platelet and hardening, collect the platelet, the theoretical collection volume of plasma is calculated according to the patient's blood item parameter of inputing in advance to the machine, and during the collection plasma, first valve is closed, the second valve is opened, and weak platelet plasma gets into and shifts the bag, and control system has set up the colour of line inductor in advance or after the extinction printing opacity data, reaches the value of settlement after, and control module controls first valve and opens, and the second valve is closed, and the platelet gets into the product bag, accomplishes crude collection.

Further, the fine tuning comprises the following steps:

the method comprises the following steps: extracting a sample from the roughly collected platelets, and measuring the actual platelet concentration;

step two: according to the difference value between the actual concentration and the target concentration, the machine re-matches the plasma content to achieve the purpose of accurately adjusting the platelet concentration.

(3) Has the advantages that:

the invention can realize component separation of blood in a totally closed pipeline, and is safer and more efficient.

The invention can collect large-capacity platelet rich plasma (more than 50 ml) and small-capacity platelet rich plasma (about 10 ml).

The temperature control device is designed in the separator body, so that the activity of platelets is not affected.

The concentration of the blood platelet collected by the invention is adjustable.

The invention can facilitate the combing and fixing of the first conduit, the pump pipe and other pipelines through the arranged mounting plate, can facilitate the mounting on the collecting equipment, saves the mounting time and avoids the occurrence of mounting errors.

The liquid channel arranged in the centrifuge cup can also be used for conveying liquid, and the liquid can be more concentrated in the middle of the bottom of the cup due to the fact that the bottom of the centrifuge cup is transported by the symmetrical liquid channel, and waste is reduced.

According to the silicone rubber sealed connector structure arranged on the subpackaging pipe, the protective agent is injected into the subpackaging pipe through the silicone rubber sealed connector, so that the storage of blood components is facilitated, the subsequent addition or extraction of liquid or blood components into the subpackaging pipe is facilitated, and the cleanness and sanitation of the interior of the subpackaging pipe are favorably maintained.

The use method of the blood separator provided by the invention enables the platelet collection process to be simpler and more convenient.

Drawings

FIG. 1 is a schematic perspective view of a blood component separator and method of using the same according to an embodiment of the present invention;

FIG. 2 is a schematic view of a blood component separator and method of using the same of FIG. 1;

FIG. 3 is a schematic diagram of the blood component separator and method of use of the blood component separator of FIG. 2;

FIG. 4 is a schematic view of the blood component separator and method of use of the blood component separator of the present invention and the collection system of FIG. 2;

FIG. 5 is a schematic view of the blood component separator and method of use of the blood component separator of the present invention, illustrating the construction of the cup bottom of FIG. 3;

FIG. 6 is a system flow diagram of a temperature control device in a blood component separator and method of use of the blood component separator of the present invention;

FIG. 7 is a schematic view of the blood component separator and method of use of the blood component separator of the present invention showing the structure of the control device of FIG. 6;

FIG. 8 is a schematic diagram of the structure of the centrifuge lid lock of the blood component separator and method of using the same of the present invention;

FIG. 9 is a schematic diagram of the structure of the centrifuge lid of the blood component separator and method of using the same of the present invention;

FIG. 10 is a schematic view of a hinge of a blood component separator and a method of using the same according to the present invention;

FIG. 11 is a schematic view of the construction of a centrifuge bowl of the blood component separator and method of use of the blood component separator of the present invention;

FIG. 12 is a schematic view of a hinge rotary base of the blood component separator and the method of using the same according to the present invention;

FIG. 13 is a schematic view of a coil spring configuration of the blood component separator and method of use of the blood component separator of the present invention;

FIG. 14 is a system flow diagram of a temperature control device of a blood component separator and a method for using the same according to another embodiment of the present invention.

