JPH0463860B2 - - Google Patents

Info

Publication number

JPH0463860B2

JPH0463860B2 JP10944384A JP10944384A JPH0463860B2 JP H0463860 B2 JPH0463860 B2 JP H0463860B2 JP 10944384 A JP10944384 A JP 10944384A JP 10944384 A JP10944384 A JP 10944384A JP H0463860 B2 JPH0463860 B2 JP H0463860B2

Authority

JP

Japan

Prior art keywords

mecobalamin

present

ulcers

peptic

mice

Prior art date

1984-05-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
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• JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 claims description 29
• 229960005321 mecobalamin Drugs 0.000 claims description 28
• 239000011585 methylcobalamin Substances 0.000 claims description 28
• 235000007672 methylcobalamin Nutrition 0.000 claims description 28
• 208000008469 Peptic Ulcer Diseases 0.000 claims description 9
• 208000011906 peptic ulcer disease Diseases 0.000 claims description 3
• 239000004615 ingredient Substances 0.000 claims description 2
• 239000003814 drug Substances 0.000 description 9
• 230000000694 effects Effects 0.000 description 9
• 241000699670 Mus sp. Species 0.000 description 7
• 229940124597 therapeutic agent Drugs 0.000 description 6
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
• 208000025865 Ulcer Diseases 0.000 description 4
• 238000000034 method Methods 0.000 description 4
• 231100000397 ulcer Toxicity 0.000 description 4
• 230000015572 biosynthetic process Effects 0.000 description 3
• 230000000144 pharmacologic effect Effects 0.000 description 3
• 230000001737 promoting effect Effects 0.000 description 3
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• 230000001988 toxicity Effects 0.000 description 3
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• 102000001554 Hemoglobins Human genes 0.000 description 2
• 108010054147 Hemoglobins Proteins 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 206010029240 Neuritis Diseases 0.000 description 2
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• 208000007502 anemia Diseases 0.000 description 2
• 239000002775 capsule Substances 0.000 description 2
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• 238000002474 experimental method Methods 0.000 description 2
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
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• SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 2
• 229940088594 vitamin Drugs 0.000 description 2
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• 239000011782 vitamin Substances 0.000 description 2
• 229930003231 vitamin Natural products 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• 206010002065 Anaemia megaloblastic Diseases 0.000 description 1
• 208000035404 Autolysis Diseases 0.000 description 1
• 201000006390 Brachial Plexus Neuritis Diseases 0.000 description 1
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• 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
• 241000483002 Euproctis similis Species 0.000 description 1
• 208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
• 206010023177 Jejunal ulcer Diseases 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 208000000682 Megaloblastic Anemia Diseases 0.000 description 1
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• 206010049567 Miller Fisher syndrome Diseases 0.000 description 1
• 208000012902 Nervous system disease Diseases 0.000 description 1
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• 206010036105 Polyneuropathy Diseases 0.000 description 1
• 208000037062 Polyps Diseases 0.000 description 1
• 241000700157 Rattus norvegicus Species 0.000 description 1
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• 230000007665 chronic toxicity Effects 0.000 description 1
• 231100000160 chronic toxicity Toxicity 0.000 description 1
• FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical class [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
• 239000005515 coenzyme Substances 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 239000013078 crystal Substances 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 231100000517 death Toxicity 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 238000001647 drug administration Methods 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 230000002183 duodenal effect Effects 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• 231100001016 megaloblastic anemia Toxicity 0.000 description 1
• 210000003007 myelin sheath Anatomy 0.000 description 1
• 230000023105 myelination Effects 0.000 description 1
• 210000004126 nerve fiber Anatomy 0.000 description 1
• 208000004296 neuralgia Diseases 0.000 description 1
• 201000001119 neuropathy Diseases 0.000 description 1
• 230000007823 neuropathy Effects 0.000 description 1
• 230000001175 peptic effect Effects 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 208000019629 polyneuritis Diseases 0.000 description 1
• 230000002980 postoperative effect Effects 0.000 description 1
• 239000001054 red pigment Substances 0.000 description 1
• 230000008929 regeneration Effects 0.000 description 1
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• 206010044652 trigeminal neuralgia Diseases 0.000 description 1