JPH0437861Y2 - - Google Patents

Description

[Detailed description of the invention] (a) Industrial application field The present invention relates to an external patch for covering and protecting a wound or for continuously administering a drug into a living body through the outer skin.

(b) Prior art Transdermal administration of drugs is less troublesome during administration than oral administration, injections, suppositories, etc., and also does not undergo liver metabolism, does not cause gastrointestinal disorders, and is easy to release drugs. It has advantages such as being able to reduce the number of times of administration and being painless during administration because it is administered continuously, and it is expected that more and more types of drugs will be administered transdermally in the future.

A variety of external patches are known, including bandages, but when applied to curved parts of the human body or areas where the skin stretches and contracts, they cannot follow the bending and expansion and contraction of the skin. Poor adhesives cause peeling, while adhesives with good adhesiveness prevent the skin from stretching and bending, resulting in a feeling of tightness or discomfort.

Therefore, in order to make it applicable to bent parts of the human body and areas where the skin is highly elastic, an ultra-thin stretchable film or other support should be used as a support for supporting the pressure-sensitive adhesive composition layer. is being attempted.

Conventionally, this type of topical patch is shown in Figure 9a.
The one shown in (and FIG. 9b) is known.

In the figure, a rectangular external patch 1 includes a flexible support 2, a pressure-sensitive adhesive polymer composition layer 3 formed on one side of the support 2, and an exposed pressure-sensitive adhesive polymer composition layer 3. It consists of a release sheet 4 provided on the surface.

The release sheet 4 is divided into two parts by cuts 5, 5 parallel to the left and right side edges 4', 4' at the middle part of the left and right sides of the release sheet 4, whereby the release sheet 4 is separated from the left and right release sheet pieces 4a. , 4b and a central release sheet piece 4c.

(c) Problems to be solved by the invention When applying the above external patch 1 to the outer skin of the human body, the central release sheet piece 4c is rolled up as shown in Figure 9a and the pressure-sensitive adhesive polymer composition is removed. After partially exposing the material layer 3 and adhering the exposed portion 3' to the outer skin, for example, the right release sheet piece 4b is rolled up while being pulled to the right to release the pressure-sensitive adhesive polymer composition. While exposing the right side of layer 3, attach this exposed area to the outer skin, and then attach the release sheet piece 4 on the left side.
A was pulled to the left and rolled up to expose the left side of the pressure-sensitive adhesive polymer composition layer 3, and this exposed portion was adhered to the outer skin.

However, since the support 2 of the external patch 1 is made of a flexible film, when the central release sheet piece 4c is peeled off, as shown in FIG. 9b, the pressure-sensitive adhesive polymer composition As a result of the problem that the exposed portion 3' of the layer 3 is bent approximately at the center of the left and right sides, and both sides thereof adhere to each other and become difficult to peel off, the above-mentioned topical patch has a serious problem in terms of handling. It was hot.

(d) Means for solving the problem In order to solve the above problem, the inventors of the present invention have made various changes in the form of the release sheet, and as a result, they have found that this kind In external patches applied to areas with large degrees of skin elasticity,
When removing the release sheet piece that is to be peeled off first, the remaining release sheet pieces are configured so that they partially butt against each other, thereby preventing the exposed areas of the pressure-sensitive adhesive polymer composition layer from folding over. find something to do, that is, to prevent them from gluing together,
This led to the completion of this invention.

That is, the gist of the topical patch of the present invention is that a polymer composition layer having pressure-sensitive adhesive properties at room temperature is formed on a flexible support, and the exposed surface of the polymer composition layer is covered with a release sheet. In the patch consisting of, the release sheet is composed of at least three release sheet pieces,
A part of the release sheet pieces other than the part to be peeled off and removed first is characterized in that at least one part of the release sheet pieces is in contact with or close to each other in the part to be removed. be.

The above-mentioned external patch is not particularly limited as long as it can be applied to the human body, such as a so-called bandage that does not itself contain drugs,
Alternatively, various adhesive patches such as tape preparations containing a transdermally absorbable drug in a pressure-sensitive adhesive polymer composition layer are included.

The present invention provides the above-mentioned various external patches, in which the release sheet is formed of at least three release sheet pieces, and when the first release sheet piece is peeled off, the remaining release sheet pieces partially overlap each other. A major feature is that the exposed areas of the pressure-sensitive adhesive polymer composition layer are not overlapped by sticking together.

The remaining release sheet pieces stick together at least one of the upper and lower ends of the exposed area of the pressure-sensitive adhesive polymer composition layer, the upper and lower intermediate positions, or one of the upper and lower ends of the exposed area of the pressure-sensitive adhesive polymer composition layer. There are various forms, such as two places, the upper and lower middle places, and three places, the upper and lower ends and the upper and lower middle places, but in particular, the above-mentioned butt-pushing places are the exposed places where the upper and lower ends are 2
It is preferable that there are three or more locations, or a total of three or more locations, including both upper and lower ends and upper and lower middle locations.

In addition, the release sheet pieces may stick to each other partially, or when the release sheet pieces are rolled up, the pressure-sensitive adhesive polymer composition This also includes cases where the exposed areas of the material layer are close enough to each other that they do not overlap.

(e) Effect The release sheet of the topical patch of the present invention is composed of at least three release sheet pieces, and when the first of these release sheet pieces is peeled off, the remaining release sheet pieces do not touch each other. By sticking them together, the exposed portions of the pressure-sensitive adhesive polymer composition layer do not overlap.

