CN103800954A - Device and method for separating small-capacity blood components - Google Patents

Device and method for separating small-capacity blood components Download PDF

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Publication number
CN103800954A
CN103800954A CN201410059408.6A CN201410059408A CN103800954A CN 103800954 A CN103800954 A CN 103800954A CN 201410059408 A CN201410059408 A CN 201410059408A CN 103800954 A CN103800954 A CN 103800954A
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China
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pipeline
blood
bag
whole blood
anticoagulant
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CN201410059408.6A
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CN103800954B (en
Inventor
李飞
谢新强
杨周伟
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Sichuan Nigale Biomedical Inc
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Sichuan Nigale Biomedical Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation

Abstract

The invention discloses a device and method for separating small-capacity blood components. The device and method aim to solve the problems that currently, domestically voluntary blood donation blood components are mainly separated in a manual work mode, in the mode, the purity of the blood components acquired through separation is low, blood resources are severely wasted, labor and time are wasted, efficiency is extremely low, and blood can be further wasted due to breakage of blood bags. The device comprises a machine hemostix, a first pipeline, a first three-way connector, a combination pump clamp, a second pipeline, an anticoagulant adding device and the like, wherein the first pipeline is connected with the machine hemostix, and the second pipeline is arranged on the combination pump clamp. When the device is used for voluntary blood donation (300ml to 400ml), rapid blood collection can be achieved and the blood components of whole blood can be separated immediately, and the multiple blood components can be gathered, separated and collected at one time. In the process of use, the whole blood can be automatically gathered only through a blood collection point or a blood collection vehicle, the device is used for separating and collecting the blood components, and eventually collection bags filled with the blood components are taken down.