The reference numbers are as follows:

100-centrifuge cup, 101-cup body, 102-cup bottom, 103-outer core, 104-inner core, 105-liquid channel, 106-support frame, 107-protective head, 108-central conduit, 109-inner umbrella, 110-outer umbrella, 111-support sheet, 112-elastic ring, 200-collection system, 201-collection bag, 202-blood transfusion socket, 203-second three-way pipe, 205-five-way pipe, 206-dispensing pipe, 207-silicon rubber sealing connector, 208-second sampling bag, 300-pipeline system, 301-first conduit, 302-T type three-way, 303-pressure detector, 304-outer cone straight-through, 305-straight-through protective sleeve, 306-pump pipe, 307-blood filter component, 308-first three-way pipe, 309-Y-shaped tee joint, 310-first sampling bag, 311-needle holder, 312-mounting plate, 313-liquid medicine filter, 314-transfer bag, 315-needle protector, 316-puncture needle protective sleeve, 400-centrifugal bowl, 500-centrifugal machine bin cover, 501-hinge, 502-coil spring, 503-rotating shaft, 504-hinge rotating seat, 505-cup cover hook, 600-centrifugal machine bin cover lock, 601-toggle plate, 602-backing plate, 603-fixture block, 604-connecting bulge, 605-support frame, 606-locking block, 607-first clamping groove, 608-second clamping groove, 609-reset spring, 700-control device, 701-support box, 702-heat conducting plate, moving piston 704, 703-moving support rod, 705-sealing plate, 706-return spring, 707-supporting plate, 708-first electrode contact, 709-second electrode contact, 710-third electrode contact, 711-fourth electrode contact, 10-peristaltic pump, 20-bowl photoelectric sensor, 30-first valve, 40-second valve and 50-platelet balance.

Detailed Description

The invention will be further illustrated with reference to the following figures 1 to 14 and examples:

example 1

As shown in fig. 1-13, a blood component separator comprises a separator body, a consumable component used in cooperation with the separator body, and a temperature control device for controlling the temperature of the separator, wherein the consumable component comprises a centrifuge cup 100, and a collection system 200 and a pipeline system 300 connected with the centrifuge cup; the centrifugal cup 100 comprises a cup body 101 and a cup bottom 102, and the cup bottom 102 of the centrifugal cup 100 is provided with a plurality of liquid channels 105 for separating plasma and platelets from human blood. Wherein, the centrifugal cup 100 is used for separating blood after centrifugal rotation, the pipeline system 300 is used for conveying blood of a human body and returning the separated blood to the human body, and the collection system 200 is used for storing and continuously processing separated blood components. The products for separating blood components are numerous, and the embodiment focuses on separating plasma and platelets from small amounts of blood, so that small volume is a key issue for centrifuge cups. The volume of the centrifugal cup (the volume in the centrifugal state) used in the market at present is 200-.

In this embodiment, an outer core 103 is disposed in the cup body 101, and a lower end of the outer core 103 is disposed on an upper end surface of the cup bottom 102, the inner cavity of cup 101 is divided by said outer core 103 into a first chamber located outside outer core 103, and a second cavity positioned in the outer core 103, wherein the inner top wall of the outer core 103 is connected with an inner core 104, the lower end of the inner core 104 is fixedly connected with the upper end surface of the cup bottom 102, a third chamber is separated in the outer core 103 by the inner core 104, the first chamber and the third chamber are communicated by the liquid channel 105, the upper end of the cup body 101 is fixedly connected with a protective head 107 through a supporting frame 106, the lower end of the protective head 107 is fixedly connected with a central guide pipe 108, the lower end of the protective head 107 is fixedly connected with an inner umbrella 109, the upper end of the inner umbrella 109 is fixedly connected with an outer umbrella 110, the support plate 111 is padded at the lower end of the support frame 106, and the elastic ring 112 is installed in the lower end of the protection head 107. The liquid channel 105 arranged in the centrifugal cup 100 can also ensure that the liquid is more concentrated in the middle of the bottom of the cup and the waste is reduced because the liquid channel which is uniformly distributed is adopted for transportation at the bottom when the liquid is transported.