(f) Examples Hereinafter, examples of the present invention will be explained in more detail with reference to the drawings, but the present invention is not limited thereto, and various embodiments are possible without departing from the technical idea. .

In Figures 1a to 1c, 1 is a rectangular external patch in plan view, and the external patch 1 includes a flexible support 2 and a pressure-sensitive adhesive at room temperature formed on one side of the support 2. It is comprised of a polymer composition layer 3 showing the following: and a release sheet 4 covering the exposed surface of the polymer composition layer 3.

In addition, external patch 1 shown in FIGS. 2 to 8, respectively.
Although not shown in the drawings, it has the same configuration as the external patch 1 described above.

In the present invention, the release sheet 4 is constructed as described below.

That is, the release sheet 4 is composed of at least three release sheet pieces, and when the release sheet piece to be peeled off first among the release sheet pieces is peeled off, the remaining release sheet pieces partially stick to each other. It is configured as follows.

Examples of the configuration in which the release sheet pieces are stuck together include the following configuration.

As shown in FIG. 1a, the left and right intermediate parts of the release sheet 4 are divided into spindle shapes, thereby forming the release sheet piece 4 into three pieces: the left and right release sheet pieces 4a, 4b and the central release sheet piece 4c. Alternatively, as shown in FIG. 2, the left and right center portions of the release sheet 4 are divided 5 into an inverted Y-shape, thereby forming an isosceles triangular release layer at the lower center. It may be composed of three sheets: the sheet piece 4c and the left and right release sheet pieces 4a and 4b.
In this case, by widening the angle of the apex of the isosceles triangular release sheet piece 4c, as shown in FIG.
Each of a and 4b may be formed into a trapezoidal shape.

Also, instead of forming the isosceles triangular release sheet pieces 4c, 4c in the central part as shown in FIGS. 2 and 3, respectively, the central part is formed as shown in FIGS. 4 and 5. The release sheet pieces 4c, 4c may be cut into a parabolic shape to form approximately semi-elliptical release sheet pieces 4c, 4c in the center, respectively.Alternatively, as shown in FIG. The release sheet piece 4c may be formed in an isosceles triangular shape with a size extending from the top to the bottom end.

The release sheet 4 shown in FIGS. 1 to 6 above is
All of them are divided into three parts, and three release sheet pieces 4a,
4b, 4c, when peeling off the center release sheet piece 4c, the left and right release sheet pieces 4a,
As a result, a part of the release sheet piece 4b comes into contact with the central release sheet piece 4c at a location corresponding to the apex and sticks together.
During this peeling, the exposed portions 3' of the polymer composition layer 3 do not overlap and adhere to each other.

Furthermore, the release sheet 4 shown in FIG. 7 has a different form from the one described above, and the center part of the release sheet 4 is cut into an approximately gourd shape, thereby forming left and right release sheet pieces 4a. , 4b are configured to be close to each other at two locations in total: the upper end and the upper and lower middle locations.

In this configuration, when the central release sheet piece 4c is rolled up from the upper end, the exposed portion of the polymer composition layer 3 tends to overlap, but the left and right release sheet pieces 4a and 4b are rolled up from the upper end and above and below. As a result of the close tautness at the intermediate locations, folding of the exposed locations is prevented.

Furthermore, the release sheet 4 shown in FIG. 8 is a modification of the release sheet 4 shown in FIG.
Instead of placing the parts close to each other, the left and right release sheet pieces 4a and 4b are configured to come into contact with each other at the two parts, and therefore,
The release sheets 4 shown in FIGS. 1 to 7 are all 3
In contrast, in this embodiment, it is composed of four release sheet pieces 4a, 4b, 4c, and 4d.

The release sheet 4 of this embodiment has the same effect as the one in FIG. 7, but in this case, the left and right release sheet pieces 4a and 4b come into contact at two places, especially at their upper ends and at the upper and lower intermediate points. As a result, folding of the exposed portion of the polymer composition layer 3 is more reliably prevented.

(g) Effects of the invention The external patch of the invention comprises a release sheet that covers the exposed surface of the polymer composition layer that has pressure-sensitive adhesive properties at room temperature, consisting of at least three release sheet pieces;
When this external patch is applied to the human body, when the first release sheet piece is peeled off and removed, the remaining release sheet pieces partially stick to each other, causing the polymer composition to The exposed portions of the layers do not overlap and adhere to each other, and as a result, it can be easily handled by any number of people.

[Brief explanation of the drawing]

Fig. 1a is a plan view showing an embodiment of the present invention, Fig. 1b is a sectional view thereof, Fig. 1c is a perspective view showing a state in which the release sheet piece to be peeled off first is peeled off, and Figs.
Fig. 8 is a plan view showing other embodiments, Fig. 9a
9 is a perspective view showing a conventional external patch, and FIG. 9b is a sectional view showing its disadvantageous effect. 1... External patch, 2... Support, 3... Polymer composition layer, 4... Release sheet, 4a, 4b, 4
c, 4d...Peelable sheet piece.

Claims (1)

[Scope of utility model registration request] A patch comprising a polymer composition layer having pressure-sensitive adhesive properties at room temperature formed on a flexible support, and the exposed surface of the polymer composition layer covered with a release sheet,
The release sheet is composed of at least three release sheet pieces, and a part of the release sheet piece other than the part to be peeled and removed first among the release sheet pieces is at least one place in the removal part of the release sheet piece, A patch for external use that is characterized by being in contact with or in close proximity to each other.