JPH0443052B2 - - Google Patents

Info

Publication number
JPH0443052B2
JPH0443052B2 JP57502451A JP50245182A JPH0443052B2 JP H0443052 B2 JPH0443052 B2 JP H0443052B2 JP 57502451 A JP57502451 A JP 57502451A JP 50245182 A JP50245182 A JP 50245182A JP H0443052 B2 JPH0443052 B2 JP H0443052B2
Authority
JP
Japan
Prior art keywords
theophylline
sustained release
micropellets
polyvinylpyrrolidone
coat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP57502451A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58501128A (ja
Inventor
Chiin Hishingu Hishiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Key Pharmaceuticals Inc
Original Assignee
Key Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Key Pharmaceuticals Inc filed Critical Key Pharmaceuticals Inc
Publication of JPS58501128A publication Critical patent/JPS58501128A/ja
Publication of JPH0443052B2 publication Critical patent/JPH0443052B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP57502451A 1981-07-15 1982-07-08 徐放性テオフイリン Granted JPS58501128A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28344681A 1981-07-15 1981-07-15
US283446 1981-07-15
US37230082A 1982-04-27 1982-04-27
US372300 1982-04-27

Publications (2)

Publication Number Publication Date
JPS58501128A JPS58501128A (ja) 1983-07-14
JPH0443052B2 true JPH0443052B2 (pt) 1992-07-15

Family

ID=26962050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57502451A Granted JPS58501128A (ja) 1981-07-15 1982-07-08 徐放性テオフイリン

Country Status (6)

Country Link
EP (1) EP0083372B1 (pt)
JP (1) JPS58501128A (pt)
AT (1) ATE34300T1 (pt)
DE (1) DE3278491D1 (pt)
MY (1) MY100081A (pt)
WO (1) WO1983000284A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984000004A1 (en) * 1982-06-14 1984-01-05 Key Pharma Sustained release aspirin
EP0113373B1 (en) * 1982-07-09 1991-08-28 Key Pharmaceuticals, Inc. Sustained release quinidine dosage form
IE55745B1 (en) * 1983-04-06 1991-01-02 Elan Corp Plc Sustained absorption pharmaceutical composition
JPH0729927B2 (ja) * 1983-04-09 1995-04-05 日研化学株式会社 テオフィリン徐放性製剤
SE8404808L (sv) * 1983-10-03 1985-04-04 Avner Rotman Mikrokapslat lekemedel i sot matris
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
IE58246B1 (en) * 1984-12-21 1993-08-11 Byk Gulden Lomberg Chem Fab Theophylline sustained release formulation
WO1987006098A1 (en) * 1986-04-07 1987-10-22 Rorer International (Overseas) Inc. Method for the preparation of a sustained release pharmaceutical composition and the composition prepared thereby
US5026709A (en) * 1986-04-07 1991-06-25 Rorer Pharmaceutical Corporation Method for the preparation of a theophylline sustained release pharmaceutical composition and the composition prepared thereby
US4891223A (en) * 1987-09-03 1990-01-02 Air Products And Chemicals, Inc. Controlled release delivery coating formulation for bioactive substances
US5068110A (en) * 1987-09-29 1991-11-26 Warner-Lambert Company Stabilization of enteric coated dosage form
US4925675A (en) * 1988-08-19 1990-05-15 Himedics, Inc. Erythromycin microencapsulated granules
US4925674A (en) * 1988-08-25 1990-05-15 Himedics, Inc. Amoxicillin microencapsulated granules
US5255228A (en) * 1989-01-10 1993-10-19 Matsushita Electronics Corporation Semiconductor memory device with redundancy circuits
US5162110A (en) * 1990-12-19 1992-11-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Binding theophylline to ion exchange resins
WO2009112874A1 (en) * 2008-03-10 2009-09-17 Eurodrug Laboratories B.V. Modified release composition comprising doxofylline

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2811483A (en) * 1954-12-09 1957-10-29 Pfizer & Co C Pharmaceutical composition and process for preparing the same
US2853420A (en) * 1956-01-25 1958-09-23 Lowey Hans Ethyl cellulose coatings for shaped medicinal preparations
US2928770A (en) * 1958-11-28 1960-03-15 Frank M Bardani Sustained action pill
US3081233A (en) * 1960-08-08 1963-03-12 Upjohn Co Enteric-coated pilules
NL297088A (pt) * 1961-01-31
US3247066A (en) * 1962-09-12 1966-04-19 Parke Davis & Co Controlled release dosage form containing water-swellable beadlet
NL297631A (pt) * 1963-06-03
US3400185A (en) * 1965-04-08 1968-09-03 Bristol Myers Co Agglomeration of smaller pharmaceutical particles into larger microspherules and enteic-coating thereof
DE2010416B2 (de) * 1970-03-05 1979-03-29 Hoechst Ag, 6000 Frankfurt Oral anwendbare Arzneiform mit Retardwirkung
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
JPS5512411B2 (pt) * 1974-03-12 1980-04-02
US4173626A (en) * 1978-12-11 1979-11-06 Merck & Co., Inc. Sustained release indomethacin

Also Published As

Publication number Publication date
EP0083372A1 (en) 1983-07-13
MY100081A (en) 1989-08-18
DE3278491D1 (en) 1988-06-23
WO1983000284A1 (en) 1983-02-03
EP0083372A4 (en) 1985-02-28
JPS58501128A (ja) 1983-07-14
ATE34300T1 (de) 1988-06-15
EP0083372B1 (en) 1988-05-18

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