In this embodiment, the pipeline system 300 includes two first conduits 301, the first conduits 301 are fixedly connected to one side of the upper end of the centrifuge cup 100, a T-shaped tee 302 is fixedly connected to the first conduit 301 at the lower end, a pressure monitor 303 is fixedly connected to the lower end of the T-shaped tee 302, an outer cone through 304 is fixedly connected to one side of the first conduit 301 at the lower end, which is far from the centrifuge cup 100, a through protective sleeve 305 is fixedly connected to one side of the outer cone through 304, the outer cone through 304 is connected to the collection system 200 through the through protective sleeve 305, the first conduit 301 at the upper end is fixedly connected to a pump tube 306, a hemofilter assembly 307 is fixedly connected to one side of the pump tube 306, an inner cone through 317 is fixedly connected to one side of the hemofilter assembly 307, a first tee 308 is fixedly connected to an upper end of the inner cone 317, the upper end of the first three-way pipe 308 is fixedly connected with a Y-shaped tee 309, the upper end of the Y-shaped tee 309 is fixedly connected with a first sampling bag 310 and a needle holder 311, the pump pipe 306 and the first guide pipe 301 are both fixedly installed on an installation plate 312, one side of the pump pipe 306 is fixedly connected with a liquid medicine filter 313, one side of the pump pipe 306 is fixedly connected with a transfer bag 314, the top end of the first three-way pipe 308 is fixedly installed with a needle guard 315, and the upper end of the needle guard 315 is fixedly connected with a puncture needle protective sleeve 316. The provision of mounting plate 312 in piping system 300 provides for the pre-positioning of complex conduits on mounting plate 312. The arrangement of the mounting plate 312 can facilitate the combing and fixing of the first guide pipe 301, the pump pipe 306 and other pipelines, can facilitate the mounting on the collecting equipment, saves the mounting time and avoids the occurrence of mounting errors.

In this embodiment, the collection system 200 includes a collection bag 201, a blood transfusion socket 202 is disposed on one side of an upper end of the collection bag 201, the middle portion of the upper end of the collection bag 201 is fixedly connected to a second three-way pipe 203 through a hose, the second three-way pipe 203 is connected to an outer cone through pipe 304, a five-way pipe 205 is fixedly connected to a side of the second three-way pipe 203 away from the outer cone through pipe 304, ports of the five-way pipe 205 are fixedly connected to a sub-packaging pipe 206 through a hose, an upper end of the sub-packaging pipe 206 is fixedly connected to a silicone rubber sealing connector 207, and a second sampling bag 208 is fixedly connected to a side of the upper end of the collection bag 201 away from the blood transfusion socket 202. A plurality of dispensing tubes 206 are provided in the collection system 200, and the dispensing tubes 206 are used for storage of blood components and subsequent processing, such as centrifugation. The dispensing tube 206 is provided with a connector, which may be silicone rubber, with which liquid or blood components may be conveniently added to or withdrawn from the dispensing tube 206, while remaining clean. The traditional method is to use a blood transfusion socket, and once the socket is opened, the socket cannot be closed again. According to the silicone rubber sealed connector structure arranged on the split charging pipe 206, the protective agent is injected into the split charging pipe 206 through the silicone rubber sealed connector 207, so that the storage of blood components is facilitated, the subsequent addition or extraction of liquid or blood components in the split charging pipe 206 is facilitated, and the cleanness and sanitation of the interior of the split charging pipe 206 are favorably kept.

In this embodiment, the separator body is further provided with a peristaltic pump 10, a bowl photosensor 20, a first valve 30, a second valve 40, and a platelet scale 50, wherein the peristaltic pump 10 is disposed on the upper portion of the separator body, the bowl photosensor 20 is disposed on the sidewall of the centrifuge cup 100, the first valve 30 and the second valve 40 are disposed on the outer front surface of the separator body, and the platelet scale 50 is disposed on the outer side surface of the separator body.