Description

A kind of low capacity blood ingredient separator and separation method thereof
Technical field
The present invention relates to medical instruments field, especially blood sampling medical instruments field, is specially a kind of low capacity blood ingredient separator and separation method thereof.Blood bag manual method used when device of the present invention can substitute blood station blood donation (300ml~400ml) both at home and abroad at present gathers whole blood, can realize and automatically gather, separate, collect multiple blood component, there is quick, accurate, easy, pollution-free, blood component separation purity advantages of higher.
Background technology
At present, the separation of the domestic blood component to blood donation mainly relies on the mode of manual work to complete.The process of its separation is as follows: first medical personnel put by blood sampling or blood-collecting car gathers whole blood, and whole blood composition is kept in blood bag; The whole blood being kept in blood bag is admitted in blood station, and carries out heavy centrifugalize by Beckman centrifuge, then adopts manual clamping plate to separate each blood constituent, separates the component blood obtaining and is transferred in transfering bag, finally adopts heat sealing pipeline.
Adopt the mode of this manual separating blood constituents, the blood component purity obtaining is low, and blood resource waste is serious, time-consuming, efficiency is extremely low, and blood bag need to carry out high speed centrifugation simultaneously, has the loss of broken bag rate 3%, causes further aggravation of blood waste.Blood is as precious resource, extremely precious, should avoid its waste, therefore, and in the urgent need to a kind of new device is provided, to address the above problem.
Summary of the invention
Goal of the invention of the present invention is: separate the main manual work mode that relies on for the at present domestic blood component to blood donation and complete, which exists and separates the problem that the blood component purity obtaining is low, blood resource waste is serious, time-consuming, efficiency is extremely low, the breakage of blood bag can cause blood further to be wasted, and a kind of low capacity blood ingredient separator and separation method thereof are provided.When device of the present invention is used for blood donation (300ml~400ml), can realize the blood component separation of taking a blood sample fast and immediately completing whole blood, the object that once realization gathers, separates and collect multiple blood component.That the present invention has is quick, accurate, easy, pollution-free, the response rate is high, safety, blood component separation purity advantages of higher, can effectively simplify blood separation flow process, improves the quality of blood separation composition, avoids the unnecessary waste of blood.When use, only need to automatically gather whole blood by blood sampling point/blood-collecting car, and use device of the present invention to separate and collect, finally take off and collect the collecting bag that has blood constituent.
To achieve these goals, the present invention adopts following technical scheme:
A kind of low capacity blood ingredient separator, comprises machine hemostix, the first pipeline being connected with hemostix with machine, the first three way cock, combination pump card, be arranged on the second pipe on combination pump card, anticoagulant adding set, that be connected with anticoagulant adding set and be arranged on the 3rd pipeline on combination pump card, the second three way cock, the 5th pipeline, be connected with the 5th pipeline for collecting the whole blood bag of whole blood, the 6th pipeline, the 3rd three way cock, the 7th pipeline, be provided with the 8th pipeline of intermediate plate, the erythrocyte bag being connected with the 8th pipeline, whole blood pump card, separate cup, plasma bags, leukocyte bag, platelet bag, be arranged on the 9th pipeline being connected on whole blood pump card and with the entrance point of separate cup, be arranged on the tenth pipeline being connected on whole blood pump card and with plasma bags, the pipeline sniffer being connected with the port of export of separate cup, described the first three way cock's three ends respectively with the first pipeline, second pipe, the 3rd pipeline be connected, described the second three way cock's three ends respectively with second pipe, the 5th pipeline, the 6th pipeline be connected, described the 3rd three way cock's three ends respectively with the 6th pipeline, the 7th pipeline, the 8th pipeline be connected, described the 7th pipeline respectively with the 9th pipeline, the tenth pipeline is connected, and the port of export of described separate cup is respectively by being provided with flexible pipe and the plasma bags of intermediate plate, leukocyte bag, platelet bag is connected.Between each several part, form the blood circulation of sealing.
On described the first pipeline, be provided with liquid stopping clamp.
Described machine hemostix is blood taking needle.
Described the first three way cock is Y-type three way type joint.
Described the second three way cock is T-shaped three way cock.
The volume of described separate cup is 125mL.
Described anticoagulant adding set comprises the perforator, the dropping funnel that are connected with anticoagulant, and described perforator is connected with the 3rd pipeline by dropping funnel.
Described combination pump card, whole blood pump card are connected with peristaltic pump respectively.
The method that adopts aforementioned means separating whole blood, comprises the steps:
(1) whole blood collection: first machine is connected with blood donor's vein with hemostix, drive second pipe, the 3rd pipeline on combination pump card by peristaltic pump again, the anticoagulant being connected with anticoagulant adding set is sent in the first three way cock by anticoagulant adding set, the 3rd pipeline successively, after anticoagulant mixes with the blood in the first pipeline, again in second pipe is sent into whole blood bag, reach and set after blood sampling volume, stop blood sampling, complete quantitative whole blood collecting work;
(2) blood separation, collect: drive whole blood pump card by peristaltic pump, blood in whole blood bag is sent into and in separate cup, carried out centrifugalize by the 9th pipeline, according to the density variation of blood component, first separate cup is sent to blood plasma in plasma bags by flexible pipe, and then by moving the tenth pipeline of whole blood pump cassette tape of peristaltic pump, the 9th pipeline, blood plasma in plasma bags is passed through to the tenth pipeline successively, the 9th pipeline is sent in separate cup, platelet is gone out to the separate cup port of export and enter in platelet bag, leukocyte in last separate cup is sent in leukocyte bag by flexible pipe, after pipeline sniffer detects that leukocyte has been collected, separate cup stops operating, then peristaltic pump reversion is by moving the 9th pipeline of whole blood pump cassette tape, the 7th pipeline, erythrocyte in separate cup is entered in erythrocyte bag, complete blood separation, collection work.
In described step 1, anticoagulant is sodium citrate anticoagulant.
For the problem of aforementioned existence, the invention provides a kind of low capacity blood ingredient separator and separation method thereof, blood collection, separation, collection work while can be used in blood donation (300ml~400ml).
When device work of the present invention, blood is successively by machine hemostix, the first pipeline, and mix with the anticoagulant of sending in the first three way cock after the 3rd pipeline, after mixing, send in whole blood bag through second pipe, the 5th pipeline successively again, complete the collection work of blood.In the present invention, combination pump card is simultaneously to the 3rd pipeline, second pipe effect, and it mainly contains the advantage of three aspects:: 1) make anticoagulant can mix in specific proportions with blood, mixing uniformity is good, and anticoagulant consumption is controlled; 2) guarantee that anticoagulant and blood have corresponding interpolation speed, have simplified operating process; 3) anticoagulant, blood are adopted respectively independent peristaltic pump drive, change into and adopt same peristaltic pump to drive, reduced equipment investment, reduced use cost, improved the stability of system.
Blood after collection, under the drive of whole blood pump card, is sent into and in separate cup, is carried out centrifugalize through the 5th pipeline, the second three way cock, the 6th pipeline, the 7th pipeline, the 9th pipeline successively.According to the density variation of blood component, first separate cup exports the blood plasma of density minimum to be sent in plasma bags by separate cup and collects; And then by moving the tenth pipeline of whole blood pump cassette tape, the 9th pipeline of peristaltic pump, blood plasma in the plasma bags being connected with the 9th pipeline is sent in separate cup by the tenth pipeline, the 9th pipeline successively, platelet is gone out the separate cup port of export by the blood plasma being sent in separate cup, and send in platelet bag, complete hematoblastic collection work; Then the leukocyte in separate cup is sent in leukocyte bag by flexible pipe; After pipeline sniffer detects that leukocyte has been collected, separate cup stops operating, then peristaltic pump reversion, by moving the 9th pipeline of whole blood pump cassette tape, the 7th pipeline, enters in erythrocyte bag the erythrocyte in separate cup, completes blood separation, collection work.Pipeline sniffer can be Electro-Optical Sensor Set, is arranged on the flexible pipe of the separate cup port of export.Because hematoblastic density ratio blood plasma is slightly large, the platelet purity that adopts usual manner to obtain is lower, second-rate, and therefore, the present invention has carried out brand-new improvement and design.The present invention is by ingehious design, and for the feature of different component, the disposable mask work that completes respective components, has and separate the feature quick, purity is good, efficiency is high, and saving of work and time, significantly improves efficiency.Meanwhile, the present invention has avoided the damaged risk causing when blood bag is carried out to centrifugalize, can effectively avoid blood resource waste, improves the utilization rate of blood.
Device collection whole blood of the present invention collection, blood component separate, automatically monitor and be collected as one, realize efficient, automatic collection, separated and collect, can substitute the manual hard work that gathers whole blood, manual separation and collect by hand of domestic and international generally employing at present.Device of the present invention is that a kind of collection efficiency is high, separating effect is better, the time is short, the blood component automatic separating apparatus of clinical low capacity blood easy to use, in conjunction with method of the present invention, can complete fast whole blood collection, component separating and collection work.
Accompanying drawing explanation
Examples of the present invention will be described by way of reference to the accompanying drawings, wherein:
Fig. 1 is the structural representation of device of the present invention.
Labelling in figure: 1 is machine hemostix, and 2 is the first pipeline, and 3 is the first three way cock, 4 is combination pump card, and 5 is second pipe, and 6 is the 3rd pipeline, 9 is the second three way cock, and 10 is the 5th pipeline, and 11 is whole blood bag, 12 is the 6th pipeline, and 13 is the 3rd three way cock, and 14 is the 7th pipeline, 15 is the 8th pipeline, 16 is erythrocyte bag, and 17 is whole blood pump card, and 18 is separate cup, 19 is plasma bags, 20 is leukocyte bag, and 21 is platelet bag, and 22 is the 9th pipeline, 23 is the tenth pipeline, 24 is pipeline sniffer, and 25 is perforator, and 26 is dropping funnel.
The specific embodiment
Disclosed all features in this description, or step in disclosed all methods or process, except mutually exclusive feature and/or step, all can combine by any way.
Disclosed arbitrary feature in this description, unless narration especially all can be replaced by other equivalences or the alternative features with similar object.,, unless narration especially, each feature is an example in a series of equivalences or similar characteristics.
Embodiment 1
As shown in the figure, the inventive system comprises machine hemostix, the first pipeline, the first three way cock, combination pump card, second pipe, the 3rd pipeline, anticoagulant adding set, the second three way cock, the 5th pipeline, whole blood bag, the 6th pipeline, the 3rd three way cock, the 7th pipeline, be provided with the 8th pipeline of intermediate plate, erythrocyte bag, whole blood pump card, separate cup, plasma bags, leukocyte bag, platelet bag, the 9th pipeline, the tenth pipeline, pipeline sniffer, second pipe, the 3rd pipeline is separately positioned on combination pump card, that is: second pipe, the 3rd pipeline is respectively through combination pump card.On the first pipeline, be provided with liquid stopping clamp, the first three way cock is preferably Y-type three way type joint, and the second three way cock is T-shaped three way cock, and anticoagulant adding set comprises the perforator, the dropping funnel that are connected with anticoagulant, and perforator is connected with the 3rd pipeline by dropping funnel.Machine is connected with the first three way cock by the first pipeline with hemostix, and the first three way cock's three ends are connected with the first pipeline, second pipe, the 3rd pipeline respectively.The second three way cock's three ends are connected with second pipe, the 5th pipeline, the 6th pipeline respectively, and the 5th pipeline is connected with whole blood bag.The 3rd three way cock's three ends are connected with the 6th pipeline, the 7th pipeline, the 8th pipeline respectively, and the 8th pipeline is connected with erythrocyte bag, and the 7th pipeline is connected with the 9th pipeline, the tenth pipeline that are arranged on whole blood pump card respectively.One end of whole blood being sent into separate cup is entrance point, and the other end is the port of export.The 9th pipeline is connected with the entrance point of separate cup, and the tenth pipeline is connected with plasma bags, and pipeline sniffer is connected with the port of export of separate cup, and the port of export of separate cup is connected with plasma bags, leukocyte bag, platelet bag by the flexible pipe that is provided with intermediate plate respectively simultaneously.Between each several part, be tightly connected into closed self-circulating system.Wherein, whole blood bag is used for collecting whole blood, and plasma bags is used for collecting blood plasma, and leukocyte bag is used for collecting leukocyte, and platelet bag is for hematoblastic collection, and separate cup is low capacity separate cup.
The using method of this device is as follows.
(1) whole blood collection
First machine is connected with blood donor's vein with hemostix, drive second pipe, the 3rd pipeline on combination pump card by peristaltic pump again, sodium citrate anticoagulant in the anticoagulant bag being connected with anticoagulant adding set is sent in the first three way cock by anticoagulant adding set, the 3rd pipeline successively, after anticoagulant mixes with the blood in the first pipeline, again in second pipe is sent into whole blood bag, reach and set after blood sampling volume, stop blood sampling, complete quantitative whole blood collecting work.
(2) blood separation, collection
Drive whole blood pump card by peristaltic pump, blood in whole blood bag is sent into and in separate cup, carried out centrifugalize by the 9th pipeline, according to the density variation of blood component, first separate cup is sent to blood plasma in plasma bags by flexible pipe, and then by moving the tenth pipeline of whole blood pump cassette tape of peristaltic pump, the 9th pipeline, blood plasma in plasma bags is passed through to the tenth pipeline successively, the 9th pipeline is sent in separate cup, platelet is gone out to the separate cup port of export and enter in platelet bag, leukocyte in last separate cup is sent in leukocyte bag by flexible pipe, after pipeline sniffer detects that leukocyte has been collected, separate cup stops operating, then peristaltic pump reversion is by moving the 9th pipeline of whole blood pump cassette tape, the 7th pipeline, erythrocyte in separate cup is entered in erythrocyte bag, complete blood separation, collection work.
The present invention is not limited to the aforesaid specific embodiment.The present invention expands to any new feature or any new combination disclosing in this manual, and the arbitrary new method disclosing or step or any new combination of process.