In this embodiment, a centrifuge body is disposed in the middle of the separator body, a centrifuge bowl 400 for fixing the centrifuge cup 100 is disposed in the centrifuge body, a centrifuge cover 500 for sealing the centrifuge bowl 400 is disposed at an outer end of the centrifuge body, one end of the centrifuge cover 500 is movably connected to an upper end surface of the centrifuge body through a hinge 501, a coil spring 502 capable of automatically opening the centrifuge cover 500 is disposed in the hinge 501, one end of the hinge 501 is connected to an inner side of the centrifuge body through a rotation shaft 503, the coil spring 502 is wound on the rotation shaft 503, the other end of the hinge 501 is fixedly connected to the centrifuge cover 500 through a hinge rotation base 504, a centrifuge cover lock 600 is disposed at the other end of the centrifuge cover 500, the centrifuge cover 500 is locked to the upper end surface of the centrifuge body through the centrifuge cover lock 600, the centrifuge cover lock 600 includes a toggle plate 601 disposed on the upper end surface of the centrifuge body, a backing plate 602 fixedly connected to the upper end of the centrifugal bin body is arranged on the front side of the toggle plate 601, a clamping block 603 is connected to the upper end of the backing plate 602 in a swinging mode, a clamping protrusion 604 is arranged at the front end of the clamping block 603, a limiting block 610 is arranged at the rear end of the clamping block 603, the limiting block 610 is located above the backing plate 602, a supporting frame 605 fixedly connected to the upper end of the centrifugal bin body is arranged on the front side of the clamping block 603, a locking block 606 is arranged at the upper end of the supporting frame 605 in a swinging mode, a first clamping groove 607 matched with the clamping protrusion 604 is formed in one side of the locking block 606, a second clamping groove 608 is formed in the upper end of the locking block 606, and a reset spring 609 is arranged between the lower end of the locking block 606 and the supporting frame 605 in a cushioning mode; the outer end of the centrifuge bin cover 500 is provided with a cup cover hook 505, and the cup cover hook 505 is matched with the second clamping groove 608. Centrifuge storehouse cover 500 turns over on hinge 501, can open centrifuge storehouse cover 500, pushes down centrifuge storehouse cover 500, and accessible bowl cover couple 505 card is gone into in second joint groove 608, bowl cover couple 505 continues to push down second joint groove 608, and locking piece 606 upset to drive first joint groove 607 and the protruding 604 combinations of joint before the fixture block 603, and then, link together fixture block 603 and locking piece 606, at this moment, bowl cover couple 505 top supports the inboard at second joint groove 608, plays the effect of stable connection, and is equipped with the torsional spring at the lateral part of fixture block 603, guarantees going on smoothly of fixture block 603 and locking piece 606 block process, and operation is simple and convenient, and work efficiency is higher, and connection stability is good.

In this embodiment, the temperature control device includes a temperature sensor, a refrigerator, a radiator, and a control device 700, the temperature sensor is disposed inside the centrifugal bin, the refrigerator and the radiator are both disposed outside the centrifugal bin, the temperature sensor is connected to the control device 700, the temperature inside the centrifugal bin is conducted into the control device 700, and the control device 700 controls the on/off of the series circuit, so as to control the refrigerator and the radiator.

In this embodiment, the control device 700 includes a support box 701 and a heat conducting plate 702, the heat conducting plate 702 is fixedly inserted into the support box 701, one end of the heat conducting plate 702, which is located outside the support box 701, is connected to the temperature sensor, a movable piston 703 is movably disposed in the support box 701, the support box 701 is divided into a first accommodating cavity and a second accommodating cavity by the movable piston 703, the heat conducting plate 702 is disposed in the second accommodating cavity, mercury is stored in the second accommodating cavity, a movable support rod 704 is fixedly connected to one end of the movable piston 703, which is away from the second accommodating cavity, and the movable support rod 704 is movably inserted into a sealing plate 705, the sealing plate 705 is fixedly connected to the support box 701, a return spring 706 is wound around the movable support rod 704, and two ends of the return spring 706 are respectively fixedly connected to a side wall of the movable support rod 704 and a side wall of the sealing plate 705, the free end of the movable supporting rod 704 is fixedly connected with a supporting plate 707, the side wall of the supporting plate 707 is fixedly connected with a second electrode contact 709, the inner side wall of the supporting box 701 is fixedly connected with a first electrode contact 708 matched with the second electrode contact 709, one end of the supporting plate 707 far away from the second electrode contact 709 is fixedly connected with a third electrode contact 710, a fourth electrode contact 711 matched with the third electrode contact 710 is fixedly connected to the sealing plate 705, and the fourth electrode contact 711 is movably sleeved outside the movable supporting rod 704. In the invention, the temperature control device is designed in the separator body, so that the activity of the platelets is not influenced.

The operation principle of the control device 700 includes the following processes:

the temperature sensor can sense the temperature in the centrifugal bin, the temperature sensor enters the second accommodating cavity through the conduction of the heat conducting plate 702, if the temperature is lower than 22 ℃, the temperature of mercury in the second accommodating cavity can be reduced, so under the characteristic of mercury expansion caused by heat and contraction caused by cold, the mercury can be contracted by cold, the mercury can lose the leftward conflict on the movable piston 703, so under the action of the elastic force of the reset spring 706, the movable supporting rod 704 can be pushed to move rightwards, the movable supporting rod 704 moves rightwards, the supporting plate 707 can drive the third electrode contact 710 to move towards the fourth electrode contact 711, after the third electrode contact 710 and the fourth electrode contact 711 are contacted, the series circuit of the radiator is connected, the radiator starts to work, the centrifugal bin is heated, and the temperature of the centrifugal bin is increased to 22 ℃; after the temperature in the centrifugal bin reaches 22 ℃, the temperature sensor can raise the temperature, and the mercury is heated and expanded after entering the mercury through the conduction of the heat conducting plate 702, so that the movable piston 703 is pushed to move leftwards, the movement of the movable piston 703 can drive the third electrode contact 710 to move leftwards through the movable supporting rod 704 and the supporting plate 707, the third electrode contact 710 is separated from the fourth electrode contact 711, the circuit of the radiator is disconnected, and the intelligent temperature control effect is achieved.

If the temperature in centrifugal bin is higher than 22 ℃, can make mercury be heated and take place the inflation, thereby push away mobile piston 703 and move left, the left motion of mobile piston 703, can take bearing board 707 to move left through removing bracing piece 704, thereby make No. two electrode contact 709 move left and contact with No. one electrode contact 708, thereby make the series circuit switch-on of refrigerator, the refrigerator begins to work, reduce in the centrifugal bin, along with the reduction of the interior temperature of centrifugal bin, again can make mercury receive the cold shrink, make bearing board 707 move right, No. one electrode contact 508 and No. two electrode contact 709 break away from, thereby reach intelligent accuse temperature's effect.

In this embodiment, through the setting of the control device 700, the effect of intelligently controlling the temperature of the refrigerator and the radiator can be realized, so that a constant temperature environment of 22 ℃ is always maintained in the centrifugal bin.

Example 2

In another embodiment, as shown in fig. 14, the temperature control device comprises a temperature sensor, a refrigerator and a control device 700, the temperature sensor is disposed inside the centrifugal bin body, the refrigerator is disposed outside the centrifugal bin body, the temperature sensor is connected to the control device 700, the temperature inside the centrifugal bin is conducted into the control device 700, and the control device 700 controls the on and off of the series circuit, so as to control the refrigerator.

A method of using a blood component separator comprising a blood component separator including coarse collection and fine adjustment, the coarse collection comprising the steps of:

the method comprises the following steps: anticoagulated whole blood is collected into a centrifugal cup 100 which rotates at a high speed through a peristaltic pump 10;

step two: the blood components are stratified in the high-speed rotating centrifuge cup 100;

step four: after the bowl photoelectric sensor 20 detects the interface between the plasma and the red blood cells, the collection of anticoagulated whole blood is stopped at a proper time;

step six: after washing platelet hardening, collecting platelets, calculating the theoretical collection amount of plasma according to the blood parameter of a patient input in advance by the machine, wherein when plasma is collected, the first valve 30 is closed, the second valve 40 is opened, platelet-poor plasma enters the transfer bag, after the color or light absorption and transmission data of the line sensor is preset by the control system and reaches a set value, the control module controls the first valve 30 to be opened, the second valve 40 to be closed, platelets enter the product bag, and coarse collection is completed.