Claims (8)

1. a low capacity blood ingredient separator, is characterized in that, comprises machine hemostix, the first pipeline being connected with hemostix with machine, the first three way cock, combination pump card, be arranged on the second pipe on combination pump card, anticoagulant adding set, that be connected with anticoagulant adding set and be arranged on the 3rd pipeline on combination pump card, the second three way cock, the 5th pipeline, be connected with the 5th pipeline for collecting the whole blood bag of whole blood, the 6th pipeline, the 3rd three way cock, the 7th pipeline, be provided with the 8th pipeline of intermediate plate, the erythrocyte bag being connected with the 8th pipeline, whole blood pump card, separate cup, plasma bags, leukocyte bag, platelet bag, be arranged on the 9th pipeline being connected on whole blood pump card and with the entrance point of separate cup, be arranged on the tenth pipeline being connected on whole blood pump card and with plasma bags, the pipeline sniffer being connected with the port of export of separate cup, described the first three way cock's three ends respectively with the first pipeline, second pipe, the 3rd pipeline be connected, described the second three way cock's three ends respectively with second pipe, the 5th pipeline, the 6th pipeline be connected, described the 3rd three way cock's three ends respectively with the 6th pipeline, the 7th pipeline, the 8th pipeline be connected, described the 7th pipeline respectively with the 9th pipeline, the tenth pipeline is connected, and the port of export of described separate cup is respectively by being provided with flexible pipe and the plasma bags of intermediate plate, leukocyte bag, platelet bag is connected.
2. low capacity blood ingredient separator according to claim 1, is characterized in that, on described the first pipeline, is provided with liquid stopping clamp.
3. low capacity blood ingredient separator according to claim 1, is characterized in that, described machine hemostix is blood taking needle.
4. according to low capacity blood ingredient separator described in claim 1-3 any one, it is characterized in that, described the first three way cock is Y-type three way type joint.
5. low capacity blood ingredient separator according to claim 1, is characterized in that, described the second three way cock is T-shaped three way cock.
6. according to low capacity blood ingredient separator described in claim 1-5 any one, it is characterized in that, described anticoagulant adding set comprises the perforator, the dropping funnel that are connected with anticoagulant, and described perforator is connected with the 3rd pipeline by dropping funnel.
7. according to the method for installing separating whole blood described in claim 1-6 any one, it is characterized in that, comprise the steps:
(1) whole blood collection: first machine is connected with blood donor's vein with hemostix, drive second pipe, the 3rd pipeline on combination pump card by peristaltic pump again, the anticoagulant being connected with anticoagulant adding set is sent in the first three way cock by anticoagulant adding set, the 3rd pipeline successively, after anticoagulant mixes with the blood in the first pipeline, again in second pipe is sent into whole blood bag, reach and set after blood sampling volume, stop blood sampling, complete quantitative whole blood collecting work;
(2) blood separation, collect: drive whole blood pump card by peristaltic pump, blood in whole blood bag is sent into and in separate cup, carried out centrifugalize by the 9th pipeline, according to the density variation of blood component, first separate cup is sent to blood plasma in plasma bags by flexible pipe, and then by moving the tenth pipeline of whole blood pump cassette tape of peristaltic pump, the 9th pipeline, blood plasma in plasma bags is passed through to the tenth pipeline successively, the 9th pipeline is sent in separate cup, platelet is gone out to the separate cup port of export and enter in platelet bag, leukocyte in last separate cup is sent in leukocyte bag by flexible pipe, after pipeline sniffer detects that leukocyte has been collected, separate cup stops operating, then peristaltic pump reversion is by moving the 9th pipeline of whole blood pump cassette tape, the 7th pipeline, erythrocyte in separate cup is entered in erythrocyte bag, complete blood separation, collection work.
8. method according to claim 7, is characterized in that, in described step 1, anticoagulant is sodium citrate anticoagulant.
CN201410059408.6A 2014-02-21 2014-02-21 A kind of low capacity blood ingredient separator Active CN103800954B (en)

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Cited By (3)

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CN105816928A (en) * 2016-05-27 2016-08-03 四川南格尔生物科技有限公司 Blood composition acquisition device and method
CN108577863A (en) * 2018-04-26 2018-09-28 江苏伯纳德生物科技发展有限公司 A kind of full-automatic whole blood acquisition piece-rate system
CN110732051A (en) * 2019-09-19 2020-01-31 刘雅 kinds of blood platelet collecting and storing device

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CN108577863A (en) * 2018-04-26 2018-09-28 江苏伯纳德生物科技发展有限公司 A kind of full-automatic whole blood acquisition piece-rate system
CN110732051A (en) * 2019-09-19 2020-01-31 刘雅 kinds of blood platelet collecting and storing device
CN110732051B (en) * 2019-09-19 2021-11-12 山东中保康医疗器具有限公司 Platelet collection and storage device

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