In this embodiment, the fine tuning includes the following steps:

step two: according to the difference value between the actual concentration and the target concentration, the plasma content is re-proportioned by the machine, so that the aim of accurately adjusting the platelet concentration is fulfilled.

Starting and monitoring of a specific acquisition process

1. Venipuncture: puncturing and fixing the blood taking needle in the puncture needle protective sleeve 316 on the arm of a blood taker for taking blood;

2. observation apparatus and blood person

(1) During the collection process, attention is paid to observing the blood flow condition of the blood person;

(2) during collection, if the pressure in the blood vessel is low, the blood vessel should be alternately released and clenched to facilitate blood flow;

(3) setting a proper pump speed to enable the DPM pressure of the blood sample to be in a reasonable area;

second, end operation

After the device successfully collects the set blood platelets, the steps when the plasma collection operation is stopped are as follows:

1. clamping the whole blood pipeline to prevent blood from flowing out of the blood taking needle when the blood taking needle is pulled out;

2. clamping the plasma line prevents contamination or loss of plasma.

3. Ending the venipuncture;

4. covering the lancet with a lancet sheath 316;

the invention has the beneficial effects that:

the invention can realize the component separation of the blood in a totally closed pipeline, and is safer and more efficient.

In the invention, the temperature control device is designed in the separator body, so that the activity of the platelets is not influenced.

According to the silicone rubber sealed connector structure arranged on the subpackage pipe, the protective agent is injected into the subpackage pipe through the silicone rubber sealed connector, so that the storage of blood components is facilitated, the subsequent addition or extraction of liquid or blood components in the subpackage pipe is facilitated, and the cleanness and sanitation of the interior of the subpackage pipe 206 are favorably maintained.

The embodiments of the present invention are disclosed as the preferred embodiments, but not limited thereto, and those skilled in the art can easily understand the spirit of the present invention and make various extensions and changes without departing from the spirit of the present invention.

Claims

1. A blood component separator is characterized by comprising a separator body, a consumable component matched with the separator body, and a temperature control device for controlling the temperature of the separator; the consumable component comprises a centrifugal cup (100) and a collecting system (200) and a pipeline system (300) which are connected with the centrifugal cup; the centrifugal cup (100) comprises a cup body (101) and a cup bottom (102), and the cup bottom (102) of the centrifugal cup (100) is provided with a plurality of liquid channels (105).

2. A blood component separator according to claim 1, wherein: an outer core (103) is arranged in the cup body (101), the lower end of the outer core (103) is arranged on the upper end face of the cup bottom (102), and the inner cavity of the cup body (101) is divided into a first cavity located outside the outer core (103) and a second cavity located in the outer core (103) through the outer core (103).

3. A blood component separator according to claim 2, wherein: be connected with on the outer core (103) interior roof inner wall inner core (104), and the lower extreme fixed connection of inner core (104) is on the up end of bottom of cup (102), through inner core (104) separates the third chamber in outer core (103), first chamber with the third chamber passes through liquid channel (105) intercommunication, support frame (106) fixed connection protection head (107) is passed through to cup (101) upper end, protection head (107) lower extreme fixed connection central catheter (108), umbrella (109) in protection head (107) lower extreme fixed connection, umbrella (110) outside inner umbrella (109) upper end fixed connection, support frame (106) lower extreme has filled up backing sheet (111), it has elastic ring (112) to install in protection head (107) lower extreme.

4. A blood component separator according to claim 3, wherein: the pipeline system (300) comprises two first conduits (301), the first conduits (301) are fixedly connected with one side of the upper end of the centrifugal cup (100), a T-shaped tee joint (302) is fixedly connected onto the first conduit (301) at the lower end, a pressure monitor (303) is fixedly connected onto the lower end of the T-shaped tee joint (302), one side, far away from the centrifugal cup (100), of the first conduit (301) at the lower end is fixedly connected with an outer cone straight-through sleeve (304), one side, far away from the centrifugal cup (100), of the outer cone straight-through sleeve (304) is fixedly connected with a straight-through protective sleeve (305), the outer cone straight-through sleeve (304) penetrates through the straight-through protective sleeve (305) to be connected with the collection system (200), the first conduit (301) at the upper end is fixedly connected with a pump pipe (306), one side, far away from the first conduit (301), of the pump pipe (306) is fixedly connected with a blood filter assembly (307), one side, far away from the pump pipe (306), of the blood filter assembly (307) is fixedly connected with an inner cone straight-through sleeve (317), the inner cone straight-through (317) upper end fixed connection first three-way pipe (308), first three-way pipe (308) upper end fixed connection Y type tee bend (309), first sampling bag (310) and needle holder (311) of Y type tee bend (309) upper end fixed connection, pump line (306) and first pipe (301) are all fixed mounting on mounting panel (312), pump line (306) one side fixed connection liquid medicine filter (313), pump line (306) one side fixed connection shifts bag (314), first three-way pipe (308) top fixed mounting needle guard (315), needle guard (315) upper end fixed connection pjncture needle protective sheath (316).

5. A blood component separator according to claim 4, wherein: the collection system (200) comprises a collection bag (201), a blood transfusion socket (202) is formed in one side of the upper end of the collection bag (201), the middle of the upper end of the collection bag (201) is fixedly connected with a second three-way pipe (203) through a hose, the second three-way pipe (203) is connected with an outer cone straight-through pipe (304), the second three-way pipe (203) is far away from a five-way pipe (205) fixedly connected to one side of the outer cone straight-through pipe (304), the ports of the five-way pipe (205) are respectively fixedly connected with a sub-packaging pipe (206), the upper end of the sub-packaging pipe (206) is respectively fixedly connected with a silicon rubber sealing connector (207), and the upper end of the collection bag (201) is far away from a second sampling bag (208) fixedly connected to one side of the blood transfusion socket (202).

6. A blood component separator according to claim 5, wherein: the centrifuge body is further provided with a peristaltic pump (10), a bowl photoelectric sensor (20), a first valve (30), a second valve (40) and a platelet scale (50), wherein the peristaltic pump (10) is arranged on the upper portion of the centrifuge body, the bowl photoelectric sensor (20) is arranged on the side wall of the centrifuge cup (100), the first valve (30) and the second valve (40) are respectively arranged on the outer front face of the centrifuge body, and the platelet scale (50) is arranged on the outer side face of the centrifuge body.

7. A blood component separator according to claim 6, wherein: the centrifuge comprises a centrifuge body, wherein a centrifuge bowl (400) used for fixing a centrifuge cup (100) is arranged in the centrifuge body, a centrifuge bin cover (500) used for sealing the centrifuge bowl (400) is arranged at the outer end of the centrifuge bin body, one end of the centrifuge bin cover (500) is movably connected to the upper end face of the centrifuge body through a hinge (501), a coil spring (502) capable of enabling the centrifuge bin cover (500) to be automatically opened is arranged in the hinge (501), one end of the hinge (501) is connected to the inner side of the centrifuge bin body through a rotating shaft (503), the coil spring (502) is wound on the rotating shaft (503), the other end of the hinge (501) is fixedly connected to the centrifuge bin cover (500) through a hinge rotating seat (504), a centrifuge bin cover lock (600) is arranged at the other end of the centrifuge bin cover (500), and the centrifuge bin cover lock (600) locks the centrifuge bin cover (500) on the upper end face of the centrifuge bin body, the centrifuge cover lock (600) comprises a toggle plate (601) arranged on the upper end surface of the centrifuge body, a backing plate (602) fixedly connected with the upper end of the centrifugal bin body is arranged at the front side of the poking plate (601), a clamping block (603) is connected to the upper end of the backing plate (602) in a swinging manner, a clamping protrusion (604) is arranged at the front end of the clamping block (603), a limiting block (610) is arranged at the rear end of the clamping block (603), the limiting block (610) is positioned above the backing plate (602), the front side of the clamping block (603) is provided with a supporting frame (605) which is fixedly connected with the upper end of the centrifugal bin body, a locking block (606) is arranged at the upper end of the supporting frame (605) in a swinging way, one side of the locking block (606) is arranged in a first clamping groove (607) matched with the clamping bulge (604), a second clamping groove (608) is formed in the upper end of the locking block (606), and a return spring (609) is arranged between the lower end of the locking block (606) and the support frame (605) in a cushioning mode; the outer end of the centrifuge bin cover (500) is provided with a cup cover hook (505), and the cup cover hook (505) is matched with the second clamping groove (608).

8. A blood component separator according to any one of claims 1-7, wherein: the temperature control device comprises a temperature sensor, a refrigerator, a radiator and a control device (700), the temperature sensor is arranged inside the centrifugal bin body, the refrigerator and the radiator are both arranged outside the centrifugal bin body, the temperature sensor is connected with the control device (700), the temperature in the centrifugal bin is conducted into the control device (700), and the control device (700) controls the on and off of the series circuit, so that the control of the refrigerator and the radiator is realized.

9. A blood component separator according to claim 8, wherein: the control device (700) comprises a support box (701) and a heat conducting plate (702), the heat conducting plate (702) is fixedly inserted in the support box (701), one end, located outside the support box (701), of the heat conducting plate (702) is connected with a temperature sensor, a movable piston (703) is movably arranged in the support box (701), the support box (701) is divided into a first accommodating cavity and a second accommodating cavity by the movable piston (703), the heat conducting plate (702) is arranged in the second accommodating cavity, mercury is stored in the second accommodating cavity, one end, far away from the second accommodating cavity, of the movable piston (703) is fixedly connected with a movable support rod (704), the movable support rod (704) is movably inserted on a sealing plate (705), the sealing plate (705) is fixedly connected in the support box (701), and a reset spring (706) is wound outside the movable support rod (704), and the both ends of reset spring (706) are fixed connection respectively on the lateral wall of removal bracing piece (704) and the lateral wall of closing plate (705), the free end fixedly connected with supporting plate (707) of removal bracing piece (704), and the lateral wall fixedly connected with No. two electrode contact (709) of supporting plate (707), fixedly connected with and No. two electrode contact (709) assorted electrode contact (708) on the inside wall of supporting box (701), the one end fixedly connected with No. three electrode contact (710) of No. two electrode contact (709) are kept away from to supporting plate (707), fixedly connected with and No. three electrode contact (711) assorted electrode contact (710) on closing plate (705), and No. four electrode contact (711) movable sleeve is established outside removal bracing piece (704).

10. A method of using a blood component separator comprising the blood component separator of any one of claims 1-9, comprising coarse collection and fine conditioning, the coarse collection comprising the steps of:

the method comprises the following steps: anticoagulated whole blood is collected into a centrifuge cup which rotates at high speed through a peristaltic pump (10);

step three: separating out plasma, and collecting the plasma in a plasma transferring bag;

step four: after the bowl photoelectric sensor (20) detects the interface of the plasma and the red blood cells, the collection of anticoagulated whole blood is stopped at the right time;

step six: after washing the platelet and hardening, collect the platelet, the theoretical collection volume of plasma is calculated according to patient's blood item parameter of inputing in advance to the machine, and control module control valve, platelet poor plasma get into and shift the bag, and control system sets up the colour of line inductor or after the extinction printing opacity data in advance, reaches the value of settlement, and control module control valve, platelet get into the product bag, accomplish the coarse collection.

The fine adjustment comprises the following steps: